Jon-Våbenø
Jon-Våbenø
Department of Pharmacy jon.vabeno@uit.no +4777620909 92096133 Tromsø FARM F3.110

Jon Våbenø


Associate Professor


  • Larsen, Olav; van der Velden, Wijnand J.C.; Mavri, Maša; Schuermans, Sara; Rummel, Pia C.; Karlshøj, Stefanie; Gustavsson, Martin; Proost, Paul; Våbenø, Jon; Rosenkilde, Mette M.. Identification of a conserved chemokine receptor motif that enables ligand discrimination. Science Signaling 2022; Volum 15 (724). ISSN 1945-0877.s doi: 10.1126/scisignal.abg7042.
  • Berg, Christian; Wedemeyer, Michael J.; Melynis, Motiejus; Schlimgen, Roman R.; Hansen, Lasse H.; Våbenø, Jon; Peterson, Francis C.; Volkman, Brian F.; Rosenkilde, Mette M.; Lüttichau, Hans R.. The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-Terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist. PLoS Pathogens 2022; Volum 18 (3). ISSN 1553-7366.s doi: 10.1371/journal.ppat.1010355.
  • Kjær, Viktoria M. S.; Ieremias, Loukas; Daugvilaite, Viktorija; Lückmann, Michael; Frimurer, Thomas; Ulven, Trond; Rosenkilde, Mette M.; Våbenø, Jon. Discovery of GPR183 Agonists Based on an Antagonist Scaffold. ChemMedChem 2021; Volum 16 (17). ISSN 1860-7179.s 2623 - 2627.s doi: 10.1002/cmdc.202100301.
  • Jørgensen, Astrid Sissel; Daugvilaite, Viktorija; De Filippo, Katia; Berg, Christian; Mavri, Masa; Benned-Jensen, Tau; Juzenaite, Goda; Hjortø, Gertrud; Rankin, Sara; Våbenø, Jon; Rosenkilde, Mette M.. Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization. Communications Biology 2021; Volum 4. ISSN 2399-3642.s doi: 10.1038/s42003-021-02070-9.
  • Berg, Christian; Daugvilaite, Viktorija; Steen, Anne; Jørgensen, Astrid Sissel; Våbenø, Jon; Rosenkilde, Mette Marie. Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4. ACS Chemical Biology 2018; Volum 13 (4). ISSN 1554-8929.s 881 - 886.s doi: 10.1021/acschembio.8b00061.
  • Di Cagno, Massimiliano Pio; Clarelli, Fabrizio; Våbenø, Jon; Lesley, Christina; Rahman, Sokar Darsim; Cauzzo, Jennifer; Franceschinis, Erica; Realdon, Nicola; Stein, Paul C. Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements. Molecular Pharmaceutics 2018; Volum 15 (4). ISSN 1543-8384.s 1488 - 1494.s doi: 10.1021/acs.molpharmaceut.7b01053.
  • Baumann, Markus; Nome, Lina Marie; Zachariassen, Zack Georg; Karlshøj, Stepfanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism. Tetrahedron 2017; Volum 73 (27-28). ISSN 0040-4020.s 3866 - 3877.s doi: 10.1016/j.tet.2017.05.057.
  • Baumann, Markus; Hussain, Mohammad Musarraf; Henne, Nina; Garrote, Daniel Moya; Karlshøj, Stefanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry 2017; Volum 25 (2). ISSN 0968-0896.s 646 - 657.s doi: 10.1016/j.bmc.2016.11.036.
  • Zachariassen, Zack Georg; Karlshøj, Stefanie; Haug, Bengt Erik; Rosenkilde, Mette M.; Våbenø, Jon. Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636). Journal of Medicinal Chemistry 2015; Volum 58 (20). ISSN 0022-2623.s 8141 - 8153.s doi: 10.1021/acs.jmedchem.5b00987.
  • Våbenø, Jon; Haug, Bengt Erik; Rosenkilde, Mette M.. Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists. Future Medicinal Chemistry 2015; Volum 7 (10). ISSN 1756-8919.s 1261 - 1283.s doi: 10.4155/fmc.15.64.
  • Thiele, Stefanie; Mungalpara, Jignesh; Steen, Anne; Rosenkilde, Mette M.; Våbenø, Jon. Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis. British Journal of Pharmacology 2014; Volum 171 (23). ISSN 0007-1188.s 5313 - 5329.s doi: 10.1111/bph.12842.
  • Zachariassen, Zack Georg; Thiele, Stefanie; Berg, Erik; Rasmussen, Pernille; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik. Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorganic & Medicinal Chemistry 2014; Volum 22 (17). ISSN 0968-0896.s 4759 - 4769.s doi: 10.1016/j.bmc.2014.07.004.
  • Mungalpara, Jignesh; Zachariassen, Zack Georg; Thiele, Stefanie; Rosenkilde, MM; Våbenø, Jon. Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists. Organic and biomolecular chemistry 2013; Volum 11 (47). ISSN 1477-0520.s 8202 - 8208.s doi: 10.1039/c3ob41941j.
  • Mungalpara, Jigneshbhai C; Thiele, Stefanie; Eriksen, Øystein; Eksteen, Jacobus Johannes; Rosenkilde, MM; Våbenø, Jon. Rational Design of Conformationally Constrained Cyclopentapeptide Antagonists for C-X-C Chemokine Receptor 4 (CXCR4). Journal of Medicinal Chemistry 2012; Volum 55 (22). ISSN 0022-2623.s 10287 - 10291.s doi: 10.1021/jm300926y.
  • Nielsen, Carsten Uhd; Våbenø, Jon; Andersen, Rikke; Brodin, B; Steffansen, Bente. Recent advances in therapeutic applications of human peptide transporters. Expert Opinion on Therapeutic Patents 2005; Volum 15. ISSN 1354-3776.
  • Våbenø, Jon; Ingebrigtsen, Truls Erik; Luthman, K; Lejon, Tore Sigvard; Hansen, Lars Kr. Benzyl-5-[N-(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoate. Acta Crystallographica Section E: Structure Reports Online 2005; Volum 61. ISSN 1600-5368.
  • Våbenø, Jon; Nielsen, Carsten Uhd; Steffansen, Bente; Lejon, Tore Sigvard; Sylte, Ingebrigt; Jørgensen, Flemming Steen; Luthman, Kristina. Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs. Bioorganic & Medicinal Chemistry 2005; Volum 13. ISSN 0968-0896.s 1977 - 1988.
  • Våbenø, Jon; Lejon, Tore Sigvard; Nielsen, Carsten Uhd; Steffansen, Bente; Chen, Weiqing; Borchardt, Ronald T.; Ouyang, Hui; Luthman, Kristina. Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: Synthesis and biological investigations. Journal of Medicinal Chemistry 2004; Volum 47. ISSN 0022-2623.s 1060 - 1069.
  • Våbenø, Jon; Nielsen, Carsten Uhd; Ingebrigtsen, Truls Erik; Lejon, Tore Sigvard; Steffansen, Bente; Luthman, Kristina. Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: Design, synthesis, stability, and biological investigations. Journal of Medicinal Chemistry 2004; Volum 47 (19). ISSN 0022-2623.s 4755 - 4765.
  • Gullbo, J; Tullberg, M; Våbenø, Jon; Ehrsson, H; Lewensohn, R; Nygren, P; Larsson, R; Luthman, Kristina. Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives. Oncology Research 2003; Volum 14. ISSN 0965-0407.s 113 - 132.
  • Våbenø, Jon; Brisander, M.; Lejon, Tore Sigvard; Luthman, K.. Diastereoselective Reduction of a Chiral N- and C-Protected a,b-Unsaturated g-Keto Dipeptidomimetic. Journal of Organic Chemistry 2002; Volum 67. ISSN 0022-3263.s 9186 - 9189.
  • Haug, Bengt Erik; Baumann, Markus; Stefanie, Karlshøj; Rosenkilde, Mette M.; Våbenø, Jon. Scaffold-based tripeptidomimetic CXCR4 antagonists. 34th European Peptide Symposium 2016-09-04 - 2016-09-09 2016.
  • Baumann, Markus; Haug, Bengt Erik; Våbenø, Jon. Synthesis of Bicyclic CXCR4 Antagonists. 2016 ISBN 978-82-308-3169-4.
  • Baumann, Markus; Våbenø, Jon; Haug, Bengt Erik. Synthetic studies towards peptidomimetic CXCR4 antagonists. 24th American Peptide Symposium 2015-06-20 - 2015-06-25 2015.
  • Baumann, Markus; Våbenø, Jon; Haug, Bengt Erik. Synthetic studies towards CXCR4 antagonists. 30. Organisk kjemisk vintermøte 2015-01-08 - 2015-01-11 2015.
  • Baumann, Markus; Våbenø, Jon; Haug, Bengt Erik. Synthetic studies towards CXCR4 antagonists. PhD conference Norwegian PhD School of Pharmacy 2014-06-12 - 2014-06-13 2014.
  • Henne, Nina; Våbenø, Jon; Haug, Bengt Erik. Synthetic studies towards CXCR4 antagonists. 29. Organisk kjemisk vintermøte 2014-01-09 - 2014-01-12 2014.
  • Våbenø, Jon. Vant pris for forskning på HIV. 2014.
  • Mungalpara, Jigneshbhai C; Thiele, S; Rosenkilde, MM; Våbenø, Jon. SAR and Binding Mode for Cyclopentapeptide CXCR4 Antagonists. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 483 - 483.
  • Zachariassen, Zack Georg; Thiele, S; Rosenkilde, MM; Haug, Bengt Erik; Våbenø, Jon. SAR and Binding Mode for CXCR4 Antagonists Based on an Arg-Arg-Nal Tripeptide Motif. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 492 - 492.
  • Våbenø, Jon. HIV Entry Inhibitors: Ligand-Based Design of Peptidomimetic CXCR4 Antagonists. Pre-Satellite Meeting of the 3rd Pharmaceutical Sciences World Congress 2007-04-20 - 2007-04-21 2007.
  • Våbenø, Jon; Nielsen, Carsten Uhd; Ingebrigtsen, Truls Erik; Lejon, Tore Sigvard; Sylte, Ingebrigt; Jørgensen, Flemming Steen; Steffansen, Bente; Luthman, Kristina. Ketomethylene Based Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs. XVIII´th International Symposium on Medicinal Chemistry 2004-08-15 - 2004-08-19 2004.
  • Våbenø, Jon. Ketomethylene Based Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs. Midnight Sun Meeting on Drug Transport and Drug Delivery 2004-07-01 - 2004-07-03 2004.
  • Våbenø, Jon. Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs: Design, Synthesis, Biological Evaluation and Computational Investigations. 2004 ISBN 82-497-0206-9.
  • Våbenø, Jon; Nielsen, Carsten Uhd; Steffansen, Bente; Jørgensen, Flemming Steen. Kan lægemiddelstoffer smugles ind i organismen?. Lægemiddelforskning 2003. ISSN 0905-0051.s 18 - 19.
  • Våbenø, Jon; Lejon, Tore Sigvard; Nielsen, Carsten Uhd; Steffansen, Bente; Jørgensen, Flemming Steen; Luthman, Kristina. Structure-Affinity and Structure-Transport Relationships for the Intestinal Oligopeptide Transporter PEPT1. The 4th European Workshop in Drug Design 2003-05-25 - 2003-06-01 2003.
  • Våbenø, Jon. Design, syntese og testing av cytotoksisk effekt av aminosyre- og dipeptidderivater. 1999.
  • Look at all works in CRIStin →


    Research interests

    I have a general interest in all steps of the drug discovery process, i.e. hit identification, hit-to-lead strategies, and lead optimization. My main research interest is design and synthesis of bioactive peptides and peptidomimetics, with a special emphasis on:

      • Reverse-turn mimetics 
      • Peptidergic seven-transmembrane domain (7TM) receptors (a.k.a. GPCRs)

    • Computer-aided drug design (3D pharmacophore modeling, scaffold hopping, receptor modeling, and docking)

    Teaching

    FAR-2301

    FAR-3301




    FARM F3.110

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