Jon Våbenø
Jon Våbenø,
Marta Oliva-Santiago,
Astrid S. Jørgensen,
Stefanie Karlshøj,
Mette M. Rosenkilde
:
Identification of a Salt Bridge That Is Functionally Important for Chemokine Receptor CXCR1 but not CXCR2
ACS Pharmacology & Translational Science 2023 DOI
Olav Larsen,
Sara Schuermans,
Anna Walser,
Stavroula Louka,
Ida Aaberg Lillethorup,
Jon Våbenø
et al.:
Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
FEBS Letters 2023 DOI
Olav Larsen,
Wijnand J.C. van der Velden,
Maša Mavri,
Sara Schuermans,
Pia C. Rummel,
Stefanie Karlshøj
et al.:
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Science Signaling 2022 DOI
Christian Berg,
Michael J. Wedemeyer,
Motiejus Melynis,
Roman R. Schlimgen,
Lasse H. Hansen,
Jon Våbenø
et al.:
The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-Terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist
PLoS Pathogens 2022 DOI
Astrid Sissel Jørgensen,
Viktorija Daugvilaite,
Katia De Filippo,
Christian Berg,
Masa Mavri,
Tau Benned-Jensen
et al.:
Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
Communications Biology 2021 DOI
Viktoria M. S. Kjær,
Loukas Ieremias,
Viktorija Daugvilaite,
Michael Lückmann,
Thomas Frimurer,
Trond Ulven
et al.:
Discovery of GPR183 Agonists Based on an Antagonist Scaffold
ChemMedChem 2021 DOI
Christian Berg,
Viktorija Daugvilaite,
Anne Steen,
Astrid Sissel Jørgensen,
Jon Våbenø,
Mette Marie Rosenkilde
:
Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4
ACS Chemical Biology 2018 DOI
Massimiliano Pio Di Cagno,
Fabrizio Clarelli,
Jon Våbenø,
Christina Lesley,
Sokar Darsim Rahman ,
Jennifer Cauzzo
et al.:
Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements
Molecular Pharmaceutics 2018 DOI
Markus Baumann,
Lina Marie Nome,
Zack Georg Zachariassen,
Stepfanie Karlshøj,
Torgils Fossen,
Mette M. Rosenkilde
et al.:
Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism
Markus Baumann,
Mohammad Musarraf Hussain,
Nina Henne,
Daniel Moya Garrote,
Stefanie Karlshøj,
Torgils Fossen
et al.:
Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Jon Våbenø,
Bengt Erik Haug,
Mette M. Rosenkilde
:
Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists
Zack Georg Zachariassen,
Stefanie Karlshøj,
Bengt Erik Haug,
Mette M. Rosenkilde,
Jon Våbenø
:
Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636)
Stefanie Thiele,
Jignesh Mungalpara,
Anne Steen,
Mette M. Rosenkilde,
Jon Våbenø
:
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis
Zack Georg Zachariassen,
Stefanie Thiele,
Erik Berg,
Pernille Rasmussen,
Torgils Fossen,
Mette M. Rosenkilde
et al.:
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Jignesh Mungalpara,
Zack Georg Zachariassen,
Stefanie Thiele,
MM Rosenkilde,
Jon Våbenø
:
Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists
Jigneshbhai C Mungalpara,
Stefanie Thiele,
Øystein Eriksen,
Jacobus Johannes Eksteen,
MM Rosenkilde,
Jon Våbenø
:
Rational Design of Conformationally Constrained Cyclopentapeptide Antagonists for C-X-C Chemokine Receptor 4 (CXCR4)
Journal of Medicinal Chemistry 2012 DOI
Carsten Uhd Nielsen,
Jon Våbenø,
Rikke Andersen,
B Brodin,
Bente Steffansen
:
Recent advances in therapeutic applications of human peptide transporters
Expert Opinion on Therapeutic Patents 2005
Jon Våbenø,
Carsten Uhd Nielsen,
Bente Steffansen,
Tore Sigvard Lejon,
Ingebrigt Sylte,
Flemming Steen Jørgensen
et al.:
Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs
Bioorganic & Medicinal Chemistry 2005
Jon Våbenø,
Truls Erik Ingebrigtsen,
K Luthman,
Tore Sigvard Lejon,
Lars Kr Hansen
:
Benzyl-5-[N-(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoate
Acta Crystallographica Section E: Structure Reports Online 2005
Jon Våbenø,
Carsten Uhd Nielsen,
Truls Erik Ingebrigtsen,
Tore Sigvard Lejon,
Bente Steffansen,
Kristina Luthman
:
Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: Design, synthesis, stability, and biological investigations
Journal of Medicinal Chemistry 2004
Jon Våbenø,
Tore Sigvard Lejon,
Carsten Uhd Nielsen,
Bente Steffansen,
Weiqing Chen,
Ronald T. Borchardt
et al.:
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: Synthesis and biological investigations
Journal of Medicinal Chemistry 2004
J Gullbo,
M Tullberg,
Jon Våbenø,
H Ehrsson,
R Lewensohn,
P Nygren
et al.:
Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives
Oncology Research 2003
Jon Våbenø,
M. Brisander,
Tore Sigvard Lejon,
K. Luthman
:
Diastereoselective Reduction of a Chiral N- and C-Protected a,b-Unsaturated g-Keto Dipeptidomimetic
Journal of Organic Chemistry 2002
Markus Baumann,
Bengt Erik Haug,
Jon Våbenø
:
Synthesis of Bicyclic CXCR4 Antagonists
Universitetet i Bergen 2016
Bengt Erik Haug,
Markus Baumann,
Karlshøj Stefanie,
Mette M. Rosenkilde,
Jon Våbenø
:
Scaffold-based tripeptidomimetic CXCR4 antagonists
2016
Markus Baumann,
Jon Våbenø,
Bengt Erik Haug
:
Synthetic studies towards peptidomimetic CXCR4 antagonists
2015
Markus Baumann,
Jon Våbenø,
Bengt Erik Haug
:
Synthetic studies towards CXCR4 antagonists
2015
Markus Baumann,
Jon Våbenø,
Bengt Erik Haug
:
Synthetic studies towards CXCR4 antagonists
2014
Nina Henne,
Jon Våbenø,
Bengt Erik Haug
:
Synthetic studies towards CXCR4 antagonists
2014
Jon Våbenø
:
Vant pris for forskning på HIV
28. April 2014
Jigneshbhai C Mungalpara,
S Thiele,
MM Rosenkilde,
Jon Våbenø
:
SAR and Binding Mode for Cyclopentapeptide CXCR4 Antagonists
Biopolymers 2011
Zack Georg Zachariassen,
S Thiele,
MM Rosenkilde,
Bengt Erik Haug,
Jon Våbenø
:
SAR and Binding Mode for CXCR4 Antagonists Based on an Arg-Arg-Nal Tripeptide Motif
Biopolymers 2011
Jon Våbenø
:
HIV Entry Inhibitors: Ligand-Based Design of Peptidomimetic CXCR4 Antagonists
2007
Jon Våbenø
:
Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs: Design, Synthesis, Biological Evaluation and Computational Investigations
UiT Norges arktiske universitet 2004
Jon Våbenø
:
Ketomethylene Based Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs
2004
Jon Våbenø,
Carsten Uhd Nielsen,
Truls Erik Ingebrigtsen,
Tore Sigvard Lejon,
Ingebrigt Sylte,
Flemming Steen Jørgensen
et al.:
Ketomethylene Based Dipeptidomimetics as Pro-Moieties for hPEPT1 Targeted Prodrugs
2004
Jon Våbenø,
Carsten Uhd Nielsen,
Bente Steffansen,
Flemming Steen Jørgensen
:
Kan lægemiddelstoffer smugles ind i organismen?
Lægemiddelforskning 2003
Jon Våbenø,
Tore Sigvard Lejon,
Carsten Uhd Nielsen,
Bente Steffansen,
Flemming Steen Jørgensen,
Kristina Luthman
:
Structure-Affinity and Structure-Transport Relationships for the Intestinal Oligopeptide Transporter PEPT1
2003
Jon Våbenø
:
Design, syntese og testing av cytotoksisk effekt av aminosyre- og dipeptidderivater
UiT Norges arktiske universitet 1999
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Research interests
JOB DESCRIPTION
Jon Våbenø has an Associate Professor II (20%) position at the Department of Pharmacy, UiT the Arctic University of Norway, in addition to his main position as a research scientist/leader at Helgeland Hospital Trust.
He has a medicinal chemistry background and a general interest in all steps of the drug discovery process, i.e. hit identification, hit-to-lead strategies, and lead optimization.
RESEARCH INTERESTS
His main research interest is pharmacological modulation of the complex chemokine system, which represents attractive drug targets for inflammatory/immunological diseases, cancer, and virus infections:
1) Understand/explain the activation pattern on the molecular level:
- Binding interaction
- Activation mechanisms
- Chemokine selectivity
2) Exploit this knowledge to develop:
- A better understand of the disease processes
- Selective drugs
TEACHING
Bachelor level
FAR-2301 Medicinal Chemistry and Natural Products Chemistry – Lectures and seminars
Master level
FAR-3301 Advanced Pharmaceutical Chemistry - Lectures and computerlab
Teaching
FAR-2301
FAR-3301
