Inflammation in human disease
This group works with reaseasch areas related to inflammation in human disease, with focus on the following topics:
- Sepsis: in vitro-studies of bacteria in a human whole blood model.
- Hereditary angioedema: the role of C1-inhibitor in e.g. capillary leakage.
- Cardiovascular conditions and risk factors: metabolic syndrome, atherosclerosis including in vitro endothelial cell studies, atrial fibrillation and heart failure, where inflammation plays an important role in the pathogenesis.
- Biocompatibility of medical biomaterials: activation of the inflammatory process by polymeric surfaces and apheresis filters.
- Placenta physiology and pathophysiology with focus on vascular and inflammatory reaction.
- Perinatology closely linked to the placenta research.
- Astma and inflammatory lung disease.
The innate immune system, in particular complement and the cytokine network, is the main focus of this research group. Mechanisms of activation of the inflammatory network is studied with emphasize on the damaging effects on the host of such activation. Various inhibitors of the innate immune system are tested for possible application in future therapy of diseases where inflammation contributes in the pathogenesis.
The group has access to modern equipment located in the reseach laborotory at Nordlandssykehuset HF, Bodø. Both commercial and own-developed methods are used by the highly skilled biomedical laboratory scientists, who have high competence in flowcytometri, gente technology, luminex and other immuno-assays.
The group is a typical ”networking group” with close collaboration between the clinical departments and the research laboratory. There is also an extensive collaboration with several national and international research groups.