Åsa Birna Birgisdottir
Job description
Associate professor and deputy leader of the Cardiovascular research group at the Dept of Clinical Medicine. Leads the experimental molecular biology research activity of the group.
Mireia Nager,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Trine Kalstad,
Judith Rössinger,
Truls Myrmel
et al.:
Mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion
Journal of Cell Science 2025 DOI
Gustav Godtliebsen,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Ida Sundvor Opstad,
Mireia Nager Grifo,
Abhinanda Ranjit Punnakkal
et al.:
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
Abhinanda Ranjit Punnakkal,
Gustav Godtliebsen,
Ayush Somani,
Sebastian Andres Acuna Maldonado,
Åsa birna Birgisdottir,
Dilip K. Prasad
et al.:
Analyzing Mitochondrial Morphology Through Simulation Supervised Learning
Ayush Somani,
Arif Ahmed Sekh,
Ida Sundvor Opstad,
Åsa birna Birgisdottir,
Truls Myrmel,
Balpreet Singh Ahluwalia
et al.:
Virtual labeling of mitochondria in living cells using correlative imaging and physics-guided deep learning
Ida Sundvor Opstad,
Gustav Godtliebsen,
Florian Ströhl,
Truls Myrmel,
Balpreet Singh Ahluwalia,
Krishna Agarwal
et al.:
Three-dimensional structured illumination microscopy data of mitochondria and lysosomes in cardiomyoblasts under normal and galactose-adapted conditions
Florian Ströhl,
Daniel Henry Hansen,
Mireia Nager Grifo,
Åsa Birna Birgisdottir
:
Multifocus microscopy with optically sectioned axial superresolution
Florian Ströhl,
Daniel Henry Hansen,
Mireia Nager Grifo,
Åsa birna Birgisdottir
:
Multifocus microscopy with optical sectioning and high axial resolution
Luis Villegas,
Vishesh Kumar Dubey,
Mona Nystad,
Jean-Claude Tinguely,
David Andre Coucheron,
Firehun Tsige Dullo
et al.:
Chip-based multimodal super-resolution microscopy for histological investigations of cryopreserved tissue sections
Ida Sundvor Opstad,
Gustav Godtliebsen,
Balpreet Singh Ahluwalia,
Truls Myrmel,
Krishna Agarwal,
Åsa birna Birgisdottir
:
Mitochondrial dynamics and quantification of mitochondria-derived vesicles in cardiomyoblasts using structured illumination microscopy
Ayush Somani,
Arif Ahmed Sekh,
Ida Sundvor Opstad,
Åsa Birna Birgisdottir,
Truls Myrmel,
Balpreet Singh Ahluwalia
et al.:
Digital Staining of Mitochondria in Label-free Live-cell Microscopy
2021 DOI
Arif Ahmed Sekh,
Ida Sundvor Opstad,
Gustav Godtliebsen,
Åsa Birna Birgisdottir,
Balpreet Singh Ahluwalia,
Krishna Agarwal
et al.:
Physics-based machine learning for subcellular segmentation in living cells
Daniel J. Klionsky,
Amal Kamal Abdel-Aziz,
Sara Abdelfatah,
Mahmoud Khaled Abdellatif,
Asghar Abdoli,
Yakubu Princely Abudu
et al.:
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021 DOI
Åsa birna Birgisdottir,
Terje Johansen
:
Autophagy and endocytosis – interconnections and interdependencies
Arif Ahmed Sekh,
Ida Sundvor Opstad,
Åsa Birna Birgisdottir,
Truls Myrmel,
Balpreet Singh Ahluwalia,
Krishna Agarwal
et al.:
Learning nanoscale motion patterns of vesicles in living cells
Åsa birna Birgisdottir,
Stephane Mouilleron,
Zambarlal Bhujabal,
Martina Wirth,
Eva Sjøttem,
Gry Evjen
et al.:
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Ida Sundvor Opstad,
Florian Ströhl,
Åsa birna Birgisdottir,
Sebastián Andrés Acuña Maldonado,
Trine Kalstad,
Truls Myrmel
et al.:
Adaptive fluctuation imaging captures rapid subcellular dynamics
Mads Skytte Rasmussen,
Åsa birna Birgisdottir,
Terje Johansen
:
Use of Peptide Arrays for Identification and Characterization of LIR Motifs
Zambarlal Bhujabal,
Åsa birna Birgisdottir,
Eva Sjøttem,
Hanne Britt Brenne,
Aud Karin Øvervatn,
Sabrina Habisov
et al.:
FKBP8 recruits LC3A to mediate Parkin-independent mitophagy
EMBO Reports 05. April 2017 DOI
Terje Johansen,
Åsa birna Birgisdottir,
J Huber,
A Kniss,
Volker Dötsch,
V Kirkin
et al.:
Methods for studying interactions between Atg8/LC3/GABARAP and LIR-containing proteins.
Methods in Enzymology 2017 DOI
Kristen J Bubb,
Cindy Kok,
Owen Tang,
Nathalie B Rasko,
Åsa birna Birgisdottir,
Thomas Hansen
et al.:
The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling
Free Radical Biology & Medicine 2017 DOI
Kristen J. Bubb,
Åsa birna Birgisdottir,
Owen Tang,
Thomas Hansen,
Gemma A. Figtree
:
Redox modification of caveolar proteins in the cardiovascular system- role in cellular signalling and disease
Free Radical Biology & Medicine 2017 DOI
Åsa birna Birgisdottir,
Trond Lamark,
Terje Johansen
:
The LIR motif - crucial for selective autophagy
Journal of Cell Science 2013 DOI
Endalkachew Ashenafi Alemu,
Trond Lamark,
Knut Martin Torgersen,
Åsa birna Birgisdottir,
Kenneth Bowitz Larsen,
Ashish Jain
et al.:
ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS
Åsa birna Birgisdottir,
Henrik Nielsen,
Bertrand Beckert,
Benoît Masquida,
Steinar Daae Johansen
:
Intermolecular interaction between a branching ribozyme and associated homing endonuclease mRNA
Biological chemistry 2011 DOI
Yunjia Tang,
Henrik Nielsen,
Åsa birna Birgisdottir,
Steinar Daae Johansen
:
A natural fast-cleaving branching ribozyme from the amoeboflagellate Naegleria pringsheimi
RNA Biology 2011 DOI
Tonje Fiskaa,
Åsa birna Birgisdottir
:
RNA reprogramming and repair based on trans-splicing group I ribozymes
New Biotechnology 2010 DOI
Åsa Birna Birgisdottir,
Steinar Johansen
:
Reverse splicing of a mobile twin-ribozyme group I intron into the natural small subunit rRNA insertion site
Biochemical Society Transactions 2005
Åsa Birna Birgisdottir,
Steinar Johansen
:
Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA
Peik Haugen,
Åsa Birna Birgisdottir,
S Johansen,
Steinar Johansen
:
Hydrolytic cleavage by a group I intron ribozyme is dependent on RNA structures not important for splicing
European Journal of Biochemistry (EJB) 2004
Henrik Nielsen,
Tonje Fiskaa,
Åsa Birna Birgisdottir,
Peik Haugen,
christer Einvik,
Steinar Johansen
:
The ability to form full-length intron RNA circles is a general property of nuclear group I introns
RNA: A publication of the RNA Society 2003
Steinar Daae Johansen,
morten Andreassen,
Åsa birna Birgisdottir,
Dag-Hugo Coucheron,
Christer Einvik,
Tonje Fiskaa
et al.:
Group I introns are very common in nuclear SSU rDNA and LSU rDNA of Myxomycetes
Scripta Botanica Belgica 2002
Ida Sundvor Opstad,
Sebastian Andres Acuna Maldonado,
Åsa birna Birgisdottir,
Balpreet Singh Ahluwalia,
Krishna Agarwal
:
From super-resolution imaging to cellular dynamics
2023
Ida Sundvor Opstad,
Gustav Godtliebsen,
Balpreet Singh Ahluwalia,
Truls Myrmel,
Krishna Agarwal,
Åsa birna Birgisdottir
:
Mitochondrial dynamics and quantification of mitochondria-derived vesicles (MDVs) in cardiomyoblasts using 3DSIM
2022
Florian Ströhl,
Daniel Henry Hansen,
Jon-Richard Sommernes,
Marie Reischke,
Mireia Nàger,
Åsa birna Birgisdottir
:
Instant Volume Microscopy
2022
Ida Sundvor Opstad,
Gustav Godtliebsen,
Balpreet Singh Ahluwalia,
Truls Myrmel,
Krishna Agarwal,
Åsa birna Birgisdottir
:
Quantification of mitochondria‐derived vesicles in cardiomyoblasts using 3DSIM & machine learning-based segmentation
2022
Vishesh Kumar Dubey,
Luis Enrique Villegas Hernández,
Mona Nystad,
Jean-Claude Tinguely,
David Andre Coucheron,
Firehun Tsige Dullo
et al.:
Photonic-chip for multimodal super-resolution imaging in histopathology applications
2021
Sebastian Andres Acuña Maldonado,
Ida Sundvor Opstad,
Luis Enrique Villegas Hernandez,
Mona Nystad,
Milton O Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classiflcation
Algorithm (MUSICAL): From Electromagnetics Inverse
Scattering Problem to Optics Inverse Source Problem
2019
Andres Maldonado,
Ida Sundvor Opstad,
Luis Hernández,
Mona Nystad,
Milton Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
2019
Ida Sundvor Opstad,
Florian Ströhl,
Åsa birna Birgisdottir,
Sebastián Andrés Acuña Maldonado,
Trine Kalstad,
Truls Myrmel
et al.:
Adaptive fluctuation imaging captures rapid subcellular
dynamics
2019
Deanna Wolfson,
Luis Villegas,
Ida Sundvor Opstad,
Åsa birna Birgisdottir,
Cristina Ionica Øie,
Balpreet Singh Ahluwalia
:
Structured Illumination Microscopy of Biological Structures
2018 ARKIV
Krishna Agarwal,
Ida Sundvor Opstad,
Jean-Claude Tinguely,
Sören Abel,
Trine Kalstad,
Åsa birna Birgisdottir
et al.:
High-Speed, Multi-Color Live Cell Nanoscopy using MUSICAL
2018
Yunjia Tang,
Bertrand Beckert,
Åsa birna Birgisdottir,
Steinar Daae Johansen,
Henrik Nielsen
:
A new model of group I-like ribozyme - structure and function study of Naegleria pringsheimi GIR1
2011
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Research interests
The overall aim of our research is to uncover molecular mechanisms involved in cardiovascular diseases. We are currently focusing on cellular functions that serve as mitochondria quality control mechanisms in cardiac cells.
I have established human engineered heart tissue (EHT) as a research model in our group. The EHT consists of cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs). In EHT, beating cardiomyocytes are embedded in a fibrin-based matrix between flexible silicone posts allowing the three-dimensional EHT to perform contractile work. The resulting beating heart tissue in a dish presents a unique opportunity to investigate molecular mechanisms in the human heart.
Teaching
Mentor in the “Mentor group PhD program in Health Sciences” at the faculty. Main supervisor of Bachelor, Master and PhD students in Biomedicine. Organizes lab visits for students in molecular cell biology (MBI-2012).
