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Bilde av Sveinbjørnsson, Baldur
Bilde av Sveinbjørnsson, Baldur
Professor Department of Medical Biology bsv000@post.uit.no +4777644682 413 44682 Tromsø

Baldur Sveinbjørnsson

Job description

Present employment:
Professor, Immunology Research Group, Faculty of Health Sciences
Institute of Medical Biology, University of Tromsø

  • Mar Falquet, Carla Prezioso, Maria A. Ludvigsen, Jack-Ansgar Bruun, Sara Passerini, Baldur Sveinbjørnsson et al.:
    Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation
    International Journal of Molecular Sciences 2023 ARKIV / DOI
  • Ugo Moens, Sara Passerini, Mar Falquet, Mar Falquet, Baldur Sveinbjørnsson, Valeria Pietropaolo :
    Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
    Viruses 2023 ARKIV / DOI
  • Kashif Rasheed, Ugo Moens, Benedetta Policastro, John Inge Johnsen, Virve Koljonen, Harri Sihto et al.:
    The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Ilio Vitale, Takahiro Yamazaki, Erik Wennerberg, Baldur Sveinbjørnsson, Øystein Rekdal, Sandra Demaria et al.:
    Targeting Cancer Heterogeneity with Immune Responses Driven by Oncolytic Peptides
    Trends in Cancer 2021 DOI
  • Karianne Giller Fleten, Jacobus Johannes Eksteen, Brynjar Mauseth, Ketil André Camilio, Terje Vasskog, Baldur Sveinbjørnsson et al.:
    Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
    Scientific Reports 2021 ARKIV / DOI
  • James Spicer, Aurélien Marabelle, Jean-Francois Baurain, Nina Louise Jebsen, Dag Eirik Jøssang, Ahmad Awada et al.:
    Safety, Antitumor Activity, and T-cell Responses in a Dose-ranging Phase I Trial of the Oncolytic peptide LTX-315 in Patients With Solid Tumors
    Clinical Cancer Research 2021 DOI
  • Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens :
    Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins.
    Virology Journal 2021 ARKIV / DOI
  • Takahiro Yamazaki, Erik Wennerberg, Michal Hensler, Aitziber Buqué, Jeffrey Kraynak, Jitka Fucikova et al.:
    LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells
    Oncoimmunology 2021 ARKIV / DOI
  • Balint Csoboz, Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens :
    Merkel cell polyomavirus and non-Merkel cell carcinomas: Guilty or circumstantial evidence?
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2020 ARKIV / DOI
  • Ibrahim Afolabi Abdulsalam, Kashif Rasheed, Baldur Sveinbjørnsson, Bernhard Ehlers, Ugo Moens :
    Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line.
    Virology Journal 2020 ARKIV / DOI
  • Ketil Andre Camilio, Mengyu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal et al.:
    Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model
    Breast Cancer Research 2019 ARKIV / DOI
  • Hsin-Wei Liao, Christopher Garris, Christina Pfirschke, Steffen Rickelt, Sean Arlauckas, Marie Siwicki et al.:
    LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects
    Cell stress 2019 ARKIV / DOI
  • Conny Tümmler, Gianina Dumitriu, Malin Wickström, Peter Coopman, Andrey Yurjevich Valkov, Per Kogner et al.:
    SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro
    Cancers 2019 ARKIV / DOI
  • Wei Xie, Laura Mondragon, Brynjar Mauseth, Yan Wang, Jonathan Pol, Sarah Levesque et al.:
    Tumor lysis with LTX-401 creates anticancer immunity
    Oncoimmunology 2019 ARKIV / DOI
  • Brynjar Mauseth, Ketil Andre Camilio, Jihua Shi, Clara Louise Hammarström, Øystein Rekdal, Baldur Sveinbjørnsson et al.:
    The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma
    Molecular Therapy Oncolytics 2019 ARKIV / DOI
  • Heng Zhou, Laura Mondragón, Wei Xie, Brynjar Mauseth, Marion Leduc, Allan Sauvat et al.:
    Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals
    Cell Death & Disease 2018 ARKIV / DOI
  • Aelita Gloria Virginia Konstantinell, Dag H Coucheron, Baldur Sveinbjørnsson, Ugo Moens :
    MicroRNAs as potential biomarkers in Merkel cell carcinoma
    International Journal of Molecular Sciences 2018 ARKIV / DOI
  • Lígia C. Gomes-Da-Silva, Liwei Zhao, Lucillia Bezu, Heng Zhou, Allan Sauvat, Peng Liu et al.:
    Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus
    EMBO Journal 2018 DOI
  • Lígia C. Gomes-da-Silva, Ana Joaquina Jimenez, Allan Sauvat, Wei Xie, Sylvie Souquere, Severine Divoux et al.:
    Recruitment of LC3 to damaged Golgi apparatus
    Cell Death and Differentiation 2018 DOI
  • Øyvind Holsbø Hald, Lotte Olsen, Gabriel Gallo-Oller, Lotta Helena Maria Elfman, Cecilie Løkke, Per Kogner et al.:
    Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.
    Oncogene 2018 ARKIV / DOI
  • Kashif Rasheed, Ibrahim Afolabi Abdulsalam, Silje Fismen, Øystein Grimstad, Baldur Sveinbjørnsson, Ugo Moens :
    CCL17/TARC and CCR4 expression in Merkel cell carcinoma
    OncoTarget 2018 ARKIV / DOI
  • Janne M. Nestvold, Mengyu Wang, Ketil Andre Camilio, Severin Zinöcker, Torunn Elisabeth Tjelle, Alf Lindberg et al.:
    Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
    Oncoimmunology 2017 ARKIV / SAMMENDRAG / FULLTEKST / DOI
  • Baldur Sveinbjørnsson, Ketil Andre Camilio, Bengt Erik Haug, Øystein Rekdal :
    LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment
    Future Medicinal Chemistry 2017 ARKIV / DOI
  • Cecilia Dyberg, Susanne Fransson, Teodora Andonova, Baldur Sveinbjørnsson, Jessika Lannerholm-Palm, Thale Kristin Olsen et al.:
    Rho-associated kinase is a therapeutic target in neuroblastoma
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2017 ARKIV / DOI
  • Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Maria Elfman et al.:
    Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
    OncoTarget 2017 ARKIV / DOI
  • Timofey Sovershaev, Dusten Unruh, Baldur Sveinbjørnsson, John T. Fallon, John-Bjarne Hansen, Vladimir Y. Bogdanov et al.:
    A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human monocytic cells
    Thrombosis Research 2016 DOI
  • Liv-Marie Eike, Brynjar Mauseth, Ketil Andre Camilio, Øystein Rekdal, Baldur Sveinbjørnsson :
    The cytolytic amphipathic β(2,2)-amino acid LTX-401 induces DAMP release in melanoma cells and causes complete regression of B16 melanoma
    PLOS ONE 2016 ARKIV / DOI
  • Christian Rushfeldt, Uwe Agledahl, Baldur Sveinbjørnsson, Kjetil Søreide, Tom Wilsgaard :
    Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis
    World Journal of Surgery 2016 ARKIV / DOI
  • Aelita Gloria Virginia Konstantinell, Jack-Ansgar Bruun, randi Olsen, Augusta Hlin Aspar, Natasa Skalko-Basnet, Baldur Sveinbjørnsson et al.:
    Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines
    Proteomics 2016 DOI
  • Cristina Ionica Øie, Igor Snapkov, Kjetil Elvevold, Baldur Sveinbjørnsson, Bård Smedsrød :
    FITC conjugation markedly enhances hepatic clearance of N-formyl peptides
    PLOS ONE 2016 ARKIV / DOI
  • Igor Snapkov, Carl Otto Öqvist, Yngve Anton Figenschau, Per Kogner, John Inge Johnsen, Baldur Sveinbjørnsson :
    The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
    BMC Cancer 2016 ARKIV / DOI
  • Malin Wickström, Cecilia Dyberg, Jelena Milosevic, Christer Einvik, Raul Calero, Baldur Sveinbjørnsson et al.:
    Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
    Nature Communications 2015 ARKIV / DOI
  • Liv-Marie Eike, Nannan Yang, Øystein Rekdal, Baldur Sveinbjørnsson :
    The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells
    OncoTarget 13. October 2015 ARKIV / DOI
  • Ann Kristin Hansen, Jill-Tove Indrevik, Yngve Anton Figenschau, Inigo Zubiavrre Martinez, Baldur Sveinbjørnsson :
    Human articular chondrocytes express functional leukotriene B<sub>4</sub> receptors
    Journal of Anatomy 2015 ARKIV / DOI
  • Ingvild Nygård, Kim Erlend Mortensen, Jakob Hedegaard, Lene Nagstrup Conley, Christian Bendixen, Baldur Sveinbjørnsson et al.:
    Tissue remodelling following resection of porcine liver
    BioMed Research International 2015 ARKIV / DOI
  • Ugo Moens, Kashif Rasheed, Ibrahim Abdulsalam, Baldur Sveinbjørnsson :
    The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer
    Viruses 2015 ARKIV / DOI
  • Ketil Andre Camilio, Øystein Rekdal, Baldur Sveinbjørnsson :
    LTX-315 (Oncopore™): A short synthetic anticancer peptide and novel immunotherapeutic agent
    Oncoimmunology 2014 DOI
  • Ketil Andre Camilio, gerd Berge, Chandra Sekhar Ravuri, Øystein Rekdal, Baldur Sveinbjørnsson :
    Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315
    Cancer Immunology and Immunotherapy 2014 ARKIV / DOI
  • Lena-Maria Carlson, Anna De Geer, Baldur Sveinbjørnsson, Abiel Orrego, Tommy Martinsson, Per Kogner et al.:
    The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes
    Oncoimmunology 2013 DOI
  • Nina Wolmer-Solberg, Ninib Baryawno, Afsar Rahbar, Dieter Fuchs, Jenny Odeberg, Chato Taher et al.:
    Frequent detection of human cytomegalovirus in neuroblastoma: A novel therapeutic target?
    International Journal of Cancer 2013 DOI
  • Annika Wilzén, Cecilie Krona, Baldur Sveinbjørnsson, Erik Kristiansson, Daniel Dalevi, Ingrid Øra et al.:
    ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
    Molecular Cancer 2013 ARKIV / DOI
  • Ugo Moens, Sergiy Viktorovich Kostenko, Baldur Sveinbjørnsson :
    The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation
    Genes 2013 DOI
  • Kashif Rasheed, Ugo Moens, Baldur Sveinbjørnsson :
    The MCPyV st-ag and IL33/ST2 axis: critical role in merkel cell carcinoma
    Cancer Research 2019 DOI
  • Balint Csoboz, Aelita Gloria Virginia Konstantinell, Natasa Skalko-Basnet, Lui Weng-Onn, Baldur Sveinbjørnsson, Ugo Moens :
    Exosomal microRNA Profiles of Polyomavirus–Positive and -Negative Merkel Cell Carcinomas
    2019
  • Aelita Gloria Virginia Konstantinell, IS Furuholmen, Baldur Sveinbjørnsson, Ugo Moens :
    Effect of Merkel Cell Polyomavirus Lage and Small T-antigen on the Thrombospondin and the Periostin Promoters
    2017
  • Aelita Gloria Virginia Konstantinell, randi Olsen, Augusta Hlin Aspar, Natasa Skalko-Basnet, Dimitar Borisov Iliev, Gianina Dumitriu et al.:
    Characterization and proteome profiling of exosome originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines
    2015
  • Liv-Marie Eike, Nannan Yang, Øystein Rekdal, Baldur Sveinbjørnsson :
    In vitro cytotoxic activities of the membrane active nonapeptide LTX-315 (OncoporeTM) against human melanoma cells
    2014
  • Conny Tümmler, Igor Snapkov, Ugo Moens, Baldur Sveinbjørnsson :
    Chemerin and chemerin receptors in neuroblastoma tumor microenvironment
    2014
  • Igor Snapkov, Per Kogner, John-Inge Johnsen, Baldur Sveinbjørnsson :
    Expression of formyl peptide receptor 1 (FPR1) in neuroblastoma: Implications in tumorigenesis
    2014
  • Ann Kristin Hansen, Jill-Tove Indrevik, Yngve Anton Figenschau, Inigo Zubiavrre Martinez, Baldur Sveinbjørnsson :
    Expression and function of Leukotriene B4 receptors in human articular chondrocytes
    2013 ARKIV

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    Research interests

    • Oncolytic substances
    • preclinical models
    • immunoterapi
    • drug development

    CV

    Qualifications:
    1998: Dr. Philos, Dept. of Experimental Pathology, UiTø, Norway.
    Dr. Philos thesis: Immunomodulation of murine tumors - Studies on cellular mechanisms and mediators.