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Bilde av Larsen, Terje
Bilde av Larsen, Terje
Department of Medical Biology terje.larsen@uit.no +4777644694 90518896 Tromsø MH L7.225B

Larsen, Terje

Professor emeritus

  • Kirsten Maria Jansen, Norma Dahdah, Pau Gama-Perez, Pauke C. Schots, Terje Larsen, Pablo M. Garcia-Roves :
    Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration
    Frontiers in Endocrinology 2023 DOI
  • Marek Štěpán, Klára Dad’ová, Miloš Matouš, Eva Krauzová, Lenka Sontáková, Michal Koc et al.:
    Exercise training combined with calanus oil supplementation improves the central cardiodynamic function in older women
    Nutrients 2022 ARKIV / DOI
  • Lucas Christian Tauschek, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen, Trine Karlsen :
    No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study.
    International Journal of Sport Nutrition & Exercise Metabolism 2022 ARKIV / DOI
  • Terje Larsen, Kirsten Jansen :
    Impact of obesity-related inflammation on cardiac metabolism and function
    Journal of Lipid and Atherosclerosis (JLA) 2021 ARKIV / DOI
  • Pauke C. Schots, Kirsten Maria Jansen, Jakub Mrazek, Alice Marie Pedersen, Ragnar Ludvig Olsen, Terje Larsen :
    Obesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oil
    Nutrition Research 2020 ARKIV / DOI
  • Pauke C. Schots, Alice Marie Pedersen, Karl-Erik Eilertsen, Ragnar Ludvig Olsen, Terje Larsen :
    Possible Health Effects of a Wax Ester Rich Marine Oil
    Frontiers in Pharmacology 2020 ARKIV / DOI
  • Martin Iversen Hagve, Petter Fosse Gjessing, Mikal Jacob Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes et al.:
    Perioperative infusion of glucagon-like peptide-1 prevents insulin resistance after surgical trauma in female pigs
    Endocrinology 2019 ARKIV / DOI
  • Kirsten Jansen, Sonia Moreno, Pablo M Garcia-Roves, Terje Larsen :
    Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice
    American Journal of Physiology. Heart and Circulatory Physiology 2019 ARKIV / DOI
  • Marina Makrecka-Kuka, Edgars Liepinsh, Andrew J. Murray, Hélène Lemieux, Maija Dambrova, Kersti Tepp et al.:
    Altered mitochondrial metabolism in the insulin-resistant heart
    Acta Physiologica 2019 ARKIV / DOI
  • Angel Moldes-Anaya, Thomas Sæther, Silvio Uhlig, Hilde Irene Nebb, Terje Larsen, Hans Christian Eilertsen et al.:
    Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
    Marine Drugs 2017 ARKIV / FULLTEKST / DOI
  • Wahida Salma, Veronika Franeková, trine Lund, Anje Christina Höper, Stian Ludvigsen, Jim Lund et al.:
    Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice
    Prostaglandins, Leukotrienes and Essential Fatty Acids 2016 DOI
  • Chad M. Cook, Terje Larsen, Linda D. Derrig, Kathleen M Kelly, Kurt Tande :
    Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption
    Lipids 2016 DOI
  • Martin Hagve, Petter Fosse Gjessing, Ole-Martin Fuskevåg, Terje S Larsen, Øivind Irtun :
    Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance
    American Journal of Physiology. Endocrinology and Metabolism 2015 DOI
  • Jim Lund, Anne Dragøy Hafstad, Neoma Tove Boardman, Line Rossvoll, Natale Pinheiro Lage Rolim, Muhammad Shakil Ahmed et al.:
    Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
    American Journal of Physiology. Heart and Circulatory Physiology 2015 DOI
  • Veronika Franeková, Yeliz Angin, Nicole T.H. Hoebers, Will A. Coumans, Peter J. Simons, Jan F.C. Glatz et al.:
    Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure
    American Journal of Physiology - Cell Physiology 2015 DOI
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    Circulation: Heart Failure 2015 DOI
  • Alice Marie Pedersen, Wahida Salma, Anje Christina Höper, Terje Larsen, Ragnar Ludvig Olsen :
    Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil
    European Journal of Lipid Science and Technology 2014 DOI
  • Anje Christina Höper, Wahida Salma, Selene Julie Sollie, Anne Dragøy Hafstad, Jim Lund, Ahmed Murtaz Khalid et al.:
    Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice
    Journal of Nutrition 2014 DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Espen Sanden, Ole-Jakob How, Martin Hagve, Kirsti Ytrehus et al.:
    The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations
    PLOS ONE 2014 ARKIV / DOI
  • Anje Christina Höper, Wahida Salma, Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Selene Julie Sollie, Jan Raa et al.:
    Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
    British Journal of Nutrition 2013 DOI
  • Anne Dragøy Hafstad, Jim Lund, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen, Ellen Aasum :
    High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity
    Diabetes 2013 DOI
  • Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert et al.:
    Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
    American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
  • Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Terje Larsen, david lester Severson, Neoma Tove Boardman, Martin Hagve et al.:
    Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Neoma Tove Boardman, Terje Larsen, david lester Severson, M Fadiel Essop, Ellen Aasum :
    Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Finn P. Reinholt, Terje Larsen, Lars Uhlin-Hansen, Trond Geir Jenssen et al.:
    Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy
    ISRN Endocrinology 2011 ARKIV / DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ahmed Murtaz Khalid, Ulrik Wisløff et al.:
    High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
    Journal of applied physiology 2011 DOI
  • Trine Karlsen, Lucas Taucheck, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen :
    The effect of Calanus Finmarchicus oilnon maximal oxygen uptake: a randomized controlled study
    2020
  • Trine Karlsen, Lucas Taucheck, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen :
    The effect of Calanus Finmarchicus oil (Calanus® Oil ) on maximal oxygen uptake: a randomized controlled study
    2020
  • Jan F.C. Glatz, Coert J. Zuurbier, Terje Larsen :
    Targeting metabolic pathways to treat cardiovascular diseases
    Biochimica et Biophysica Acta - Molecular Basis of Disease 2020 DOI
  • Terje Larsen, Terje Steigen, Kirsti Ytrehus :
    Hjertets patofysiologi
    Gyldendal Akademisk 2019
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
    Circulation: Heart Failure 2015 DOI
  • Kirsti Ytrehus, Terje Larsen, Geir Arve Christensen, Kåre-Olav Stensløkken, Finn Olav Levy :
    In memory of Guro Valen (1960-2014)
    Journal of Molecular and Cellular Cardiology 2015 DOI
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs)
    2014
  • Alice Marie Pedersen, Wahida Salma, Anje Christina Höper, Terje Larsen, Ragnar Ludvig Olsen :
    Digestion and absorption of marine wax esters as a dietary supplement
    2013
  • Alice Marie Pedersen, Anje Christina Höper, Wahida Salma, Terje Larsen, Ragnar Ludvig Olsen :
    Digestion and absorption of Calanus Oil
    2013
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim-Larsen, Hilde Irene Nebb, Terje Larsen, Steinar Paulsen :
    Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae
    2013
  • Terje Larsen :
    Calanusolje har oppsiktsvekkende egenskaper
    2013 FULLTEKST / DATA
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim Larsen, Terje Larsen, Steinar Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Wahida Salma, Anje Christina Höper, trine Lund, Stian Ludvigsen, Kirsti Ytrehus, Ellen Aasum et al.:
    Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice
    2013
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim Larsen, Terje Larsen, Hilde Irene Nebb, Steinar Paulsen :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Anne Dragøy Hafstad, Jim Lund, Martin Hagve, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen et al.:
    High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function
    2012
  • Anje Christina Höper, Terje Larsen, Ahmed Murtaz Khalid, Wahida Salma, Selene Julie Sollie, Jim Lund et al.:
    Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding
    2012
  • Jim Lund, Anne Dragøy Hafstad, Terje Larsen, Ellen Aasum :
    High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat
    2012
  • Anne Dragøy Hafstad, Jim Lund, Terje Larsen, Ellen Aasum :
    Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak
    2012
  • Marcia Alves, Ulrik Wisloff, Danilo Roman-Campos, Pedro Almeida, Terje Larsen, Jaqueline Alvarez-Leite et al.:
    Lipotoxicity In Cardiomyocytes: Reversal By Aerobic Training
    Medicine & Science in Sports & Exercise 2012
  • Wahida Salma, Anje Christina Höper, Ahmed Murtaz Khalid, Selene Julie Sollie, Jim Lund, Anne Dragøy Hafstad et al.:
    Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
    2012
  • Wahida Salma, Selene Julie Sollie, Anje Christina Höper, Ahmed Murtaz Khalid, Jim Lund, Anne Dragøy Hafstad et al.:
    Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
    2012
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    2011
  • Anje Christina Høper, Terje Larsen, Jim Lund, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ellen Aasum :
    Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice
    2011

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    Research interests

    My research activity focuses on alterations in myocardial metabolism during obesity and type 2 diabetes and how such changes may influence the mechanical function of the heart, using the genetically diabetic (db/db) mouse, as well as diet-induced obese mice and rats as diabetic models. We have demonstrated marked changes in cardiac metabolism in these animals, with a clear over-reliance on fatty acid oxidation for energy production and a corresponding reduction in glucose oxidation. In addition, they show cardiomyopathy and/or reduced cardiac efficiency (the relationship between cardiac work and oxygen consumption), as well as reduced tolerance to ischemia-reperfusion.

    We are investigating possible mechanisms of diabetes-induced cardiac dysfunction, hypothesizing that the metabolic disorders accompanying the diabetic state play a central role in the development of cardiac disease. Of particular interest is the transcriptional regulation of myocardial substrate supply and utilization via activation of the nuclear peroxisome proliferator-activated receptors (PPARs) - both in the heart, adipose tissue and liver. Current experimental activity includes use of various (lipid-lowering) PPAR agonists, exercise training and dietary modifications of metabolism to determine its impact on the mechanical function of the heart.


    Member of research group

    Kardiovaskulær forskningsgruppe IMB   Norsk innhold Cardiovascular Research Group IMB   English content

    CV

    Name: Terje Steinar Larsen

    Present position and address: Professor, Cardiovascular Research Group, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

    Born: April 18, 1950, 8432 Alsvåg, Norway.

    Status: Married, three children.

    Private address: Ryllikveien 47, 9100 Kvaløysletta, Norway

    Education:

    1972-1976: University of Tromsø, Norway; Bachelor of Science

    1976-1978: University of Tromsø, Norway; Master of Science

    1978-1985: University of Tromsø, Norway; PhD

    Professional experience and research positions:

    1978-1980: Research Fellow (Department of Medical Physiology, University of Tromsø)

    1980-1985: Research Fellow (Norwegian Research Council for Science and the Humanities), Department of Arctic Biology, University of Tromsø

    1985-1986: Postdoctoral Fellow (Alberta Heritage Foundation for Medical Research), Faculty of Medicine, The University of Calgary, Canada

    1986-1990: Postdoctoral Fellow (Norwegian Research Council), Department of Medical Physiology, University of Tromsø

    1990-1992: Associate professor, Department of Medical Physiology, University of Tromsø

    1992-1996: Professor, Chairman, Department of Medical Physiology, University of Tromsø

    1996-1997: Sabbatical stay at The Faculty of Medicine, The University of Calgary, Canada

    1997-present: Professor, Department of Medical Physiology, University of Tromsø.

    1998-2005: Professor, Department of Medical Physiology, University of Tromsø/Chairman, Institute of Medical Biology, University of Tromsø.

    1998-present: Professor & Chairman, Department of Medical Physiology, University of Tromsø

    2009-present: Professor, Cardiovascular Research Group IMB; Chairman, Institute of Medical Biology, University of Tromsø.