Photo: Christian Halvorsen
Terje Johansen
Professor
Job description
Professor in Biochemistry and Cell Biology.
Leader and PI of the Autophagy Research Group with selective autophagy as main research interest.
Basic research into the cellular- and molecular mechanisms of selective autophagy involving selective autophagy receptors, ATG8 family proteins, other components of the autophagy machinery.
Scientific leader of Proteomics and Metabolomics Core Facility (PRiME).
Biography
Terje has all his academic education from the University of Tromsø, now UiT The Arctic University of Norway. He obtained a Cand. scient. degree (equivalent to Masters degree) in 1985 on studies of "Vector construction and DNA transformation of Physarum polycephalum" in the Cell Biology group, Department of Medical Biology, Faculty of Health Sciences, with professor Finn Haugli as supervisor. His Dr. scient. degree (equivalent to PhD) was obtained in 1988 in the same group also with FInn Haugli as supervisor. From 1988 to 1991 he was a postdoc on grant from the Research Council of Norway working in the Virology group, Department of Medical Biology, before serving as an associate professor 1990-1991 in the Biotehcnology Group. From 1991 onwards Terje Johansen has been Professor and PI leading his own research group at Department of Medical Biology.
Jianwen Zhou,
Nikoline Lander Rasmussen,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Stéphanie Kaeser-Pebernard,
Trond Lamark,
Joern Dengjel
et al.:
The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR
Autophagy 2023 DOI
Hallvard Lauritz Olsvik,
Terje Johansen
:
AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
PLoS Biology 2023 DOI
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
Nikoline Lander Rasmussen,
Athanasios Kournoutis,
Trond Lamark,
Terje Johansen
:
NBR1: The archetypal selective autophagy receptor
Juncal Garcia Garcia,
Anne Kristin McLaren Berge,
Katrine Stange Overå,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Andreas Brech
et al.:
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage
Yahyah Aman,
Tomas Schmauck-Medina,
Malene Hansen,
Richard I. Morimoto,
Anna Katharina Simon,
Ivana Bjedov
et al.:
Autophagy in healthy aging and disease
Nature Aging 2021 DOI
Aurore Claude-Taupin,
Jingyue Jia,
Zambarlal Bhujabal,
Meriem Garfa-Traore,
Suresh Kumar,
Gustavo Peixoto Duarte da Silva
et al.:
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
Yakubu Princely Abudu,
Stephane Mouilleron,
Sharon A Tooze,
Trond Lamark,
Terje Johansen
:
SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Trond Lamark,
Terje Johansen
:
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
Trond Lamark,
Terje Johansen
:
Mechanisms of Selective Autophagy
Daniel J. Klionsky,
Amal Kamal Abdel-Aziz,
Sara Abdelfatah,
Mahmoud Khaled Abdellatif,
Asghar Abdoli,
Yakubu Princely Abudu
et al.:
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021 DOI
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
Yakubu Princely Abudu,
Birendra Kumar Shrestha,
Wenxin Zhang,
Anthimi Palara,
Hanne Britt Brenne,
Kenneth Bowitz Larsen
et al.:
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
Daniel J. Klionsky,
Giulia Petroni,
Ravi K Amaravadi,
Eric H Baehrecke,
Andrea Ballabio,
Patricia Boya
et al.:
Autophagy in major human diseases
Caiyue Xu,
Lu Wang,
Parinaz Fozouni,
Gry Evjen,
Vemika Chandra,
Jing Jiang
et al.:
SIRT1 is downregulated by autophagy in senescence and ageing
Lu Wang,
Caiyue Xu,
Terje Johansen,
Shelley L. Berger,
Zhixun Dou
:
SIRT1 - a new mammalian substrate of nuclear autophagy
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Eva Sjøttem,
Trond Lamark,
Terje Johansen
:
CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
Anne-Claire Jacomin,
Stavroula Petridi,
Marisa Di Monaco,
Zambarlal Bhujabal,
Ashish Jain,
Nitha C. Mulakkal
et al.:
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Åsa birna Birgisdottir,
Terje Johansen
:
Autophagy and endocytosis – interconnections and interdependencies
Journal of Cell Science 2020 DOI
Thaddaeu Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
CALCOCO1 is a soluble reticulophagy receptor
Autophagy 2020 DOI
S. Petridi,
A.-C. Jacomin,
Zambarlal Bhujabal,
Terje Johansen,
Ioannis P Nezis
:
Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins.
Methods in Cell Biology 2020 DOI
Rocío de la Riva-Carrasco,
Sebastián Perez-Pandolfo,
Sofía Suárez Freire,
Nuria M. Romero,
Zambarlal Bhujabal,
Terje Johansen
et al.:
The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
Anne-Claire Jacomin,
Raksha Gohel,
Zunoon Hussain,
Agnes Varga,
Tamas Maruzs,
Mark Eddison
et al.:
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Arjen J. Jakobi,
Stefan T. Huber,
Simon A. Mortensen,
Sebastian Schultz,
Anthimi Palara,
Tanja Kuhm
et al.:
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
Yakubu Princely Abudu,
Serhiy Pankiv,
Benan John Mathai,
Trond Lamark,
Terje Johansen,
Anne Simonsen
:
NIPSNAP1 and NIPSNAP2 act as “eat me” signals
to allow sustained recruitment of autophagy
receptors during mitophagy
Autophagy 2019 DOI
Aurélien Schwob,
Elodie Teruel,
Louise Dubuisson,
Florence Lormières,
Pauline Verlhac,
Yakubu Princely Abudu
et al.:
SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
Petri Pölonen,
Ashik Jawahar Deen,
Hanna M. Leinonen,
Henna-Kaisa Jyrkkänen,
Suvi Kuosmanen,
Mimmi Mononen
et al.:
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Nicolas Mercado,
Thomas Colley,
Jonathan R. Baker,
Chaitanya Vuppussetty,
Yuta Kono,
Colin Clarke
et al.:
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease
Terje Johansen,
Trond Lamark
:
Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
Yakubu Princely Abudu,
Serhiy Pankiv,
Benan John Mathai,
Alf Håkon Lystad,
Christian Bindesbøll,
Hanne Britt Brenne
et al.:
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
Gry Hoem,
Kenneth Bowitz Larsen,
Aud Karin Øvervatn,
Andreas Brech,
Trond Lamark,
Eva Sjøttem
et al.:
The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
Birendra Kumar Shrestha,
Mads Skytte Rasmussen,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Endalkachew Ashenafi Alemu
et al.:
NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
Stephanie R Kehl,
Brandy-Lee A Soos,
Bhaskar Saha,
Seong Won Choi,
Anthony W Herren,
Terje Johansen
et al.:
TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
Suresh Kumar,
Yuexi Gu,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Ashish Jain,
Farzin Farzam
et al.:
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Mads Skytte Rasmussen,
Åsa birna Birgisdottir,
Terje Johansen
:
Use of Peptide Arrays for Identification and Characterization of LIR Motifs
Yuexi Gu,
Yakubu Princely Abudu,
Suresh Kumar,
Bhawana Bissa,
Seong Won Choi,
Jingyue Jia
et al.:
Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs
Åsa birna Birgisdottir,
Stephane Mouilleron,
Zambarlal Bhujabal,
Martina Wirth,
Eva Sjøttem,
Gry Evjen
et al.:
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Terje Johansen
:
Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1
Katrine Stange Overå,
Juncal Garcia Garcia,
Zambarlal Bhujabal,
Ashish Jain,
Aud Karin Øvervatn,
Kenneth Bowitz Larsen
et al.:
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
Martina Wirth,
Wenxin Zhang,
Minoo Razi,
Lynet Nyoni,
Dhira Joshi,
Nicola O'Reilly
et al.:
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
Terje Johansen
:
Selektiv autofagi: Kildesortering i cellene våre gir sunn aldring
2022 DATA
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TNIP1 is degraded by selective autophagy upon proinflammatory signalling
2021
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
Journal of Molecular Biology (JMB) 2021 DOI
Sebastian Andres Acuña Maldonado,
Ida Sundvor Opstad,
Luis Enrique Villegas Hernandez,
Mona Nystad,
Milton O Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classiflcation
Algorithm (MUSICAL): From Electromagnetics Inverse
Scattering Problem to Optics Inverse Source Problem
2019
Andres Maldonado,
Ida Sundvor Opstad,
Luis Hernández,
Mona Nystad,
Milton Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
2019
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Research interests
Basic research into the cellular- and molecular mechanisms of selective autophagy and cell signaling relevant for cancer, neurodegenerative diseases, aging, inflammation and host defense against intracellular pathogens.
Keywords: Selective autophagy receptors, ATG8 family proteins, LIR motifs, aggrephagy, mitophagy, ER-phagy, Golgiphagy
Teaching
Lecturing on courses:
MBI-2001 Biochemistry - 10 ECTS
MBI-2012 Molecular Cell Biology - Cell structure - 10 ECTS
MBI-3004 The Biology of Cancer - 10 ECTS
MBI-3012 Advanced methods in experimental biomedicine - 30 ECTS
MBI-8007 Molecular and Clinical Aspects of Cancer - Block I - 10 ECTS
