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Bilde av Småbrekke, Lars
Photo: i.k.smabrekke
Bilde av Småbrekke, Lars
Klinisk farmasi og farmakoepidemiologi, forskningsgruppe lars.smabrekke@uit.no +4777645792 +4799249663 Tromsø FARM f 4.206

Lars Småbrekke

Professor. Research group leader. Pharmacoepidemiology

Job description

I'm responsible for the courses Far-2101 and Far-3101, and contributes in teaching in several other courses at department of pharmacy and department of community medicine (master & PhD level).


The research projects are mainly focused on consumption of antibiotrics, and are based on data from population studies (e.g. The Tromsø studies & FitFutures), the Norwegian Prescription Database and clinical data from hospital practice.

  • Trine Strand Bergmo, Vilde Sandsdalen, Unn Sollid Manskow, Lars Småbrekke, Marit Waaseth :
    Internet Use for Obtaining Medicine Information: Cross-sectional Survey
    JMIR Formative Research 2023 DOI
  • Jeanette Schultz Johansen, Kjell H. Halvorsen, Kristian Svendsen, Kjerstin Havnes, Eirin Guldsten Robinson, Hilde Ljones Wetting et al.:
    Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial
    BMC Health Services Research 2022 ARKIV / DOI
  • Mari Johannessen Walquist, Kristian Svendsen, Beate Hennie Garcia, Trine Strand Bergmo, Anne Elise Eggen, Kjell H. Halvorsen et al.:
    Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study
    BMC Public Health 2022 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population
    Epidemiology and Infection 2022 FULLTEKST / ARKIV / DOI
  • Dina Benedicte Berg Stensen, Rafael Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen et al.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    International Journal of Infectious Diseases 2022 ARKIV / FULLTEKST / DOI
  • Sigbjørn Svalestuen, Kristian Svendsen, Anne Elise Eggen, Lars Småbrekke :
    Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study
    BMJ Open 2022 ARKIV / DOI
  • Therese von Hanno, Live Lund Hareide, Lars Småbrekke, Bente Morseth, Monica Sneve, Maja Gran Erke et al.:
    Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study
    Investigative Ophthalmology and Visual Science 2022 ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen et al.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Sanna Beckstrøm, Kristian Svendsen, Lars Småbrekke :
    Antibacterial use by birth year and birth season in children 0-2 years in Norway
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    European Journal of Endocrinology (EJE) 2021 FULLTEKST / ARKIV / DOI
  • June Utnes Høgli, Beate Hennie Garcia, Kristian Svendsen, Vegard Skogen, Lars Småbrekke :
    Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study
    BMC Pulmonary Medicine 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
    BMC Endocrine Disorders 2020 ARKIV / DOI
  • Kirsten Midttun Gravningen, Nigel Field, Hege Salvesen Blix, Anne Mette Asfeldt, Lars Småbrekke :
    Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study
    PLOS ONE 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
    PLOS ONE 2019 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen et al.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population
    PLOS ONE 2019 ARKIV / FULLTEKST / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study
    Scientific Reports 2019 ARKIV / DOI
  • Cecilia S. Sambakunsi, Lars Småbrekke, Christine A. Varga, Vernon Solomon, John S. Mponda :
    Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi
    Malawi Medical Journal 2019 ARKIV / DOI
  • O D'Annibali, G Bonaldo, Monia Donati, Lars Småbrekke, Domenico Motola, A Vaccheri :
    Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database
    Journal of Antimicrobial Chemotherapy 01. August 2019 DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. November 2019 ARKIV / DOI
  • Pål Haugen, Gunnar Skov Simonsen, Raul Primicerio, Anne-Sofie Furberg, Lars Småbrekke :
    Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study.
    Pharmaceutical statistics 2018 ARKIV / DOI
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
    Journal of Crohn's and Colitis 2018 ARKIV / DOI
  • Bjørg Haldorsen, Christian G Giske, Dennis S Hansen, Kristjan Orri Helgason, Gunnar Kahlmeter, Iren Høyland Löhr et al.:
    Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
    Journal of Antimicrobial Chemotherapy 2018 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord et al.:
    Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
    Antimicrobial Agents and Chemotherapy 2018 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study
    PLOS ONE 2017 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database
    Pharmacoepidemiology and Drug Safety 2017 DOI
  • June Utnes Høgli, Beate Hennie Garcia, frode Skjold, Vegard Skogen, Lars Småbrekke :
    An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital
    BMC Infectious Diseases 2016 SAMMENDRAG / FULLTEKST / ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
    Pharmacoepidemiology and Drug Safety 2016 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Arnfinn Sundsfjord, Lars Småbrekke, Ørjan Samuelsen :
    The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011
    Infectious Diseases 2015 DOI
  • Mauro Melis, Chiara Biagi, Lars Småbrekke, Francesco Nonino, Elena Buccellato, Monia Donati et al.:
    Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database
    CNS Drugs 2015 DOI
  • Beate Hennie Garcia, Trude Giverhaug, June U. Høgli, Frode Skjold, Lars Småbrekke :
    A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado]
    Pharmacy Practice 2015 ARKIV / DOI
  • June Utnes Høgli, Lars Småbrekke, Beate Garcia :
    MAT-CAP: A novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia
    Pharmacoepidemiology and Drug Safety 2014 DOI
  • Beate Hennie Garcia, Sissel Lisa Storli, Lars Småbrekke :
    A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences
    BMC Research Notes 2014 ARKIV / DOI
  • Angela Lupattelli, Øystein Karlstad, Anders Engeland, Lars Småbrekke, Kristine Olsen, Aina Øvrebust et al.:
    The Norwegian Society for Pharmacoepidemiology
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Johanna Ericson Sollid, Gunnar Skov Simonsen et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general population in Norway
    2021
  • Dina Benedicte Berg Stensen, Rafael A. Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen et al.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    2021
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna Ericson Sollid et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    2021
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    Erratum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study (Journal of Crohn's and Colitis DOI: 10.1093/ecco-jcc/jjy008)
    Journal of Crohn's and Colitis 2019 DOI
  • Ann Helen Jakobsen, Kjell H. Halvorsen, Lars Småbrekke :
    Forslag til kvalitetsindikatorer for primærapotek
    2019
  • Lyn Middleton, F Lampiao, Tomas F. Zimba, SM Muzime, Gunnar Skov Simonsen, Lars Småbrekke et al.:
    Sharing Knowledge Transforming Societies. The Norhed Programme 2013-2020
    African Minds 2019
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    To the editor
    JAMA Internal Medicine 2018 DOI
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    Lower cancer incidence-warfarin effect or immortal time bias?
    JAMA Internal Medicine 2018 DOI
  • Martin Sørensen, Annette Kuehn, E.N. Clare Mills, Carol Ann Costello, Markus Ollert, Lars Småbrekke et al.:
    Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial
    Journal of Allergy and Clinical Immunology 2017 DOI
  • Dina Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen et al.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. The Tromsø Study Fit Futures 2.
    2017
  • Kristian Svendsen, Håvard Wahl Kongsgård, Pål Haugen, Lars Småbrekke :
    Does travel time to pharmacies and general physicians influence the use of antibiotics in Norway?
    2016
  • Tone Ruud Engen, Beate Hennie Garcia, Kjell H. Halvorsen, Marit Waaseth, Lars Småbrekke, Hilde Ljones Wetting :
    Er det trygt å velge billigere resept-medisiner?
    22. January 2015 DATA
  • Beate Hennie Garcia, Trude Giverhaug, J. Utnes, Lars Småbrekke :
    A follow-up program for patients with established coronary heart disease led by a clinical pharmacist: a randomized controlled trial
    International Journal of Clinical Pharmacology Research 2013
  • June Utnes Høgli, Lars Småbrekke, Beate Garcia :
    A medication assessment tool for community acquired pneumonia (MAT-CAP): design and validation
    International Journal of Clinical Pharmacology Research 2013
  • Kjell H. Halvorsen, Lars Småbrekke, Anne Gerd Granås :
    Use of drugs for opeptic ulcer and gastro-oesophageal reflux disease (GORD) in older patients
    2013
  • Kjell Hermann Halvorsen, Lars Småbrekke, Anne Gerd Granås :
    Legemidler mot ulcus og gastroøsofageal reflukssykdom (GERD) hos eldre pasienter
    2013
  • Kjell H. Halvorsen, Lars Småbrekke, Anne Gerd Granås :
    Use of drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) in older patients
    International Journal of Clinical Pharmacology Research 2013

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    Research interests

    Clinical pharmacy and drug consumption on population level, mainly focusing on antibiotics.


    Member of research group

    Klinisk farmasi og farmakoepidemiologi (IPSUM)   Norsk innhold Clinical Pharmacy and Pharmacoepidemiology (IPSUM)   English content

    CV

    Lars Småbrekke

    Birth date     18.1.1959

     

    Education

    1985                Candidatus pharmaciae, University of Oslo (UiO)

    1999               Master of Public Health, University of Tromsø (UiT)

    2009               PhD. UiT

     

    Work experience

    1986-98         Hospital pharmacy.

    1998-2008     Regional Drug Information Centre of North Norway.

    2008-09         PhD student.

    2009-              UiT. Associate professor. IPSUM Research group.

     

    Relevant commotions

    1999-2000     Board member. National Board of Pharmacovigilance

    2008-2012     Board member. National Board of Reimbursement

    2010-              Board member. Norwegian Society of Pharmacoepidemiology

    2016-              Board member. Regional Health Authority

     

    Research and development (International journals)

    Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen, I. Impact of improved treatment of Sexually Transmitted disease on HIV infection. Lancet 1995; 346 (8983): 1157.

    Småbrekke L, Braathen P. Drugs with lactose in patients with lactose intolerance? Tidsskr Nor Medical Association 2000; 120 (19): 2303-4.

    Småbrekke L. Large differences in the consumption profile of antibiotics at two university hospitals in Norway. Nor J Epidemiol 2001; 11 (1): 61-5.

    Småbrekke L, Berild D, Giaever A, et al. Educational Intervention for Parents and Health Care providers Leads to Reduced Antibiotic Use in Otitis Media. Scand J Infect Dis 2002; 34 (9): 657-9.

    Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL et al. Prevalence of resistance two ampicillin, gentamicin and vancomycin in Enterococcus faecalis and E. faecium from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003: 51 (2): 323-31.

    Berild D, Småbrekke L, Halvorsen DS et al. Clostridium difficile Infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect 2003; 54 (3): 202-6.

    Klingenberg C, Småbrekke L, Lier T, Flægstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis 2004; 36 (6-7): 474-9.

    Raknes G, Småbrekke L. Echinacea spp and upper respiratory tract infections. Tidsskr Nor Medical Association 2006; 126: 2526-7.

    Småbrekke L, Melbye H. Pharmacological treatment of acute cough. Tidsskr Nor Medical Association 2009:129 (10): 998-9.

    Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Oral antibiotic treatment of urinary tract infection in children. Tidsskr Nor Medical Association 2009; 129 (13): 1342-4.

    Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed two lamotrigine in breast milk. Ann Pharmacother 2009; 43 (11): 1893-7

    Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP two assess guideline adherence in prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol 2013; 69 (3): 703-9.

    Utnes J, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence two clinical practice guidelines in community acquired pneumonia. Pharmacoepidemiol Drug Saf 2014 Sep;23 (9): 933-41.

    Garcia BH, Trovik T, Giver Haug T, L Småbrekke. Pharmacist-led follow-up program after discharge from hospital to improve secondary prevention of coronary heart disease. Submitted.

    Garcia BH, Storli LS, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences. BMC Research Notes.2014, 7:197. DOI: 10.1186/1756-0500-7-197

    Zykov I, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infectious diseases 2015. http://dx.doi.org/10.3109/23744235.2015.1087648.

    Melis M, Biagi C, Nonino F, Buccellato E, Donati M, Småbrekke L, Vaccheri A, Motola D. Drug induced progressive multifocal leukoencephalopathy: A comprehensive analysis of the WHO adverse drug reaction database. CNS drugs 2015; 29: 879-91

    Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased appropriate antibiotic prescribing at a Norwegian hospital. BMC Infect Dis 2016;16(1):96. doi: 10.1186/s12879-016-1426-1.

    Antibiotics to outpatients in Norway – assessing effect of latitude and municipality population size using quantile regression. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)

    Exploring antibiotic prescribing in Norway using multivariate analysis. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)

    Raknes G, Småbrekke L. The Norwegian Low Dose Naltrexone tsunami. Patient and prescriber characteristics, and dispense patterns. A cohort study. Pharmacoepidemiol Drug Saf 2016; doi: 10.1002/pds.4110.

    Raknes G, Småbrekke L. Low Dose Naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf 2017; DOI: 10.1002/pds.4201

     

    Supervision of PhD students

    Beate Garcia (Dissertation in 2012 – A thesis in clinical pharmacy)

    June Utnes (Dissertation October 2015 – A thesis in clinical pharmacy)

    Paul Haugen (Dissertation March 2015 – A thesis in pharmacoepidemiology)

    Ilya Zykov (Project in microbiology)

    Tomas Zimba (Project in microbiology)

     

    Supervision of Master students

    Approxemately 25 students in the pharmacy program in Norway, Malawi and Mozambique. Eight medical students (fifth year semester thesis).

     

    Teaching

    Bachelor-/Master level in epidemiology/pharmacoepidemiology. Also teaching at courses PhD courses in EPINOR

     

    International projects

    2013    NORHED. Antimicrobial stewardship and conservancy in Africa. For further information: http://www.norad.no/en/support/norhed/projects?index=30

    FARM f 4.206