Disputas – Cand. Med. Vidar Tor Nyborg Stefansson

Disputas – Cand. Med. Vidar Tor Nyborg Stefansson

Cand. Med. Vidar Tor Nyborg Stefasson disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:

Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population

 

Kort sammendrag av avhandlingen:

Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, elevated triglycerides and lowered high-density lipoprotein cholesterol levels. Both obesity and the metabolic syndrome are known risk factors for chronic kidney disease and end-stage renal disease, but their effect on kidney function before reaching those disease states is less clear. The results from previous studies on these subjects are divergent and inconclusive. The concept of hyperfiltration, a state of elevated GFR (glomerular filtration rate, a measure of kidney function), may contribute to the inconsistency of research results on the subject. Hyperfiltration is present in diabetes, obesity and hypertension, and is a state of distress which may cause kidney damage in the long term. In the short and medium term, however, it may present as higher or increasing GFR. It may also cause albuminuria, which is an early marker of endothelial damage. In this thesis, the association between obesity, the metabolic syndrome, changes in GFR and hyperfiltration were explored in the population-based Renal Iohexol Clearance Survey. GFR was measured with an accurate method (iohexol clearance) in 1627 persons in 2007-09 and repeated in 1324 of the same persons in 2013-15. The relationship between changes in GFR and changes in albuminuria was also explored, to further explore the concept of hyperfiltration as an increase in GFR over time. We found that obesity was associated with hyperfiltration, but not with accelerated GFR decline. Increased albuminuria was associated with increased GFR. The metabolic syndrome was associated with accelerated GFR decline. The results point to hyperfiltration as an important factor in the relationship between obesity and GFR, and that hyperfiltration is associated with albuminuria.

 

Veiledere
Hovedveileder professor Bjørn Odvar Eriksen
Bi-veileder førsteamanuensis Toralf Melsom
Bi-veileder professor II Trond Geir Jenssen

 

Bedømmelseskomiteen
Professor Per‐Henrik Groop, University of Helsinki, Finland - 1. opponent

Seniorforsker Marie Evans, Karolinska Institutt, Sverige - 2. opponent

professor Lill Tove Rasmussen Busund, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT– Norges arktiske universitet - Leder av komite

 

Disputasleder
Førsteamanuensis Sigrid Brækkan, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, Universitetet i Tromsø – Norges arktiske universitet

 

Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Hvordan forårsaker fedme høyt blodtrykk?”

Få utskriftsvennlig versjon ved å trykke på denne
Information
When: 11. June 2019 kl. 12.15–15.15
Where: AUD Cortex
Location / Campus: Tromsø
Target group: Employees
Kontakt: Susanne Fomsgaard How