Marius Haugland-Grange
Job description
Research and teaching in organic chemistry.
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Publications outside Cristin
Amaral, M.; Asiki, H.; Sear, C. E.; Singh, S.; Pieper, P.; Haugland, M. M.; Anderson, E. A.; Tempone, A. G. Biological activity and structure-activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis. RSC Med. Chem. 2023, 14, 1344–1350. https://doi.org/10.1039/D3MD00081H
McNamee, R. E.; Haugland, M. M.; Nugent, J.; Chan, R.; Christensen, K. E.; Anderson, E. A. Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via direct bridgehead functionalization. Chem. Sci. 2021, 12, 7480–7485. https://doi.org/10.1039/D1SC01836A
Sear, C. E.; Pieper, P.; Amaral, M.; Romanelli, M. M.; Costa-Silva, T. A.; Haugland, M. M.; Tate, J. A.; Lago, J. H. G.; Tempone, A. G.; Anderson, E. A. Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi. ACS Infect. Dis. 2020, 6, 2872–2878. https://doi.org/10.1021/acsinfecdis.0c00523
Hardwick, J. S.; Haugland, M. M.; El-Sagheer, A. H.; Ptchelkine, D.; Beierlein, F. R.; Lane, A. N.; Brown, T.; Lovett, J. E.; Anderson, E. A. 2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis. Nucleic Acids Res. 2020, 48, 2830-2840. https://doi.org/10.1093/nar/gkaa086
Haugland, M. M.; Borsley, S.; Cairns-Gibson, D. F.; Elmi, A.; Cockroft, S. L. Synthetically Diversified Protein Nanopores: Resolving Click Reaction Mechanisms. ACS Nano 2019, 13, 4101-4110. https://doi.org/10.1021/acsnano.8b08691
Borsley, S.; Haugland, M. M.; Oldknow, S.; Cooper, J. A.; Burke, M. J.; Scott, A.; Grantham, W.; Vallejo, J.; Brechin, E. K.; Lusby, P. J.; Cockroft, S. L. Electrostatic Forces in Field-Perturbed Equilibria: Nanopore Analysis of Cage Complexes. Chem 2019, 5, 1275-1292. https://doi.org/10.1016/j.chempr.2019.03.004
Haugland, M. M.; Lovett, J. E.; Anderson, E. A. Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling. Chem. Soc. Rev. 2018, 47, 668-680. https://doi.org/10.1039/C6CS00550K
Haugland, M. M.; Anderson, E. A.; Lovett, J. E. Tuning the properties of nitroxide spin labels for use in electron paramagnetic resonance spectroscopy through chemical modification of the nitroxide framework. In Electron Paramagnetic Resonance: Volume 25, The Royal Society of Chemistry: 2017; pp 1-34. https://doi.org/10.1039/9781782629436-00001
Haugland, M. M.; El-Sagheer, A. H.; Porter, R. J.; Peña, J.; Brown, T.; Anderson, E. A.; Lovett, J. E. 2′-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA. J. Am. Chem. Soc. 2016, 138, 9069-9072. https://doi.org/10.1021/jacs.6b05421
Research interests
I have wide-ranging interests within the fields of organic chemistry and chemical biology, amongst other things in stable radicals (molecules containing unpaired electrons). Another focus is the development of new antibiotics and methods to counteract antibacterial resistance. I am also interested in studies and chemical modification of transmembrane proteins, in particular proteins which are relevant to antibacterial resistance. I'm a member of the Centre for New Antibacterial Strategies (CANS) at UiT.
For more information about my research, please see the website of my research group.
Teaching
KJE-1002 Organic chemistry
Member of research group
Member of project
CV
2020–: Associate professor, Department of Chemistry and Centre for New Antibacterial Strategies (CANS), UiT The Arctic University of Norway, Tromsø, Norway
2019–2020: Postdoc with Prof. Edward Anderson at the University of Oxford, UK
2018: Postdoc with Prof. Alison Hulme at the University of Edinburgh, UK
2017–2018: Postdoc with Prof. Scott Cockroft at the University of Edinburgh, UK
2016–2017: Postdoc with Prof. Edward Anderson at the University of Oxford, UK
2012–2016: DPhil under the supervision of Prof. Edward Anderson, at St Peter's College, University of Oxford, UK
2010–2012: MSc in Organic Chemistry from the Norwegian University of Science and Technology, Trondheim, Norway. Master's project under the supervision of Prof. Vassilia Partali
2007–2010: BSc in Chemistry from the Norwegian University of Science and Technology, Trondheim, Norway