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Bilde av Hansen, John Bjarne
Photo: Bjørn-Kåre Iversen
Bilde av Hansen, John Bjarne
Professor Department of Clinical Medicine john-bjarne.hansen@uit.no +4777625105 41472374

John Bjarne Hansen

Job description

Head of Thrombosis Research Group (TREC)

Head of Thrombosis Research Center (TREC), University Hospital of North Norway

  • Eduarda Mazagao Guerreiro, Sergei G. Kruglik, Samantha Swamy, Nadezhda Latysheva, Bjarne Østerud, Jean-Michel Guigner et al.:
    Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity
    Journal of Thrombosis and Haemostasis 2024 ARKIV / DOI
  • Paul S. de Vries, Paula Reventun, Michael R. Brown, Adam S. Heath, Jennifer E. Huffman, Ngoc-Quynh Le et al.:
    A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels
    Blood 2024 DOI
  • Vania Maris Morelli, Omri Snir, Kristian Dalsbø Hindberg, Kristian Hveem, Sigrid Kufaas Brækkan, John Bjarne Hansen :
    High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
    Blood 2024 DOI
  • Carl-Arne Arnesen, Line Holtet Evensen, Kristian Hveem, Maiken Elvestad Gabrielsen, John Bjarne Hansen, Sigrid Kufaas Brækkan :
    Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 ARKIV / DOI
  • Birgitte Gladsø Tøndel, Joakim Knutsen Sejrup, Vania Maris Morelli, Maja-Lisa Løchen, Inger Njølstad, Ellisiv B. Mathiesen et al.:
    Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 ARKIV / DOI
  • Luuk J.J. Scheres, Sigrid Kufaas Brækkan, Judith P.L. Verlaan, Suzanne C. Cannegieter, John Bjarne Hansen, Vania Maris Morelli :
    The fatty liver index and risk of incident venous thromboembolism: the Tromsø Study
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 ARKIV / DOI
  • Amandine Bonifay, Nigel Mackman, Yohei Hisada, Ana Teresa Azevedo Sachetto, Chi Hau, Elaine Gray et al.:
    Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology
    Journal of Thrombosis and Haemostasis 2024 DOI
  • Daniël Duijzer, Maria A. de Winter, Marc Carrier, Alexander T. Cohen, John Bjarne Hansen, Karin A.H. Kaasjager et al.:
    Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 ARKIV / DOI
  • Steven P. Grover, Tomohiro Kawano, Jun Wan, Pansakorn Tanratana, Zsofia Polai, Young J. Shim et al.:
    C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
    Blood 2023 ARKIV / DOI
  • Steven P. Grover, Omri Snir, Kristian Dalsbø Hindberg, Tatianna M. Englebert, Sigrid Kufaas Brækkan, Vania Maris Morelli et al.:
    High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Safak Caglayan, John Bjarne Hansen, Omri Snir :
    Optimized workflow to modify microRNA expression in primary human intravascular cells
    BMC Immunology 2023 ARKIV / DOI
  • Sigrid Kufaas Brækkan, John Bjarne Hansen :
    VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
    Thrombosis Update 2023 ARKIV / DOI
  • Magnus Edvardsen, Ellen-Sofie Hansen, Thor Ueland, Pål Aukrust, Sigrid Kufaas Brækkan, Vania Maris Morelli et al.:
    Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Monique J.T. Crobach, Rayna J.S. Anijs, Sigrid Kufaas Brækkan, Marianne T. Severinsen, Jens Hammerstrøm, Hanne Skille et al.:
    Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
    Blood Advances 2023 ARKIV / DOI
  • Ellen-Sofie Hansen, Magnus Edvardsen, Pål Aukrust, Thor Ueland, John Bjarne Hansen, Sigrid Kufaas Brækkan et al.:
    Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Samantha Swamy, Thor Ueland, John Bjarne Hansen, Omri Snir, Sigrid Kufaas Brækkan :
    Plasma levels of P-selectin and future risk of incident venous thromboembolism
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Maria A. de Winter, Alicia Uijl, Harry R. Büller, Marc Carrier, Alexander T. Cohen, John Bjarne Hansen et al.:
    Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Fridtjof Balteskard Rinde, Camilla Tøvik Jørgensen, Heidi Hassel Pettersen, John Bjarne Hansen, Waleed Ghanima, Sigrid Kufaas Brækkan :
    Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
    Journal of Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Espen Waage Skjeflo, Line Holtet Evensen, Søren Beck Jensen, Nadezhda Latysheva, Annika Elisabet Michelsen, Thor Ueland et al.:
    Complement factors B, D, C3bBbP and risk of future venous thromboembolism
    Clinical Immunology 2023 ARKIV / DOI
  • Oda Leknessund, Vania Maris Morelli, John Bjarne Hansen, Sigrid Kufaas Brækkan :
    Hand grip strength in venous thromboembolism: risk of recurrence and mortality
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2023 ARKIV / DOI
  • Maria A. De Winter, Harry R. Büller, Marc Carrier, Alexander T. Cohen, John Bjarne Hansen, Karin A. H. Kaasjager et al.:
    Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
    European Heart Journal 2023 ARKIV / DOI
  • Dana Meknas, Sigrid Kufaas Brækkan, John Bjarne Hansen, Vania Maris Morelli :
    Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
    TH Open 2023 ARKIV / DOI
  • Vårin Eiriksdatter Wikan, Birgitte Gladsø Tøndel, Vania Maris Morelli, Ellen Elisabeth Brodin, Sigrid Kufaas Brækkan, John Bjarne Hansen :
    Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
    Diagnostics (Basel) 2023 ARKIV / DOI
  • Casper Jan Elis Ullsten-Wahlund, Safak Caglayan, Paulo Czarnewski, John Bjarne Hansen, Omri Snir :
    Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation
    Frontiers in Immunology 2023 ARKIV / DOI
  • Tobias Frischmuth, Birgitte Gladsø Tøndel, Sigrid Kufaas Brækkan, John Bjarne Hansen, Vania Maris Morelli :
    The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
    Thrombosis and Haemostasis 2023 ARKIV / DOI
  • Helle Jørgensen, Erzsébet Horváth-Puhó, Kristina Laugesen, Sigrid Kufaas Brækkan, John Bjarne Hansen, Henrik Toft Sørensen :
    The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
    Clinical Epidemiology 2022 ARKIV / DOI
  • Tobias Frischmuth, Kristian Hindberg, Pål Aukrust, Thor Ueland, Sigrid Kufaas Brækkan, John Bjarne Hansen et al.:
    Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
    Journal of Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Lisa Jakobsen, Tobias Frischmuth, Sigrid Kufaas Brækkan, John Bjarne Hansen, Vania Maris Morelli :
    Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism
    Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Paul L. den Exter, Scott C. Woller, Helia Robert-Ebadi, Camila Masias, Pierre-Emmanuel Morange, David Castelli et al.:
    Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease
    Journal of Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Line Holtet Evensen, Carl-Arne Arnesen, Frits Richard Rosendaal, Maiken Elvestad Gabrielsen, Ben Michael Brumpton, Kristian Hveem et al.:
    The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
    Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Christabel Esi Damoah, Omri Snir, Kristian Dalsbø Hindberg, Peter Garred, Judith K Ludviksen, Sigrid Kufaas Brækkan et al.:
    High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
    Arteriosclerosis, Thrombosis and Vascular Biology 2022 ARKIV / DOI
  • Oda Leknessund, Vania Maris Morelli, Bjørn Heine Strand, John Bjarne Hansen, Sigrid Kufaas Brækkan :
    Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 FULLTEKST / ARKIV / DOI
  • Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner et al.:
    Stroke genetics informs drug discovery and risk prediction across ancestries
    Nature 2022 ARKIV / DOI
  • Florian Thibord, Derek Klarin, Jennifer A. Brody, Ming-Huei Chen, Michael G. Levin, Daniel I. Chasman et al.:
    Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
    Circulation 2022 ARKIV / DOI
  • Scott C. Woller, Kerstin de Wit, Helia Robert-Ebadi, Camila Masias, Frederikus A. Klok, Paul L. den Exter et al.:
    A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 ARKIV / DOI
  • Birgitte Gladsø Tøndel, Vania Maris Morelli, John Bjarne Hansen, Sigrid Kufaas Brækkan :
    Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
    Journal of Thrombosis and Haemostasis 11. July 2022 ARKIV / DOI
  • Joakim Knutsen Sejrup, Birgitte Gladsø Tøndel, Vania Maris Morelli, Maja-Lisa Løchen, Inger Njølstad, Ellisiv B. Mathiesen et al.:
    Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
    Journal of Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Elias Allarai, Wei-Hsuan Lee, Stephen Burgess, Susanna C. Larsson, Sara Lindstrom, Lu Wang et al.:
    Genetically predicted cortisol levels and risk of venous thromboembolism
    PLOS ONE 2022 ARKIV / DOI
  • Helle Jørgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid Kufaas Brækkan, John Bjarne Hansen, Henrik Toft Sørensen :
    Venous thromboembolism and risk of depression: a population-based cohort study
    Journal of Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Carolina E. Touw, Banne Nemeth, Willem M. Lijfering, Raymond A. van Adrichem, line Wilsgård, Nadezhda Latysheva et al.:
    Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 ARKIV / DOI
  • Omri Snir, line Wilsgård, Nadezhda Latysheva, Casper Ullsten-Wahlund, Sigrid Kufaas Brækkan, Kristian Dalsbø Hindberg et al.:
    Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
    Journal of Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Espen Waage Skjeflo, Sigrid Kufaas Brækkan, Judith K Ludviksen, Omri Snir, Kristian Hindberg, Tom Eirik Mollnes et al.:
    Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
    Blood 2021 ARKIV / DOI
  • Carl Arne Løchen Arnesen, Katalin Veres, Erzsébet Horváth-Puhó, John-Bjarne Hansen, Henrik Toft Sørensen, Sigrid K. Brækkan :
    Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
    European Journal of Epidemiology (EJE) 2021 ARKIV / DOI
  • Tobias Frischmuth, Kristian Hindberg, Maiken Elvestad Gabrielsen, Ben Michael Brumpton, Kristian Hveem, Sigrid Kufaas Brækkan et al.:
    Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism
    Thrombosis and Haemostasis 2021 ARKIV / DOI
  • Hanne Skille, Benedikte Paulsen, Kristian Hveem, Marianne T. Severinsen, Maiken Elvestad Gabrielsen, Søren R. Kristensen et al.:
    Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
    Thrombosis Research 2021 ARKIV / DOI
  • Tobias Frischmuth, Kristian Hindberg, Pål Aukrust, Thor Ueland, Sigrid K. Brækkan, John-Bjarne Hansen et al.:
    Plasma levels of leptin and risk of future incident venous thromboembolism
    Thrombosis and Haemostasis 2021 ARKIV / DOI
  • Ellen-Sofie Hansen, Magnus Edvardsen, Pål Aukrust, Thor Ueland, John Bjarne Hansen, Sigrid Kufaas Brækkan et al.:
    Galectin-3-binding protein and future venous thromboembolism
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
  • Bjarne Østerud, Nadezhda Latysheva, John Bjarne Hansen, Omri Snir :
    “A rapid, sensitive, and specific assay to measure tissue factor activity based on chromogenic determination of thrombin generation”: reply
    Journal of Thrombosis and Haemostasis 2023 DOI
  • Steven P. Grover, Sigrid Kufaas Brækkan, Nigel Mackman, John Bjarne Hansen :
    “High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
    Journal of Thrombosis and Haemostasis 2023 DOI
  • Steven P. Grover, Linda Sundler Björkman, Sigrid Kufaas Brækkan, Bengt Zöller, John Bjarne Hansen, Nigel Mackman :
    “C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
    Journal of Thrombosis and Haemostasis 2023 DOI

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    Research interests

     

    Clinical epidemiology and risk factors of venous thromboembolism, Diagnostic and predictive biomarkers of venous thromboembolism, Pathophysiology of venous thromboembolism

     

    Current positions:

    Head of Thrombosis Research Group (TREC)

    Head of Thrombosis Research Center (TREC), University Hospital of North Norway

     

    Publications

    >300 original full papers in peer-reviewed journals listed in PubMed and 22 review articles and 12 book chapters.  Contributed to >370 abstracts presented at and published in conjunction with scientific international meetings/conferences. H-index: 51.

     

    Supervision of PhD-students and postdoctors

    Completed PhDs: Main supervisor: 35; Co-supervisor: 5

    Ongoing PhDs: 7 as main supervisor and 6 as co-supervisor

    Mentor for 13 previous and 3 present postdoctors

     

    Other relevant professional experiences

    2016-21           Chair of the Subcommittee Diagnostic and predictive variables,  ISTH

    2015-20           Member of the scientific program committee of the European Haematology Association (EHA)

    2015-               Member of the organization committee of the European Congress of Thrombosis and Haemostasis (ECTH)

    2015 -              Associate investigator Centre for Molecular Medicine Norway (NCMM)

    2014 -20          Associate editor Journal of Thrombosis and Haemostasis

    Teaching

    2010-2023: Section leader of course in haematology, immunology, and infectious diseases for medical                                 students at UiT

    2010-2023: Member of the examination commission for the third year exam for medical students at UiT


    Member of research group

    Tromboseforskning (TREC)   Norsk innhold Thrombosis Research Group (TREC)   English content

    Member of project

    PREVENT Mission-VTE Milestone VTE Genetics and VTE PEPSI-VTE Obesity-related VTE Biomarkers of VTE risk Diagnostic biomarkers of VTE Cancer-associated VTE (CAT) Sex-differences in VTE Arterial and venous thrombosis Life-style factors and VTE VTE recurrence Extracellular vesicles in thrombogenesis and VTE Hypoxia-dependent proteins and VTE Comorbidities and VTE Risk of bleeding after VTE Socioeconomic position and VTE

    CV

    Academic degree

    1989                Cand.med (MD), University of Tromsø

    1997                Dr. med (PhD in cardiovascular medicine), University of Tromsø

    Previous academic positions

    1991-1994: Research fellow, University of Tromsø (Norw. Council on cardiovascular diseases)

    1994-1995: Postdoctor, University of Tromsø

    1996-2005: Associate professor in medicine, University of Tromsø (20-50% position)

    2006-2008: Professor I in Internal medicine/Hematology, University of  Tromsø (100% position)

    2007-2008: Vice Dean for Research, Faculty of Health Sciences, University of Tromsø

    2008-2009: Visiting professor, The Scripps Research Institute, La Jolla, CA, USA

    2009-        : Professor I in Internal medicine/Hematology, University of Tromsø (100% position)

    2009-2011: Vice Dean for Research, Faculty of Health Sciences, University of Tromsø

    2023         : Visiting professor, La Fe, University of Valencia, Valencia, Spain

     Publications

    >300 original full papers in peer-reviewed journals listed in PubMed and 22 review articles and 12 book chapters.  Contributed to >370 abstracts presented at and published in conjunction with scientific international meetings/conferences.

    Supervision of PhD-students and postdoctors

    Completed PhDs: Main supervisor: 35; Co-supervisor: 5

    Ongoing PhDs    : 7 as main supervisor and 6 as co-supervisor

    Mentor for 13 previous and 3 present postdoctors