Professor

Kirsti Ytrehus

Professor Department of Medical Biology

77644781
95106332

kirsti.ytrehus@uit.no

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Tromsø

MH L7.225B (Click for map directions)

Cardiovascular physiology

Myocardial infarction and myocardial protection

The role of reactive oxygen species in cardiovascular physiology and pathophysiology

Role of gender in heart disease

Born in 1953. Mother of 3

Education

Univ of Oslo, Faculty of Math and Nat Sciences and Faculty of Medicine

Cand. Med. 1980

University of Tromsoe, Faculty of Medicine

Dr. Med.1988:

Thesis title Oxygen radicals and myocardial injury

Appointments

Clinical medicine:

Internship and part time positions, 1981- 1992

Academic positions:

Research fellow University of Tromsoe, Institute for Medical Biology 1982 - 87

Assistant professor University of Tromsoe 1987 - 1994

Guest researcher/ visiting University of South Alabama, Dept of Physiology 1994-95

Professor University of Bergen, Dept of Anatomy and Cell Biology 1995-96

Guest researcher National Institute of Aging, National Institute of Health, Lab of Cardiovasc Sciences 2001-2002

Professor Dept of Medical Biology, University of Tromsoe 1994 -1995 and 1996 - present

Guest professor Cardiovascular division, Kings College Hospital, University of London

Medical Physiology and Cardiac Research

Scientific articles and book chapters
Other

Perrino, Cinzia; Ferdinandy, Péter; Bøtker, Hans Erik; Brundel, Bianca J. J. M; Collins, Peter; Davidson, Sean M; Den Ruijter, Hester M.; Engel, Felix B.; Gerdts, Eva; Girao, Henrique; Gyöngyösi, Mariann; Hausenloy, Derek J.; Lecour, Sandrine; Madonna, Rosalinda; Marber, Michael; Murphy, Elizabeth; Pesce, Maurizio; Regitz-Zagrosek, Vera; Sluijter, Joost P.G.; Steffens, Sabine; Gollmann-Tepeköylü, Can; Van Laake, Linda W.; Van Linthout, Sophie; Schulz, Rainer; Ytrehus, Kirsti. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research (CVR) 2021; Volum 117 (2). ISSN 0008-6363.s 367 - 385.s doi: 10.1093/cvr/cvaa155.

Andreadou, Ioanna; Schulz, Rainer; Papapetropoulos, Andreas; Turan, Belma; Ytrehus, Kirsti; Ferdinandy, Peter; Daiber, Andreas; Di Lisa, Fabio. The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection. Journal of Cellular and Molecular Medicine 2020; Volum 24 (12). ISSN 1582-1838.s 6510 - 6522.s doi: 10.1111/jcmm.15279.

Madonna, Rosalinda; Van Laake, Linda W.; Bøtker, Hans Erik; Davidson, Sean M.; De Caterina, Raffaele; Engel, Felix B.; Eschenhagen, Thomas; Fernandez-Aviles, Francesco; Hausenloy, Derek J.; Hulot, Jean-Sebastien; Lecour, Sandrine; Leor, Jonathan; Menasché, Philippe; Pesce, Maurizio; Perrino, Cinzia; Prunier, Fabrice; Van Linthout, Sophie; Ytrehus, Kirsti; Zimmermann, Wolfram-Hubertus; Ferdinandy, Péter; Sluijter, Joost P.G.. ESC working group on cellular biology of the heart: Position paper for Cardiovascular Research: Tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure. Cardiovascular Research (CVR) 2019; Volum 115 (3). ISSN 0008-6363.s 488 - 500.s doi: 10.1093/cvr/cvz010.

Ruiz-Meana, Marisol; Boengler, Kerstin; Garcia-Dorado, David; Hausenloy, Derek John; Kaambre, Tuuli; Kararigas, Georgios; Perrino, Cinzia; Schulz, Rainer; Ytrehus, Kirsti. Ageing, sex and cardioprotection.. British Journal of Pharmacology 2019. ISSN 0007-1188.s 1 - 17.s doi: 10.1111/bph.14951.

Boardman, Neoma Tove; Falck, Aleksander Tank; Lund, Trine; Chu, Xi; Martin, Armas Maria Montserrat; Norvik, Jon Viljar; Jenssen, Trond Geir; Ytrehus, Kirsti. Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Canadian Journal of Physiology and Pharmacology 2019; Volum 98 (3). ISSN 0008-4212.s 139 - 146.s doi: 10.1139/cjpp-2019-0024.

Brovold, Henrik; Lund, Trine; Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Ytrehus, Kirsti; Zykova, Svetlana. Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men. Scientific Reports 2019; Volum 9 (10513). ISSN 2045-2322.s doi: 10.1038/s41598-019-46935-w.

Ludvigsen, Stian; Mancusi, Costantino; Kildal, Simon; de Simone, Giovanni; Gerdts, Eva; Ytrehus, Kirsti. Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation. Physiological Reports 2018; Volum 6:e13593 (3). ISSN 2051-817X.s 1 - 14.s doi: 10.14814/phy2.13593.

Ytrehus, Kirsti; Hulot, Jean-Sébastien; Perrino, Cinzia; Schiattarella, Gabriele Giacomo; Madonna, Rosalinda. Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?. Vascular pharmacology 2018; Volum 107. ISSN 1537-1891.s 78 - 83.s doi: 10.1016/j.vph.2018.04.007.

Sluijter, Joost Petrus Geradus; Davidson, Sean Michael; Boulanger, Chantal M; Buzas, Edit Iren; De Kleijn, Dominique P.V.; Engel, Felix Benedikt; Giricz, Zoltán; Hausenloy, Derek J.; Kishore, Raj; Lecour, Sandrine; Leor, Jonathan; Madonna, Rosalinda; Perrino, Cinzia; Prunier, Fabrice; Sahoo, Susmita; Schiffelers, Ray Michel; Schulz, Rainer; Van Laake, Linda Wilhelmina; Ytrehus, Kirsti; Ferdinandy, Péter. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovascular Research (CVR) 2018; Volum 114 (1). ISSN 0008-6363.s 19 - 34.s doi: 10.1093/cvr/cvx211.

Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eggen, Anne Elise; Eriksen, Bjørn Odvar; Solbu, Marit Dahl. Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study. BMC Cardiovascular Disorders 2017; Volum 17:79. ISSN 1471-2261.s 1 - 10.s doi: 10.1186/s12872-017-0509-2.

Perrino, Cinzia; Barabási, Albert-Laszló; Condorelli, Gianluigi; Davidson, Sean Michael; De Windt, Leon; Dimmeler, Stefanie; Engel, Felix Benedikt; Hausenloy, Derek John; Hill, Joseph Addison; Van Laake, Linda Wilhelmina; Lecour, Sandrine; Leor, Jonathan; Madonna, Rosalinda; Mayr, Manuel; Prunier, Fabrice; Sluijter, Joost Petrus Geradus; Schulz, Rainer; Thum, Thomas; Ytrehus, Kirsti; Ferdinandy, Péter. Epigenomic and transcriptomic approaches in the post-genomic era: Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research (CVR) 2017; Volum 113 (7). ISSN 0008-6363.s 725 - 736.s doi: 10.1093/cvr/cvx070.

Hausenloy, Derek J.; Garcia-Dorado, David; Bøtker, Hans Erik; Davidson, Sean M.; Downey, James; Engel, Felix B.; Jennings, Robert; Lecour, Sandrine; Leor, Jonathan; Madonna, Rosalinda; Ovize, Michel; Perrino, Cinzia; Prunier, Fabrice; Schulz, Rainer; Sluijter, Joost P.G.; Van Laake, Linda W.; Vinten-Johansen, Jakob; Yellon, Derek M.; Ytrehus, Kirsti; Heusch, Gerd; Ferdinandy, Péter. Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research (CVR) 2017; Volum 113 (6). ISSN 0008-6363.s 564 - 585.s doi: 10.1093/cvr/cvx049.

Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Storhaug, Hilde-Merete; Jenssen, Trond Geir; Eriksen, Bjørn Odvar; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Solbu, Marit Dahl. Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013. ESC Heart Failure 2017; Volum 4. ISSN 2055-5822.s 154 - 161.s doi: 10.1002/ehf2.12134.

Salma, Wahida; Franeková, Veronika; Lund, trine; Höper, Anje Christina; Ludvigsen, Stian; Lund, Jim; Aasum, Ellen; Ytrehus, Kirsti; Belke, Darrell D.; Larsen, Terje. Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 2016; Volum 108. ISSN 0952-3278.s 13 - 21.s doi: 10.1016/j.plefa.2016.03.006.

Madonna, Rosalinda; Van Laake, Linda W.; Davidson, Sean M.; Engel, Felix B.; Hausenloy, Derek J.; Lecour, Sandrine; Leor, Jonathan; Perrino, Cinzia; Schulz, Rainer; Ytrehus, Kirsti; Landmesser, Ulf; Mummery, Christine L.; Janssens, Stefan; Willerson, James; Eschenhagen, Thomas; Ferdinandy, Péter; Sluijter, Joost P.G.. Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. European Heart Journal 2016; Volum 37 (23). ISSN 0195-668X.s 1789 - 1798.s doi: 10.1093/eurheartj/ehw113.

Bliksøen, Marte; Mariero, Lars Henrik; Torp, May-Kristin; Baysa, Anton; Ytrehus, Kirsti; Haugen, Fred; Seljeflot, Ingebjørg; Vaage, Ingvar Jarle; Valen, Guro; Stensløkken, Kåre-Olav. Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes. Basic Research in Cardiology 2016; Volum 111 (42). ISSN 0300-8428.s doi: 10.1007/s00395-016-0553-6.

Norvik, Jon Viljar; Storhaug, Hilde-Merete; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eriksen, Bjørn Odvar; Solbu, Marit Dahl. Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. BMC Cardiovascular Disorders 2016; Volum 16 (85). ISSN 1471-2261.s doi: 10.1186/s12872-016-0265-8.

Songstad, Nils Thomas; Kaspersen, Knut-Helge; Hafstad, Anne Dragøy; Basnet, Purusotam; Ytrehus, Kirsti; Acharya, Ganesh. Effects of high intensity interval training on pregnant rats, and the placenta, heart and liver of their fetuses. PLOS ONE 2015; Volum 10 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0143095.

Songstad, Nils Thomas; Johansen, David; How, Ole-Jakob; Kaaresen, Per Ivar; Ytrehus, Kirsti; Acharya, Ganesh. Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats. PLOS ONE 2014; Volum 9 (2). ISSN 1932-6203.s doi: 10.1371/journal.pone.0089559.

Stenberg, Thor Allan; Kildal, Anders Benjamin; Sanden, Espen; How, Ole-Jakob; Hagve, Martin; Ytrehus, Kirsti; Larsen, Terje; Myrmel, Truls. The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations. PLOS ONE 2014; Volum 9 (9(e105213)). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105213.

Songstad, Nils Thomas; Serrano, Maria; Sitras, Vasilis; Johansen, David; Ytrehus, Kirsti; Acharya, Ganesh. Coronary flow reserve in pregnant rats with increased left ventricular afterload. (Fulltekst: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0102147 PLOS ONE 2014; Volum 9 (7:e102147). ISSN 1932-6203.s doi: 10.1371/journal.pone.0102147.

Aljabri, Mohammad Belal; Songstad, Nils Thomas; Lund, trine; Serrano, Maria; Andreasen, Thomas Vennø; Al-Saad, Samer; Lindal, Sigurd; Sitras, Vasilis; Acharya, Ganesh; Ytrehus, Kirsti. Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts. Acta Physiologica 2011; Volum 201 (4). ISSN 1748-1708.s 445 - 456.s doi: 10.1111/j.1748-1716.2010.02234.x.

Larsen, Terje; Ytrehus, Kirsti. Hjertets patofysiologi. Gyldendal Norsk Forlag A/S 2011 ISBN 978-82-05-39914-3.s 151 - 179.

Johansen, David; Cruciani, Véronique; Sundset, Rune; Ytrehus, Kirsti; Mikalsen, Svein-Ole. Ischemia Induces Closure of Gap Junctional Channels and Opening of Hemichannels in Heart-derived Cells and Tissue. Cellular Physiology and Biochemistry 2011; Volum 28 (1). ISSN 1015-8987.s 103 - 114.s doi: 10.1159/000331719.

Hermansen, Stig Eggen; Lund, trine; Kalstad, Trine; Ytrehus, Kirsti; Myrmel, Truls. Adrenomedullin augments the angiogenic potential of late outgrowth endothelial progenitor cells. American Journal of Physiology - Cell Physiology 2011; Volum 300 (4). ISSN 0363-6143.s C783 - C791.s doi: 10.1152/ajpcell.00044.2010.

Johansen, David; Sanden, Espen; Hagve, Martin; Chu, Xi; Sundset, Rune; Ytrehus, Kirsti. Heptanol triggers cardioprotection via mitochondrial mechanisms and mitochondrial potassium channel opening in rat hearts. Acta Physiologica 2011; Volum 201 (4). ISSN 1748-1708.s 435 - 444.s doi: 10.1111/j.1748-1716.2010.02221.x.

Aljabri, Mohammad Belal; Lund, trine; Høper, Anje Christina; Andreasen, thomas vennØ; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti. Gene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin II. Cardiovascular Toxicology 2011; Volum 11 (1). ISSN 1530-7905.s 38 - 47.s doi: 10.1007/s12012-010-9100-0.

Jakobsen, Øyvind; Steensrud, Tor; Ytrehus, Kirsti; Sørlie, Dag Glen. Adenosine protects against hypoxic injury at hypothermia in guinea pig papillary muscles. Scandinavian Cardiovascular Journal 2010. ISSN 1401-7431.s doi: 10.3109/14017430903469910.

Aljabri, Mohammad Belal; Lund, trine; Høper, Anje Christina; Andreasen, Thomas Vennø; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti. Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of Angiotensin II. Cardiovascular Toxicology 2010; Volum 11 (1). ISSN 1530-7905.s 38 - 47.s doi: 10.1007/s12012-010-9100-0.

Lund, Trine; Hermansen, Stig Eggen; Andreasen, Thomas Vennø; Olsen, Jan Ole; Østerud, Bjarne; Myrmel, Truls; Ytrehus, Kirsti. Shear stress regulates inflammatory and thrombogenic gene transcripts in cultured human endothelial progenitor cells. Thrombosis and Haemostasis 2010; Volum 104 (3). ISSN 0340-6245.s 582 - 591.s doi: 10.1160/TH09-12-0854.

Fuglesteg, Britt Nanny; Tiron, C; Jonassen, Anne Kristine; Mjøs, Ole Danbolt; Ytrehus, Kirsti. Pretreatment with insulin before ischaemia reduces infarct size in Langendorff-perfused rat hearts. Acta Physiologica 2009; Volum 195 (2). ISSN 1748-1708.s 273 - 282.s doi: 10.1111/j.1748-1716.2008.01901.x.

Ytrehus, Kirsti; Tveita, Torkjel; Bugge, Einar. Loss of heart phospholipid arachidonic acid without phospholipid peroxidation in anaesthetized rats rewarmed after prolonged deep hypothermia. Cryobiology 2009; Volum 59 (3). ISSN 0011-2240.s 297 - 301.s doi: 10.1016/j.cryobiol.2009.08.006.

Sundset, Rune; Ytrehus, Kirsti; Mikalsen, Svein-Ole. Connexin, connection, conductance: Towards understanding induction of arrhythmias?. Heart Rhythm 2009; Volum 6 (11). ISSN 1547-5271.s 1639 - 1640.s doi: 10.1016/j.hrthm.2009.08.021.

Genade, S; Genis, Amanda; Ytrehus, Kirsti; Huisamen, Barbara; Lochner, Amanda. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. Journal of Pineal Research 2008; Volum 45 (4). ISSN 0742-3098.s 449 - 458.s doi: 10.1111/j.1600-079X.2008.00615.x.

Wærhaug, Kristine; Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Langbakk, Bodil; Ingebretsen, Ole C; Ytrehus, Kirsti; Bjertnaes, Lars J.. Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep. (Omtale: Editorial http://ccforum.com/content/12/5/179) Critical Care 2008; Volum 12 (4). ISSN 1364-8535.s R104 - .s doi: 10.1186/cc6985.

Arvola, Laila; Bertelsen, Geir; Ytrehus, Kirsti. Bradykinin induced sustained anti-adrenergic actions in guinea pig heart muscle involves PKC. Scandinavian Cardiovascular Journal 2007; Volum 41. ISSN 1401-7431.s 89 - 94.s doi: 10.1080/14017430601187124.

Sundset, Rune; Ytrehus, Kirsti; Zhang, Y; Saffitz, J.E.; Yamada, K.A.. Repeated Simulated Ischemia and Protection Against Gap Junctional Uncoupling. Cell Communication & Adhesion 2007; Volum 14 (5). ISSN 1541-9061.s 239 - 249.

Johansen, David; Ytrehus, Kirsti; Baxter, Gary. Exogenous hydrogen sulfide (H(2)S) protects against regional myocardial ischemia-reperfusion injury Evidence for a role of KATP channels. Basic Research in Cardiology 2006; Volum 101 (1). ISSN 0300-8428.s 53 - 60.

Lochner, Amanda; Genade, S; Davids, A; Ytrehus, Kirsti; Moolman, JA. Short- and long-term effects of melatonin on myocardial post-ischemic recovery. Journal of Pineal Research 2006; Volum 40 (1). ISSN 0742-3098.s 56 - 63.

Steensrud, Tor; Jakobsen, Øyvind; Ytrehus, Kirsti; Sørlie, Dag Glen. Contractile recovery of heart muscle after hypotermic hypoxia is improved by nicorandil via mitochondrial KATP channels. European Journal of Cardio-Thoracic Surgery 2006; Volum 30. ISSN 1010-7940.s 256 - 262.

Genade, S; Ytrehus, Kirsti; Lochner, Amanda. Melatonin prevents cardioprotection induced by a multi-cycle ischaemic precondition protocol in the isolated perfused rat heart. Cardiovascular Journal of South Africa 2006; Volum 17 (5). ISSN 1015-9657.s 239 - 244.

Starkopf, Joel; Hegna, Stig; Johansen, Odd Erik; Munch-Ellingsen, Jens; Mjøs, Ole Danbolt; Ytrehus, Kirsti. In vivo chronic carvedilol treatment in rats attenuates ex vivo regional infarction of the heart. Scandinavian Cardiovascular Journal 2006; Volum 40. ISSN 1401-7431.s 240 - 247.

Ytrehus, Kirsti. Models of myocardial ischemia. Drug Discovery Today : Disease Models 2006; Volum 3 (3). ISSN 1740-6757.s 263 - 271.

Arvola, Laila; Bertelsen, eirin listau; Lochner, Amanda; Ytrehus, Kirsti. Sustained anti-beta-adrenergic effect of melatonin in guinea pig heart papillary muscle. Scandinavian Cardiovascular Journal 2006; Volum 40 (1). ISSN 1401-7431.s 37 - 42.

Sovershaev, Mikhail; Egorina, Elena; Andreasen, Thomas Vennø; Jonassen, Anne Kristine; Ytrehus, Kirsti. Preconditioning by 17 beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS. American Journal of Physiology. Heart and Circulatory Physiology 2006; Volum 291. ISSN 0363-6135.s H1554 - H1562.

Kuklin, Vladimir; Sovershaev, Mikhail; Andreasen, thomas vennØ; Skogen, Vegard; Ytrehus, Kirsti; Bjertnaes, Lars J.. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture. (Online version, http://www.biomedcentral.com/content/qcpdf/cc3882.pdf) Critical Care 2005; Volum 9. ISSN 1364-8535.s R677 - 686.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Andreasen, thomas vennØ; Ingebretsen, Ole Christian; Ytrehus, Kirsti; Bjertnaes, Lars J.. Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. Critical Care 2005; Volum 9. ISSN 1364-8535.s R211 - 7.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Ingebretsen, Ole Christian; Andreasen, thomas vennØ; Ytrehus, Kirsti; Bjertnaes, Lars J.. Dual Endothelin-1 receptor blocker attenuates endotoxin-induced lung injury by reducing the activation of protein kinase C. Critical Care 2004; Volum 8. ISSN 1364-8535.s R451 - R458.

Arvola, Laila; Bertelsen, Geir; Hassaf, Diaa; Ytrehus, Kirsti. Positive inotropic and sustained anti-beta-adrenergic effect of diadenosine pentaphosphate in human and guinea pig hearts. Role of dinucleotide receptors and adenosine receptors. Acta Physiologica Scandinavica 2004; Volum 182. ISSN 0001-6772.s 277 - 285.

Cooper, Marie; Ytrehus, Kirsti. Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: The role of p38 MAP kinase. Molecular and Cellular Biochemistry 2004; Volum 259. ISSN 0300-8177.s 83 - 90.

Juhaszova, Magdalena; Zorov, Dmitry B.; Kim, Suhn-Hee; Pepe, Salvatore; Fu, Qin; Fishbein, Kenneth W.; Ziman, Bruce D.; Wang, Su; Ytrehus, Kirsti; Antos, Christopher L.; Olson, Eric N.; Sollott, Steven J.. Glycogen synthase kinase-3 beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. Journal of Clinical Investigation 2004; Volum 113. ISSN 0021-9738.s 1535 - 1549.

Sundset, Rune; Cooper, Marie; Mikalsen, Svein-Ole; Ytrehus, Kirsti. Ischemic preconditioning protects against gap junctional uncoupling in cardiac myofibroblasts. Cell Communication & Adhesion 2004; Volum 11. ISSN 1541-9061.s 51 - 66.

Sundset, Rune; Bertelsen, Geir; Ytrehus, Kirsti. Role of the Na+-H+ exchanger (NHE1) in heart muscle function during transient acidosis. A study in papillary muscles from rat and guinea pig hearts. Canadian Journal of Physiology and Pharmacology 2003; Volum 81 (10). ISSN 0008-4212.s 937 - 943.

Tveita, Torkjel; Hevrøy, Olav; Refsum, Helga; Ytrehus, Kirsti. Coronary endothelium-derived vasodilation during cooling and rewarmin of the in situ dog heart. Canadian Journal of Physiology and Pharmacology 1999; Volum 77. ISSN 0008-4212.s 56 - 63.

Larsen, Terje; Steigen, Terje; Ytrehus, Kirsti. Hjertets patofysiologi. Gyldendal Akademisk 2019 ISBN 9788205527881.

Ytrehus, Kirsti; Boardman, Neoma Tove; Lund, trine; Zykova, Svetlana; Jenssen, Trond Geir. The uric acid paradox, a confounder in cardiovascular research and experimental studies of cardioprotection. Conditioning Medicine 2019; Volum 2 (1). ISSN 2577-3240.s 40 - 49.

Norvik, Jon Viljar; Solbu, Marit Dahl; Ytrehus, Kirsti. Uric acid and adiponectin in cardiovascular disease. 2017 ISBN 978-82-7589-535-4.

Ytrehus, Kirsti; Larsen, Terje; Christensen, Geir Arve; Stensløkken, Kåre-Olav; Levy, Finn Olav. In memory of Guro Valen (1960-2014). Journal of Molecular and Cellular Cardiology 2015; Volum 79. ISSN 0022-2828.s 254 - 255.s doi: 10.1016/j.yjmcc.2014.11.026.

Ytrehus, Kirsti. Spesialist-PhD, et tankeeksperiment. LVS-info 2014.s 8 - 9.

Ytrehus, Kirsti. Medisinske professorer, antall og alder. LVS-info 2014.s 9 - 9.

Ytrehus, Kirsti; Augestad, Liv Ariane; Hagve, Tor-Arne; Kristoffersen, Espen Saxhaug; Kvernmo, Siv; Middelfart, Anna; Pettersen, Helge Bjørnstad; Vedeler, Christian A.. Satsingen på medisinsk forskning kan bli svekket. Dagens medisin 2014; Volum 19. ISSN 1501-4290.

Ytrehus, Kirsti. Kjære medlemmer. LVS-info 2014.s 3 - 3.

Ytrehus, Kirsti. Kjære kollegaer!. LVS-info 2014.s 3 - 3.

Ytrehus, Kirsti. Kjære medlemmer!. LVS-info 2014.s 3 - 3.

Salma, Wahida; Höper, Anje Christina; Lund, trine; Ludvigsen, Stian; Ytrehus, Kirsti; Aasum, Ellen; Larsen, Terje. Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice. Society for heart and vascular metabolism (SHVM) 2013-09-29 - 2013-10-02 2013.

Songstad, Nils Thomas; Johansen, David; How, Ole-Jakob; Ytrehus, Kirsti; Acharya, Ganesh. Effect of chronic pressure load on heart structure and function in pregnant rats. European Congress of Periantal Medicine 2012-06-13 - 2012-06-16 2012.

Aljabri, Mohammad Belal; Ytrehus, Kirsti. Angiotensin II and heart remodelling. Role of ischemia, gender and pregnancy. 2011 ISBN 978-82-7589-308-4.

Johansen, David; Sanden, Espen; Chu, Xi; Sundset, Rune; Ytrehus, Kirsti. Heptanol triggers cardio protection via mitochondrial potassium channels and not by gap junction uncoupling. Cardiovascular Research (CVR) 2010; Volum 87. ISSN 0008-6363.s S85 - S85.

Songstad, Nils Thomas; Serrano, Maria; Sitras, Vasilis; Ytrehus, Kirsti; Acharya, Ganesh. Endothelial function in the coronary circulation evaluated by coronary flow reserve is not impaired by angiotensin II in pregnant rats. Acta Physiologica International Symposium: Cardiovascular Physiology and Metabolism 2009-09-30 - 2009-10-01 2009.

Aljabri, Mohammad Belal; Lund, trine; Ytrehus, Kirsti. Female and male rat hearts are equally affected by chronic exogenous angiotensin II. European Journal of Heart Failure. Supplements 2009; Volum 8 (2). ISSN 1567-4215.

Hermansen, Stig eggen; Lund, trine; Ytrehus, Kirsti; Myrmel, truls. Adrenomedullin enhance proliferation and angiogenetic potential of late outgrowth endothelial progenitor cells. European Journal of Heart Failure. Supplements 2009; Volum 8 (2). ISSN 1567-4215.

Lund, trine; Hals, Margareth Bergesen; Paulssen, Ruth H; Ytrehus, Kirsti. Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC). European Journal of Heart Failure. Supplements 2009; Volum 8 (2). ISSN 1567-4215.

Sundset, Rune; Ytrehus, Kirsti; Mikalsen, S O. Connexin, connection, conductance: Towards understanding induction of arrhythmias?. Heart Rhythm 2009; Volum 6 (11). ISSN 1547-5271.s 1639 - 1640.s doi: 10.1016/j.hrthm.2009.08.021.

Hermansen, Stig eggen; Lund, trine; Ytrehus, Kirsti; Myrmel, truls. Adrenomedullin enhance proliferation and angiogenetic potential of late outgrowth endothelial progenitor cells. Regional forskingskonferanse innen medisin og helse 2009-03-25 - 2009-03-26 2009.

Lund, trine; Hals, Margareth Bergesen; Paulssen, Ruth H; Ytrehus, Kirsti. Increased gene expression diversity between female and male mice hearts after transverse aortic constriction (TAC). Regional forskningskonferanse innen medisin og helse 2009-03-25 - 2009-03-26 2009.

Aljabri, Mohammad Belal; Lund, trine; Ytrehus, Kirsti. Female and male rat hearts are equally affected by chronic exogenous angiotensin II. Heart Failure 2009 2009-05-30 - 2009-06-02 2009.

Fuglesteg, Britt Nanny; Ytrehus, Kirsti; Mjøs, Ole Danbolt. Reducing Infarct Size by Ischemic Preconditioning versus Insulin Treatment in the Heart. 2008 ISBN 978-82-7589-214-8.

Ytrehus, Kirsti. Hypoxia-inducible factor 1 alpha: a new piece in the preconditioning puzzle. Cardiovascular Research (CVR) 2008; Volum 77 (4). ISSN 0008-6363.s 443 - 444.s doi: 10.1093/cvr/cvm104.

Mikalsen, Svein-Ole; Sundset, Rune; Ytrehus, Kirsti; Cruciani, Veronique. Studies on the phosphorylation of the extreme C-terminal tail of connexin43. International Gap Junction Conferende 2007-08-04 - 2007.

Aljabri, Mohammad Belal; Fuglesteg, Britt Nanny; Andreasen, Thomas Vennø; Ytrehus, Kirsti. Angiotensin II and postconditioning in reperfusion of isolated rat heart. Journal of Molecular and Cellular Cardiology 2007; Volum 42. ISSN 0022-2828.s doi: 10.1016/j.yjmcc.2007.03.561.

Fuglesteg, Britt Nanny; Andreasen, Thomas Vennø; Mjøs, Ole Danbolt; Ytrehus, Kirsti. Insulin and ischemic preconditioning induce cardioprotective GSK3B blockade via STAT3 signalling in the isolated rat heart. Journal of Molecular and Cellular Cardiology 2007; Volum 42. ISSN 0022-2828.s doi: 10.1016/j.yjmcc.2007.03.541.

Mikalsen, Svein-Ole; Sundset, Rune; Ytrehus, Kirsti; Seglen, P O; Fleckenstein, B; Cruciani, Veronique. Phosphorylation sites in the C-terminal tail of connexin43 and antibody specificity. 3rd Norwegian Proteomics Conference 2007-09-14 - 2007-09-15 2007.

Fuglesteg, Britt Nanny; Andreasen, Thomas Vennø; Mjøs, Ole Danbolt; Ytrehus, Kirsti. Insulin and ischemic preconditioning induce cardioprotective GSK3B blockade via STAT3 signalling in the isolated rat heart. XIX World congress of the ISHR 2007-06-22 - 2007-06-25 2007.

Aljabri, Mohammad Belal; Fuglesteg, Britt Nanny; Andreasen, Thomas Vennø; Ytrehus, Kirsti. Angiotensin II and postconditioning in reperfusion of isolated rat heart. XIX World congress of the ISHR 2007-06-22 - 2007-06-25 2007.

Larsen, I; Weydahl, HM; Fredenfeldt, T; Ytrehus, Kirsti; Lu, T; Traasdahl, ER; Sundset, Rune. Nukleærmedisinsk metode for å selektere hjertesviktpasienter til resynkroniseringsterapi (biventrikulær pacemaker behandling). Regional forskningskonferanse innen medisin og helse 2006-11-01 - 2006-11-02 2006.

Arvola, Laila; Ytrehus, Kirsti. Anti-beta-adrenergic memory in the heart? A study of contractile force in heart papillary muscle. (http://uit.no/77/688/38) 2006 ISBN 82-7589-161-2.

Fuglesteg, Britt Nanny; Tiron, C; Jonassen, Anne Kristine; Mjøs, Ole Danbolt; Ytrehus, Kirsti. Insulin and ischemic preconditioning induce cardioprotective GSK3B blockade via STAT3 signalling in the isolated rat heart. Protecting the heart against ischaemia 2006-08-11 - 2006.

Jakobsen, Øyvind; Steensrud, tor; Ytrehus, Kirsti; Sørlie, Dag Glen. Nicorandil, dose-response in guinea pig papillary muscle. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

Sundset, Rune; Ytrehus, Kirsti; Saffitz, J.E.; Yamada, K.A.. Preconditioning and protection against gap junctional uncoupling. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1073 - 1073.

Lund, Trine; Sovershaev, Mikhail; Egorina, Elena; Johansen, David; Riemersma, Rudolph; Wulfert, Erik; Ytrehus, Kirsti. Cardioprotection by 7beta-hydroxylated epiandrosterone (7-OH-EPIA). Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1043 - 1043.

Johansen, David; Sundset, Rune; Ytrehus, Kirsti. Gap junction uncoupling protects the heart against ischemia. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1031 - 1031.

Sovershaev, Mikhail; Egorina, Elena; Andreasen, Thomas Vennø; Jonassen, Anne Kristin; Ytrehus, Kirsti. Signalling consequences of preconditioning with 17 beta-estradiol in isolated rat heart. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1069 - 1069.

Arvola, Laila; Bertelsen, Eirin; Ytrehus, Kirsti. Anti-adrenergic effect of melatonin, bradykinin and opioid peptides in the myocardium. Hjerteforum 2005; Volum 2 (178). ISSN 0802-1465.

Jakobsen, Øyvind; Steensrud, Tor; Ytrehus, Kirsti; Sørlie, Dag Glen. Nicorandil, dose-response in guinea pig papillary muscle. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1031 - 1031.

Chu, Xi; Ytrehus, Kirsti. Cardiac myocytes - Evaluation of cell integrity and mitochondrial function using laser scanning confocal imaging. 2005.

Sundset, Rune; Ytrehus, Kirsti. Gap junction intercellular communication in ischemia & heart failure. (http://uit.no/medbiologi/medfys/37) (Omtale: http://uit.no/nyheter/904/2864) 2005 ISBN 82-7589-159-0.

Arvola, Laila; Bertelsen, Eirin Listau; Ytrehus, Kirsti. Anti-adrenergic effect of melatonin, bradykinin and opioid peptides in the myocardium. Kardiologisk vintermøte 2005-01-28 - 2005-01-30 2005.

Sovershaev, Mikhail; Egorina, elena; Andreasen, Thomas Vennø; Jonassen, anne kristine; Ytrehus, Kirsti. Signalling consequences of preconditioning with 17beta-estradiol in isolated rat heart. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

Sundset, Rune; Ytrehus, Kirsti; Saffitz, J.E.; Yamada, K.A.. Preconditioning and protection against gap junctional uncoupling. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

Lund, Trine; Sovershaev, Mikhail; Egorina, elena; Johansen, David; Riemersma, Rudolph; Wulfert, Erik; Ytrehus, Kirsti. Cardioprotection by 7beta-hydroxylated epiandrosterone (7-OH-EPIA). European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

Johansen, David; Sundset, Rune; Ytrehus, Kirsti. Gap junction uncoupling protects the hear against ischemia. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

Arvola, Laila; Bertelsen, Geir; Lochner, Amanda; Ytrehus, Kirsti. Anti-Beta-Adrenergic effects of melatonin in guinea pig hearts. Satelitt symposium 2004-08-13 - 2004.

Steensrud, Tor; Sørlie, Dag Glen; Ytrehus, Kirsti. Contractile recovery after hypotherm hypoxia is improved by nicorandil via mitochondrial K-ATP-channels. Journal of Molecular and Cellular Cardiology 2004; Volum 36. ISSN 0022-2828.s 771 - 772.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Kuklina, N; Ytrehus, Kirsti; Bjertnæs, Lars J.. Tezosentan prevents endothelin-induced fluid filtration in rat lungs. Helse Nord konferansen 2004-11-10 - 2004-11-12 2004.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Ingebretsen, Ole Christian; Andreasen, Thomas Vennø; Ytrehus, Kirsti; Bjertnæs, Lars J.. Tezosentan-induced attenuation of lung injury is associated with blockade of protein kinase C. Kongress (Omtale: Awarded the Prize for best oral presentation; Berlin October 13, 2004) 2004-10-10 - 2004-10-10 2004.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Kuklina, N; Ytrehus, Kirsti; Bjertnæs, Lars J.. Tezosentan prevents endothelin-induced fluid filtration in rat lungs. 2004. The 17th Annual Congress of the European Society of Intensive Care Medicine, Berlin, Germany, October 10-13, 2004-10-10 - 2004-10-13 2004.

Steensrud, Tor; Sørlie, Dag Glen; Ytrehus, Kirsti. Contractile Recovery after Hypotherm Hypoxia is improved by Nicorandil in guinea pig papillary muscles via Mitochondrial KATP Channels. Annual meeting of he scandinavian society for research in cardiothoracic surgery 2004-02-05 - 2004-02-08 2004.

Arvola, Laila; Bertelsen, Geir; Ytrehus, Kirsti. Sustained anti-beta-adrenergic effect of opioids and bradykinin in guinea-pig papillary muscle. ISHR-konferanse 2003-06-21 - 2003.

Kuklin, Vladimir; Kirov, Mikhail Y; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Kuklina, Natalia; Ytrehus, Kirsti; Bjertnaes, Lars J.. Endothelin receptor antagonist prevents endothelin-induced increase in microvascular permeability by reducing translocation of protein kinase C.. NAForum 2003;16(3):56. 2003-10-21 - 2003-10-24 2003.

Kuklin, Vladimir; Kirov, Mikhail Y; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Ytrehus, Kirsti; Bjertnaes, Lars J.. Endothelin receptor blockade attenuates endotoxin-induced lung injury in sheep by reducing translocation of protein kinase C.. NAForum 2003;16(3):58. 2003-10-21 - 2003-10-24 2003.

Kuklin, Vladimir; Kirov, Mikhail Y; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Kuklina, Natalia; Ytrehus, Kirsti; Bjertnaes, Lars J.. Tezosentan prevents endothelin-induced fluid filtration in rat lungs.. The 16th Annual Congress of the European Society of Intensive Care Medicine, In: Intensive Care Med 2003;29 (suppl. 1):S5. 2003-10-05 - 2003-10-08 2003.

Kuklin, Vladimir; Kirov, Mikhail Y; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Ytrehus, Kirsti; Bjertnaes, Lars J.. Endothelin-1: physiology and role in acute lung injury.. The 2nd Congress of Association of Anesthesiologists and Reanimatologists of Northwestern Russia. Arkhangelsk, Russia, June 25-27, 2003, pp. 150-152. 2003-06-25 - 2003-06-27 2003.

Sundset, Rune; Ytrehus, Kirsti. Adaptive responses of gap junctional communication and increased myocyte survival with preconditioning. ISHR kongress 2003-06-21 - 2003-06-23 2003.

Kuklin, Vladimir; Kirov, Mikhail; Sovershaev, Mikhail; Andreasen, Thomas Vennø; Ytrehus, Kirsti; Bjertnæs, Lars J.. Endothelin-1 receptor blockade attenuates acute lung injury. The 27th. Congress of the Scandinavian Society of Anaesthesiologists 2003-08-16 - 2003-08-20 2003.

Gilhus, Nils Erik; Ottersen, Ole Petter; Ytrehus, Kirsti; Iversen, Ole-Jan. Hvorfor forskerlinje for medisinske studenter. Tidsskrift for Den norske legeforening 2001; Volum 121 (15). ISSN 0029-2001.s 1846 - .