Bilde av Johannessen, Mona
Bilde av Johannessen, Mona
Department of Medical Biology mona.johannessen@uit.no +4777646225 Tromsø MH L9.212

Mona Johannessen


Professor

Job description

I am head of Research Group for Host-Microbe interaction (HMI) that studies the interplay between host and microbe with the goal to find new strategies for rapid diagnostic as well as colonization and infection prevention/treatment. I am also highly involved in tearching at courses at bachelor-, master- and PhD level.


  • Lisa Myrseth Hemmingsen, Pimmat Panchai, Kjersti Julin, Purusotam Basnet, Mona Nystad, Mona Johannessen et al.:
    Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine
    Frontiers in Microbiology 2022 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection
    Biomacromolecules 2021 ARKIV / DOI
  • Laura Schulte Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Natasa Skalko-Basnet et al.:
    Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
    Pharmaceutics 2021 ARKIV / DOI
  • Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad et al.:
    Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus
    Microorganisms 2021 ARKIV / DOI
  • Lisa Myrseth Hemmingsen, Kjersti Julin, Luquman Mian Ahsan, Purusotam Basnet, Mona Johannessen, Natasa Skalko-Basnet :
    Chitosomes-in-chitosan hydrogel for acute skin injuries: Prevention and infection control
    Marine Drugs 2021 ARKIV / DOI
  • Bishnu Joshi, Bhupender Singh, Aftab Nadeem, Fatemeh Askarian, Sun Nyunt Wai, Mona Johannessen et al.:
    Transcriptome profiling of staphylococcus aureus associated extracellular vesicles reveals presence of small RNA-cargo
    Frontiers in Molecular Biosciences 13. January 2021 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections
    Journal of Controlled Release 2020 ARKIV / DOI
  • Adriana Maria Sanabria-Moreno, Erik Hjerde, Mona Johannessen, Johanna U Ericson Sollid, Gunnar Skov Simonsen, Anne Merethe Hanssen :
    Shotgun-Metagenomics on Positive Blood Culture Bottles Inoculated With Prosthetic Joint Tissue: A Proof of Concept Study
    Frontiers in Microbiology 2020 ARKIV / DOI
  • May Wenche Jøraholmen, Mona Johannessen, Kirsten Midttun Gravningen, Mirja Puolakkainen, Ganesh Acharya, Purusotam Basnet et al.:
    Liposomes-in-hydrogel delivery system enhances the potential of resveratrol in combating vaginal chlamydia infection
    Pharmaceutics 11. December 2020 ARKIV / DOI
  • May Wenche Jøraholmen, Abhilasha Bhargava, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    The Antimicrobial Properties of Chitosan Can be  Tailored by Formulation
    Marine Drugs 2020 ARKIV / DOI
  • Adriana Maria Sanabria-Moreno, Merethe E.O. Røkeberg, Mona Johannessen, Johanna U Ericson Sollid, Gunnar Skov Simonsen, Anne Merethe Hanssen :
    Culturing periprosthetic tissue in BacT/Alert® Virtuo blood culture system leads to improved and faster detection of prosthetic joint infections
    BMC Infectious Diseases 2019 ARKIV / DOI
  • Selenia Ternullo, Eivind Gagnat, Kjersti Julin, Mona Johannessen, Purusotam Basnet, Željka Vanić et al.:
    Liposomes augment biological benefits of curcumin for multitargeted skin therapy
    European journal of pharmaceutics and biopharmaceutics 2019 DOI
  • Jorunn Pauline Cavanagh, Fatemeh Askarian, Maria Pain, Jack-Ansgar Bruun, Ilona Urbarova, Sun Nyunt Wai et al.:
    Proteome profiling of secreted and membrane vesicle associated proteins of an invasive and a commensal Staphylococcus haemolyticus isolate.
    Data in Brief 2019 ARKIV / DOI
  • Mitesh Dongre, Bhupender Singh, Kyaw Min Aung, Per Larsson, Regina Miftakhova, Karina Persson et al.:
    Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts
    Communications Biology 2018 ARKIV / DOI
  • Fatemeh Askarian, John D. Lapek Jr., Mitesh Dongre, Chih-Ming Tsai, Monika Kumaraswamy, Armin Kousha et al.:
    Staphylococcus aureus Membrane-derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
    Frontiers in Microbiology 2018 ARKIV / DOI
  • Clement Ajayi, espen Åberg, Fatemeh Askarian, Johanna U Ericson Sollid, Mona Johannessen, Anne Merethe Hanssen :
    Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.
    BMC Microbiology 16. April 2018 ARKIV / DOI
  • Theresa Wagner, Bishnu Joshi, Jessin Janice James Peter, Fatemeh Askarian, Natasa Skalko-Basnet, Ole Christian Hagestad et al.:
    Enterococcus faecium produces membrane vesicles containing virulence factors and antimicrobial resistance related proteins
    Journal of Proteomics 2018 ARKIV / DOI
  • Fatemeh Askarian, Theresa Wagner, Mona Johannessen, Victor Nizet :
    Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors
    FEMS Microbiology Reviews 2018 DOI
  • Theresa Wagner, Jessin Janice James Peter, Fernanda Paganelli, Rob J.L. Willems, Fatemeh Askarian, Torunn Annie Pedersen et al.:
    Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood
    International Journal of Microbiology 2018 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Maria Pain, Fatemeh Askarian, Jack-Ansgar Bruun, Ilona Urbarova, Sun Nyunt Wai et al.:
    Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
    Journal of Proteomics 2018 ARKIV / DOI
  • Kjersti Julin, Annette Bayer, Morten Bøhmer Strøm, Mona Johannessen, Natasa Skalko-Basnet, Sybil Akua Okyerewa Obuobi :
    DNA Nanocarriers for improved biofilm penetration
    2022
  • Mona Johannessen :
    Antibiotika-resistens- hva er det og hva gjør vi med det?
    Foredrag for skoleelever i forbindelse med Forskningsdagene 2022 2022
  • Ingeborg Mathiesen, Mona Johannessen, Kristin Hegstad, Theresa Wagner :
    Characterisation of putative virulence factors in Enterococcus faecium
    2022
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Zwitterionic Nanohybrids for the Treatment of Wound Biofilms
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Zwitterionic hybrid nanoparticles for the treatment of biofilm wound infections
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Multi-responsive and Zwitterionic Nanohybrids for the Treatment of Biofilm Wound Infections
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    ZWITTERIONIC NUCLEIC ACID HYBRIDS FOR THE TREATMENT OF BIOFILM INFECTIONS
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Multi-responsive and Zwitterionic Nanohybrids for the Treatment of Biofilm Wound Infections
    2021
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of Nucleic Acid Nanogels to Enhance Entrapment Efficiency and Sustain Release of Antibiotics against Staphylococcal intracellular infections
    2020
  • Srijana Bastakoti, Clement Ajayi, Mona Johannessen, Anne Merethe Hanssen :
    Identification of key determinants for S. aureus throat colonization: A transcriptomic approach
    2020
  • Theresa Wagner, Mona Johannessen, Kristin Hegstad :
    Towards a vaccine based on enterococcal membrane vesicles
    2020
  • Theresa Wagner, Clement Ajayi, Mona Johannessen, Kristin Hegstad, Gro Grimnes, Ingrid Hemmingsen :
    Brukermøte 2020
    2020
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Pål Jarle Johnsen, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of antibiotic loaded DNA nanogels against intracellular infections
    2020
  • Adriana Maria Sanabria-Moreno, Gunnar Skov Simonsen, Mona Johannessen, Johanna U Ericson Sollid, Erik Hjerde, Anne Merethe Hanssen :
    Metagenomics on prosthetic joint tissue samples inoculated in blood culture bottles: a proof of concept study
    2019
  • Theresa Wagner, Clement Ajayi, Kristin Hegstad, Mona Johannessen, Gro Grimnes, Ingrid Hemmingsen :
    Brukermøte 2019
    2019
  • Bishnu Joshi, Sun Nyunt Wai, Mona Johannessen, Kristin Hegstad :
    Extracellular vesicle -associated small RNA released by Staphylococcus aureus (MSSA476) grown under stress condition
    2019
  • Theresa Wagner, Mona Johannessen, Kristin Hegstad :
    Investigating the immune response towards enterococcal membrane vesicles
    2019
  • Theresa Wagner, Mona Johannessen, Kristin Hegstad :
    Investigating the immune response towards enterococcal membrane vesicles.
    2019
  • Adriana Maria Sanabria-Moreno, Gunnar Skov Simonsen, Johanna U Ericson Sollid, Mona Johannessen, Anne Merethe Hanssen, Erik Hjerde :
    Metagenomics on prosthetic joint tissue samples inoculated in blood culture bottles
    2019
  • Adriana Maria Sanabria-Moreno, Mona Johannessen, Johanna U Ericson Sollid, Gunnar Skov Simonsen, Anne-Merethe Hanssen :
    Evaluation of BacT/Alert Virtuo blood culture system for culturing of periprosthetic tissue specimens
    2018
  • Selenia Ternullo, Eivind Gagnat, Laura Schulte-Werning, Kjersti Julin, Mona Johannessen, Purusotam Basnet et al.:
    Curcumin-loaded liposomes-in-hydrogel for improved wound therapy: when traditional medicine meets advanced drug delivery systems
    2018
  • Selenia Ternullo, Eivind Gagnat, Laura Schulte-Werning, Kjersti Julin, Mona Johannessen, Purusotam Basnet et al.:
    Curcumin-loaded liposomes-in-hydrogel for improved wound therapy: when traditional medicine meets advanced drug delivery systems
    2018
  • Clement Ajayi, Joan Geoghegan, Fatemeh Askarian, Mona Johannessen :
    Unraveling Staphylococcus aureus MSSA476 SasG virulence properties
    2018 FULLTEKST
  • May Wenche Jøraholmen, Kirsten Midttun Gravningen, Mona Johannessen, Purusotam Basnet, Ganesh Acharya, Natasa Skalko-Basnet :
    Liposomes-in-hydrogel for the local treatment of chlamydia: Controlled delivery of natural substances
    2018
  • Theresa Wagner, Bishnu Joshi, Jessin Janice, Fernanda Paganelli, Rob Willems, Fatemeh Askarian et al.:
    Virulence factors and antibiotic resistance related proteins are associated with membrane vesicles produced by clinically relevant Enterococcus faecium strains (poster)
    2018
  • Theresa Wagner, Bishnu Joshi, Jessin Janice, Fernanda Paganelli, Rob Willems, Fatemeh Askarian et al.:
    Virulence factors and antibiotic resistance related proteins are associated with membrane vesicles produced by clinically relevant Enterococcus faecium strains (talk)
    2018
  • Theresa Wagner, Kristin Hegstad, Mona Johannessen, Torunn Annie Pedersen :
    How to Be a Bad Bug: Virulence Determinants of Enterococcus faecium
    2018
  • Theresa Wagner, Bishnu Joshi, Jessin Janice, Fatemeh Askarian, Natasa Skalko-Basnet, Sun Nyunt Wai et al.:
    Enterococcus faecium releases membrane vesicles containing virulence factors and resistance determinants (poster)
    2017
  • Theresa Wagner, Fernanda Paganelli, Jessin Janice, Rob Willems, Jos Strijp, Mona Johannessen et al.:
    Tir-domain proteins of nosocomial Enterococcus faecium interfere with TLR-2 signaling and enhance growth in blood (talk)
    2017
  • Theresa Wagner, Fernanda Paganelli, Rob Willems, Mona Johannessen, Kristin Hegstad :
    A TIR domain protein of Enterococcus faecium interferes with TLR-2 signaling and enhances growth in blood (poster)
    2017

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    Research interests

    The alarming increase in multidrug resistant bacterial pathogens challenge efficient treatment of common infections. A fundamental understanding of the molecular interactions driving bacterial adhesion to host, and bacterial escape from host immunity, is a key step toward the development of novel antimicrobial therapies.

    We use various approaches to evaluate the adhesive properties of bacterial virulence factors, and have previously shown that S. aureus SdrD specifically with Desmoglein 1, a intercellular junction-protein, expressed by keratinocytes. We have also shown that SdrD have immune evasive properties, and increases bacterial survival in presence of host immunity in vitro and in vivo. By use of similar approach, we are evaluating other virulence factors in their adhesive, invasive and immune evasive properties.