Heidi Erlandsen
Senior Engineer, Biomolecular and Structural Chemistry, Lab manager
Publications outside Cristin
Krucinska J, Lombardo MN, Erlandsen H, Estrada A, Si D, Viswanathan K, Wright DL. «Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens». Commun Biol. 2022 May 13;5(1):459. doi: 10.1038/s42003-022-03384-y.
Heidi Erlandsen, Anne M Jecrois, Jeffry C Nichols, James L Cole, William E Royer Jr. “NADH/NAD + binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2». FEBS Lett. 2022 Feb;596(4):479-490
Jolanta Krucinska, Michael N Lombardo, Heidi Erlandsen, Akram Hazeen, Searle S Duay, Jason G Pattis, Victoria L Robinson, Eric R May, Dennis L Wright. "Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate" Sci Rep. 2019 Nov 19;9(1):17106.
Christopher B Mayo, Heidi Erlandsen, David J Mouser, Aaron G Feinstein, Victoria L Robinson, Eric R May, James L Cole. "Structural Basis of Protein Kinase R Autophosphorylation" Biochemistry 2019 Jul 9; 58(27): 2967–2977.
Behnoush Hajian, Eric Scocchera, Carolyn Shoen, Jolanta Krucinska, Kishore Viswanathan, Narendran G-Dayanandan, Heidi Erlandsen, Alexavier Estrada, Katarína Mikušová, Jana Korduláková, Michael Cynamon, Dennis Wright. "Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents". Cell Chem Biol. 2019 Jun 20;26(6):781-791.e6.
Brian Maniaci, Colin H Lipper, Deepthi L Anipindi, Heidi Erlandsen, James L Cole, Boguslaw Stec, Tom Huxford, John J Love. "Design of High-Affinity Metal-Controlled Protein Dimers" Biochemistry. 2019 Apr 30;58(17):2199-2207.
Jolanta Krucinska, Eric Falcone, Heidi Erlandsen, Akram Hazeen, Michael N Lombardo, Alexavier Estrada, Victoria L Robinson, Amy C Anderson, Dennis L Wright. "Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens" Biochemistry. 2019 Mar 5;58(9):1188-1197.
Frank Rutsch, Mary MacDougall, Changming Lu, Insa Buers, Olga Mamaeva, Yvonne Nitschke, Gillian I. Rice, Heidi Erlandsen, Hans Gerd Kehl, Holger Thiele, Peter Nürnberg, Wolfgang Höhne, Yanick J. Crow, Annette Feigenbaum, Raoul C. Hennekam. "Early vascular calcifications and dental inflammation caused by a specific IFIH1 gain-of-function mutation". Am J Hum Genet. 2015 Feb 5;96(2):275-82.
«The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold” Nature Communications 5:4339. doi: 10.1038/ncomms5339 · Jan 1, 2014
«Pleiotrophin Expression During Odontogenesis» Journal of Histochemistry and Cytochemistry, 60(5) 366–375 · Jan 1, 2012
«Structural and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesins» J. Biol. Chem. 286: 27048-57. · Jan 1, 2011
«Expression, purification, crystallization and preliminary X-ray analysis of ORF60, the small subunit (R2) of ribonucleotide reductase from Kaposi’s sarcoma-associated herpesvirus (KSHV)» Acta Cryst. F66: 734-737. · Jan 1, 2010
«Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma associated herpesvirus“ FEBS J. 276: 6636-6645 · Jan 1, 2009
«The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins» Proteins. 74:18-31. · Jan 1, 2009
«The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain» J. Mol. Biol. 360:774-87 · Jan 1, 2006
«Biopterin responsive phenylalanine hydroxylase deficiency» Genet Med.6:27-32. · Jan 1, 2004
«Correction of kinetic and stability defects by the cofactor BH4 in PKU patients with certain phenylalanine hydroxylase mutations” Proceeding of the National Academy of Sciences USA. 101:16903-16908. · Jan 1, 2004
«Mechanisms Underlying Responsiveness to Tetrahydrobiopterin in Mild Phenylkeotnuria Mutations» Hum. Mut. 24:388-399. · Jan 1, 2004
«Structure of a HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution» Proteins. 54:806-809. · Jan 1, 2004
«The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency» Molecular Genetics and Metabolism. 82:101-111. · Jan 1, 2004
«Trends in enzyme therapy for phenylketonuria» Molecular Therapy 10: 220-224. · Jan 1, 2004
“HEPN: domain involved in NTP binding and present in antibiotic resistance proteins in bacteria and human gene responsible for a neurodegenerative disease» Trends in Biomedical Sciences, 28: 224-226. · Jan 1, 2003
«PAHdb 2003: What a locus-specific knowledgebase can do» Human Mutation, 21: 333-344. · Jan 1, 2003
«Structural Studies on Phenylalanine Hydroxylase and Implications Towards Understanding and Treating Phenylketonuria» Pediatrics, 112: 1557-1565. · Jan 1, 2003
«A structural hypothesis for BH4 responsiveness in phenylketonuria patients» Journal of Inherited Metabolic Disease, 24, 213-230 · Jan 1, 2002
«Structural Comparison of Bacterial and Human Iron-dependent Phenylalanine Hydroxylases: Similar Fold, Different Stability and Reaction Rates» Journal of Molecular Biology, 320, 645-661 · Jan 1, 2002
«Tree-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin» Biochemistry, 41, 12569-12574 · Jan 1, 2002
«Combining Structural Genomics and Enzymology: Completing the Picture in Metabolic Pathways and Enzyme Active Sites» Current Opinion in Structural Biology, 10, 719-730. · Jan 1, 2000
«Crystal Structure and Site Specific Mutagenesis of Pterin Bound Human Phenylalanine Hydroxylase” Biochemistry, 39, 2208-2217 · Jan 1, 2000
«Regulatory properties of tetrahydrobiopterin cofactor bound at the active site of phenylalanine hydroxylase» Pteridines, 11, 34-36 · Jan 1, 2000
«The Structural Basis of Phenylketonuria» Molecular Genetics and Metabolism · Jan 1, 1999
«Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria» Nature Structural Biology, 4, 995-1000 · Jan 1, 1998
«Crystallographic analysis of human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0Å resolution» Biochemistry, 37, 15638-15646 · Jan 1, 1998
«Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria» Journal of Biological Chemistry, 273, 16962-16967 · Jan 1, 1998
«Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase» FEBS Letters, 406, 171-176 · Jan 1, 1997
Research interests
Protein biophysical characterization and structure determination.