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Bilde av Butler, Lynn
Bilde av Butler, Lynn
Translational Vascular Research Group lynn.m.butler@uit.no +4777625104 Here you can find me

Lynn Butler

Associate Professor, Group Leader

Job description

Leader of the Translational Vascular Research Group

  • Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath et al.:
    Targeting NETs using dual-active DNase1 variants
    Frontiers in Immunology 2023 ARKIV / DOI
  • Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi et al.:
    Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
    Nature Communications 2023 ARKIV / DOI
  • Fredrik Edfors, Maria Jesus Iglesias, Lynn Butler, Jacob Odeberg :
    Proteomics in thrombosis research
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 ARKIV / DOI
  • Sandra Konrath, Reiner K. Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta et al.:
    Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
    Frontiers in Cardiovascular Medicine 2022 ARKIV / DOI
  • Marthe Norreen-Thorsen, Eike Christopher Struck, Sofia Maria Öling, Martin Zwahlen, Kalle Von Feilitzen, Jacob Odeberg et al.:
    A human adipose tissue cell-type transcriptome atlas
    Cell reports 2022 ARKIV / DOI
  • Misbah Razzaq, Maria Jesus Iglesias, Manal Ibrahim-Kosta, Louisa Goumidi, Omar Soukarieh, Carole Proust et al.:
    An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism
    Scientific Reports 2021 ARKIV / DOI
  • Max Karlsson, Zhang Cheng, Lorén Mear, Wen Zhong, Andreas Digre, Barbola Katona et al.:
    A single-cell type transcriptomics map of human tissues
    Science Advances 2021 ARKIV / DOI
  • Reiner K. Mailer, Mikel Allende, Marco Heestermans, Michaela Schweizer, Carsten Deppermann, Maike Frye et al.:
    Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
    Blood 2021 ARKIV / DOI
  • Marco Heestermans, Clement Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä et al.:
    Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
    Nature Communications 2021 ARKIV / DOI
  • Maria Jesus Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip James Dusart, Mun-Gwan Hong et al.:
    Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
    Arteriosclerosis, Thrombosis and Vascular Biology 2021 ARKIV / DOI
  • Philip James Dusart, Björn M. Hallström, Thomas Renne, Jacob Olof Odeberg, Mathias Uhlén, Lynn Butler :
    A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes
    Cell reports 2019 ARKIV / DOI

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    Research interests

    The primary focus of the Translational Vascular Research group is the study of endothelial cells that line the inside of all blood vessels. These cells have many functions, such as providing an anti-thrombotic surface to prevent blood clotting and controlling leukocyte recruitment to tissue during inflammation. Our research is based around the identification of genes that are highly specifically expressed in endothelial cells (compared to other cell types) and the role of these genes in vascular function. Through this work, we identify potential plasma biomarker candidates for the clinical assessment of vascular health and risk stratification, diagnosis and prognosis of diseases of the cardiovascular system, such as venous and arterial thrombosis and COVID-19 complications.

    ORCID: https://orcid.org/0000-0002-2352-8217

    Member of research group

    Translational Vascular Research   English content

    Member of project

    Endothelial response to inflammation Uncharacterised endothelial cell gene function Plasma biomarkers for endothelial dysfunction Plasma biomarkers for COVID-19 vascular pathology

    CV