Ellen Aasum


Professor

Job description

Professor in the Cardiovascular Research Group

Academic responsibility for the teaching of Physiology at the Department of Medical Biology, Faculty of Health Sciences


  • Synne Hansen, Tina Myhre Pedersen, Julie Marin, Neoma Tove Boardman, Ajay M. Shah, Ellen Aasum et al.:
    Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling
    Antioxidants 2022 ARKIV / DOI
  • Neoma Tove Boardman, Tina Myhre Pedersen, Line Rossvoll, Anne Dragøy Hafstad, Ellen Aasum :
    Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance
    American Journal of Physiology. Heart and Circulatory Physiology 2020 ARKIV / DOI
  • Anne Dragøy Hafstad, Synne Simonsen Hansen, Jim Lund, Celio X.C. Santos, Neoma Tove Boardman, Ajay M. Shah et al.:
    NADPH oxidase 2 mediates myocardial oxygen wasting in obesity
    Antioxidants 2020 ARKIV / DOI
  • Neoma Tove Boardman, Line Rossvoll, Jim Lund, Anne Dragøy Hafstad, Ellen Aasum :
    3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice
    Frontiers in Physiology 02. October 2019 ARKIV / DOI
  • Tina Myhre Pedersen, Neoma Boardman, Anne Dragøy Hafstad, Ellen Aasum :
    Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart
    PLOS ONE 2018 ARKIV / DOI
  • Synne Simonsen Hansen, Ellen Aasum, Anne Dragøy Hafstad :
    The role of NADPH oxidases in diabetic cardiomyopathy
    Biochimica et Biophysica Acta - Molecular Basis of Disease 2018 ARKIV / DOI
  • Neoma Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum :
    Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load
    American Journal of Physiology. Heart and Circulatory Physiology 2017 DOI
  • Adam A. Nabeebaccus, Anna Zoccarato, Anne Dragøy Hafstad, Celio X.C. Santos, Ellen Aasum, Alison C. Brewer et al.:
    Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
    JCI Insight 2017 DOI
  • Latt S. Mansor, Keshavi Metha, Dunja Aksentijevic, Carolyn A. Carr, trine Lund, Mark A. Cole et al.:
    Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation
    Journal of Physiology 2016 DOI
  • Wahida Salma, Veronika Franeková, trine Lund, Anje Christina Höper, Stian Ludvigsen, Jim Lund et al.:
    Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice
    Prostaglandins, Leukotrienes and Essential Fatty Acids 2016 DOI
  • Mark A. Cole, Amira H. Abd Jamil, Lisa C Heather, Andrew J Murray, Elizabeth R Sutton, Mary Slingo et al.:
    On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
    The FASEB Journal 2016 DOI
  • Jim Lund, Anne Dragøy Hafstad, Neoma Tove Boardman, Line Rossvoll, Natale Pinheiro Lage Rolim, Muhammad Shakil Ahmed et al.:
    Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
    American Journal of Physiology. Heart and Circulatory Physiology 2015 DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Ellen Aasum :
    How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy
    Antioxidants and Redox Signaling 2015 ARKIV / DOI
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    Circulation: Heart Failure 2015 DOI
  • Neoma Tove Boardman, Jan Magnus Aronsen, William Edward Louch, Ivar Sjaastad, Frode Willoch, Geir Arve Christensen et al.:
    Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
    American Journal of Physiology. Heart and Circulatory Physiology 2014 ARKIV / DOI
  • Anje Christina Höper, Wahida Salma, Selene Julie Sollie, Anne Dragøy Hafstad, Jim Lund, Ahmed Murtaz Khalid et al.:
    Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice
    Journal of Nutrition 2014 DOI
  • Neoma Tove Boardman, Jan Magnus Aronsen, William Edward Louch, Ivar Sjaastad, Frode Willoch, Geir Arve Christensen et al.:
    Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
    American Journal of Physiology. Heart and Circulatory Physiology 2014 DOI
  • Ellen Aasum :
    Relationship Between Substrate Metabolism and Cardiac Efficiency
    Springer Science+Business Media B.V. 2014 DOI
  • Anje Christina Höper, Wahida Salma, Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Selene Julie Sollie, Jan Raa et al.:
    Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
    British Journal of Nutrition 2013 DOI
  • Anne Dragøy Hafstad, Jim Lund, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen, Ellen Aasum :
    High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity
    Diabetes 2013 DOI
  • Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert et al.:
    Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
    American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
  • Ellen Aasum :
    Myocardial energetics and efficiency
    Hearts and Metabolism 2011
  • Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Terje Larsen, david lester Severson, Neoma Tove Boardman, Martin Hagve et al.:
    Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Neoma Tove Boardman, Terje Larsen, david lester Severson, M Fadiel Essop, Ellen Aasum :
    Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ahmed Murtaz Khalid, Ulrik Wisløff et al.:
    High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
    Journal of applied physiology 2011 DOI
  • Ellen Aasum :
    Obesity/diabetes-induced alterations in cardiac metabolism and mechanoenergetics
    2023
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
    Circulation: Heart Failure 2015 DOI
  • Anne Dragøy Hafstad, Ellen Aasum, Jim Lund, Santos Celio X, Ajay Shah :
    A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
    2015
  • Ellen Aasum :
    Exercise and its beneficial role on the diabetic heart
    2014
  • Ellen Aasum :
    Cardiac efficiency and mechanoenergetics in diabetic cardiomyopathy
    2014
  • Ellen Aasum :
    Cardiac Efficiency and Mechanoenergetics in Diabetic Cardiomyopathy
    2014
  • Jim Lund, Ellen Aasum :
    The effect of nitrate/nitrite on cardiac energetics
    2014
  • Anne Dragøy Hafstad, Jim Lund, Ellen Aasum, Celio X Santos, Ajay Shah :
    A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
    2014
  • Anne Dragøy Hafstad, Jim Lund, Ellen Aasum, C Santos, Ajay Shah :
    Prevention of obesity-induced myocardial oxygen-wasting through NADPH-oxidase inhibition
    2013
  • Wahida Salma, Anje Christina Höper, trine Lund, Stian Ludvigsen, Kirsti Ytrehus, Ellen Aasum et al.:
    Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice
    2013
  • Anne Dragøy Hafstad, Jim Lund, Martin Hagve, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen et al.:
    High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function
    2012
  • Anje Christina Höper, Terje Larsen, Ahmed Murtaz Khalid, Wahida Salma, Selene Julie Sollie, Jim Lund et al.:
    Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding
    2012
  • Jim Lund, Anne Dragøy Hafstad, Terje Larsen, Ellen Aasum :
    High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat
    2012
  • Ellen Aasum :
    Diabetic cardiomyopathy - metabolic interventions and exercise
    2012
  • Anne Dragøy Hafstad, Jim Lund, Terje Larsen, Ellen Aasum :
    Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak
    2012
  • Wahida Salma, Anje Christina Höper, Ahmed Murtaz Khalid, Selene Julie Sollie, Jim Lund, Anne Dragøy Hafstad et al.:
    Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
    2012
  • Wahida Salma, Selene Julie Sollie, Anje Christina Höper, Ahmed Murtaz Khalid, Jim Lund, Anne Dragøy Hafstad et al.:
    Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
    2012
  • Neoma Tove Boardman, Ellen Aasum :
    Cardiometabolic adaptations to altered fuel supply, Ca2+ handling and exercise
    UiT Norges arktiske universitet 2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    2011
  • Anje Christina Høper, Terje Larsen, Jim Lund, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ellen Aasum :
    Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice
    2011
  • Ellen Aasum :
    Prevention of cardiac inefficiency in type 2 diabetes by means of high-intensity exercise training
    2011
  • Ellen Aasum :
    Heart function and metabolism in type 2 diabetic db/db mice
    2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice
    2011
  • Martin Hagve, Espen Sanden, Ellen Aasum, Terje Larsen :
    Palmitate-induced uncoupling reduces oxidative stress in cardiac mitochondria respiring on complex II substrate
    2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    Circulation 2011

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    Research interests

     

    Research interests
    My research activity has been related to cardiac metabolism in relation to the development of heart failure, focusing on metabolic diseases such as insulin resistance, obesity, and diabetes. We have used different mouse models of obesity/diabetes to study the effect of pharmacological treatments, exercise training (intensity-controlled treadmill running), and nutrient supplementation on the development of obesity/diabetes-induced cardiometabolic changes, and have extensive experience using the isolated perfused hearts for assessment of myocardial substrate utilization, oxygen consumption, mechanical function and efficiency/mechanoenergetics. In addition, we have experience measuring mitochondrial respiration using high-resolution respirometry (in cardiomyocytes, tissue homogenate, or isolated mitochondria).
     
     
    Teaching
    I have been teaching physiology to medical, odontology, psychology, and biomedicine students since 1997 (including topics like electrophysiology, cardiovascular physiology, respiratory physiology, endocrinology, and muscle physiology). I have served as a member/leader of the committee for the first-year exam since 2003. In addition, I have been responsible for the curriculum and coordination of all teaching in Physiology at the Department of Medical Biology since 2008. I have given lectures for PhD students at international workshops and at courses arranged by the NORHEART (Norwegian PhD School of Heart Research) at UiT (2015, 2017) and UiO (2015-2023).

     
    Mentorship:   (* as main supervisor)
    Post Docs:  Anne Hafstad (2008-2012)* and Neoma T Boardman (2016-2019)* , Wei Li (2022-current)*
    PhD students: Ole Jakob How (2006), Anne D Hafstad (2007)*, Ahmed M Khalid (2009), Neoma T Boardman (2011)*, Anje Hoper (2014), Wahida Salma (2015), Jim Lund (2015)*, Tina M Pedersen (2019)*, Kirsten Janssen (2021), Synne Hansen (2022), Pauke C Schots (ongoing)
    Medical research students:  Rune Sundset (2000), Martin Hagve (2012), Line Rossvoll (2017)*
    About 30 master's and undergraduate medicine and biomedicine students
     
    Opponents for doctoral defenses:
    2004 (South Africa; Univ. Cape Town), 2006 (Katholieke Univ. Leuven), 2009 (Denmark; Univ. of Aarhus), 2012 (South Africa; Univ. Stellenbosch), 2012 (The Netheland; Univ. Maastricht), 2014 (UK; Univ. Oxford), 2015 (Norway; Univ. Bergen), 2015 (Sweden; Univ. Goteborg), 2018 (UK; Univ. Oxford), 2020 (Norway; Univ. Oslo), 2022 (Norway; Univ. Oslo)
     
     
    Currently lecturing at the following courses at UiT: 
    MED-1501 Medical school (Delemne 1.2 ) - Topics: electrophysiology, laboratory exercises in nerve conductance
    MED-1501 Medical school (Course leader Delemne 1.4). Topics: respiratory physiology, cardiac physiology, laboratory exercises: cardiac electrophysiology (ECG), lung function and blood pressure
    MED-2501 Medical school UiT (Delemne 2.6) - Topics: Synaptic transmission
    MED-2510 Medical school UiT (Delemne 3.2, 3.3) - Topics: respiratory (pato)physiology, cardiac electrophysiology
    MBI-3012 Master BioMedisin- Advanced methods in experimental biomedicine - Topics: Respirometry
    MBI-3016 Master BioMedisin - Medical Physiology  - Topic: advanced respiratory physiology
    ODO-2008 Odontology - Topics: Synaptic transmission
    ODO-2009 Odontology - Topic: respiratory (pato)physiology
     
     

    Member of research group



    CV

    EDUCATION
    1998                PhD, University of Tromsø, Norway
    1992                Master of Science, University of Tromsø, Norway
    1990                Bachelor of Science, University of Oslo, Norway

     

    RESEARCH POSITIONS

    RESEARCH POSITIONS
    2009-                  Professor University of Tromsø

    2011 (Oct-Des)    Visiting Prof., University of Oxford, UK
    2002 - 2008         Associate Professor University of Tromsø
    2006 - 2007         Visiting scientist, University of Oxford, UK
    1999 (Oct-Des)    Visiting scientist, University of Calgary, Canada
    1999 - 2002         Post. Doctoral research fellow, University of Tromsø
    1993 – 1998         PhD. Student, University of Tromsø