Angel Salvador Moldes-Anaya
Job description
Unit Manager Cyclotron and Radiochemistry
Cyclotron and Radiochemistry Unit
PET Imaging Center, University Hospital of North Norway (UNN)
Work areas
Isotopes / Chromatorgraphy / MicroCT scanning / MicroPET scanning / Radioactivity / Radiation protection / Teaching
Piyapan Suwattananuruk,
Sukanya Yaset,
Chanisa Chotipanich,
Angel Moldes-Anaya,
Rune Sundset,
Rodrigo Berzaghi
et al.:
Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma
Ahmet Oguzhan Bicakci,
Mousumi Sarkar,
Yu-Hsin Chang,
Evelyn Kahl,
Lorenzo Ragazzi,
Angel Moldes-Anaya
et al.:
Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity
Marcel Lindemann,
Ana Oteiza,
Montserrat Martin-Armas,
Yngve Guttormsen,
Angel Moldes-Anaya,
Rodrigo Berzaghi
et al.:
Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer
Hanne Friis Berntsen,
Angel Moldes-Anaya,
Cesilie Granum Bjørklund,
Lorenzo Ragazzi,
Trude M Haug,
Rønnaug Strandabø
et al.:
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
Richard Fjellaksel,
Angel Moldes-Anaya,
Terje Vasskog,
Ana Oteiza,
Maria Montserrat Martin-Armas,
Ole Kristian Hjelstuen
et al.:
Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging
Hanne Friis Berntsen,
Cesilie Granum Bjørklund,
Rønnaug Strandabø,
Trude Haug,
Angel Moldes-Anaya,
Judit Fuentes-Lazaro
et al.:
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
Angel Moldes-Anaya,
Thomas Sæther,
Silvio Uhlig,
Hilde Irene Nebb,
Terje Larsen,
Hans Christian Eilertsen
et al.:
Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
Hanne Friis Berntsen,
Inger Lise Bogen,
Mattis B Wigestrand,
Frode Fonnum,
S. Ivar Walaas,
Angel Moldes-Anaya
:
The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations
Christiane Kruse Fæste,
Angel Moldes-Anaya
:
Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes
Toxicon 2016 DOI
H F Berntsen,
Mattis Brænne Wigestrand,
Inger Lise Bogen,
Frode Fonnum,
S. Ivar Walaas,
Angel Moldes-Anaya
:
Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABA(A) receptors and oxidative processes
Neurotoxicology 2013 DOI
Gunnar Sundstøl Eriksen,
Angel Moldes-Anaya,
Christiane Kruse Fæste
:
Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance
World Mycotoxin Journal 09. August 2013 DOI
Angel Moldes-Anaya,
Thomas Rundberget,
Christiane Kruse Fæste,
Gunnar Sundstøl Eriksen,
Aksel Bernhoft
:
Neurotoxicity of Penicillium crustosum secondary metabolites: Tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice
Toxicon 2012 DOI
Angel S. Moldes-Anaya,
Frode Fonnum,
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
S. Ivar Walaas,
Mattis Brænne Wigestrand
:
In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system
Neurochemistry International 2011 DOI
Angel Moldes-Anaya,
Thomas Rundberget,
Silvio Uhlig,
Frode Rise,
Alistair Lawrence Wilkins
:
Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom
Toxicon 2011 DOI
Gunnar Sundstøl Eriksen,
Karin Hultin Jæderlund,
Angel Moldes,
Jurgen Schonheit,
Aksel Bernhoft,
Gry Jæger
et al.:
Poisoning of dogs with tremorgenic Penicillium toxins
Medical Mycology 2010 DOI
Aksel Bernhoft,
Angel Moldes,
T Rudberget,
Ida Skaar
:
Mykotoksinet penitrem A gir hjerneskader hos hunder
Norsk veterinærtidsskrift 2010
Angel S Moldes-Anaya,
Tone Normann Asp,
Gunnar Sundstøl Eriksen,
Ida Skaar,
Thomas Rundberget
:
Determination of cyclopiazonic acid in food and feeds by liquid chromatography-tandem mass spectrometry
Journal of Chromatography A 2009 DOI
Angel S. Moldes-Anaya,
Alistair L. Wilkins,
Thomas Rundberget,
Christiane Kruse Fæste
:
In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A
Drug and chemical toxicology (New York, N.Y. 1978) 2009 DOI
Karoline Nordli,
Hanna Bähr,
Mathias Kranz,
Angel Moldes-Anaya,
Jørn H Hansen
:
Towards a Novel Radiotracer for PET – Imaging of Glioblastoma
Targeting the Notch Signaling Pathway
2023
Michel Herranz Carnero,
Angel Moldes-Anaya,
Bengt Erik Haug,
Turid Hellevik,
Inigo Zubiavrre Martinez
:
Innovative molecular imaging technique for Granzyme-B characterization as an emerging biomarker for radio-immunotherapy combinations
2022
Karoline Nordli,
Hanna Bähr,
Angel Moldes-Anaya,
Jørn H Hansen,
Mathias Kranz
:
Towards a novel radiotracer for PET – imaging of glioblastoma
targeting the Notch signaling pathway
2022
Yngve Guttormsen,
Angel Moldes-Anaya,
Richard Fjellaksel,
Ana Oteiza,
Montserrat Martin-Armas,
Marcel Lindemann
et al.:
Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma
Journal of Nuclear Medicine 2021
Yngve Guttormsen,
Mathias Kranz,
Richard Fjellaksel,
Montserrat Martin-Armas,
Ana Oteiza,
Julia Bihler
et al.:
SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging
Nuclear Medicine and Biology 2021 DOI
Richard Fjellaksel,
Ana Oteiza,
armas maria montserrat Martin,
Jørn H Hansen,
Angel Moldes-Anaya,
Terje Vasskog
et al.:
Development and evaluation of gonadotropin releasing hormone SPECT radioligands
2018 DATA
Richard Fjellaksel,
Jørn H Hansen,
Angel Moldes-Anaya,
armas maria montserrat Martin,
Ana Oteiza,
Patrick Riss
et al.:
Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Anniken Olberg,
Andreas Lande,
Kirsten Brun Kjelstrup,
Vegard Brun
:
Intrahippocampal growth hormone modulates spatial memory
2017
Angel Moldes-Anaya,
Lorenzo Ragazzi,
Samuel Kuttner,
Daniel Vincenz,
Jürgen Goldschmidt,
Vegard Brun
et al.:
Targetting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
2017
Lorenzo Ragazzi,
Angel Moldes-Anaya,
Vegard Brun,
Kirsten Brun Kjelstrup
:
Contextual fear encoded by hippocampal single units
2016
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar M Paulsen,
Ingebrigt Sylte
et al.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2016
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
Intrahippocampal growth hormone modulates spatial memory
2016
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar Martin Paulsen,
Ingebrigt Sylte
et al.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2015
KG Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
The role of intrahippocampal Growth hormone in spatial memmory
2015
Angel Moldes-Anaya,
Samuel Kuttner,
Daniel Vincenz,
Jürgen Goldschmidt,
Vegard Brun,
Kirsten Brun Kjelstrup
:
Targeting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
2015
Kamilla Gjerland Haugland,
Angel Moldes-Anaya,
Kirsten Brun Kjelstrup,
Vegard Brun
:
The role of intrahippocampal growth hormone in spatial memory
2015
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim-Larsen,
Terje Larsen,
Steinar M Paulsen,
Hilde Irene Nebb
:
Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs)
2014
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim-Larsen,
Terje Larsen,
Steinar M Paulsen,
Hilde Irene Nebb
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel Moldes-Anaya,
Thomas Sæther,
Laila Norrheim-Larsen,
Hilde Irene Nebb,
Terje Larsen,
Steinar Paulsen
:
Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae
2013
Thomas Sæther,
Angel Moldes-Anaya,
Laila Norrheim Larsen,
Terje Larsen,
Steinar Paulsen,
Hilde Irene Nebb
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel Moldes-Anaya,
Thomas Sæther,
Laila Norrheim Larsen,
Terje Larsen,
Hilde Irene Nebb,
Steinar Paulsen
:
Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
2013
Angel S. Moldes-Anaya
:
Undervurdert muggsoppgift
Forskning.no 2012
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
Mattis Brænne Wigestrand,
Frode Fonnum,
Aksel Bernhoft,
Angel Moldes-Anaya
:
Poisoning by penicillium toxins-Clinical and brain receptor effects
Toxicology Letters 2012 DOI
Angel Moldes-Anaya
:
Hunden kan dø av muggsopp i matavfall
Forskning.no 2012
Angel Moldes-Anaya
:
Neurological disorders caused by fungal toxins: the case of penitrem-induced neuromycotoxicosis in dogs
2012
Angel Moldes-Anaya
:
Toxicokinetics and toxicodinamics of penitrem A, a fungal neuroactive compound causing neurological disease in humans and animals
2012
Angel S. Moldes-Anaya
:
Penitrem-induced neurological disease in Norway : clinical cases in dogs. Neuropharmacology and toxicokinetics of penitrem A. Structural elucidation of a novel penitremanalogue
Unipub forlag 2011
Angel S. Moldes-Anaya,
Frode Fonnum,
Gunnar Sundstøl Eriksen,
Thomas Rundberget,
S. Ivar Walaas,
Mattis Brænne Wigestrand
:
Hepatic metabolism and neuropharmacological evaluation of fungal tremorgenic syndromes: implication of the GABAergic and glutamatergic systems
2009
Angel S. Moldes-Anaya,
Thomas Rundberget,
Christiane Kruse Fæste,
Gunnar Sundstøl Eriksen
:
In vitro metabolism of tremorgenic mycotoxins in rat hepatocytes and microsomes: identification and potential toxic effects of produced metabolites
2007
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Research interests
Radio- and Nuclear Chemistry (Use of specific radiotracers for imaging brain function by PET and SPECT technologies)
C-11 and F-18 Radiochemistry
Radiometals
Neuropharmacology and neurotoxicology
Neuroimaging (SPECT/PET/CT and PET/MR)
PET tracer pharmacokinetics
Teaching
Course Organizer Radiochemistry and Nuclear Chemistry:
KJE-3316 Radiopharmaceutical Chemistry (10 ETCS, offered at the Dpt. of Chemistry, Master degree course)
KJE-8316 Radiopharmaceutical Chemistry (10 ECTS, offered at the Dpt. of Chemistry, PhD degree course)
Responsible for the areas Neuroanatomy/Neurophysiology and Neuropsychopharmacology at:
MED-2501, Mental Functions I
MED-2521, Mental Functions II
FARM-2202, CNS anatopatophysiology and psychopharmacology
Member of research group
CV
Certificate of Advance Studies (CAS) in Radiopharmacy, ETH-Zürich (2020)
Certified Toxicologist (EUROTOX-registered toxicologist) (2013)
PhD in veterinary medicine (neurotoxicology and analytical organic chemistry) (2011)
MSc in neuroscience and behavioural biology (2013)
MSc in Chemistry (analytical organic chemistry) (2003)