Perander-Maria-Face.jpg
Perander-Maria-Face.jpg
Department of Medical Biology maria.perander@uit.no +4777649253 Tromsø MH L9.251

Maria Perander


Associate Professor

Job description

Associate Professor at the Department of Medical Biology, RNA and Molecular Pathology group


  • Tellez Gabriel, Marta; Tekpli, Xavier; Reine, Trine M.; Hegge, Beate; Nielsen, Stephanie Rose; Chen, Meng; Moi, Line; Normann, Lisa Svartdal; Rasmussen Busund, Lill-Tove; Calin, George A.; Mælandsmo, Gunhild Mari; Perander, Maria; Theocharis, Achilleas D.; Kolset, Svein Olav; Knutsen, Erik. Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue. Frontiers in Oncology 2022; Volum 12:868868. ISSN 2234-943X.s 1 - 13.s doi: 10.3389/fonc.2022.868868.
  • Knutsen, Erik; Harris, Adrian; Perander, Maria. Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer. British Journal of Cancer 2021. ISSN 0007-0920.s doi: 10.1038/s41416-021-01588-3.
  • Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria. Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies. International Journal of Molecular Sciences 2020. ISSN 1661-6596.s doi: 10.3390/ijms21249457.
  • Knutsen, Erik; Lellahi, Seyed Mohammad; Aure, Miriam Ragle; Nord, Silje; Fismen, Silje; Larsen, Kenneth Bowitz; Tellez Gabriel, Marta; Hedberg, Annica; Bjørklund, Sunniva; Bofin, Anna M.; Mælandsmo, Gunhild Mari; Sørlie, Therese; Mortensen, Elin Synnøve; Perander, Maria. The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers. Scientific Reports 2020; Volum 10:1277. ISSN 2045-2322.s 1 - 14.s doi: 10.1038/s41598-020-57759-4.
  • Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria. The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response. Journal of Biological Chemistry 2018; Volum 293 (49). ISSN 0021-9258.s 18965 - 18976.s doi: 10.1074/jbc.RA118.004473.
  • Figenschau, Stine; Knutsen, Erik; Urbarova, Ilona; Fenton, Christopher Graham; Elston, Bryan; Perander, Maria; Mortensen, Elin Synnøve; Fenton, Kristin Andreassen. ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Scientific Reports 2018; Volum 8:11720. ISSN 2045-2322.s 1 - 12.s doi: 10.1038/s41598-018-29604-2.
  • Hedberg, Annica; Knutsen, Erik; Løvhaugen, Anne Silje; Jørgensen, Tor Erik; Perander, Maria; Johansen, Steinar Daae. Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair. Mitochondrial DNA. Part A, DNA Mapping, Sequencing, and Analysis 2018; Volum 30 (1). ISSN 2470-1394.s 82 - 91.s doi: 10.1080/24701394.2018.1461852.
  • Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2. Scientific Reports 2017; Volum 7. ISSN 2045-2322.s doi: 10.1038/srep43471.
  • Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar. Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition. Cancer Letters 2017; Volum 396. ISSN 0304-3835.s 117 - 129.s doi: 10.1016/j.canlet.2017.03.019.
  • Perander, Maria; Keyse, Stephen M; Seternes, Ole Morten. New insights into the activation, interaction partners and possible functions of MK5/PRAK. Frontiers in Bioscience 2016; Volum 21 (2). ISSN 1093-9946.s 374 - 384.
  • Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, maria; Seternes, Ole Morten. Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines. PLOS ONE 2016; Volum 11 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0161824.
  • Knutsen, Erik; Perander, maria; Fiskaa, Tonje; Johansen, Steinar Daae. Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research. Springer 2015 ISBN 978-3-319-15811-2.s doi: 10.1007/978-3-319-15811-2_15.
  • Knutsen, Erik; Fiskaa, Tonje; Ursvik, anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar; Andreassen, morten. Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines. PLOS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0075813.
  • Åberg, espen; Torgersen, Knut Martin; Johansen, Bjarne Herold; Keyse, Stephen M; Perander, maria; Seternes, ole morten. Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif. Journal of Biological Chemistry 2009; Volum 284 (29). ISSN 0021-9258.s 19392 - 19401.s doi: 10.1074/jbc.M109.023283.
  • Perander, maria; Keyse, Stephen M; Seternes, ole morten. Does MK5 reconcile classical and atypical MAP kinases?. Frontiers in Bioscience 2008; Volum 13. ISSN 1093-9946.s 4617 - 4624.
  • Perander, maria; Åberg, espen; Johansen, Bjarne Herold; Dreyer, Bo; Guldvik, Ingrid Jenny; Outzen, heidi; Keyse, Stephen M; Seternes, ole morten. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. Biochemical Journal 2008; Volum 411. ISSN 0264-6021.s 613 - 622.s doi: 10.1042/BJ20071369.
  • Michaelsen, espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. Journal of Biological Chemistry 2006; Volum 281 (46). ISSN 0021-9258.s 35499 - 35510.
  • Bjørkøy, G; Lamark, T; Brech, Andreas; Outzen, H; Perander, M; Øvervatn, A; Stenmark, Harald Alfred; Johansen, T.. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. Journal of Cell Biology 2005; Volum 171. ISSN 0021-9525.s 603 - 614.
  • Bjørkøy, Geir; Lamark, Trond; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. Journal of Cell Biology 2005; Volum 171. ISSN 0021-9525.s 603 - 614.
  • Lamark, Trond; Perander, maria; Outzen, Heidi; Kristiansen, kurt; Øvervatn, Aud Karin; Michaelsen, Espen; Bjørkøy, Geir; Johansen, Terje. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.. (fulltekst) Journal of Biological Chemistry 2003; Volum 10 (278(36)). ISSN 0021-9258.s 34568 - 34581.s doi: 10.1074/jbc.M303221200.
  • Nornes, Svanhild; Mikkola, Ingvild; Krauss, Stefan; Delghandi, Madjid; Perander, maria; Johansen, Terje. Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences. Journal of Biological Chemistry 1996; Volum 271 (43). ISSN 0021-9258.s 26914 - 26923.
  • Knutsen, Erik; Perander, Maria. Forhøyede nivåer av NEAT1 er assosiert med HER2 positiv brystkreft. 2020.
  • Knutsen, Erik; Perander, maria; Johansen, Steinar Daae; Andreassen, morten. Study of functional RNA using high-throughput profiling technologies in a human cell model system. Cell Symposia: Functional RNA’s 2012-12-02 - 2012-12-04 2012.
  • Perander, maria; Stiberg, Trine; Myhren, Lene Elisabeth; Hansen, Espen; Seternes, ole morten; Herfindal, Lars; Andersen, Jeanette hammer; Jørgensen, Trond Ø.. Characterization of cytotoxic activities in extracts from two marine invertebrates. Bioprosp 2011 2011-02-23 - 2011-02-25 2011.
  • Stiberg, Trine; Perander, maria; Andersen, Jeanette hammer; Jørgensen, Trond Ø.. Screening for compounds from Artic and sub_Artic marine invertebrates with anti-canser activities. BIOPROSP2009 2009-02-24 - 2009-02-26 2009.
  • Åberg, Espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4. 15th Protein Kinase Meeting 2006-09-21 - 2006-09-24 2006.
  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. Imaging Week 2006-11-13 - 2006-11-15 2006.
  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. 4th International Symposium on Autophagy: Exploring the Froniers of Autophagy Research 2006-10-01 - 2006-10-05 2006.
  • Bjørkøy, Geir; Lamark, Trond; Pankiv, Serliy; Brech, A; Outzen, heidi; Perander, maria; Øvervatn, Aud; Stenmark, H; Johansen, Terje. P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3. Invited oral presentation 2006-11-16 - 2006-11-16 2006.
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    Research interests

    My research group is interested in long non-coding RNAs that have a potential role in breast cancer development and therapy. Currently, we have two on-going projects:

    1.       Identification and characterization of lncRNAs with regulatory functions in epithelial-mesenchymal transition (EMT)

    2.       Unravelling the function of Nuclear paraspeckle assembly transcript 1 (NEAT1) and paraspeckles in cellular stress responses and breast cancer

    We have performed whole-transcriptome RNA sequencing of 3 mammary EMT cell models (MCF10A, HMLE, and D492). Several EMT-associated lncRNAs have been identified that are abnormally expressed in breast cancer. We are conducting experimental assays to determine their cellular functions.

    NEAT1 is an abundant nuclear lncRNA that is conserved among mammals. The NEAT1 gene is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear ribonucleoprotein bodies called paraspeckles. Abnormal NEAT1 expression and paraspeckle formation are associated with human diseases such as neurodegenerative disorders and cancer. NEAT1 levels and paraspeckle formation are upregulated in response to cellular stress, and emerging evidence suggests that they play a cytoprotective role. In line with this, high NEAT1 levels are associated with therapy resistance in cancer.  We are currently studying the function of NEAT1 and paraspeckles in cellular stress response pathways such as the heat shock response and autophagy. We are also interested in the role of the NEAT1 isoforms in breast cancer.