Master's thesis
2023
Victoria Stenbakk: Application of outer membrane vesicles from ESKAPE pathogens as native models of bacterial membranes. Supervisors: Maxim Bril'kov and Gøril Eide Flaten
Agnhild Johansen: Liposomes with Docetaxel and Curcumin – Formulation and in vitro Cytotoxicity.
Supervisors: Ann Mari Holsæter (main-supervisor), May Wenche Jøraholmen, Synnøve Magnussen og Kjersti Sellæg
Trine Marie Henriksen: Liposomes containing curcumin for the localized therapy of vaginal infections: The effect of surface modification on drug efficacy. Supervisors: May Wenche Jøraholmen (main) and Silje Mork (co-supervisor)
Miranda Ramadani: Liposomal quercetin for localized therapy of vaginal infections: Optimizing mucoadhesive properties. Supervisors: May Wenche Jøraholmen (main) and Silje Mork (co-supervisor)
Tariq Zuboon: Characterization and quantification of protein corona on the surface of liposomes.
Supervisors: Eirik Rustad (main), Natasa Skalko-Basnet (co-supervisor)
Aly Mohamed: Design and optimization of liposomal formulation intended for phagocyte targeting in cancer treatment. Supervisor: Natasa Skalko-Basnet (main), Elena Markova (co-supervisor)
Hassan Ali Alkedro: Lipid Nanoparticle Enabled Co-Delivery of Tetrahedral DNA Framework and Antimicrobial Peptides. Supervisors: Sybil Obuobi and Natasa Skalko-Basnet
2022
Linda Kourng: An Evaluation of Cu(DDC)2-Liposome Production via Dual Centrifugation, Optimization of Production Parameters for Novel Liposomes. Supervisors: Laurens Kersch (University of Freiburg, main) and Natasa Skalko-Basnet (co-supervisor)
Mari Salamonsen: Dual delivery of chlorogenic acid and mimic of antimicrobial peptide – towards wound treatment. Supervisors: Lisa Hemmingsen (main) and Natasa Skalko-Basnet (co-supervisor)
Vegård Borøy: Development of DNA Nanoparticles with Properties for Enhanced Biofilm Uptake. Supervisors: Sybil Obuobi (main), Alexandra de Sousa (co-supervisor) and Natasa Skalko-Basnet (co-supervisor)
Robin Kumar: Characterization of pH-responsive liposomes and the effect of PEGylation and serum on pH-responsiveness. Supervisors: Natasa Skalko-Basnet (main) and Eirik Rustad (co-supervisor)
Pimmat Panchai: Chitosan-modified liposomes for delivery of membrane-active antimicrobials – exploring the role of the polymer. Supervisors: Lisa Hemmingsen (main) and Natasa Skalko-Basnet (co-supervisor)
Cindy Jia Ru Zhang: Process optimization of albumin-stabilized mitotane nanoparticle preparation by dual centrifugation and first lyophilization study. Supervisors: Carolin Langer (University of Freiburg, main) and Natasa Skalko-Basnet (co-supervisor)
2021
Aya Ahmed Tawfeq (2021) Localized therapy of vaginal infections: Liposomes-in-hydrogel delivery system containing curcumin. Supervisor May Wenche Jøraholmen, co-supervisor Natasa Skalko-Basnet
Anna Ngoc Phung (2021) Zwitterionic antimicrobial nanoparticles for biofilm therapy. Supervisor Sybil Obuobi, co-supervisor Natasa Skalko-Basnet
Anjanah Murugaiah (2021) The development of electrospun chloramphenicol containing wound dressing. Supervisors: Ann Mari Holsæter and Laura Victoria Schulte-Werning
2020
Ann Kristin Pettersen: Liposomal formulations for membrane active antimicrobials – Assuring safety through an optimised drug delivery system. Supervisors: Natasa Skalko-Basnet and Lisa Myrseth Hemmingsen
Julie Wik Olaussen: Electrospinning of nanofibers with chitosan and β-glucan as active wound healing ingredients - Optimization and characterization. Supervisors: Ann Mari Holsæter and Laura Victoria Schulte-Werning
Sunniva Brurok: High throughput lipolysis-permeation in vitro model employing the mucus-PVPA-mucus barriers to assess drug absorption from lipid based delivery systems. Supervisors: Margherita Falavigna and Gøril Eide Flaten
Kasi Rashid Shorsh: Liposome and chitosan-based delivery systems for epicatechin: Targeting the local treatment of vaginal infections. Supervisors: May Wenche Jøraholmen and Nataša Škalko-Basnet
Silje Mork: Microfluidized liposomes for cellular uptake imaging: Optimization.
Supervisors: Natasa Skalko-Basnet and Jennifer Cauzzo
Luquman Ahsan: Development of chitosan-based delivery system for membrane active antimicrobials. Supervisors: Natasa Skalko-Basnet and Lisa Myrseth Hemmingsen
2019
Eirik André Lindeløff Rustad: Evaluation and late-stage fluorinate of small molecule GnRH-R antagonists. Supervisors: richard Fjellaksel, Ole Kristian Hjelstuen and Jørn H. Hansen
Sonali Bala: Osmotically-active liposomes for nasal drug delivery. Supervisors: Iren Yeeling Wu and Massimiliano di Cagno
Abhilasha Bhargava: Chitosan-based mucoadhesive drug delivery systems for vaginal infections. Supervisor Natasa Skalko-Basnet, co-supervisor May Wenche Jøraholmen
2018
Eivind Gagnat: Improved chronic wound therapy: surface charged deformable liposomes for dermal delivery of curcumin. Supervisor Selenia Ternullo, co-supervisor Natasa Skalko-Basnet
Mia Tostrup: Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections. Supervisor May Wenche Jøraholmen, co-supervisor Natasa Skalko-Basnet
Sabrin Moueffaq: Topical vaginal therapy: Development of a liposome-in-hydrogel delivery system for epicatechin. Supervisor May Wenche Jøraholmen, co-supervisor Natasa Skalko-Basnet
Nicklas Ekblad: Melt processability of amorphous solid dispersions during hot-melt extrusion. Supervisor Jukka Rantanen (University of Copenhagen), co-supervisor Natasa Skalko-Basnet
Iselin Karlsen: Docetaxel in liposomes: the effect of lipid composition on the achieved drug entrapment. Supervisor Ann Mari Holsæter, co-supervisor Natasa Skalko-Basnet
Trygg Einar Nikolaisen: Influence of environmental tonicity changes on lipophilic drug release from liposomes. Supervisor Massimiliano Pio di Cagno, co-supervisor Iren Yeeling Wu
Nikolay Fadeev: B-cyclodextrin polymers as cholesterol sequestrating agents. Supervisor Massimiliano Pio di Cagno
2017
Christoffer J. Løkse: Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach. Supervisor Sandra Ristori, University of Florence and co-supervisor Natasa Skalko-Basnet, UiT
2016
Awfa Al-Shamkawy: Interaction of CPZEN-45, a novel anti-tubercular drug candidate, with immune cells in vitro. Supervisor Carsten Ehrhardt, Trinity College Dublin, co-supervisor Gøril Eide Flaten, UiT
Lloyd Mbugua Kangu: Chitosan lecithin nanoparticles with New Chemical Entity, Nanotoxicity evaluation. Supervisor Natasa Skalko-Basnet, UiT and co-supervisor Gry Stensrud, Photocure
Damir Dugalic: Assessment of Anchimerically-Assisted Finkelstein Reaction of Application in Late-Stage Radioiodination. Supervisor Ole Kristian Hjelstuen UiT, co-supervisors Jørn Hansen UiT and Richard Fjellaksel UiT/UNN
2015
Ayantu Edossa Chemeda: Topical liposomes treted by probe-sonication: Study on process and composition using statistical experimental design and multivariate evaluation. Supervisor Ann Mari Holsæter, co-supervisor Sveinung Gaarden Ingebrigtsen
Hege-Kristine Lorentzen: Konsekvensene av deling og knusing av enteroformuleringer - Metodeutvikling og evaluering. Supervisor Daniel Zeiss (HiNT), co-supervisor Gøril Eide Flaten
Iren Yeeling Wu: Can nanomedicine improve the semen quality? The potentials of liposomal curcumin. Supervisor Purusotam Basnet (UNN, IKM), co-supervisor Natasa Skalko-Basnet
Lisa Myrseth Hemmingsen: Chitosan lecithin nanoparticles with New Chemical Entity, Antimicrobial evaluation. Supervisor Natasa Skalko-Basnet, co-supervisor Gry Stensrud (Photocure)
Evrard Louis A B Betoko: Development of orodispersable films: A new age-appropriate dosage form for children. Supervisor Ingunn Tho (University of Oslo), co-supervisor Natasa Skalko-Basnet
Irja Alainezhad Kjærvik:Electrospun amphiphilic nanofibers for the in situ preparation and delivery of drug-loaded liposomes. Supervisors Jyrki Heinämäki, Karin Kogermann, Ivo Laidmäe (University of Tartu, Estonia), co-supervisor Natasa Skalko-Basnet
Kristina Rybak: Mucus-penetrating drug carriers for vaginal drug delivery. Supervisor May Wenche Jøraholmen, co-supervisor Natasa Skalko-Basnet
Joseph Azumah: Liposomes as potential carrier for bioactive β2,2-amino acid derivatives A feasibility study. Supervisors Mørten Strøm, Dominik Ausbacher, co-supervisor Natasa Skalko-Basnet
2014
Anna N. Troyan: Novel Liposome Formulation from algae membranes as carriers for bioactive compounds (supervisor Sandra Ristori (University of Florence, Italy), co-supervisor Natasa Skalko-Basnet)
Marthe Karoline Grønvold: Coating of neutral liposomes with hydrophobically modified hydroxyethyl cellulose (supervisor Gro Smistad (UiO), co-supervisor Natasa Skalko-Basnet)
Muna Abukar Hadafow: Chitosan-based drug delivery system for a chemical entity for photodynamic wound therapy (supervisors Natasa Skalko-Basnet and Gry Stensrud (Photocure ASA))
Ida Emilie Thoresen: Advanced drug delivery system for new chemical entity destined for wound therapy: Anti-biofilm potential of novel drug delivery system(supervisors Natasa Skalko-Basnet and Gry Stensrud (Photocure ASA))
Malin Nyland Aalberg: Mukus-penetrerende legemiddelbærere: Hvordan modifisering av overflaten påvirker terapeutisk effect (supervisors Natasa Skalko-Basnet and May Wenche Jøraholmen)
Kurt Jonny Johansen: Undersøkelse av en ny topikal antimykotisk “liposom-i-hydrogel” legemiddelformulering med virkestoffet flukonazol (supervisors Ann Mari Holsæter and Sveinung G. Ingebrigtsen)
Herra Iqbal: Kompatibilitetstesting av TPN og legemidler gitt som Y-infusjon til barn (supervisors Ingunn Tho and Vigdis Staven)
2013
Eirik Hagen. Orally disintegrating mini-tablets for children: Using interactive mixtures to obtain mini-tablets of high dose-homogeneity (Supervisor Ingunn Tho, co-supervisor Sofia Mattsson (Umeå University))
Rebwar Salar Nori Saleh. Development of mucoadhesive polymer-caoted liposomes for hydration of the oral mucosa (Supervisor Gro Smistad(UiO), co-supervisors Marianne Hiorth (UiO) and Natasa Skalko-Basnet)
Samia Riaz. Limitations of pig skin as in vitro model mimicking skin with damaged barrier properties(G.E. Flaten, N. Skalko-Basnet, A. Engesland)
Elena Fedreheim. Development of an in vitro model to study compromised skin: pigskin versus the phospholipid vesicle-based permeation assay (G.E. Flaten, N. Skalko-Basnet, A. Engesland)
2012
May Wenche Bakke Jøraholmen. Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazol as model drug (N. Skalko-Basnet, I. Tho)
Else Mari Ødegaard-Jensen. Liposomes as drug delivery system in mitochondrial targeting
(N. Skalko-Basnet, R. Süss (University of Freiburg, Germany))
Truc Phuong Nguyen. Optimization of antimicrobial wound dressings: Liposomal hydrogels with mupirocin (N. Skalko-Basnet, J. Hurler)
Sveinung Gaarden Ingebrigtsen. Development of targeted liposomal drug delivery vehicle (G.E. Flaten, R. Whitaker)
Johanne Naper Trønnes. Development of liposomal formulation for green tea catechins targeted for the treatment of vaginal inflammation. (N. Skalko-Basnet, P. Basnet)
2011
Kristin Aasarød. Metodeutvikling og innledende kompatibilitetsstudie mellom antiinfektiva og Olimel N5E gjennom Y-sett infusjon til barn fra 10 - 50 kg (I. Tho, N. Skalko-Basnet)
Vigdis Staven. Kompatibilitetsstudie mellom legemidler og TPN gitt som parallellinfusjon til pediatriske pasienter – metodeutvikling og innledende tester med fem ulike legemidler og én total parenteral ernæringspose (I. Tho, N. Skalko-Basnet)
Elenaz Naderkhani. Investigation and optimization of liposome formulations for use as drug carrier for the anticancer agent Camptothecin (G.E. Flaten, R. Whitaker)
Ole Aleksander Berg. Advanced delivery systems for skin and burns thersapy: Mupirocin as an antibacterial model drug (N. Skalko-Basnet, J. Hurler)
Hilde-Gunn Meland. Development of mucoadhesive MUDS for improved vaginal therapy (I. Tho, N. Skalko-Basnet)
Fredrik Sandberg Løding. Use of ordered mixtures to obtain high dose homogeneity in mini-tablets: Studies of orally disintegrating systems for children (I. Tho, S. Mattsson (Umeå University, Sweden))
2010
Haider Hussain. Development of liposomal curcumin for vaginal drug delivery (N. Skalko-Basnet and I. Tho)
Bahador Poorahmary Kermany. Carbopol hydrogels for topical administration: treatment of wounds (N. Skalko-Basnet)
André Engesland. Hydrogels of natural origin in wound healing: Formulation development (N. Skalko-Basnet)
2009
Susanne Nilssen. Utvikling av en oral formulering baset på minitableter for bruk til diagnostisering av tykktarmskreft. (I. Tho).
Judit Chipo Tendeland. Karakterisering og optmalisering av myke omega-3-kapsler med kalsium. (I. Tho)
Tormund Møkleby. Active loading of gemcitabine into liposomes. (M. Brandl; U. Massing(Tumor Bio, Freiburg, Germany))
2008
Vincent Ruca Kagabo. Studie av tørking av myke gelatinkapsler med varierende filmtykkelse. Et prosjekt i samarbeid med ProBio AS. (I. Tho)
Helene Moen. Influence of osmotic stress on liposome size and morphology. (S. Hupfeld; M. Brandl)
Julia Hurler. Ion exchange for drug delivery: Drug binding of propranolol HCl to polymer sulfonates of different shape and structure. (A. Bauer-Brandl)
2007
Skjalg Nyheim Solum. Komprimeringsegenskaper hos minitabletter sammenlignet med vanlige tabletter (A. Bauer-Brandl; I. Tho)
Lene Holst. Myke Gelatinekapsler; en studie av tørkebetingelser og egenskaper. (I. Tho)
Ateh Nkem Atabong. Development and Validation of a non- destructive method for quantification of the active ingredient and rest water content in Metformin Hydrochloride granules based on Near Infrared Spectroscopy (NIRS). (I. Tho, B. Sæten (Weifa))
Mari K.S. Lawrence. Development of small scale production of pH-sensitive liposomes. (M. Brandl, U. Massing (Tumor Bio, Freiburg, Germany))
Berit K.S. Solvik. A novel recombinant protein promoting cell adhesion for use in tissue engineering. (M. Brandl ; C. van der Walle (University of Strathclyde))
Tove Julie Evjen. Development of improved bendamustin-liposomes. (M. Brandl; U. Massing (Tumor Bio, Freiburg, Germany))
Opeyemi Awoyemi. Transfer of the phospholipid vesicle-based drug permeability assay to an automated laboratory handling system.(M. Brandl, G. E. Flaten, U. Massing (Tumor Bio, Freiburg, Germany))
Sarah Fischer. Ion exchange for drug delivery: Drug binding of Propranolol HCl to polystyrene and dextran sulfonates (R. Schubert, A. Bauer-Brandl)
Dominik Ausbacher. A4F/MALS-analysis of liposomes: influence of key factors on fractionation behavior and evaluation of MALS fit routins. (S. Hupfeld; M. Brandl)
2006
Hilde Gravem. Gemcitabine containing liposomes. (M. Brandl)
Nina B. Brynjulfsen. Potential utility of the reactarray workstation for the rapid development of novel 18-F fluoride radiolabelled compounds. (O.K. Hjelstuen; N.Osborn (GE Healthcare, Amersham))
Kine H. Brækkan. Formulation and purification of a radiolabelled compound for imaging of Alzheimer's disease. (O.K. Hjelstuen; R)
2005
Therese Riis. Development of extended release formulations (mini matrix tablets) for different drug substances by using Kollidon® SR (A. Bauer-Brandl)
Ingvild Klevan. Evaluation of compression parameters in the Shapiro equation. (A. Bauer-Brandl)
2004
Morten Herman Vogt. Water granulation of hydrophillic matrix polymers. (A. Bauer-Brandl; A. Larsson (Chalmers, Göteborg))
2003
Jan Erik Olsen. AmoLac-a new excipient for tableting (A. Bauer-Brandl)
Simon B. Jensen. Effect of amorphous content on the compactability of lactose. (A. Bauer-Brandl)
Gøril Eide Flaten. Incorporation of camptothecin in liposomes, method development and incorporation efficacy screening using different liposome formulations. (M. Brandl; A. Sætern)
Nguyen Binh Nguyen. Effekt av pH og hydroksypropyl-beta-cyclodekstrin på løselighet av camptothecin og dens lakton-karboksylat likevekt; en faseoppløselighetsstudie. (M. Brandl; A. Sætern)
Christer Bakke Frantzen. Studies on the size distribution of submicron particles using Photon Correlation Spectroscopy and Size Exclusion Chromatography. (M. Brandl; U. Massing (Tumor Bio, Freiburg, Germany))
Nina Pettersen. Wetting and swelling behaviour of novel film-coating materials for colon drug targeting. (A. Bauer-Brandl)
Kjetil Bjørkli.Ekstraksjon og rensing av marine fosfolipider: farmasøytiske og nutrasøytiske anvendelser (E. Løvaas; M. Brandl; H. Grohganz; M. Moe)
2002
Åsmund Braaten. Bestemmelse av fosfolipidhydrolyse i liposomer med cellegiften camptothecin ved hjelp av tynnsjiktsanalyse. (M. Brandl; A. Sætern)
Gro Dahlseng Håkonsen. Development and validation of a high performance liquid chromatographic assay for the determination of gemcitabine (dFdC) and its metabolite dFdU in human plasma. (M. Brandl; U. Massing (Tumor Bio, Freiburg, Germany))
2001
Hassan Tarraf. Performance of virus inactivation procedures in horse serum: recombinant adenovirus (AdLox) as a potential tool (O. Schläfli)
Lars Ingebrigtsen. Size analysis of submicron particles and liposomes by size exclusion chromatography and photon correlation spectroscopy (M. Brandl)
2000
Liv Johanne Sætern. En pilotstudie for opprettelse av en liposomemodell for studier av legemiddelsubstansers evne til passiv absorpsjon gjennom biologiske membraner. (M. Brandl; K. Luthman)
Beate Løseth Tverberg. Vesicular phospholipid gels as implantable depot systems: influence of lipid composition on in vitro release behaviour (M. Brandl)
Anne Cecilie Larsen. Liposome production by detergent removal using saturated phospholipids: feasibility & formulations variables. (M.Brandl; GE Healtcare)
1999
Ann Mari Sætern. Utvikling av et preparasjonssett for merking av antisens oligonukleotider med Technetium-99m. (O.K. Hjelstuen)
Truls Bjørknes. Stabilitet av petidin injeksjonsvæske i plastampullar (P. Waaler)