Bilde av Hafstad, Anne Dragøy
Bilde av Hafstad, Anne Dragøy
Department of Medical Biology anne.hafstad@uit.no +4777625183 Tromsø MH L7.225C

Anne Dragøy Hafstad



  • Synne Hansen, Tina Myhre Pedersen, Julie Marin, Neoma Tove Boardman, Ajay M. Shah, Ellen Aasum et al.:
    Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling
    Antioxidants 2022 ARKIV / DOI
  • Lisa C. Heather, Anne Dragøy Hafstad, Ganesh V. Halade, Romain Harmancey, Kimberley M. Mellor, Paras K. Mishra et al.:
    Guidelines on models of diabetic heart disease
    American Journal of Physiology. Heart and Circulatory Physiology 2022 ARKIV / DOI
  • Anne Dragøy Hafstad, Synne Simonsen Hansen, Jim Lund, Celio X.C. Santos, Neoma Tove Boardman, Ajay M. Shah et al.:
    NADPH oxidase 2 mediates myocardial oxygen wasting in obesity
    Antioxidants 2020 ARKIV / DOI
  • Matteo Beretta, Celio X.C. Santos, Chris Molenaar, Anne Dragøy Hafstad, Chris CJ Miller, Aram Revazian et al.:
    Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival
    EMBO Journal 2020 ARKIV / DOI
  • Neoma Tove Boardman, Tina Myhre Pedersen, Line Rossvoll, Anne Dragøy Hafstad, Ellen Aasum :
    Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance
    American Journal of Physiology. Heart and Circulatory Physiology 2020 DOI
  • Neoma Tove Boardman, Line Rossvoll, Jim Lund, Anne Dragøy Hafstad, Ellen Aasum :
    3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice
    Frontiers in Physiology 02. October 2019 ARKIV / DOI
  • Tina Myhre Pedersen, Neoma Boardman, Anne Dragøy Hafstad, Ellen Aasum :
    Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart
    PLOS ONE 2018 ARKIV / DOI
  • Matthew Hancock, Anne Dragøy Hafstad, Adam A. Nabeebaccus, Norman Catibog, Angela Logan, Ioannis Smyrnias et al.:
    Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise
    eLIFE 2018 ARKIV / DOI
  • Synne Simonsen Hansen, Ellen Aasum, Anne Dragøy Hafstad :
    The role of NADPH oxidases in diabetic cardiomyopathy
    Biochimica et Biophysica Acta - Molecular Basis of Disease 2018 ARKIV / DOI
  • Neoma Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum :
    Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load
    American Journal of Physiology. Heart and Circulatory Physiology 2017 DOI
  • Adam A. Nabeebaccus, Anna Zoccarato, Anne Dragøy Hafstad, Celio X.C. Santos, Ellen Aasum, Alison C. Brewer et al.:
    Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
    JCI Insight 2017 DOI
  • Celio X.C. Santos, Anne Dragøy Hafstad, Matteo Beretta, Min Zhang, Chris Molenaar, Jola Kopec et al.:
    Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling
    EMBO Journal 2016 ARKIV / DOI
  • Nils Thomas Songstad, Knut-Helge Kaspersen, Anne Dragøy Hafstad, Purusotam Basnet, Kirsti Ytrehus, Ganesh Acharya :
    Effects of high intensity interval training on pregnant rats, and the placenta, heart and liver of their fetuses
    PLOS ONE 13. November 2015 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    Journal of Cellular Physiology 2015 ARKIV / DOI
  • Jim Lund, Anne Dragøy Hafstad, Neoma Tove Boardman, Line Rossvoll, Natale Pinheiro Lage Rolim, Muhammad Shakil Ahmed et al.:
    Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
    American Journal of Physiology. Heart and Circulatory Physiology 2015 DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Ellen Aasum :
    How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy
    Antioxidants and Redox Signaling 2015 ARKIV / DOI
  • Anje Christina Höper, Wahida Salma, Selene Julie Sollie, Anne Dragøy Hafstad, Jim Lund, Ahmed Murtaz Khalid et al.:
    Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice
    Journal of Nutrition 2014 DOI
  • Anje Christina Höper, Wahida Salma, Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Selene Julie Sollie, Jan Raa et al.:
    Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
    British Journal of Nutrition 2013 DOI
  • Anne Dragøy Hafstad, Jim Lund, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen, Ellen Aasum :
    High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity
    Diabetes 2013 DOI
  • Anne Dragøy Hafstad, Adam Nabeebaccus, Ajay Shah :
    Novel aspects of ROS signalling in heart failure
    Basic Research in Cardiology 2013 DOI
  • Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Terje Larsen, david lester Severson, Neoma Tove Boardman, Martin Hagve et al.:
    Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ahmed Murtaz Khalid, Ulrik Wisløff et al.:
    High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
    Journal of applied physiology 2011 DOI
  • Neoma Tove Boardman, Anne Dragøy Hafstad, Terje Larsen, DL Severson, Ellen Aasum :
    Increased O-2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice
    American Journal of Physiology. Heart and Circulatory Physiology 2009 DOI
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Martin Hagve, trine Lund, Terje Larsen, DL Severson et al.:
    Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss
    Cardiovascular Research (CVR) 2009 ARKIV / DOI
  • Kåre-Olav Stensløkken, Arkady Rutkovskiy, Mari-Liis Kaljusto, Anne Dragøy Hafstad, Terje Larsen, Jarle Vaage :
    Inadvertent phosphorylation of survival kinases in isolated perfused hearts: a word of caution
    Basic Research in Cardiology 2009 DOI
  • Anne Dragøy Hafstad :
    Flere har meldt seg til å teste dette plasteret - kan gi ny helt ny kunnskap
    20. May 2021 FULLTEKST
  • Anne Dragøy Hafstad, Astri Jeanette Meen :
    Trenger frivillige til forskning på smartplaster
    12. May 2021 FULLTEKST
  • Anne Dragøy Hafstad, Ellen Aasum, Jim Lund, Santos Celio X, Ajay Shah :
    A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
    2015
  • Anne Dragøy Hafstad :
    Trening normaliserte hjertefunksjonen hos overvektige mus
    2014 DATA
  • Anne Dragøy Hafstad :
    Hjertegod trening ved fedme og diabetes
    2014
  • Anne Dragøy Hafstad :
    Positive effekter av trening på hjertets forbrenning ved fedme og diabetes
    2014
  • Anne Dragøy Hafstad, Jim Lund, Ellen Aasum, Celio X Santos, Ajay Shah :
    A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
    2014
  • Anne Dragøy Hafstad, Jim Lund, Ellen Aasum, C Santos, Ajay Shah :
    Prevention of obesity-induced myocardial oxygen-wasting through NADPH-oxidase inhibition
    2013
  • Anne Dragøy Hafstad :
    Hjertegod trening av feite mus
    2013
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    2013
  • Knut-Helge Kaspersen, Nils Thomas Songstad, Anne Dragøy Hafstad, Ganesh Acharya :
    High intensity training in pregnant rats
    2012
  • Nils Thomas Songstad, Knut-Helge Kaspersen, Anne Dragøy Hafstad, Ganesh Acharya :
    Høyintesitets intervalltrening hos gravide rotter
    2012
  • Anne Dragøy Hafstad, Jim Lund, Martin Hagve, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen et al.:
    High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function
    2012
  • Anje Christina Höper, Terje Larsen, Ahmed Murtaz Khalid, Wahida Salma, Selene Julie Sollie, Jim Lund et al.:
    Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding
    2012
  • Jim Lund, Anne Dragøy Hafstad, Terje Larsen, Ellen Aasum :
    High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat
    2012
  • Anne Dragøy Hafstad, Jim Lund, Terje Larsen, Ellen Aasum :
    Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak
    2012
  • Wahida Salma, Anje Christina Höper, Ahmed Murtaz Khalid, Selene Julie Sollie, Jim Lund, Anne Dragøy Hafstad et al.:
    Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
    2012
  • Wahida Salma, Selene Julie Sollie, Anje Christina Höper, Ahmed Murtaz Khalid, Jim Lund, Anne Dragøy Hafstad et al.:
    Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
    2012
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    2011
  • Anje Christina Høper, Terje Larsen, Jim Lund, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ellen Aasum :
    Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice
    2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice
    2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    Circulation 2011
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ulrik Wisløff, Terje Larsen et al.:
    Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity
    2009
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ulrik Wisløff, Terje Larsen et al.:
    Metabolic adaptations in the physiologically hypertrophied heart
    2009
  • Ellen Aasum, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Rolf Berge, Terje Larsen :
    TTA - the first PPAR ligand shown to increase fatty acid oxidation in normal and diabetic myocardium when administered in vivo
    2009

  • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Publications outside Cristin

    A. A. Nabeebaccus, A. Zoccarato, A. D. Hafstad, C. X.C. Santos, E. Aasum, A. C. Brewer, M. Zhang, M. Beretta, X. Yin, J. A. West, K. Schröder, J. L. Griffin, T. R. Eykyn, E. D Abel, M. Mayr, and A. M. Shah. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. Journal of Clinical Investigation (JCI) Insight. 2018. Ahead of print.

     

    Hafstad. AD. NADPH oksidaser i diabetisk hjertesykdom BestPractise. Diabetes/Hjerte-Kar sykdommer. 2018. Review. Ahead of print.

     

    S.S. Hansen, E. Aasum, A.D. Hafstad, The role of NADPH oxidases in diabetic cardiomyopathy, Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, (2017). Review. Ahead of print

     

    N.T. Boardman, A.D. Hafstad, J. Lund, L. Rossvoll, E. Aasum. Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. American Journal of Physiology-Heart and Circulatory Physiology, 313 (2017) H1054-H1062.


    Research interests

    I have 16 years of experience within the basal research in cardiac metabolism/energetics, and diabetes/obesity, using the isolated working heart set up with a repertoire of experimental biochemical techniques. My area of expertise is measurements of myocardial substrate uptake and oxidation rates as well as assessment of cardiac function and mechanoenergetics in isolated working mouse hearts. In my Post-Doc I was studying cardiac adaptations following intensity controlled treadmill running of rodents with a focus on exercise-induced effects on cardiac function, metabolism and mechanoenergetics in lean and obese models. Lately my focus has been on the ROS producing enzymes: NADPH oxidases and their role redox signalling in the heart. I have been studing their roles in cardiac metabolism, hypertrophic responses, exercise adaptation, in the development of diabetic ventricular and energetic dysfunction and cardiac metabolism. Lately I have gained an interest for cardiotoxicity induced by anticancer therapies and have received funding to investigate the cardiometabolic response to anticancer therapies in cell lines and an animal model.