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Department of Medical Biology ole-jakob.how@uit.no +4777645450 98821821 Tromsø MH L7 .217C

Ole-Jakob How


Associate Professor


  • Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Ole-Jakob How :
    The β3 adrenergic receptor antagonist L-748,337 attenuates dobutamine-induced cardiac inefficiency while preserving inotropy in anesthetized pigs
    Journal of Cardiovascular Pharmacology and Therapeutics 23. September 2021 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs
    Journal of Cardiovascular Pharmacology and Therapeutics 14. July 2020 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs
    Physiological Reports 2020 ARKIV / DOI
  • Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Combined therapy with dobutamine and omecamtiv mecarbil in pigs with ischemic acute heart failure is attributed to the effect of dobutamine
    Journal of Cardiovascular Pharmacology and Therapeutics 2019 ARKIV / DOI
  • Leif Reidar Brenk Rønning, Jens Petter Bakkehaug, Lars Rødland, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure
    Physiological Reports 2018 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    Propulsion of blood through the right heart circulatory system
    Scandinavian Cardiovascular Journal 2017 DOI
  • Jens Petter Bakkehaug, Torvind Næsheim, Erik Torgersen Engstad, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Reversing dobutamine-induced tachycardia using ivabradine increases stroke volume with neutral effect on cardiac energetics in left ventricular post-ischaemia dysfunction
    Acta Physiologica 2016 DOI
  • Anders Benjamin Kildal, Thor Allan Stenberg, Espen Sanden, Truls Myrmel, Ole-Jakob How :
    Prolonged observation time reveals temporal fluctuations in the sublingual microcirculation in pigs given arginine vasopressin
    Journal of applied physiology 2015 DOI
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    Circulation: Heart Failure 2015 DOI
  • Nils Thomas Songstad, David Johansen, Ole-Jakob How, Per Ivar Kaaresen, Kirsti Ytrehus, Ganesh Acharya :
    Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats
    PLOS ONE 2014 ARKIV / DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Espen Sanden, Ole-Jakob How, Martin Hagve, Kirsti Ytrehus et al.:
    The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations
    PLOS ONE 2014 ARKIV / DOI
  • Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert et al.:
    Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
    American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Ole-Jakob How, Truls Myrmel :
    Adrenomedullin-epinephrine cotreatment enhances cardiac output and left ventricular function by energetically neutral mechanisms
    American Journal of Physiology. Heart and Circulatory Physiology 15. April 2012 DOI
  • Ole Magnus Filseth, Ole-Jakob How, Timofey Kondratyev, Tor Magne Gamst, Georg Sager, Torkjel Tveita :
    Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo
    Critical Care Medicine 2012 DOI
  • Ganesh Acharya, James Huhta, Mervi Haapsamo, Ole-Jakob How, Tiina Erkinaro, J Räsänen :
    Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
    Journal of Pregnancy 2011 ARKIV / DOI
  • Stig eggen Hermansen, Trine Kalstad, Ole-Jakob How, truls Myrmel :
    Inflammation and reduced endothelial function in the course of severe acute heart failure
    Translational Research: The Journal of Laboratory and Clinical Medicine 2011 ARKIV / DOI
  • Ole-Jakob How, Assami Rösner, Anders Benjamin Kildal, Thor Allan Stenberg, Petter Fosse Gjessing, Stig Eggen Hermansen et al.:
    Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock
    Translational Research: The Journal of Laboratory and Clinical Medicine 2010 DOI
  • Stig Müller, Ole-Jakob How, Øyvind Jakobsen, Stig Eggen Hermansen, Assami Røsner, Thor Allan Stenberg et al.:
    Oxygen-Wasting Effect of Inotropy Is There a Need for a New Evaluation? An Experimental Large-Animal Study Using Dobutamine and Levosimendan
    Circulation: Heart Failure 2010 DOI
  • Ole Magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita :
    Post-hypothermic cardiac left ventricular systolic dysfunction after rewarming in an intact pig model
    Critical Care 2010 FULLTEKST / DOI
  • Assami Rösner, Ole-Jakob How, Erling Johan Aarsæther, Thor Allan Stenberg, Thomas Vennø Andreasen, Timofei Kondratiev et al.:
    High Resolution Speckle Tracking Dobutamine Stress Echocardiography Reveals Heterogeneous Responses in Different Myocardial Layers: Implication for Viability Assessments
    Journal of the American Society of Echocardiography 2010 DOI
  • A Rösner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller et al.:
    Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate
    European Heart Journal-Cardiovascular Imaging 2009 DOI
  • Stig eggen Hermansen, Magna Hansen, Marius Håke Roaldsen, Stig Müller, Ole-Jakob How, truls Myrmel :
    Utilization and outcome of coronary revascularization and valve procedures in acute heart failure – an evaluation based on the classification from the European Society of Cardiology
    Interactive Cardiovascular and Thoracic Surgery 2008 DOI
  • Assami Røsner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller et al.:
    Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate
    European Heart Journal-Cardiovascular Imaging 2008
  • Stig eggen Hermansen, truls Myrmel, Magna Hansen, Ole-Jakob How, Stig Müller, Marius Håke Roaldsen :
    How many acute heart failure patients need a ventricular assist device?
    Scandinavian Cardiovascular Journal 2008 DOI
  • Stig Müller, Ole-Jakob How, Stig eggen Hermansen, Thor Allan Stenberg, Georg Sager, truls Myrmel :
    Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
    Critical Care 2008 DOI
  • Leif Erik Vinge, Thomas Von Lueder, Ellen Aasum, Eirik Qvigstad, Jørgen A. Gravning, Ole-Jakob How et al.:
    Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth – GRK3 controls cardiac a1-adrenergic receptor responsiveness
    Journal of Biological Chemistry 2008 DOI
  • Ellen Aasum, Ahmed Murtaz Khalid, Oddrun Anita Gudbrandsen, Ole-Jakob How, Rolf Berge, Terje Larsen :
    Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    Journal of Molecular and Cellular Cardiology 2008 DOI
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice
    American Journal of Physiology. Endocrinology and Metabolism 2007 DOI
  • Ole-Jakob How, Erling Sverre Nordøy :
    Seawater drinking restores water balance in dehydrated harp seals
    Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology 2007 DOI
  • Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, AJ Myrray et al.:
    Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice
    Archives of Physiology and Biochemistry 2007
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
    Circulation: Heart Failure 2015 DOI
  • Ole-Jakob How, Torvind Næsheim, Jens Petter Bakkehaug, Timofey Kondratyev, Espen W. Remme, Truls Myrmel :
    Elevated preload is critical for synchronization of myocardial lengthening (e) and mitral inflow (E) in acute ischemic acute heart failure
    The FASEB Journal 2013
  • Nils Thomas Songstad, David Johansen, Ole-Jakob How, Kirsti Ytrehus, Ganesh Acharya :
    Effect of chronic pressure load on heart structure and function in pregnant rats
    2012
  • James Huhta, Juha Rasanen, Mervi Haapsamo, Tiina Erkinaro, Ganesh Acharya, Ole-Jakob How :
    Effect of angiotensin II on the left ventricular function in fetal sheep with metabolic acidemia
    American Journal of Obstetrics and Gynecology 2011
  • Ole magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita :
    CARDIAC FUNCTION DURING SEVERE IMMERSION HYPOTHERMIA AND REWARMING IN PIGS
    Intensive Care Medicine 2010
  • OM Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Georg Sager, Torkjel Tveita :
    DOPAMINE INFUSIONS IN NORMOTHERMIA, SEVERE HYPOTHERMIA AND DURING REWARMING: PHARMACOKINETICS AND CARDIOVASCULAR FUNCTION IN A PIG MODEL OF SURFACE COOLING AND REWARMING
    Intensive Care Medicine 2010
  • Stig eggen Hermansen, T Næsheim, Ole-Jakob How, truls Myrmel :
    Circulatory assistance in acute heart failure - where do we go from here?
    Scandinavian Cardiovascular Journal 2009 DOI
  • J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum et al.:
    Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload
    2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum :
    In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function
    2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice
    2007
  • Stig Müller, O Jakobsen, Ole-Jakob How, truls Myrmel :
    Levosimendan improves mechanical efficiency in stunned pig hearts
    European Journal of Heart Failure 2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum :
    In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function
    Journal of Molecular and Cellular Cardiology 2007 DOI
  • J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum et al.:
    Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload
    European Heart Journal 2007
  • Ole-Jakob How, Ellen Aasum, Terje Larsen :
    Work-independent assessment of efficiency in ex vivo working rodent hearts within the PVA-MVO2 framework
    Acta Physiologica 2007 DOI
  • Ellen Aasum, Anne Dragøy Hafstad, Ole-Jakob How, Ahmed Murtaz Khalid, david lester Severson, Terje Larsen :
    Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes
    2006
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    The type 2 diabetic heart is not an insulin resistant organ
    2006
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice
    2006
  • Ole-Jacob How, Terje Larsen :
    Oxygen wastage in the diabetic heart. Ventricular energetics in the isolated mouse heart using PVA-MVO2 technology
    2006 DATA / OMTALE
  • Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, david lester Severson et al.:
    Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice
    2006
  • Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, david lester Severson et al.:
    Rosiglitazone improves cardiac efficiency and recovery of ventricular function following ischemia in hearts from type 2 diabetic mice
    2006

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