Prøveforelesning over oppgitt emne holdes kl. 10.15:
“Matrix metalloproteinases in bone remodelling”
Prøveforelesningen vil også bli streamet. Trykk her.
The trail lecture will also be streamed. Click here.
Rangita Dawadi disputerer for ph.d-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Biochemical characterization of Matrix Metalloproteinase-9.
Binding interactions with two small non-peptide inhibitors and the proteoglycan serglycin & Processing of serglycin”
På grunn av koronautbruddet er auditoriet stengt for publikum. Disputasen vil i stedet bli strømmet her.
Opptak av disputasen vil være tilgjengelig i en uke.
The auditorium will be closed to the public because of the corona outbreak. The defense will be streamed here.
A recording of the disputation will be available for one week.
Avhandlingen er tilgjengelig her.
The doctoralthesis, click here.
For spørsmål ex auditorium vennligst send disse på e-post til disputasleder - Ole-K. Greiner-Tollersrud.
For questions ex auditorium, please e-mail the chairperson - Ole K. Greiner-Tollersrud.
Populærvitenskapelig sammendrag av avhandlingen:
This thesis has a focus on the biochemical characterization of a proteolytic enzyme, Matrix Metalloprotease-9 (MMP-9). This enzyme can cleave a large variety of proteins and signalling molecules in the human body. It has been shown to have important functions in normal physiology in most human tissues and dysregulation of this enzyme occurs in several diseases such as cancers, heart, brain, nerve and chronic kidney diseases. Therefore, it is important to understand its interaction with various biological macromolecules as well as small molecules, and knowledge about which proteins it can cleave. Our focus has been on MMP-9s complex formation and degradation of a matrix molecule called serglycin, which has important function is health and disease. We have also studied the binding of two small non-peptide compounds with MMP-9. The methods used are a mixture of wet-lab experiments and computer based molecular modelling.
Hovedveileder Jan-Olof Winberg, Institutt for medisinsk biologi
Bedømmelseskomité
Professor Harald Thidemann Johansen, UiO - 1. opponent
Professor Marion Kusche-Gullberg, UiB – 2.opponent
Professor Ugo Moens, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder:
Ole Kristian Greiner Tollersrud, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted:
“Matrix metalloproteinases in bone remodelling”
Prøveforelesningen vil også bli streamet. Trykk her.
The trail lecture will also be streamed. Click here.
When: 17.04.20 at 10.15–15.15
Where: Streames fra Aud. Cerebrum
Location / Campus: Tromsø
Target group: Employees, Students, Guests, Invited
Contact: Andrea Jennerwein
E-mail: andrea.jennerwein@uit.no