Photo: UiT
Hanna-Kirsti Schrøder Leiros
Job description
Crystallization of proteins, structure determination, structure activity relationships (SAR), drug design, inhibitor.
Supervision of students.
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Alexandra Kondratieva,
Katarzyna Palica,
Christopher Frøhlich,
Rebekka Rolfsnes Hovd,
Hanna-Kirsti S. Leiros,
Máté Erdélyi
et al.:
Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose
Yuwen Jia,
Barbara Schroeder,
Yvonne Pfeifer,
Christopher Frøhlich,
Lihua Deng,
Christoph Arkona
et al.:
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems
Journal of Medicinal Chemistry 2023 DOI
Anne Grethe Hamre,
Rim Al-Sadawi Sørlie,
Kirsti Merete Johannessen,
Bastien Bissaro,
Åsmund Røhr Kjendseth,
Hanna-Kirsti S. Leiros
et al.:
Initial characterization of an iron superoxide dismutase from Thermobifida fusca
Katarzyna Palica,
Fritz Deufel,
Susann Skagseth,
Gabriela Paula Di Santo Metzler,
Johannes Thoma,
Anna Andersson Rasmussen
et al.:
α-Aminophosphonate inhibitors of metallo-β-lactamases NDM-1 and VIM-2
RSC Medicinal Chemistry 2023 DOI
Bjarte Aarmo Lund,
Ane Molden Thomassen,
Trine Josefine Warg Carlsen,
Hanna-Kirsti Schrøder Leiros
:
Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436
Katarzyna Palica,
Manuela Vorácová,
Susann Skagseth,
Anna Andersson Rasmussen,
Lisa Allander,
Madlen Hubert
et al.:
Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
Jolyn Pan,
Kjersti Lian,
Aili Sarre,
Hanna-Kirsti Schrøder Leiros,
Adele Kim Williamson
:
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase
Mitchell Silk,
Jason R. Price,
Biswaranjan Mohanty,
Hanna-Kirsti Schrøder Leiros,
Bjarte Aarmo Lund,
Phillip E. Thompson
et al.:
Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp
et al.:
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Ørjan Samuelsen,
Ove Alexander Høgmoen Åstrand,
Christopher Frøhlich,
Adam Heikal,
Susann Skagseth,
Trine Josefine Olsen Carlsen
et al.:
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
Christopher Frøhlich,
Vidar Sørum,
Sandra Huber,
Ørjan Samuelsen,
Fanny Berglund,
Erik Kristiansson
et al.:
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
Adele Kim Williamson,
Hanna-Kirsti S. Leiros
:
Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds
Hanna-Kirsti S. Leiros,
Ane Molden Thomassen,
Ørjan Samuelsen,
Carl-Fredrik Flach,
Stathis D. Kotsakis,
Joakim Larsson
:
Structural insights into the enhanced carbapenemase
efficiency of OXA-655 compared to OXA-10
Zeeshan Muhammad,
Susann Skagseth,
Marc Boomgaren,
Sundus Akhter,
Christopher Frøhlich,
Aya Ismael
et al.:
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim,
Zineb Bousfiha,
Christopher Fröhlich
et al.:
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Christopher Frøhlich,
Vidar Sørum,
Ane Molden Thomassen,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Ørjan Samuelsen
:
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Adele Kim Williamson,
Hanna-Kirsti S. Leiros
:
Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation
Adele Kim Williamson,
Miriam Grgic,
Hanna-Kirsti S. Leiros
:
DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases
Sundus Ahkter,
Bjarte Aarmo Lund,
Aya Ismael,
Manuel Langer,
Johan Isaksson,
Tony Christopeit
et al.:
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
Ørjan Samuelsen,
Frank Hansen,
Bettina Aasnæs,
Henrik Hasman,
Bjarte Aarmo Lund,
Hanna-Kirsti S. Leiros
et al.:
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark
Antimicrobial Agents and Chemotherapy 2018 DOI
Bjarte Aarmo Lund,
Ane Molden Thomassen,
Birgit Helene Berg Nesheim,
Trine Josefine Olsen Carlsen,
Johan Isaksson,
Tony Christopeit
et al.:
The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity
The FEBS Journal 2018 DOI
Francesca Marcoccia,
Hanna-Kirsti S. Leiros,
Massimiliano Aschi,
Gianfranco Amicosante,
Mariagrazia Perilli
:
Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase
Bjarte Aarmo Lund,
Ane Molden Thomassen,
Trine Josefine Olsen Carlsen,
Hanna-Kirsti S. Leiros
:
Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis
Susann Skagseth,
Sundus Akhter,
Marianne H. Paulsen,
Muhammad Zeeshan,
Silje Lauksund,
Ørjan Samuelsen
et al.:
Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Correction to: Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase (Nature Catalysis, (2024), 10.1038/s41929-024-01117-4)
Nature Catalysis 2024 DOI
Daniel Salamonsen,
Christopher Fröhlich,
Hanna-Kirsti S. Leiros
:
Co-selection reduces functional trade-offs in the carbapenemase OXA-48
2022
Christopher Frøhlich,
Adrian H. Bunzel,
Marc W. Van Der Kamp,
Adrian J. Mulholland,
Hanna-Kirsti Schrøder Leiros,
Pål Jarle Johnsen
et al.:
Positive epistasis drives the molecular evolution of the carbapenemase OXA-48
2022
Christopher Frøhlich,
Hanna-Kirsti S. Leiros
:
Vi må kanskje ta antibiotika hyppigere
Hanna-Kirsti S. Leiros
:
Kor ofte skal du ta antibiotika? Kanskje oftare enn vi gjer no, ifølge forskarar
Klara Stensvåg,
Arnfinn Sundsfjord,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Lise Nordgård
:
CANS - Centre for New Antibacterial Strategies
2022 PROSJEKT
Mitchell Silk,
Jason R. Price,
Biswaranjan Mohanty,
Hanna-Kirsti Schrøder Leiros,
Bjarte Aarmo Lund,
Philip E. Thompson
et al.:
Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics
Chemistry - A European Journal 2021 DOI
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Charlotte Miton,
Nobuhiko Tokuriki
:
Ceftazidime drives the evolution of the carbapenemase OXA-48
2020
Hanna-Kirsti S. Leiros
:
På Labben med Forskningsdagene 2020. På Institutt for kjemi, UiT. "Proteiner som gjør at bakterier er resistente mot antibiotika".
27. September 2020 DATA
Tore Rasmussen Steien,
Hanna-Kirsti S. Leiros
:
Kjemikerne prøver å stoppe kjeften på antibiotikadreperne
Norsk Farmaceutisk Tidsskrift 18. February 2020 DATA
Hanna-Kirsti S. Leiros
:
Vil ha 40 prosent kvinner i toppstillingar
24. September 2020 DATA
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
2019
Hanna-Kirsti S. Leiros
:
Inhibitor potential of Serine- and Metallo-beta-lactamase inhibitors, and Biochemical and Biophysical characterization
2019 DATA
Hanna-Kirsti S. Leiros
:
Antibiotika resistens er et globalt problem. Nye inhibitorer og velkjente antibiotika, kan de sammen bli ny behandlings metode?
2019
Hanna-Kirsti S. Leiros
:
Fighting the antibiotic resistant serine-beta-lactamase OXA-48 - through altered ceftazidime activity or new inhibitors?
2019
Christopher Frøhlich,
Vidar Sørum,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
2018
Adele Kim Williamson,
Erik Hjerde,
Aili Sarre,
Ingar Leiros,
Kristel Berg,
Hanna-Kirsti S. Leiros
:
Discovery and design of novel DNA ligases for biotechnology
2018
Annette Bayer,
Hanna-Kirsti S. Leiros,
Sundus Akhter,
Bjarte Aarmo Lund,
Tony Christopeit,
Aya Ismael
:
Towards Antibiotic Resistance Breakers: Fragment-Based Design of OXA- 48 Inhibitors
2017
Bjarte Aarmo Lund,
Hanna-Kirsti S. Leiros,
Annette Bayer,
Ørjan Samuelsen,
Tony Christopeit
:
The OXA-class of β-lactamases. A structural view on antibiotic resistance
UiT Norges arktiske universitet 2017
Adele Kim Williamson,
Erik Hjerde,
Hanna-Kirsti S. Leiros,
Kjersti Lian,
Miguel A. Ramirez,
Wayne M. Patrick
:
Beyond T4: discovery and design of DNA ligases for use in biotechnological applications
2017
Hanna-Kirsti S. Leiros
:
Inhibitors can help fighting antibiotic resistance bacteria, but how do we find the best inhibitors?
2017
Hanna-Kirsti S. Leiros
:
Enzymer involvert i antibiotika resistens
NBS-nytt 2017 DATA
Vibeke Os,
Susann Skagseth,
Hanna-Kirsti S. Leiros
:
"Superbugs" skal ikke lengre få herje i fred, Vil gjenreise effekten av antibiotika.
30. March 2017 FULLTEKST
Hanna-Kirsti S. Leiros
:
Fragment screening used successfully for detecting OXA, VIM or NDM inhibitors
2017
Hanna-Kirsti S. Leiros
:
Kampen. Den livsfarlige resistensen.
31. March 2017 FULLTEKST
The 50 latest publications is shown on this page. See all publications in Cristin here →
Publications outside Cristin
- An interview with NRK.no, Troms og Finnmark (12.08.22) "Kor ofte skal du ta antibiotika? Kanskje oftare enn vi gjer no, ifølge forskarar".
- Article at UiT Forskerhjørne: "Vi må kanskje ta antibiotika hyppigere". By Christopher Frøhlich and Hanna-Kirsti S. Leiros. 11.08.22.
- Here is a summary of the project shown at NRK TV in the program “Schrödingers katt”, 5.3.2015, which is called “Krystaller mot antibiotikaresistens”.
Research interests
Antibiotic resistance, β-lactams, Metallo-β-lactamases, Serine-β-lactamases, Enzymology, Fragment screening, Surface plasmon resonance (SPR), Biophysical characterization, Enzyme inhibitor design, Drug design, Protein crystallography.
I am part of the research group "Biomolecular and Structural Chemistry Group".
I am one group leader in Centre for New Antibacterial Strategies (CANS) at UiT.
Is groupleader in LacZymes.
