Bilde av Johansen, Terje
Photo: Christian Halvorsen

Terje Johansen


Professor

Job description

Professor in Biochemistry and Cell Biology.

Leader and PI of the Autophagy Research Group with selective autophagy as main research interest.

Basic research into the cellular- and molecular mechanisms of selective autophagy involving selective autophagy receptors, ATG8 family proteins, other components of the autophagy machinery.  

Scientific leader of Proteomics and Metabolomics Core Facility (PRiME).

Biography

Terje has all his academic education from the University of Tromsø, now UiT The Arctic University of Norway. He obtained a Cand. scient. degree (equivalent to Masters degree) in 1985 on studies of "Vector construction and DNA transformation of Physarum polycephalum" in the Cell Biology group, Department of Medical Biology, Faculty of Health Sciences, with professor Finn Haugli as supervisor. His Dr. scient. degree (equivalent to PhD) was obtained in 1988 in the same group also with FInn Haugli as supervisor. From 1988 to 1991 he was a postdoc on grant from the Research Council of Norway working in the Virology group, Department of Medical Biology, before serving as an associate professor 1990-1991 in the Biotehcnology Group. From 1991 onwards Terje Johansen has been Professor and PI leading his own research group at Department of Medical Biology. His research is highly cited with a total of almost 50.000 citations and an h-index of 85.

 


  • Yakubu Princely Abudu, Athanasios Kournoutis, Hanne Britt Brenne, Trond Lamark, Terje Johansen :
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    Molecular Cell 2024 DOI
  • Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    Journal of Cell Biology 2023 ARKIV / DOI
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Stéphanie Kaeser-Pebernard, Trond Lamark, Joern Dengjel et al.:
    The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR
    Autophagy 2023 DOI
  • Hallvard Lauritz Olsvik, Terje Johansen :
    AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
    PLoS Biology 2023 ARKIV / DOI
  • Viola Nahse-Kumpf, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Wenzel et al.:
    ATPase activity of DFCP1 controls selective autophagy
    Nature Communications 2023 ARKIV / DOI
  • Jingyue Jia, Fulong Wang, Zambarlal Babanrao Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque et al.:
    Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
    Journal of Cell Biology 2022 ARKIV / DOI
  • Nikoline Lander Rasmussen, Athanasios Kournoutis, Trond Lamark, Terje Johansen :
    NBR1: The archetypal selective autophagy receptor
    Journal of Cell Biology 2022 ARKIV / DOI
  • Juncal Garcia Garcia, Anne Kristin McLaren Berge, Katrine Stange Overå, Kenneth Bowitz Larsen, Zambarlal Babanrao Bhujabal, Andreas Brech et al.:
    TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
    The FEBS Journal 2022 ARKIV / DOI
  • Jingyue Jia, Fulong Wang, Zambarlal Babanrao Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque et al.:
    Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage
    Autophagy 2022 ARKIV / DOI
  • Yahyah Aman, Tomas Schmauck-Medina, Malene Hansen, Richard I. Morimoto, Anna Katharina Simon, Ivana Bjedov et al.:
    Autophagy in healthy aging and disease
    Nature Aging 2021 DOI
  • Aurore Claude-Taupin, Jingyue Jia, Zambarlal Bhujabal, Meriem Garfa-Traore, Suresh Kumar, Gustavo Peixoto Duarte da Silva et al.:
    ATG9A protects the plasma membrane from programmed and incidental permeabilization.
    Nature Cell Biology 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
    Autophagy 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Stephane Mouilleron, Sharon A Tooze, Trond Lamark, Terje Johansen :
    SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
    Autophagy 2021 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Trond Lamark, Terje Johansen :
    Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
    Journal of Cell Biology 2021 ARKIV / DOI
  • Trond Lamark, Terje Johansen :
    Mechanisms of Selective Autophagy
    Annual Review of Cell and Developmental Biology 2021 ARKIV / DOI
  • Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Khaled Abdellatif, Asghar Abdoli, Yakubu Princely Abudu et al.:
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    Autophagy 2021 DOI
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:
    Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
    Journal of Molecular Biology (JMB) 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Birendra Kumar Shrestha, Wenxin Zhang, Anthimi Palara, Hanne Britt Brenne, Kenneth Bowitz Larsen et al.:
    SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
    Journal of Cell Biology 2021 ARKIV / DOI
  • Daniel J. Klionsky, Giulia Petroni, Ravi K Amaravadi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya et al.:
    Autophagy in major human diseases
    EMBO Journal 2021 ARKIV / DOI
  • Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang et al.:
    SIRT1 is downregulated by autophagy in senescence and ageing
    Nature Cell Biology 2020 ARKIV / DOI
  • Lu Wang, Caiyue Xu, Terje Johansen, Shelley L. Berger, Zhixun Dou :
    SIRT1 - a new mammalian substrate of nuclear autophagy
    Autophagy 2020 ARKIV / DOI
  • Åsa birna Birgisdottir, Terje Johansen :
    Autophagy and endocytosis – interconnections and interdependencies
    Journal of Cell Science 2020 ARKIV / DOI
  • Thaddaeu Mutugi Nthiga, Birendra Kumar Shrestha, Trond Lamark, Terje Johansen :
    CALCOCO1 is a soluble reticulophagy receptor
    Autophagy 2020 ARKIV / DOI
  • Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Eva Sjøttem, Trond Lamark, Terje Johansen :
    CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
    EMBO Journal 2020 ARKIV / DOI
  • Anne-Claire Jacomin, Stavroula Petridi, Marisa Di Monaco, Zambarlal Bhujabal, Ashish Jain, Nitha C. Mulakkal et al.:
    Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
    Cell reports 2020 ARKIV / DOI
  • S. Petridi, A.-C. Jacomin, Zambarlal Bhujabal, Terje Johansen, Ioannis P Nezis :
    Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins.
    Methods in Cell Biology 2020 DOI
  • Rocío de la Riva-Carrasco, Sebastián Perez-Pandolfo, Sofía Suárez Freire, Nuria M. Romero, Zambarlal Bhujabal, Terje Johansen et al.:
    The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
    Traffic: The moving front of cell biology 2020 ARKIV / DOI
  • Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison et al.:
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
    Life Science Alliance (LSA) 2020 ARKIV / DOI
  • Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian Schultz, Anthimi Palara, Tanja Kuhm et al.:
    Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
    Nature Communications 2020 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Trond Lamark, Terje Johansen, Anne Simonsen :
    NIPSNAP1 and NIPSNAP2 act as “eat me” signals to allow sustained recruitment of autophagy receptors during mitophagy
    Autophagy 2019 DOI
  • Aurélien Schwob, Elodie Teruel, Louise Dubuisson, Florence Lormières, Pauline Verlhac, Yakubu Princely Abudu et al.:
    SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
    Scientific Reports 05. November 2019 ARKIV / DOI
  • Petri Pölonen, Ashik Jawahar Deen, Hanna M. Leinonen, Henna-Kaisa Jyrkkänen, Suvi Kuosmanen, Mimmi Mononen et al.:
    Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
    Oncogene 2019 ARKIV / DOI
  • Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke et al.:
    Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease
    FASEB BioAdvances 2019 ARKIV / DOI
  • Terje Johansen, Trond Lamark :
    Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
    Journal of Molecular Biology (JMB) 2019 ARKIV / DOI
  • Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, Alf Håkon Lystad, Christian Bindesbøll, Hanne Britt Brenne et al.:
    NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
    Developmental Cell 11. April 2019 ARKIV / DOI
  • Gry Hoem, Kenneth Bowitz Larsen, Aud Karin Øvervatn, Andreas Brech, Trond Lamark, Eva Sjøttem et al.:
    The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS
    Frontiers in Genetics 2019 ARKIV / DOI
  • Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Endalkachew Ashenafi Alemu et al.:
    NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
    Journal of Biological Chemistry 2019 ARKIV / DOI
  • Stephanie R Kehl, Brandy-Lee A Soos, Bhaskar Saha, Seong Won Choi, Anthony W Herren, Terje Johansen et al.:
    TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
    EMBO Reports 2019 ARKIV / DOI
  • Suresh Kumar, Yuexi Gu, Yakubu Princely Abudu, Jack-Ansgar Bruun, Ashish Jain, Farzin Farzam et al.:
    Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
    Developmental Cell 28. April 2019 ARKIV / DOI
  • Mads Skytte Rasmussen, Åsa birna Birgisdottir, Terje Johansen :
    Use of Peptide Arrays for Identification and Characterization of LIR Motifs
    Methods in molecular biology 2019 ARKIV / DOI
  • Yuexi Gu, Yakubu Princely Abudu, Suresh Kumar, Bhawana Bissa, Seong Won Choi, Jingyue Jia et al.:
    Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs
    EMBO Journal 18. October 2019 ARKIV / DOI
  • Åsa birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen et al.:
    Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
    Autophagy 2019 ARKIV / DOI
  • Athanasios Kournoutis, Terje Johansen :
    LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
    Journal of Cell Biology 2023 DOI
  • Terje Johansen :
    Selektiv autofagi: Kildesortering i cellene våre gir sunn aldring
    2022 DATA
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:
    TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
    2021
  • Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen et al.:
    TNIP1 is degraded by selective autophagy upon proinflammatory signalling
    2021
  • Martina Wirth, Stephane Mouilleron, Wenxin Zhang, Eva Sjøttem, Yakubu Princely Abudu, Ashish Jain et al.:
    Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
    Journal of Molecular Biology (JMB) 2021 DOI
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor et al.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Andres Maldonado, Ida Sundvor Opstad, Luis Hernández, Mona Nystad, Milton Aguilera, Merete Storflor et al.:
    Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
    2019

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    Research interests

    Basic research into the cellular- and molecular mechanisms of selective autophagy and cell signaling relevant for cancer, neurodegenerative diseases, aging, inflammation and host defense against intracellular pathogens. Terje and his group made a major breakthrough in our understanding of selective autophagy by discovering the first selective autophagy receptor p62/SQSTM1 and elucidated how specificity in cargo selection (waste disposal) could be achieved and how autophagy receptors could connect the cargo (waste) to the forming autophagosome. Some main discoveries by Terje and co-workers in the Autophagy Research Group are:

    • Discovered the first selective autophagy receptors p62/SQSTM1 and NBR1
    • Showed that the selective autophagy receptors bound to cargo and to Atg8 family proteins
    • Identified the LIR (LC3 Interacting Region) motif mediating the interaction in the majority of Atg8 interacting proteins
    • Discovered p62 formed protein bodies inside cells that are degraded by autophagy
    • Developed a novel tandem tag fluorescent protein assay to monitor autophagic flux
    • Described the positive feedback loop regulation between p62 and NRF2
    • Found NBR1 as the selective autophagy receptor in plants
    • Discovered NBR1 acting as a pexophagy receptor
    • Discovered the first Golgiphagy receptor, CALCOCO1, also acting in ERphagy
    • Showed Atg8 family proteins to act as membrane-bound scaffolds for autophagy core machinery proteins including the ULK1/2 complexes, the PI3K class III complex and ATG4 proteins.
    • Showed NIPSNAP1 and NIPSNAP2 to act as "Eat Me" signals for Mitophagy
    • Discovered that FKBP8 can act as a mitophagy receptor and that SAMM50 is involved in basal and OXPHOS-induced mitophagy
    • Found the inflammation repressor TNIP1/ABIN-1 to be degraded by autophagy following TBK1 activation.

    Keywords: Selective autophagy receptors, ATG8 family proteins, LIR motifs, aggrephagy, mitophagy, ER-phagy, Golgiphagy

    Teaching

    Lecturing on courses:

    MBI-2001 Biochemistry - 10 ECTS

    MBI-2012 Molecular Cell Biology - Cell structure - 10 ECTS

    MBI-3004 The Biology of Cancer - 10 ECTS

    MBI-3012 Advanced methods in experimental biomedicine - 30 ECTS

    MBI-8007 Molecular and Clinical Aspects of Cancer - Block I - 10 ECTS


    Member of research group




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