So what are we dealing with in the Drug Transport and Delivery reserach group?
DTD aims at gaining a deeper understanding of transport processes of drugs in the body and its inter-relationship with drug delivery systems. The aim is the optimization of various drug dosage forms and delivery systems (advanced formulations) destined for oral, vaginal, parenteral and topical route of drug administration. Advanced drug dosage forms and delivery systems should promote the therapeutic effects of the drug and reduce its toxic effects by increasing the amount and persistence of drug in vicinity of target cells and reducing the drug exposure to non targets cells.
Below is an overview of the main types of formulations and site of administration we are focusing on and here you can read more about the current PhD and PostDoc projects.
1. Fjellaskel et al., 2018. First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor. BMC Research Notes.
2. A. Øverbye, A. M. Holsæter, M. Fusser, N. Škalko-Basnet, T-G. Iversen, M. Lyngaas Torgersen, T. Sønstevold, O. Engebraaten, K. Flatmark, G.M. Mælandsmo, T. Skotland, K. Sandvig (2017) Ceramide-containing liposomes with doxorubicin: Time and cell-dependent effect of C6 and C12 ceramide, Oncotarget, 8(44), 76921-76924
3. J. Cauzzo, M. Nystad, A .M. Holsæter, P. Basnet and N. Škalko-Basnet (2020)
Following the fate of dye-containing liposomes in vitro. International Journal of Molecular Sciences,
4.M. Falavigna, S. Brurok, M. Klitgaard, G.E. Flaten (2021), Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs, Int J Pharm, 596,12025, DOI:https://doi.org/10.1016/j.ijpharm.2021.120258
5. M. W. Jøraholmen, M. Johannessen, K.Gravningen, M. Puolakkainen, G. Acharya, P. Basnet and N. Škalko-Basnet (2020) Liposomes-in-hydrogel delivery system enhances the potential of resveratrol in combating vaginal chlamydia infection. Pharmaceutics, Special Issue on Local Antibacterial and Antimicrobial Drug Delivery Systems, 12, 1203; doi:10.3390/pharmaceutics12121203
6.Ternullo et al., 2019. Liposomes augment biological benefits of curcumin for multitargeted skin therapy. European Journal of Pharmaceutics and Biopharmaceutics.
7.L. M. Hemmingsen, B. Giordani, A. K. Pettersen, B. Vitali, P. Basnet and N. Škalko-Basnet (2021), Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro. Carbohydrate Polymers, accepted