Doctoral Research Fellow (Microbiology) Department of Medical Biology
I am a resistance fighter; on the search for a new antibiotic. As a part of the AntiBioSpec/DigiBiotics program, I am focusing on small peptides that are similar to the human immune system. To do that I use mainly microbiological approaches.
My work divides into two topics at the moment:
Testing antibacterial properties of new compounds, provided by the AntiBioSpec/DigiBiotics program, against multi-drug resistant bacteria from the hospital.
I characterize newly synthesized compounds in regards of their antibacterial properties against bacteria of the ESKAPE-group. If I find a promising compound, the search for its target side in the bacteria begins. I zoom onto the molecular level and try to figure out where and how the compound is working.
Optimizing the standard antibiotic testing protocol.
The current testing to define the efficacy of an antibiotic (MIC) does not reflect the human body. I try to enhance the standard testing methods with supplements, which are presenting a more host-like environment. With that, I hope to obtain further insight of the “real” MICs of antibiotics.
- Karlsen, Eskil André; Stensen, Wenche; Juskewitz, Eric; Svenson, Johan; Berglin, Mattias; Svendsen, John Sigurd Mjøen. Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis. Antibiotics 2021; Volum 10 (12). ISSN 2079-6382.s 1 - 18.s doi: 10.3390/antibiotics10121516.
- Jenssen, Marte; Rainsford, Philip; Juskewitz, Eric; Andersen, Jeanette Hammer; Hansen, Espen; Isaksson, Johan; Rämä, Teppo; Østnes Hansen, Kine. Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates. Frontiers in Microbiology 2021; Volum 12. ISSN 1664-302X.s doi: 10.3389/fmicb.2021.730740.
- Paulsen, Marianne Hagensen; Engqvist, Magnus; Ausbacher, Dominik; Anderssen, Trude; Langer, Manuel K-; Haug, Tor; Morello, Glenn Robert; Liikanen, Laura; Blencke, Hans-Matti; Isaksson, Johan; Juskewitz, Eric; Bayer, Annette; Strøm, Morten B.. Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates. Journal of Medicinal Chemistry 2021; Volum 64 (15). ISSN 0022-2623.s 11395 - 11417.s doi: 10.1021/acs.jmedchem.1c00734.
I find bacteria fascinating, so small and yet highly structured. My greatest interest is to unravel the molecular basis of bacterial infections by pathogens.
Member of research group