Ellen Aasum
Job description
Professor in the Cardiovascular Research Group
Academic responsibility for the teaching of Physiology at the Department of Medical Biology, Faculty of Health Sciences
Synne Hansen,
Tina Myhre Pedersen,
Julie Marin,
Neoma Tove Boardman,
Ajay M. Shah,
Ellen Aasum
et al.:
Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling
Anne Dragøy Hafstad,
Synne Simonsen Hansen,
Jim Lund,
Celio X.C. Santos,
Neoma Tove Boardman,
Ajay M. Shah
et al.:
NADPH oxidase 2 mediates myocardial oxygen wasting in obesity
Neoma Tove Boardman,
Tina Myhre Pedersen,
Line Rossvoll,
Anne Dragøy Hafstad,
Ellen Aasum
:
Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance
Neoma Tove Boardman,
Line Rossvoll,
Jim Lund,
Anne Dragøy Hafstad,
Ellen Aasum
:
3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice
Tina Myhre Pedersen,
Neoma Boardman,
Anne Dragøy Hafstad,
Ellen Aasum
:
Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart
Synne Simonsen Hansen,
Ellen Aasum,
Anne Dragøy Hafstad
:
The role of NADPH oxidases in diabetic cardiomyopathy
Neoma Boardman,
Anne Dragøy Hafstad,
Jim Lund,
Line Rossvoll,
Ellen Aasum
:
Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load
American Journal of Physiology. Heart and Circulatory Physiology 2017 DOI
Adam A. Nabeebaccus,
Anna Zoccarato,
Anne Dragøy Hafstad,
Celio X.C. Santos,
Ellen Aasum,
Alison C. Brewer
et al.:
Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
JCI Insight 2017 DOI
Latt S. Mansor,
Keshavi Metha,
Dunja Aksentijevic,
Carolyn A. Carr,
trine Lund,
Mark A. Cole
et al.:
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation
Journal of Physiology 2016 DOI
Wahida Salma,
Veronika Franeková,
trine Lund,
Anje Christina Höper,
Stian Ludvigsen,
Jim Lund
et al.:
Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice
Prostaglandins, Leukotrienes and Essential Fatty Acids 2016 DOI
Mark A. Cole,
Amira H. Abd Jamil,
Lisa C Heather,
Andrew J Murray,
Elizabeth R Sutton,
Mary Slingo
et al.:
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
The FASEB Journal 2016 DOI
Anne Dragøy Hafstad,
Neoma Tove Boardman,
Ellen Aasum
:
How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy
Jim Lund,
Anne Dragøy Hafstad,
Neoma Tove Boardman,
Line Rossvoll,
Natale Pinheiro Lage Rolim,
Muhammad Shakil Ahmed
et al.:
Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
American Journal of Physiology. Heart and Circulatory Physiology 2015 DOI
Jens Petter Bakkehaug,
Anders Benjamin Kildal,
Erik Torgersen Engstad,
Neoma Tove Boardman,
Torvind Næsheim,
Leif R. Rønning
et al.:
Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
Circulation: Heart Failure 2015 DOI
Neoma Tove Boardman,
Jan Magnus Aronsen,
William Edward Louch,
Ivar Sjaastad,
Frode Willoch,
Geir Arve Christensen
et al.:
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
American Journal of Physiology. Heart and Circulatory Physiology 2014 DOI
Anje Christina Höper,
Wahida Salma,
Selene Julie Sollie,
Anne Dragøy Hafstad,
Jim Lund,
Ahmed Murtaz Khalid
et al.:
Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice
Journal of Nutrition 2014 DOI
Ellen Aasum
:
Relationship Between Substrate Metabolism and Cardiac Efficiency
Springer Science+Business Media B.V. 2014 DOI
Neoma Tove Boardman,
Jan Magnus Aronsen,
William Edward Louch,
Ivar Sjaastad,
Frode Willoch,
Geir Arve Christensen
et al.:
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Anne Dragøy Hafstad,
Jim Lund,
Elin Synnøve Hadler-Olsen,
Anje Christina Höper,
Terje Larsen,
Ellen Aasum
:
High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity
Diabetes 2013 DOI
Anje Christina Höper,
Wahida Salma,
Ahmed Murtaz Khalid,
Anne Dragøy Hafstad,
Selene Julie Sollie,
Jan Raa
et al.:
Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
British Journal of Nutrition 2013 DOI
Thomas Gero von Lueder,
Jørgen A. Gravning,
Ole-Jakob How,
Leif Erik Vinge,
Muhammad Shakil Ahmed,
Kurt Allen Krobert
et al.:
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
Neoma Tove Boardman,
Terje Larsen,
david lester Severson,
M Fadiel Essop,
Ellen Aasum
:
Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling
American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
Ahmed Murtaz Khalid,
Anne Dragøy Hafstad,
Terje Larsen,
david lester Severson,
Neoma Tove Boardman,
Martin Hagve
et al.:
Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
Anne Dragøy Hafstad,
Neoma Tove Boardman,
Jim Lund,
Martin Hagve,
Ahmed Murtaz Khalid,
Ulrik Wisløff
et al.:
High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
Journal of applied physiology 2011 DOI
Ellen Aasum
:
Myocardial energetics and efficiency
Hearts and Metabolism 2011
Ellen Aasum
:
Obesity/diabetes-induced alterations in cardiac metabolism and mechanoenergetics
2023
Jens Petter Bakkehaug,
Anders Benjamin Kildal,
Erik Torgersen Engstad,
Neoma Tove Boardman,
Torvind Næsheim,
Leif R. Rønning
et al.:
Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
Circulation: Heart Failure 2015 DOI
Anne Dragøy Hafstad,
Ellen Aasum,
Jim Lund,
Santos Celio X,
Ajay Shah
:
A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
2015
Ellen Aasum
:
Exercise and its beneficial role on the diabetic heart
2014
Ellen Aasum
:
Cardiac Efficiency and Mechanoenergetics in Diabetic Cardiomyopathy
2014
Anne Dragøy Hafstad,
Jim Lund,
Ellen Aasum,
Celio X Santos,
Ajay Shah
:
A role of NADPH oxidase in obesity-induced myocardial oxygen wasting
2014
Ellen Aasum
:
Cardiac efficiency and mechanoenergetics in diabetic cardiomyopathy
2014
Jim Lund,
Ellen Aasum
:
The effect of nitrate/nitrite on cardiac energetics
2014
Anne Dragøy Hafstad,
Jim Lund,
Ellen Aasum,
C Santos,
Ajay Shah
:
Prevention of obesity-induced myocardial oxygen-wasting through NADPH-oxidase inhibition
2013
Wahida Salma,
Anje Christina Höper,
trine Lund,
Stian Ludvigsen,
Kirsti Ytrehus,
Ellen Aasum
et al.:
Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice
2013
Anje Christina Höper,
Terje Larsen,
Ahmed Murtaz Khalid,
Wahida Salma,
Selene Julie Sollie,
Jim Lund
et al.:
Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding
2012
Anne Dragøy Hafstad,
Jim Lund,
Martin Hagve,
Elin Synnøve Hadler-Olsen,
Anje Christina Höper,
Terje Larsen
et al.:
High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function
2012
Wahida Salma,
Anje Christina Höper,
Ahmed Murtaz Khalid,
Selene Julie Sollie,
Jim Lund,
Anne Dragøy Hafstad
et al.:
Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
2012
Wahida Salma,
Selene Julie Sollie,
Anje Christina Höper,
Ahmed Murtaz Khalid,
Jim Lund,
Anne Dragøy Hafstad
et al.:
Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
2012
Jim Lund,
Anne Dragøy Hafstad,
Terje Larsen,
Ellen Aasum
:
High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat
2012
Ellen Aasum
:
Diabetic cardiomyopathy - metabolic interventions and exercise
2012
Anne Dragøy Hafstad,
Jim Lund,
Terje Larsen,
Ellen Aasum
:
Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak
2012
Martin Hagve,
Espen Sanden,
Ellen Aasum,
Terje Larsen
:
Palmitate-induced uncoupling reduces oxidative stress in cardiac mitochondria respiring on complex II substrate
2011
Anne Dragøy Hafstad,
Jim Lund,
Anje Christina Høper,
Elin Synnøve Hadler-Olsen,
Martin Hagve,
Ulrik Wisløff
et al.:
Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
Circulation 2011
Anne Dragøy Hafstad,
Jim Lund,
Anje Christina Høper,
Elin Synnøve Hadler-Olsen,
Martin Hagve,
Ulrik Wisløff
et al.:
Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
2011
Anje Christina Høper,
Terje Larsen,
Jim Lund,
Anne Dragøy Hafstad,
Ahmed Murtaz Khalid,
Ellen Aasum
:
Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice
2011
Ellen Aasum
:
Prevention of cardiac inefficiency in type 2 diabetes by means of high-intensity exercise training
2011
Ellen Aasum
:
Heart function and metabolism in type 2 diabetic db/db mice
2011
Anne Dragøy Hafstad,
Jim Lund,
Anje Christina Høper,
Elin Synnøve Hadler-Olsen,
Martin Hagve,
Ulrik Wisløff
et al.:
High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice
2011
Neoma Tove Boardman,
Ellen Aasum
:
Cardiometabolic adaptations to altered fuel supply, Ca2+ handling and exercise
UiT Norges arktiske universitet 2011
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Research interests
Research interests
My research activity has been related to cardiac metabolism in relation to the development of heart failure, focusing on metabolic diseases such as insulin resistance, obesity, and diabetes. We have used different mouse models of obesity/diabetes to study the effect of pharmacological treatments, exercise training (intensity-controlled treadmill running), and nutrient supplementation on the development of obesity/diabetes-induced cardiometabolic changes, and have extensive experience using the isolated perfused hearts for assessment of myocardial substrate utilization, oxygen consumption, mechanical function and efficiency/mechanoenergetics. In addition, we have experience measuring mitochondrial respiration using high-resolution respirometry (in cardiomyocytes, tissue homogenate, or isolated mitochondria).
Teaching
I have been teaching physiology to medical, odontology, psychology, and biomedicine students since 1997 (including topics like electrophysiology, cardiovascular physiology, respiratory physiology, endocrinology, and muscle physiology). I have served as a member/leader of the committee for the first-year exam since 2003. In addition, I have been responsible for the curriculum and coordination of all teaching in Physiology at the Department of Medical Biology since 2008. I have given lectures for PhD students at international workshops and at courses arranged by the NORHEART (Norwegian PhD School of Heart Research) at UiT (2015, 2017) and UiO (2015-2023).
I have been teaching physiology to medical, odontology, psychology, and biomedicine students since 1997 (including topics like electrophysiology, cardiovascular physiology, respiratory physiology, endocrinology, and muscle physiology). I have served as a member/leader of the committee for the first-year exam since 2003. In addition, I have been responsible for the curriculum and coordination of all teaching in Physiology at the Department of Medical Biology since 2008. I have given lectures for PhD students at international workshops and at courses arranged by the NORHEART (Norwegian PhD School of Heart Research) at UiT (2015, 2017) and UiO (2015-2023).
Mentorship: (* as main supervisor)
Post Docs: Anne Hafstad (2008-2012)* and Neoma T Boardman (2016-2019)* , Wei Li (2022-current)*
PhD students: Ole Jakob How (2006), Anne D Hafstad (2007)*, Ahmed M Khalid (2009), Neoma T Boardman (2011)*, Anje Hoper (2014), Wahida Salma (2015), Jim Lund (2015)*, Tina M Pedersen (2019)*, Kirsten Janssen (2021), Synne Hansen (2022), Pauke C Schots (2023)
Medical research students: Rune Sundset (2000), Martin Hagve (2012), Line Rossvoll (2017)*
About 30 master's and undergraduate medicine and biomedicine students
Post Docs: Anne Hafstad (2008-2012)* and Neoma T Boardman (2016-2019)* , Wei Li (2022-current)*
PhD students: Ole Jakob How (2006), Anne D Hafstad (2007)*, Ahmed M Khalid (2009), Neoma T Boardman (2011)*, Anje Hoper (2014), Wahida Salma (2015), Jim Lund (2015)*, Tina M Pedersen (2019)*, Kirsten Janssen (2021), Synne Hansen (2022), Pauke C Schots (2023)
Medical research students: Rune Sundset (2000), Martin Hagve (2012), Line Rossvoll (2017)*
About 30 master's and undergraduate medicine and biomedicine students
Opponent for doctoral defenses:
2004 (South Africa; Univ. Cape Town), 2006 (Katholieke Univ. Leuven), 2009 (Denmark; Univ. Aarhus), 2012 (South Africa; Univ. Stellenbosch), 2012 (The Netheland; Univ. Maastricht), 2014 (UK; Univ. Oxford), 2015 (Norway; Univ. Bergen), 2015 (Sweden; Univ. Goteborg), 2018 (UK; Univ. Oxford), 2020 (Norway; Univ. Oslo), 2022 (Norway; Univ. Oslo), 2023 (Norway, NTNU); 2024 (UK, Univ. Oxford); 2024 (Denmark; Univ. Aarhus)
Currently lecturing at the following courses at UiT:
MED-1501 Medical school (Delemne 1.2 ) - Topics: electrophysiology, laboratory exercises in nerve conductance
MED-1501 Medical school (Course leader Delemne 1.4). Topics: respiratory physiology, cardiac physiology, laboratory exercises: cardiac electrophysiology (ECG), lung function and blood pressure
MED-2501 Medical school UiT (Delemne 2.6) - Topics: Synaptic transmission
MED-2510 Medical school UiT (Delemne 3.2, 3.3) - Topics: respiratory (pato)physiology, cardiac electrophysiology
MBI-3012 Master BioMedisin- Advanced methods in experimental biomedicine - Topics: Respirometry
MBI-3016 Master BioMedisin - Medical Physiology (Course leader) - Topic: advanced respiratory physiology
MED-1501 Medical school (Delemne 1.2 ) - Topics: electrophysiology, laboratory exercises in nerve conductance
MED-1501 Medical school (Course leader Delemne 1.4). Topics: respiratory physiology, cardiac physiology, laboratory exercises: cardiac electrophysiology (ECG), lung function and blood pressure
MED-2501 Medical school UiT (Delemne 2.6) - Topics: Synaptic transmission
MED-2510 Medical school UiT (Delemne 3.2, 3.3) - Topics: respiratory (pato)physiology, cardiac electrophysiology
MBI-3012 Master BioMedisin- Advanced methods in experimental biomedicine - Topics: Respirometry
MBI-3016 Master BioMedisin - Medical Physiology (Course leader) - Topic: advanced respiratory physiology
ODO-2008 Odontology - Topics: Synaptic transmission
ODO-2009 Odontology - Topic: respiratory (pato)physiology
ODO-2009 Odontology - Topic: respiratory (pato)physiology
Member of research group
CV
EDUCATION
1998 PhD, University of Tromsø, Norway
1992 Master of Science, University of Tromsø, Norway
1990 Bachelor of Science, University of Oslo, Norway
RESEARCH POSITIONS
RESEARCH POSITIONS
2009- Professor University of Tromsø
2011 (Oct-Des) Visiting Prof., University of Oxford, UK
2002 - 2008 Associate Professor University of Tromsø
2006 - 2007 Visiting scientist, University of Oxford, UK
1999 (Oct-Des) Visiting scientist, University of Calgary, Canada
1999 - 2002 Post. Doctoral research fellow, University of Tromsø
1993 – 1998 PhD. Student, University of Tromsø