Sybil Akua Okyerewa Obuobi


Senior scientist

Job description

Sybil Obuobi is a senior scientist in the Drug Transport and Delivery Research Group (Department of Pharmacy) and a research group leader funded by the Tromsø Research Foundation's Start-up grant. The long term goal of the work in her lab seeks to fundamentally understand and overcome biological and microbial barriers to drug delivery. The findings from her research applies advanced technologies to treat recurrent infections and to manage skin diseases/disorders (e.g., inflammatory skin disorders, wound therapy). Her team has keen interest in microbial biofilms and in harnessing safe biomaterials (e.g., nucleic acids, lipids and peptides) as adjuvants to modulate drug tolerance and resistance. 

See detailed information on current project COALITION

Senior scientist in the Drug Transport and Delivery Research Group


  • Alexandra Sofia Antunes de Sousa, Anna Ngoc Phung, Natasa Skalko-Basnet, Sybil Akua Okyerewa Obuobi :
    Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features
    Journal of Controlled Release 2023 ARKIV / DOI
  • Alexandra Sofia Antunes de Sousa, Vegard Borøy, Agnethe Hansen Bæverud, Kjersti Julin, Annette Bayer, Morten B. Strøm et al.:
    Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa
    Journal of materials chemistry. B 2023 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection
    Biomacromolecules 2021 ARKIV / DOI
  • Viveka Kalidasan, Xin Yang, Ze Xiong, Renee R. Li, Haicheng Yao, Hareesh Godaba et al.:
    Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds
    Nature Biomedical Engineering 2021 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Venkatesh Mayandi, Azlyn Mohd Nor Nurul, Benedict Jiasheng Lee, Rajamani Lakshminarayanan, Rachel Ee Pui Lai :
    Nucleic acid peptide nanogels for the treatment of bacterial keratitis
    Nanoscale 2020 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections
    Journal of Controlled Release 2020 ARKIV / DOI
  • Sybil Akua Okyerewa Obuobi, Natasa Skalko-Basnet :
    Nucleic acid hybrids as advanced antibacterial nanocarriers
    Pharmaceutics 2020 ARKIV / DOI
  • Vanitha Selvarajan, Sybil Akua Okyerewa Obuobi, Rachel Ee Pui Lai :
    Silica Nanoparticles—A Versatile Tool for the Treatment of Bacterial Infections
    Frontiers in Chemistry 2020 ARKIV / DOI
  • Jian Yao Ng, Sybil Akua Okyerewa Obuobi, Mei Ling Chua, Chi Zhang, Shiqi Hong, Yogesh Kumar et al.:
    Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine - A review
    Carbohydrate Polymers 2020 ARKIV / DOI
  • Alexandra Sofia Antunes de Sousa, Jan Fredrik Frantzen, Sybil Akua Okyerewa Obuobi :
    Bacteria have a new mortal enemy: DNA
    sciencenorway.no 2024 FULLTEKST
  • Sybil Akua Okyerewa Obuobi :
    Advancing drug delivery via nanocarrier design to treat biofilm infections
    2023
  • Sybil Akua Okyerewa Obuobi :
    Advancing drug delivery via DNA nanocarrier design to treat persistent infections
    2023
  • Sybil Akua Okyerewa Obuobi :
    DNA-BASED HYBRID CARRIERS FOR BACTERIAL AND WOUND THERAPY
    2023
  • Sybil Akua Okyerewa Obuobi :
    Developing DNA-based hybrid carriers to control bacterial persistence and virulence in chronic skin wounds
    2023
  • Alexandra Sofia Antunes de Sousa, Jan Fredrik Frantzen, Sybil Akua Okyerewa Obuobi :
    Antibiotikaresistens: Fant ny måte å bekjempe biofilm på
    Farmatid.no 2023
  • Alexandra Sofia Antunes de Sousa, Kjersti Julin, Annette Bayer, Morten Bøhmer Strøm, Mona Johannessen, Natasa Skalko-Basnet et al.:
    Drug-loaded DNA nanoparticles against bioflms
    2023
  • Sybil Akua Okyerewa Obuobi :
    Getting funded
    2023
  • Sybil Akua Okyerewa Obuobi :
    Developing DNA-based hybrid carriers to control bacterial persistence and virulence in chronic skin wounds
    2023
  • Sybil Akua Okyerewa Obuobi :
    Hybrid DNA nanoparticles for the treatment of persistent S. aureus infections
    2022
  • Sybil Akua Okyerewa Obuobi :
    A personal journey beyond failure: My funding story
    2022
  • Sybil Akua Okyerewa Obuobi :
    BIOHYBRID NUCLEIC ACID CARRIERS FOR THE TREATMENT OF PERSISTENT INFECTIONS
    2022
  • Sybil Akua Okyerewa Obuobi :
    Biohybrid Nucleic Acid carriers for the treatment of persistent infections
    2022
  • Sybil Akua Okyerewa Obuobi :
    Vikingen Sigurd døde da tennene til en død mann skrapte borti leggen hans
    28. July 2022
  • Sybil Akua Okyerewa Obuobi :
    High drug loading hybrid carriers for antimicrobial applications
    2022
  • Sybil Akua Okyerewa Obuobi :
    Nanocarriers are the Trojan horses of anti­biotics
    sciencenorway.no 2022 FULLTEKST
  • Sybil Akua Okyerewa Obuobi :
    Nanocarriers are the Trojan horses of anti­biotics
    UiT Forskerhjørnet 2022 FULLTEKST
  • Sybil Akua Okyerewa Obuobi :
    Fat bubbles and DNA help sneak antibiotics into biofilms
    09. May 2022
  • Kjersti Julin, Annette Bayer, Morten Bøhmer Strøm, Mona Johannessen, Natasa Skalko-Basnet, Sybil Akua Okyerewa Obuobi :
    DNA Nanocarriers for improved biofilm penetration
    2022
  • Sybil Akua Okyerewa Obuobi :
    Dagen da Sigurd Viking døde av en bakterieinfeksjon
    2022
  • Sybil Akua Okyerewa Obuobi :
    The day that Sigurd the Viking died from a bacterial infection
    2022
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Zwitterionic Nanohybrids for the Treatment of Wound Biofilms
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Zwitterionic hybrid nanoparticles for the treatment of biofilm wound infections
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Multi-responsive and Zwitterionic Nanohybrids for the Treatment of Biofilm Wound Infections
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    ZWITTERIONIC NUCLEIC ACID HYBRIDS FOR THE TREATMENT OF BIOFILM INFECTIONS
    2021
  • Sybil Akua Okyerewa Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet :
    Multi-responsive and Zwitterionic Nanohybrids for the Treatment of Biofilm Wound Infections
    2021
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of Nucleic Acid Nanogels to Enhance Entrapment Efficiency and Sustain Release of Antibiotics against Staphylococcal intracellular infections
    2020
  • Sybil Akua Okyerewa Obuobi, Kjersti Julin, Elizabeth G. Aarag Fredheim, Pål Jarle Johnsen, Mona Johannessen, Natasa Skalko-Basnet :
    Liposomal delivery of antibiotic loaded DNA nanogels against intracellular infections
    2020

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    Research interests

    The long-term goal of our research is to fundamentally understand and overcome biological and microbial barriers to drug delivery. We apply our findings to engineer advanced technologies that can be used to treat recurrent infections and to manage skin diseases/disorders (e.g., inflammatory skin disorders, wound therapy). 

    Our research is carried out in the Drug transport and delivery research group at UiT in Tromsø, Norway. Key research areas include the following:

    • Engineering novel drug delivery systems
    • Biological/microbial barriers to drug delivery
    • Wound healing

    PhD supervision:

    • 2021 - in progress: Primary supervisor for Alexandra Sofia Antunes de Sousa (Drug transport and delivery research group - UiT). Financed: Center for New Antibacterial Strategies (CANS), UiT, Tromsø.
    • 2023 - in progress: Primary supervisor for Dmytro Kravtsov (Drug transport and delivery research group - UiT). Financed: Tromsø research foundation, Tromsø.
    • 2022 - in progress: Assistant supervisor for Tejas Athavale (Drug transport and delivery research group - UiT). Financed: UiT, Tromsø.

    Supervision of master/exchange students:

    • Since 2020, I have supervised 6 master students at UiT in the Department of Pharmacy. 

    Teaching

    Undergraduate level:

    • FAR 2402: Drug formulation and biopharmacy

    Master level:

    • FAR 3043: Nanomedicine

    PhD level:

    • FAR 8043: Nanomedicine and Nanotechnology

    Other teaching activities:

    • FSK 8003: Funding your research



    CV

    Academic background: 

    • 2014 - 2018. PhD, Department of Pharmacy, National University of Singapore (NUS), Singapore.
    • 2012 - 2013. Master in science in drug delivery, Aston University, United Kingdom.
    • 2006 - 2010. Bachelor in Pharmacy, Kwame Nkrumah University of Science & Technology, Ghana.

    Past positions: 

    • 2019 - 2022 - Marie curie individual fellow, UiT The Arctic University of Norway, Tromsø, Norway.       
    • 2017 - 2018 - Research Fellow, Max Plank Institute for Polymer Research (MPIP), Germany.

    Funding / Scholarships:

    • 2021-present: Tromsø Research Foundation Start-up grant (TFS-STG)
    • 2019 - 2022: Marie Curie Individual Fellowship.
    • 2017 - 2018 : Otto Bayer Fellowship.
    • 2014 - 2018: Singapore International Graduate Award.
    • 2012 - 2013: Commonwealth Scholarship.

    Prizes/Awards:

    • 2021: Young Researcher of the Year (Faculty of Health Sciences), UiT, Norway.
    • 2018 GPEN 2018 Abstract Award, Department of Pharmacy, NUS, Singapore.
    • 2017 Best Graduate Researcher Award, Faculty of Science, Department of Pharmacy, NUS, Singapore.
    • 2017 Best Postgraduate Research Project, Department of Pharmacy, NUS, Singapore.
    • 2004 Academic Excellence Award, Akosombo International School, Ghana.