Isaksen disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism”
Avhandlingen er tilgjengelig her!
På grunn av koronautbruddet er auditoriet stengt for publikum. Opptak av disputasen vil være tilgjengelig i en måned.
The auditorium will be closed to the public because of the corona outbreak. A recording of the disputation will be available for one month.
Prøveforelesning over oppgitt emne starter kl. 10.15
Prøveforelesning har følgende tittel: “Randomized controlled trials: how to do them and when to use them”
Prøveforelesningen vil bli strømmet her!
The trial lecture will also be streamed!
Disputas starter kl 12.15
Disputasen vil bli strømmet her!
The defence will be streamed here!
De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen here.
Opponents ex auditorio should sign up to leader of defense by e-mail.
Populærvitenskapelig sammendrag av avhandlingen:
Omega-3 fatty acids of marine origin (n-3 PUFAs) have beneficial effects on the hemostatic system. Yet, the effect on the risk of venous thromboembolism (VTE) in the population is disputed, at least in part because the assessment of n-3 PUFAs intake over time is challenging. We used comprehensive dietary data from the 4th survey of the Tromsø Study and accounted for changes in the diet in the subsequent 6th survey and calculated the total intake of n-3 PUFAs of marine origin.
First, we found that an intake of n-3 PUFAs exceeding 4.7 grams per week was associated with a 22-26% lower risk of VTE. Higher intake did not add to the effect, and this apparent threshold effect was larger for pulmonary embolism (31-47% reduced risk) than for deep vein thrombosis. In the second study, we observed a slight reduced risk of recurrent VTE in those with a high compared to a low intake of n-3 PUFAs. Finally, we found a reduced risk of having a surgery as a trigging event in VTE patients with a high compared to those with a low n-3 PUFAs intake (Odds Ratio: 4.1 vs. 11.8).
Our findings may suggest that a high dietary intake of n-3 PUFAs protect against incident and recurrent VTE along with surgery-related VTE in the general population.
Hovedveileder
Professor John-Bjarne Hansen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Biveiledere
Professor Sigrid Brækkan, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Postdoktor Line Holtet Evensen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Bedømmelseskomité
Professor Erik Berg Schmidt, Aalborg Universitetshospital, Danmark – 1. opponent
Professor My Hanna Sofia Svensson, Akershus Universitetssykehus, Norge - 2.opponent
Forsker Therese Haugdahl Nøst, Institutt for samfunnsmedisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder
Førsteamanuensis Gro Østli Eilertsen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
When: 27.11.20 at 10.15–15.15
Where: Strømmes fra aud. Cortex
Location / Campus: Digital
Target group: Employees, Students, Guests
Contact: Andrea Jennerwein
E-mail: andrea.jennerwein@uit.no