Synnøve Magnussen


Associate Professor

Job description

Associate professor.

Research group leader of the Tumour Biology Research Group.

My teaching mainly encompasses MBI-1105 - Basal Biochemistry for the Laboratory Medical Science students and MBI-3004 - The Biology of Cancer for the Masterstudents in Biomedicine. I also supervise Bachelor-, Master-, and PhD-students.


  • Kjersti Sellæg, Ruth Schwienbacher, Mathias Kranz, Anna Engan Aamodt, Anna Maria Wirsing, gerd Berge et al.:
    4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment
    Frontiers in Oncology 2024 ARKIV / DOI
  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. March 2023 ARKIV / DOI
  • Julia Baumann, Chih-Chieh Tsao, Shalmali Patkar, Sheng-Fu Huang, Simona Francia, Synnøve Norvoll Magnussen et al.:
    Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
    Fluids and Barriers of the CNS 2022 ARKIV / DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer et al.:
    The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
    Scientific Reports 2022 ARKIV / DOI
  • Anna Maria Wirsing, Inger-Heidi Bjerkli, Sonja Eriksson Steigen, Oddveig G Rikardsen, Synnøve Norvoll Magnussen, Beate Hegge et al.:
    Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort
    Cancers 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Elin Synnøve Hadler-Olsen, Tonje S. Steigedal, Gunbjørg Svineng :
    Nephronectin as a matrix effector in cancer
    Cancers 25. February 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judit Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    Scientific Reports 2020 ARKIV / DOI
  • Jimita Prashant Toraskar, Synnøve Norvoll Magnussen, Lars Hagen, Animesh Sharma, Linh Hoang, Geir Bjørkøy et al.:
    A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
    Journal of Proteome Research 01. February 2019 ARKIV / FULLTEKST / DOI
  • Jimita Prashant Toraskar, Synnøve Magnussen, Konika Chawla, Gunbjørg Svineng, Tonje S. Steigedal :
    Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif
    FEBS Open Bio 2018 ARKIV / DOI
  • Tonje S. Steigedal, Jimita Prashant Toraskar, Richard P. Redvers, Marit Valla, Synnøve Magnussen, Anna M. Bofin et al.:
    Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs
    Neoplasia 2018 ARKIV / FULLTEKST / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen et al.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Oddveig G Rikardsen, Synnøve Magnussen, Gunbjørg Svineng, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen :
    Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
    BMC Oral Health 2015 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen, Robert Hanes et al.:
    Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
    PLOS ONE 2014 ARKIV / DOI
  • Synnøve Magnussen, Oddveig G Rikardsen, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Gunbjørg Svineng :
    Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC)
    PLOS ONE 07. July 2014 ARKIV / DOI
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen :
    Plasmin and the plasminogen activator system in health and disease
    Walter de Gruyter (De Gruyter) 2012 DOI
  • Hilde Ljones, Elin Synnøve Hadler-Olsen, Synnøve Magnussen, Oddveig G Rikardsen, sonja eriksson Steigen, elisabeth Sundkvist et al.:
    S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
    American Journal of Pathology 2011 DOI
  • Agnhild Johansen, Kjersti Sellæg, Synnøve Norvoll Magnussen, May Wenche Jøraholmen, Ann Mari Holsæter :
    Docetaxel liposomes – Can curcumin be co-entrapped and improve the in vitro cytotoxicity?
    2023
  • Tonje Nygård Lillevik, Stefanie Bobe, Nadine Bauer, Kjersti Sellæg, May-Britt Five, Friedemann Kiefer et al.:
    Foreign antigen uptak by oral mucous glands, draining lymph nodes, and ovaries
    2023
  • Synnøve Magnussen, Gerd Berge, Ruth Schwienbacher, Anna Maria Wirsing, Elin Synnøve Hadler-Olsen :
    The spatiotemporal immune profile during mouse oral carcinogenesis
    Molecular Oncology 2023 DOI
  • Ruth Schwienbacher, Anna Engan Aamodt, Anna Maria Wirsing, Gerd Berge, Elin Synnøve Hadler-Olsen, Synnøve Magnussen :
    The spatiotemporal immune profile during mouse oral carcinogenesis - high-endothelial venules develop during early stages - and accumulate in late-stage disease
    2023
  • Ruth Schwienbacher, Anna Engan Aamodt, Anna Maria Wirsing, Gerd Berge, Elin Synnøve Hadler-Olsen, Synnøve Magnussen :
    The spatiotemporal immune profile during mouse oral carcinogenesis - high-endothelial venules develop during early stages - and accumulate in late-stage disease
    2023
  • Anne Kristin Mclaren Berge, Kjersti Sellæg, Stine Figenschau, Saikat Das Sajib, Hallvard Lauritz Olsvik, Maria Perander et al.:
    TRIM32 in Head and Neck Cancer
    2023
  • Kjersti Sellæg, Ruth Schwienbacher, Anna Maria Wirsing, Anna Engan Aamodt, Elin Synnøve Hadler-Olsen, Gerd Berge et al.:
    The spatiotemporal immune profile during mouse oral carcinogenesis
    2023
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
    2022
  • Susannah von Hofsten, Synnøve Norvoll Magnussen, Dominik Ausbacher, Marianne Hagensen Paulsen, Annette Bayer, Morten B. Strøm et al.:
    The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
    2020 ARKIV
  • Synnøve Norvoll Magnussen :
    Nephronectin fremmer metastatisk kolonisering av brystkreft i hjernen via dets integrin-bindende domener
    2020
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    2018
  • Synnøve Magnussen :
    Et viktig puslespill...
    Andøyposten 2017
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar et al.:
    Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains
    2017
  • Synnøve Magnussen :
    The metastasis-promoting protein Nephronectin
    2016
  • Synnøve Magnussen, Imola Wilhelm, Janos Hasko, Judith Molnar, Marit Seppola, Elin Synnøve Hadler-Olsen et al.:
    The metastasis-promoting protein Nephronectin
    2016
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen et al.:
    Stromal induced expression of uPAR
    2013
  • Chandra Sekhar Ravuri, Synnøve Magnussen, Jan-Olof Winberg, Nils-Erik Huseby, Gunbjørg Svineng :
    The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion
    2007

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    Research interests

    My research interests span tumour biology with a special emphasis on the tumour microenvironment and tumour immunology.

    My research curiosity spans how we develop and maintain tolerance towards food and microbes and whether oral cancer can take advantage of these natural processes to enable cancer immune escape. The common belief is that our intestines are the main drivers of building tolerance towards ingested substances and microbes. My hypothesis is that the oral cavity also plays a part in the development of tolerance.

    I am also involved in the multicenter research project; NORwegian Oral Cancer study (NOROC). In the NOROC study, we are searching for prognostic markers that can be implemented into clinical practice with the aim to improve treatment strategies for oral cancer patients.

    Previous research experience spans extracellular matrix proteins, proteolytic enzymes, cancer invasion and metastasis in breast cancer and head and neck cancer.

    Teaching

    Today I mainly teach biochemitry (Bachelor) and Cancer Biology (Master) where I lecture, supervise and sensor exams:

    Course leader, lecturer, supervisor and exam sensor in MBI-1105 Basal Biochemistry for the Medical Laboratory Sciences students (2023-)

    Lecturer and exam sensor in MBI-3004 The Biology of Cancer for the Master in Biomedicine students (2018-)

    I have been involved in teaching tasks since 2005, including student labs, collociums, seminars, exam sensoring (Bachelor-, Master-, and PhD students) and supervision; herein 2 Bachelors, 3 Masters and 4 current PhD students. I have experience as a course leader in MBI-3004 (2018-2020) and I currently mentor students attending the pedagogical course UNIPED-100.


    Member of research group



    CV

    2018- Research group leader for the Tumour Biology Research Group (TBRG), IMB, UiT

    2022- Associate Professor in Biomedicine - TBRG, IMB, UiT 

    2022 - Research stay (3 mo) - Max Planck Institute/EIMI, Münster, Germany in Professor Friedemann Kiefers lab. Project: Oral mucous glands as facilitators of cancer immune escape

    2018-2022 Researcher - TBRG, IMB, UiT. Project: High endothelial venules - master regulators of the immune infiltrate in oral cancer

    2015-2016 Research stay (1 yr) - Biological Research Centre in Professor Istvan Krizbai’s lab, Szeged, Hungary. Project: Breast cancer brain metastasis

    2015-2018 Post Doctoral Fellowship - TBRG, IMB, UiT. Project: The metastasis-promoting protein Nephronectin: distribution and mechanisms of action.

    2011 - Research stay (1 mo) - Uppsala University, BMC, Sweden in Professor Staffan Johansson’s lab. Project:  TIRF microscopy of adhering oral cancer cells

    2009-2015 Doctoral Research Fellow (PhD) in Tumour Biology, supervisor Professor Gunbjørg Svineng. Project: Oral Squamous Cell Carcinoma – Role of the Plasmniogen Activation System in Tumour Progression