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The Arctic University Museum of Norway bastian.fromm@uit.no Tromsø

Bastian Fromm


group leader

Job description

Dr. Fromm is the leader of the recently established research group for biosystematics and paleotranscriptomics funded by the Tromsø Research foundation. The groups main interest is animal evolution using non-coding RNA genes such as microRNAs in modern, historic and ancient samples.

See project MIRevolution


  • Peterson, Kevin; Beavan, Alan; Chabot, Peter J; McPeek, Mark A; Pisani, Davide; Fromm, Bastian; Simakov, Oleg. MicroRNAs as Indicators into the Causes and Consequences of Whole-Genome Duplication Events. Molecular Biology and Evolution (MBE) 2022; Volum 39 (1). ISSN 0737-4038.s doi: 10.1093/molbev/msab344.
  • Fromm, Bastian; Høye, Eirik; Domanska, Diana; Zhong, Xiangfu; Aparicio-Puerta, Ernesto; Ovchinnikov, Vladimir; Umu, Sinan Ugur; Chabot, Peter J; Kang, Wenjing; Aslanzadeh, Morteza; Marmol-Sanchez, Emilio; Urgese, Gianvito; Johansen, Morten; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin. MirGeneDB 2.1: toward a complete sampling of all major animal phyla. Nucleic Acids Research (NAR) 2022; Volum 50 (D1). ISSN 0305-1048.s D204 - D210.s doi: 10.1093/nar/gkab1101.
  • Hu, Rui-Si; Zhang, Xiao-Xuan; Ma, Qiao-Ni; Elsheika, Hany M; Ehsan, Muhammad; Zhao, Quan; Fromm, Bastian; Zhu, Zing-Quan. Differential expression of microRNAs and tRNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts. International Journal of Parasitology 2021. ISSN 0020-7519.s doi: 10.1016/j.ijpara.2020.10.009.
  • Kang, Wenjing; Fromm, Bastian; Houben, Anna J.; Høye, Eirik; Bezdan, Daniela; Arnan, Carme; Thrane, Kim; Asp, Michaela; Johnson, Rory; Biryukova, Inna; Friedländer, Marc R.. MapToCleave: High-throughput profiling of microRNA biogenesis in living cells. Cell reports 2021; Volum 37 (7). ISSN 2211-1247.s doi: 10.1016/j.celrep.2021.110015.
  • Rosani, Umberto; Bortoletto, Enrico; Bai, Chang-Ming; Novoa, Beatriz; Figueras, Antonio; Venier, Paola; Fromm, Bastian. Digging into bivalve miRNAomes: between conservation and innovation. Philosophical Transactions of the Royal Society of London. Biological Sciences 2021. ISSN 0962-8436.s doi: 10.1098/rstb.2020.0165.
  • Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A.. The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology 2020; Volum 159 (6). ISSN 0016-5085.s 2146 - 2162.s doi: 10.1053/j.gastro.2020.08.018.
  • Hansen, Eline P.; Fromm, Bastian; Andersen, Sidsel D.; Marcilla, Antonio; Andersen, Kasper L.; Borup, Anne; Williams, Andrew R.; Jex, Aaron R.; Gasser, Robin B.; Young, Neil D.; Hall, Ross S.; Stensballe, Allan; Ovchinnikov, Vladimir; Yan, Yan; Fredholm, Merete; Thamsborg, Stig M.; Nejsum, Peter. Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk. Journal of Extracellular Vesicles 2019; Volum 8:1578116 (1). ISSN 2001-3078.s 1 - 14.s doi: 10.1080/20013078.2019.1578116.
  • Lund-Andersen, Christin; Nakken, Sigve; Nygård, Ståle; Fromm, Bastian; Aasheim, Lars Birger; Davidson, Ben; Julsrud, Lars; Abrahamsen, Torveig Weum; Kristensen, Annette Torgunrud; Dybdahl, Brit; Larsen, Stein Gunnar; Hovig, Eivind; Flatmark, Kjersti. Integrative genomic analysis of peritoneal malignant mesothelioma: Understanding a case with extraordinary chemotherapy response. (fulltekst) Cold Spring Harbor Molecular Case Studies 2019; Volum 5:a003566 (2). ISSN 2373-2873.s 1 - 15.s doi: 10.1101/mcs.a003566.
  • Fromm, Bastian; Domanska, Diana Ewa; Høye, Eirik; Ovchinnikov, Vladimir; Kang, Wenjing; Aparicio-Puerta, Ernesto; Johansen, Morten; Flatmark, Kjersti; Mathelier, Anthony; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin J.. MirGeneDB 2.0: the metazoan microRNA complement. Nucleic Acids Research (NAR) 2019; Volum 48 (D1). ISSN 0305-1048.s D132 - D141.s doi: 10.1093/nar/gkz885.
  • Tarver, James E.; Taylor, Richard S.; Puttick, Mark N.; Lloyd, Graeme T.; Pett, Walker; Fromm, Bastian; Schirrmeister, Bettina E.; Pisani, Davide; Peterson, Kevin J.; Donoghue, Philip C.J.. Well-annotated microRNAomes do not evidence pervasive miRNA loss. Genome Biology and Evolution (GBE) 2018; Volum 10 (6). ISSN 1759-6653.s 1457 - 1470.s doi: 10.1093/gbe/evy096.
  • Ugur Umu, Sinan; Langseth, Hilde; Bucher-Johannessen, Cecilie; Fromm, Bastian; Keller, Andreas; Meese, Eckart; Lauritzen, Marianne; Leithaug, Magnus; Lyle, Robert; Rounge, Trine Ballestad. A comprehensive profile of circulating RNAs in human serum. RNA Biology 2018; Volum 15 (2). ISSN 1547-6286.s 242 - 250.s doi: 10.1080/15476286.2017.1403003.
  • Bråte, Jon; Neumann, Ralf Stefan; Fromm, Bastian; Haraldsen, Arthur Alexander Blørstad; Tarver, James E.; Suga, Hiroshi; Donoghue, Philip C.J.; Peterson, Kevin J.; Ruiz-Trillo, Iñaki; Grini, Paul Eivind; Shalchian-Tabrizi, Kamran. Unicellular origin of the animal microRNA machinery. (data) Current Biology 2018; Volum 28 (20). ISSN 0960-9822.s 3288 - 3295.e5.s doi: 10.1016/j.cub.2018.08.018.
  • Graudenzi, Alex; Cava, Claudia; Bertoli, Gloria; Fromm, Bastian; Flatmark, Kjersti; Mauri, Giancarlo; Castiglioni, Isabella. Pathway-based classification of breast cancer subtypes. Frontiers in Bioscience 2017; Volum 22 (10). ISSN 1093-9946.s 1697 - 1712.
  • Ovchinnikov, Vladimir Y.; Mordvinov, Viatcheslav A; Fromm, Bastian. Extreme conservation of miRNA complements in opisthorchiids. Parasitology international 2017; Volum 66 (6). ISSN 1383-5769.s 773 - 776.s doi: 10.1016/j.parint.2017.09.006.
  • Fromm, Bastian; Ovchinnikov, Vladimir Y.; Høye, Eirik; Bernal, Dolores; Hackenberg, Michael; Marcilla, Antonio. On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica. Parasite immunology (Print) 2017; Volum 39:e12399 (2). ISSN 0141-9838.s 1 - 9.s doi: 10.1111/pim.12399.
  • Egger, Bernhard; Bachmann, Lutz; Fromm, Bastian. Atp8 is in the ground pattern of flatworm mitochondrial genomes. (fulltekst) BMC Genomics 2017; Volum 18 (414). ISSN 1471-2164.s doi: 10.1186/s12864-017-3807-2.
  • Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman; Holden, Lars; Holden, Marit; Grytten, Ivar; Rand, Knut Dagestad; Drabløs, Finn; Johansen, Morten; Mora Ortiz, Antonio Carlos; Lund-Andersen, Christin; Fromm, Bastian; Eskeland, Ragnhild; Gabrielsen, Odd Stokke; Ferkingstad, Egil; Nakken, Sigve; Bengtsen, Mads; Nederbragt, Alexander Johan; Thorarensen, Hildur Sif; Akse, Johannes Andreas; Glad, Ingrid Kristine; Hovig, Johannes Eivind; Sandve, Geir Kjetil. GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. (fulltekst) GigaScience 2017; Volum 6 (7). ISSN 2047-217X.s 1 - 12.s doi: 10.1093/gigascience/gix032.
  • Ylla, Guillem; Fromm, Bastian; Piulachs, Maria-Dolors; Belles, Xavier. The microRNA toolkit of insects. Scientific Reports 2016; Volum 6:37736. ISSN 2045-2322.s 1 - 13.s doi: 10.1038/srep37736.
  • Ramalho-Carvalho, João; Fromm, Bastian; Henrique, Rui; Jerónimo, Carmen. Deciphering the function of non-coding RNAs in prostate cancer. Cancer Metastasis Review 2016; Volum 35 (2). ISSN 0167-7659.s 235 - 262.s doi: 10.1007/s10555-016-9628-y.
  • Flatmark, Kjersti; Høye, Erik Ulvolden; Fromm, Bastian. microRNAs as cancer biomarkers. Scandinavian Journal of Clinical and Laboratory Investigation 2016; Volum 76. ISSN 0036-5513.s S80 - S83.s doi: 10.1080/00365513.2016.1210330.
  • Haakensen, Vilde Drageset; Nygaard, Vegard; Greger, Liliana; Aure, Miriam Ragle; Fromm, Bastian; Bukholm, Ida Rashida Khan; Luders, Torben; Chin, Suet-Feung; Git, Anna; Caldas, Carlos; Kristensen, Vessela N.; Brazma, Alvis; Børresen-Dale, Anne-Lise; Hovig, Johannes Eivind; Helland, Åslaug. Subtype-specific micro-RNA expression signatures in breast cancer progression. International Journal of Cancer 2016; Volum 139 (5). ISSN 0020-7136.s 1117 - 1128.s doi: 10.1002/ijc.30142.
  • Bachmann, Lutz; Fromm, Bastian; Patella de Azambuja, Luciana; Boeger, Walter. The mitochondrial genome of the egg-laying flatworm Aglaiogyrodactylus forficulatus (Platyhelminthes: Monogenoidea). Parasites & Vectors 2016; Volum 9:285. ISSN 1756-3305.s doi: 10.1186/s13071-016-1586-2.
  • Fromm, Bastian; Billipp, Tyler; Peck, Liam E.; Johansen, Morten; Tarver, James E.; King, Benjamin L.; Newcomb, James M.; Sempere, Lorenzo F.; Flatmark, Kjersti; Hovig, Johannes Eivind; Peterson, Kevin J.. A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome. Annual Review of Genetics 2015; Volum 49. ISSN 0066-4197.s 213 - 242.s doi: 10.1146/annurev-genet-120213-092023.
  • Fromm, Bastian; Trelis, María; Hackenberg, Michael; Cantalapiedra, Fernando; Bernal, Dolores; Marcilla, Antonio. The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles. International Journal of Parasitology 2015; Volum 45 (11). ISSN 0020-7519.s 697 - 702.s doi: 10.1016/j.ijpara.2015.06.002.
  • Fromm, Bastian; Burow, Susann; Hahn, Christoph; Bachmann, Lutz. MicroRNA loci support conspecificity of Gyrodactylus salaris and G. thymalli (Platyhelminthes: Monogenea). International Journal of Parasitology 2014; Volum 44 (11). ISSN 0020-7519.s 787 - 793.s doi: 10.1016/j.ijpara.2014.05.010.
  • Hahn, Christoph; Fromm, Bastian; Bachmann, Lutz. Comparative genomics of flatworms (Platyhelminthes) reveals shared genomic features of ecto- and endoparastic neodermata. Genome Biology and Evolution (GBE) 2014; Volum 6 (5). ISSN 1759-6653.s 1105 - 1117.s doi: 10.1093/gbe/evu078.
  • Fromm, Bastian; Worren, Merete Molton; Hahn, Christoph; Hovig, Johannes Eivind; Bachmann, Lutz. Substantial loss of conserved and gain of novel microRNA families in flatworms. Molecular Biology and Evolution (MBE) 2013; Volum 30 (12). ISSN 0737-4038.s 2619 - 2628.s doi: 10.1093/molbev/mst155.
  • Fromm, Bastian; Harris, Philip David; Bachmann, Lutz. MicroRNA preparations from individual monogenean Gyrodactylus salaris – a comparison of six commercially available totalRNA extraction kits. BMC Research Notes 2011; Volum 4. ISSN 1756-0500.s doi: 10.1186/1756-0500-4-217.
  • Fromm, Bastian; Domanska, Diana; Høye, Eirik; Ovchinnikov, Vladimir; Kang, Wenjing; Aparicio-Puerta, Ernesto; Johansen, Morten; Flatmark, Kjersti; Mathelier, Anthony; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R; Peterson, Kevin J. Erratum: MirGeneDB 2.0: The metazoan microRNA complement (Nucleic Acids Research (2019) DOI: 10.1093/nar/gkz885). Nucleic Acids Research (NAR) 2020; Volum 48 (1). ISSN 0305-1048.s D1172 - .s doi: 10.1093/nar/gkz1016.
  • Fromm, Bastian; Kang, Wenjing; Rovira, Carlos; Cayota, Alfonso; Witwer, Kenneth W; Friedländer, Marc R.; Tosar, Juan Pablo. Plant microRNAs in human sera are likely contaminants. Journal of Nutritional Biochemistry 2019; Volum 65. ISSN 0955-2863.s 139 - 140.s doi: 10.1016/j.jnutbio.2018.07.019.
  • Rodriguez, Marta; Bajo-Santos, Cristina; Hessvik, Nina Pettersen; Lorenz, Susanne; Fromm, Bastian; Berge, Viktor; Sandvig, Kirsten; Line, Aija; Llorente, Alicia. Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. Molecular Cancer 2017; Volum 16:156. ISSN 1476-4598.s 1 - 6.s doi: 10.1186/s12943-017-0726-4.
  • Haraldsen, Arthur Alexander Blørstad; Bråte, Jon; Neumann, Ralf Stefan; Fromm, Bastian; Grini, Paul Eivind; Shalchian-Tabrizi, Kamran. Pre-metazoan origin of animal microRNAs. European Society of Evolutionary Developmental Biology 2016-07-26 - 2016-07-29 2016.
  • Fromm, Bastian; Bachmann, Jutta; Bachmann, Lutz. Auf der Suche nach der genetischen Basis von Ekto- und Endoparasitismus der Plattwürmer. Biologie in unserer Zeit 2015; Volum 45 (5). ISSN 0045-205X.s 281 - 283.
  • Fromm, Bastian; Bachmann, Jutta; Bachmann, Lutz. Tilpassninger i arvematerialet hos parasittiske flatormer. Naturen 2015; Volum 139 (2). ISSN 0028-0887.s 59 - 66.
  • Fromm, Bastian; Worren, Merete Molton; Hahn, Christoph; Hovig, Johannes Eivind; Bachmann, Lutz. Evolution of Parasitism in Flatworms Is Accompanied by Substantial Loss of Conserved microRNA Families and Increase of Novel microRNAs. SMBE 2013 2013-07-07 - 2013-07-11 2013.
  • Fromm, Bastian; Otto, Thomas D.; Hahn, Christoph; Harris, Philip David; Bachmann, Lutz. MiRCandRef a local assembly algorithm for description of microRNAs in non-genome organisms. SMBE 2012 2012-06-23 - 2012-06-26 2012.
  • Hahn, Christoph; Harris, Philip David; Fromm, Bastian; Bakke, Tor A.; Bachmann, Lutz. Genomic insights into the evolution of the economically important monogenean flatworm Gyrodactylus salaris. SMBE 2012 2012-06-23 - 2012-06-26 2012.
  • Fromm, Bastian; Worren, Merete Molton; Harris, Philip David; Bachmann, Lutz. The miRNA complement of Gyrodactylus salaris (Platyhelminthes, Monogenea). Deep Metazoan Phylogeny 2011 2011-10-11 - 2011-10-14 2011.
  • Fromm, Bastian; Bachmann, Lutz; Harris, Philip David. MicroRNA preparations from individual monogenean Gyrodactylus salaris – comparison of six commercially available “totalRNA” extraction kits. The 4th Conference of the Scandinavian-Baltic Society for Parasitology (SBSP) 2011-06-19 - 2011-06-22 2011.
  • Look at all works in CRIStin →


    Research interests

    Is there one driving force of animal evolution that explains the immense diversity of life and can it also help us to understand the exceptional success of parasitic species that affect us?

    The underlying and very strong feature of both processes seems in fact to be very small: microRNAs. Since the discovery that they are found in all animals and regulate important biological processes about 20 years ago, these tiny fine-tuners of cellular programs are among the most studied molecules ever. However, with more than 16,000 annual publications, the rapidly growing microRNA field became riddled with contradicting reports that hindered novel discoveries and applications. In the recent research of Dr. Bastian Fromm, this was addressed with the microRNA gene database MirGeneDB and the foundations to transform the microRNA field from a qualitative research area to the quantitative level, and ask fundamental questions, were laid.

    In his TFS-project MIRevolution, Dr. Fromm and his group will use novel sequencing approaches, state of the art single cell experiments and take advantage of the unique biodiversity in Tromso, to deepen the understanding of animal evolution, and parasites in particular. Using microRNAs, open questions in systematics and gene-regulation will be addressed. Facilitated by the ancient DNA laboratory at the Museum, and the Museums collection, the Fromm lab will further set out to use microRNAs in the novel research line paleotranscriptomics that, for the first time, enables gene expression studies in long-dead biological material.