Bilde av Larsen, Terje
Bilde av Larsen, Terje
Department of Medical Biology terje.larsen@uit.no +4777644694 90518896 Tromsø MH L7.225B

Larsen, Terje


Professor emeritus


  • Marek Štěpán, Klára Dad’ová, Miloš Matouš, Eva Krauzová, Lenka Sontáková, Michal Koc et al.:
    Exercise training combined with calanus oil supplementation improves the central cardiodynamic function in older women
    Nutrients 2022 ARKIV / DOI
  • Lucas Tauschek, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen, Trine Karlsen :
    No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study.
    International Journal of Sport Nutrition & Exercise Metabolism 2022 DOI
  • Terje Larsen, Kirsten Jansen :
    Impact of obesity-related inflammation on cardiac metabolism and function
    Journal of Lipid and Atherosclerosis (JLA) 2021 ARKIV / DOI
  • Pauke C. Schots, Kirsten Maria Jansen, Jakub Mrazek, Alice Marie Pedersen, Ragnar Ludvig Olsen, Terje Larsen :
    Obesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oil
    Nutrition Research 2020 ARKIV / DOI
  • Pauke C. Schots, Alice Marie Pedersen, Karl-Erik Eilertsen, Ragnar Ludvig Olsen, Terje Larsen :
    Possible Health Effects of a Wax Ester Rich Marine Oil
    Frontiers in Pharmacology 2020 ARKIV / DOI
  • Martin Iversen Hagve, Petter Fosse Gjessing, Mikal Jacob Hole, Kirsten M Jansen, Ole Martin Fuskevåg, Tom Eirik Mollnes et al.:
    Perioperative infusion of glucagon-like peptide-1 prevents insulin resistance after surgical trauma in female pigs
    Endocrinology 2019 ARKIV / DOI
  • Kirsten Jansen, Sonia Moreno, Pablo M Garcia-Roves, Terje Larsen :
    Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice
    American Journal of Physiology. Heart and Circulatory Physiology 2019 ARKIV / DOI
  • Marina Makrecka-Kuka, Edgars Liepinsh, Andrew J. Murray, Hélène Lemieux, Maija Dambrova, Kersti Tepp et al.:
    Altered mitochondrial metabolism in the insulin-resistant heart
    Acta Physiologica 2019 ARKIV / DOI
  • Angel Moldes-Anaya, Thomas Sæther, Silvio Uhlig, Hilde Irene Nebb, Terje Larsen, Hans Christian Eilertsen et al.:
    Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
    Marine Drugs 2017 ARKIV / FULLTEKST / DOI
  • Wahida Salma, Veronika Franeková, trine Lund, Anje Christina Höper, Stian Ludvigsen, Jim Lund et al.:
    Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice
    Prostaglandins, Leukotrienes and Essential Fatty Acids 2016 DOI
  • Chad M. Cook, Terje Larsen, Linda D. Derrig, Kathleen M Kelly, Kurt Tande :
    Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption
    Lipids 2016 DOI
  • Martin Hagve, Petter Fosse Gjessing, Ole-Martin Fuskevåg, Terje S Larsen, Øivind Irtun :
    Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance
    American Journal of Physiology. Endocrinology and Metabolism 2015 DOI
  • Jim Lund, Anne Dragøy Hafstad, Neoma Tove Boardman, Line Rossvoll, Natale Pinheiro Lage Rolim, Muhammad Shakil Ahmed et al.:
    Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
    American Journal of Physiology. Heart and Circulatory Physiology 2015 DOI
  • Veronika Franeková, Yeliz Angin, Nicole T.H. Hoebers, Will A. Coumans, Peter J. Simons, Jan F.C. Glatz et al.:
    Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure
    American Journal of Physiology - Cell Physiology 2015 DOI
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    Circulation: Heart Failure 2015 DOI
  • Alice Marie Pedersen, Wahida Salma, Anje Christina Höper, Terje Larsen, Ragnar Ludvig Olsen :
    Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil
    European Journal of Lipid Science and Technology 2014 DOI
  • Anje Christina Höper, Wahida Salma, Selene Julie Sollie, Anne Dragøy Hafstad, Jim Lund, Ahmed Murtaz Khalid et al.:
    Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice
    Journal of Nutrition 2014 DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Espen Sanden, Ole-Jakob How, Martin Hagve, Kirsti Ytrehus et al.:
    The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations
    PLOS ONE 2014 ARKIV / DOI
  • Anje Christina Höper, Wahida Salma, Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Selene Julie Sollie, Jan Raa et al.:
    Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
    British Journal of Nutrition 2013 DOI
  • Anne Dragøy Hafstad, Jim Lund, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen, Ellen Aasum :
    High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity
    Diabetes 2013 DOI
  • Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert et al.:
    Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
    American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
  • Ahmed Murtaz Khalid, Anne Dragøy Hafstad, Terje Larsen, david lester Severson, Neoma Tove Boardman, Martin Hagve et al.:
    Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Neoma Tove Boardman, Terje Larsen, david lester Severson, M Fadiel Essop, Ellen Aasum :
    Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling
    American Journal of Physiology. Heart and Circulatory Physiology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Finn P. Reinholt, Terje Larsen, Lars Uhlin-Hansen, Trond Geir Jenssen et al.:
    Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy
    ISRN Endocrinology 2011 ARKIV / DOI
  • Anne Dragøy Hafstad, Neoma Tove Boardman, Jim Lund, Martin Hagve, Ahmed Murtaz Khalid, Ulrik Wisløff et al.:
    High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
    Journal of applied physiology 2011 DOI
  • Trine Karlsen, Lucas Taucheck, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen :
    The effect of Calanus Finmarchicus oilnon maximal oxygen uptake: a randomized controlled study
    2020
  • Trine Karlsen, Lucas Taucheck, Ragnhild Røsbjørgen, Håvard Dalen, Terje Larsen :
    The effect of Calanus Finmarchicus oil (Calanus® Oil ) on maximal oxygen uptake: a randomized controlled study
    2020
  • Jan F.C. Glatz, Coert J. Zuurbier, Terje Larsen :
    Targeting metabolic pathways to treat cardiovascular diseases
    Biochimica et Biophysica Acta - Molecular Basis of Disease 2020 DOI
  • Terje Larsen, Terje Steigen, Kirsti Ytrehus :
    Hjertets patofysiologi
    Gyldendal Akademisk 2019
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
    Circulation: Heart Failure 2015 DOI
  • Kirsti Ytrehus, Terje Larsen, Geir Arve Christensen, Kåre-Olav Stensløkken, Finn Olav Levy :
    In memory of Guro Valen (1960-2014)
    Journal of Molecular and Cellular Cardiology 2015 DOI
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs)
    2014
  • Alice Marie Pedersen, Wahida Salma, Anje Christina Höper, Terje Larsen, Ragnar Ludvig Olsen :
    Digestion and absorption of marine wax esters as a dietary supplement
    2013
  • Alice Marie Pedersen, Anje Christina Höper, Wahida Salma, Terje Larsen, Ragnar Ludvig Olsen :
    Digestion and absorption of Calanus Oil
    2013
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim-Larsen, Hilde Irene Nebb, Terje Larsen, Steinar Paulsen :
    Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae
    2013
  • Terje Larsen :
    Calanusolje har oppsiktsvekkende egenskaper
    2013 FULLTEKST / DATA
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim Larsen, Terje Larsen, Steinar Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Wahida Salma, Anje Christina Höper, trine Lund, Stian Ludvigsen, Kirsti Ytrehus, Ellen Aasum et al.:
    Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice
    2013
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim Larsen, Terje Larsen, Hilde Irene Nebb, Steinar Paulsen :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Anne Dragøy Hafstad, Jim Lund, Martin Hagve, Elin Synnøve Hadler-Olsen, Anje Christina Höper, Terje Larsen et al.:
    High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function
    2012
  • Anje Christina Höper, Terje Larsen, Ahmed Murtaz Khalid, Wahida Salma, Selene Julie Sollie, Jim Lund et al.:
    Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding
    2012
  • Jim Lund, Anne Dragøy Hafstad, Terje Larsen, Ellen Aasum :
    High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat
    2012
  • Anne Dragøy Hafstad, Jim Lund, Terje Larsen, Ellen Aasum :
    Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak
    2012
  • Marcia Alves, Ulrik Wisloff, Danilo Roman-Campos, Pedro Almeida, Terje Larsen, Jaqueline Alvarez-Leite et al.:
    Lipotoxicity In Cardiomyocytes: Reversal By Aerobic Training
    Medicine & Science in Sports & Exercise 2012
  • Wahida Salma, Anje Christina Höper, Ahmed Murtaz Khalid, Selene Julie Sollie, Jim Lund, Anne Dragøy Hafstad et al.:
    Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
    2012
  • Wahida Salma, Selene Julie Sollie, Anje Christina Höper, Ahmed Murtaz Khalid, Jim Lund, Anne Dragøy Hafstad et al.:
    Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
    2012
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice
    2011
  • Anje Christina Høper, Terje Larsen, Jim Lund, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ellen Aasum :
    Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice
    2011
  • Anne Dragøy Hafstad, Jim Lund, Anje Christina Høper, Elin Synnøve Hadler-Olsen, Martin Hagve, Ulrik Wisløff et al.:
    High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice
    2011

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    Research interests

    My research activity focuses on alterations in myocardial metabolism during obesity and type 2 diabetes and how such changes may influence the mechanical function of the heart, using the genetically diabetic (db/db) mouse, as well as diet-induced obese mice and rats as diabetic models. We have demonstrated marked changes in cardiac metabolism in these animals, with a clear over-reliance on fatty acid oxidation for energy production and a corresponding reduction in glucose oxidation. In addition, they show cardiomyopathy and/or reduced cardiac efficiency (the relationship between cardiac work and oxygen consumption), as well as reduced tolerance to ischemia-reperfusion.

    We are investigating possible mechanisms of diabetes-induced cardiac dysfunction, hypothesizing that the metabolic disorders accompanying the diabetic state play a central role in the development of cardiac disease. Of particular interest is the transcriptional regulation of myocardial substrate supply and utilization via activation of the nuclear peroxisome proliferator-activated receptors (PPARs) - both in the heart, adipose tissue and liver. Current experimental activity includes use of various (lipid-lowering) PPAR agonists, exercise training and dietary modifications of metabolism to determine its impact on the mechanical function of the heart.



    CV

    Name: Terje Steinar Larsen

    Present position and address: Professor, Cardiovascular Research Group, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.

    Born: April 18, 1950, 8432 Alsvåg, Norway.

    Status: Married, three children.

    Private address: Ryllikveien 47, 9100 Kvaløysletta, Norway

    Education:

    1972-1976: University of Tromsø, Norway; Bachelor of Science

    1976-1978: University of Tromsø, Norway; Master of Science

    1978-1985: University of Tromsø, Norway; PhD

    Professional experience and research positions:

    1978-1980: Research Fellow (Department of Medical Physiology, University of Tromsø)

    1980-1985: Research Fellow (Norwegian Research Council for Science and the Humanities), Department of Arctic Biology, University of Tromsø

    1985-1986: Postdoctoral Fellow (Alberta Heritage Foundation for Medical Research), Faculty of Medicine, The University of Calgary, Canada

    1986-1990: Postdoctoral Fellow (Norwegian Research Council), Department of Medical Physiology, University of Tromsø

    1990-1992: Associate professor, Department of Medical Physiology, University of Tromsø

    1992-1996: Professor, Chairman, Department of Medical Physiology, University of Tromsø

    1996-1997: Sabbatical stay at The Faculty of Medicine, The University of Calgary, Canada

    1997-present: Professor, Department of Medical Physiology, University of Tromsø.

    1998-2005: Professor, Department of Medical Physiology, University of Tromsø/Chairman, Institute of Medical Biology, University of Tromsø.

    1998-present: Professor & Chairman, Department of Medical Physiology, University of Tromsø

    2009-present: Professor, Cardiovascular Research Group IMB; Chairman, Institute of Medical Biology, University of Tromsø.