Ann Mari Holsæter


Associate professor

Job description

Ann Mari Holsæter is a Associate Professor within the Drug Transport and Delivery (DTD) research group since January 2011

Ann Mari is a pharmacist by background (Cand.Pharm., 1999) and holds a doctoral degree in Pharmaceutics (Dr.Scient, 2004)

Ann Mari Holsæter kept different manager positions in neutraceutical and pharmaceutical companies (ProBio Neutraceuticals AS (2006-2008) og Biotec Pharmacon ASA (2008-2011), and was also approved as QP in this periode. 

 

 


  • Laura Victoria Schulte-Werning, Bhupender Singh, Mona Susan Johannessen, Rolf Einar Engstad, Ann-Mari Holsæter :
    Antimicrobial liposomes-in-nanofiber wound dressings prepared by a green and sustainable wire-electrospinning set-up
    International Journal of Pharmaceutics 2024 DOI
  • Jakob Tobias Lynnerup, Jonas Borregaard Eriksen, Annette Bauer-Brandl, Ann Mari Holsæter, Martin Brandl :
    Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
    European Journal of Pharmaceutical Sciences 2023 ARKIV / DOI
  • Ann Mari Holsæter, Kristina Wizgird, Iselin Karlsen, Jeanette Frimand Hemmingsen, Martin Brandl, Natasa Skalko-Basnet :
    How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study
    European Journal of Pharmaceutical Sciences 2022 ARKIV / DOI
  • Jostein Grip, Erik Steene, Rolf Einar Engstad, Jeff Hart, Andrea Bell, Ingrid Skjæveland et al.:
    Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
    European journal of pharmaceutics and biopharmaceutics 2021 ARKIV / DOI
  • May Wenche Jøraholmen, Selenia Ternullo, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    Advanced Drug Delivery Systems for Biologics
    John Wiley & Sons 2021
  • Laura Schulte Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Natasa Skalko-Basnet et al.:
    Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
    Pharmaceutics 2021 ARKIV / DOI
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Following the fate of dye-containing liposomes in vitro
    International Journal of Molecular Sciences 09. July 2020 ARKIV / DOI
  • Selenia Ternullo, Laura Schulte Werning, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing
    Pharmaceutics 2020 ARKIV / DOI
  • Selenia Ternullo, Purusotam Basnet, Ann Mari Holsæter, Gøril Eide Flaten, Louis de Weerd, Natasa Skalko-Basnet :
    Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Natasa Skalko-Basnet, Johan Isaksson, Purusotam Basnet et al.:
    Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Ulrich Massing, Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique
    IntechOpen 2017 FULLTEKST / DOI
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjærveland, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation
    European Journal of Pharmaceutical Sciences 2017 ARKIV / DOI
  • Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model
    European journal of pharmaceutics and biopharmaceutics 2017 ARKIV / DOI
  • Anders Øverbye, Ann Mari Holsæter, Markus Fusser, Natasa Skalko-Basnet, Tore Geir Iversen, Maria Lyngaas Torgersen et al.:
    Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
    OncoTarget 2017 ARKIV / DOI
  • Sveinung Gaarden Ingebrigtsen, Alena Didriksen, Mona Johannessen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Old drug, new wrapping – A possible comeback for chloramphenicol?
    International Journal of Pharmaceutics 2017 ARKIV / DOI
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    The isolated perfused human skin flap model: A missing link in skin penetration studies?
    European Journal of Pharmaceutical Sciences 2017 ARKIV / DOI
  • Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Cristiane de Albuquerque Cavalcanti Jacobsen, Ann Mari Holsæter :
    Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation
    European Journal of Pharmaceutical Sciences 2017 ARKIV / FULLTEKST / DOI
  • Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
    Drug Development and Industrial Pharmacy 2016 ARKIV / DOI
  • Laura Victoria Schulte-Werning, Ann-Mari Holsæter :
    Enhanced Stability and Topical Promise of Chloramphenicol in a Dry Dressing Format
    2024
  • Ann-Mari Holsæter :
    Nanofibers to combat antimicrobial resistance – How and Why?
    2024
  • Ann Mari Holsæter :
    Cancer and drug delivery
    2023
  • Agnhild Johansen, Kjersti Sellæg, Synnøve Norvoll Magnussen, May Wenche Jøraholmen, Ann Mari Holsæter :
    Docetaxel liposomes – Can curcumin be co-entrapped and improve the in vitro cytotoxicity?
    2023
  • Jakob T. Lynnerup, Jonas B. Eriksen, Ann Mari Holsæter, Martin Brandl :
    The effect of nano-milling on dissolution/permeation of poorly soluble drug compounds
    2022
  • Ann Mari Holsæter :
    Nærings-Ph.d. prosjekt for utvikling av nye sårprodukter ga etablering av forskning på nanofibre som legemiddelform i Norge
    2022
  • Paul Gottschalk, Ann Mari Holsæter :
    Optimierung der Herstellung von Liposomen mittels dualer asymmetrischer Zentrifugation
    2022
  • Laura Schulte Werning, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Needle-free electrospinning of nanofibers with chloramphenicol-liposomes using the NanospiderTM
    2022
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    In vitro testing of biocompatibility and anti-inflammatory activity of chloramphenicol loaded multifunctional nanofibers
    2021
  • Ann Mari Holsæter :
    Ann Mari Holsæter: - Etikk må læres gjennom hele livet
    01. March 2021
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Successful entrapment of chloramphenicol in electrospun nanofiber dressings
    2021
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Electrospinning of chloramphenicol-containing nanofibrous dressings for treatment of chronic wounds
    2021 ARKIV
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Dyes in Disguise: characterization of fluorescently labeled liposomes
    2020 ARKIV
  • Jeanette Frimand Hemmingsen, Martin Brandl, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Design, preparation, characterization and stability of docetaxel-containing liposomes
    2020
  • Laura Schulte Werning, Julie Wik Olaussen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Electrospinning chitosan-nanofibers using the needle-free Nanospider™ technology; Optimization of the polymer solution
    2020
  • Ann Mari Holsæter, Kristina Wizgird, Natasa Skalko-Basnet :
    Docetaxel-liposomes prepared by dual centrifugation: effect of propylene glycol and lipid charge
    2019
  • Jostein Grip, Erik Steene, Rolf Einar Engstad, Ingrid Skjæveland, Purusotam Basnet, Natasa Skalko-Basnet et al.:
    Sprayable beta-glucan hydrogel as wound dressing: in vitro and in vivo evaluation
    2019
  • Iselin Karlsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Docetaxel Liposomes - A formulation Screening Study
    2019 ARKIV
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Liposome-cell interaction: following the fate of the nanocarrier
    2019
  • Ann Mari Holsæter :
    Fokus på utnyttelse av digitale læringsressurser for økt fleksibilitet og kvalitet i undervisningen av de farmasøytiske laboratoriefagene
    2019
  • Ann Mari Holsæter, Jostein Grip, Natasa Skalko-Basnet :
    Advanced wound dressing with beta-glucans: in vivo proof of nanofibers superiority
    2018
  • Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    A Nano-Approach to Improve Local Skin Therapy: Isolated Perfused Human Skin Flap as a Tool in Optimization
    2017
  • Ann Mari Holsæter :
    New activities related to liposomes
    2017
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Development of a novel wound healing spray: soluble beta-1,3/1,6-glucan as an active ingredient in Carbopol matrix in a db/db wound model
    2017
  • Ann Mari Holsæter, Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet :
    Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
    2017 ARKIV
  • Ann Mari Holsæter :
    Vurdering av læring i laboratorieundervisning – et eksempel fra farmasiutdanningen
    2017
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: A novel tool to evaluate drug penetration through the skin
    2016
  • Anders Øverbye, Ann Mari Holsæter, Natasa Skalko-Basnet, Iversen Tore-Geir, Maria Lyngaas Torgersen, Tonje Sønstevold et al.:
    Biodegradable nanoparticles in cancer diagnosis and therapy (NANOCAN):Ceramide modulation of liposomal doxorubicin
    2016
  • Ann Mari Holsæter :
    Preparation, characterization and in vitro testing of liposomes
    2016
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin
    2016
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin II
    2016
  • Ann Mari Holsæter, Natasa Skalko-Basnet :
    Liposomes as multi-functional delivery system in cancer therapy
    2015

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    Research interests

    Her research focus is on advanced (nano)delivery systems, aiming to improve drug therapy through improved uptake, stability and/or specificity, with reduced side-effects and more effective therapy as the main goal. Her expertise and research interest are particularly focused on liposomes, nanofibers and hydrogels, either applied alone or in combination. Drug formulations are intended for topical (wounded skin) or systemic (injection) administration, possessing either antimicrobial, anti-cancer or immunomodulating effect. 

    In the DTD-research group, Ann Mari is holding a specific expertise in electrospinning of nanofibers and in applying "dual centrifugation" for the homogenization and size reduction of nanoparticle, including mainly liposomes.

    Teaching

    Teaching responsibilities;

    • FAR-2401; Ex tempore production and quality control (10 ECTs), lecturer (previous course responsible, 2012-2019)
    • FAR-2402; Drug formulation and biopharmacy (10 ECTs)- course responsible since 2019
    • FAR-3401; Advanced Pharmaceutics and biopharmaceutics (10 ECTs), lecturer
    • FAR-3911; Master project in pharmacy (pharmaceutics) (50 ECTs), supervisor
    • FAR-3043: Advanced drug delivery systems in nanomedicine (15 ECTs), lecturer
    • FAR-8043; Nanomedicine and nanotechnology (15 ECTs), lecturer