Protein Kinase Biophysics group
Protein kinase overview
Protein kinases transfer phosphate groups from ATP to proteins. The human genome encodes for over 500 structurally similar protein kinases that transfer the gamma-phosphate of ATP to serine, threonine, or tyrosine residues of proteins.
From Åberg, E. et al., "Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool", Biol. Chem. (2012) 393, 1121-1129. PMID: 23092797.