Disputas - Master of Science Diana Karina Diaz Canova
disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Evolutionary genomics of cowpox virus and recombination in vitro between a naturally occurring cowpox virus and a vaccinia virus vectored influenza vaccine”
Prøveforelesning starter kl. 12.15
“Advances in poxvirus vectored vaccines development, pros and cons in human and veterinary medicine”
Disputas starter kl. 14:15
Auditoriet er åpent for publikum, men vil også bli strømmet her
Opptak av disputasen vil være tilgjengelig i et døgn.
The auditorium is open to the public. The defense will still be streamed here
A recording of the disputation will be available for 24 hours.
Populærvitenskapelig sammendrag av avhandlingen:
Modified vaccinia virus Ankara (MVA) is a “weak” live virus used as a smallpox and monkeypox vaccine. It is also a promising vector vaccine against different diseases. One concern about the extensive use of MVA/MVA vectored vaccine is that it may exchange genes with a “stronger” relative like cowpox virus (CPXV). There is few information about the diversity, evolution and genetic exchanges among CPXV and its relatives. Therefore, we analysed the genome of CPXVs and found that CPXVs were genetically different to be grouped as one species. Additionally, we found one natural recombinant CPXV that had DNA from other three species. In the laboratory we co-infected and superinfected cells with CPXV and MVA vectored vaccine. Our analysis indicated that the viruses exchanged significant genetic material producing progeny viruses with mosaic genomes. Some hybrid viruses gained genes that were absent in MVA. This information is relevant to the production of MVA/MVA vectored vaccine with improved biosafety profile.
Professor Ugo Moens, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Assistant Professor Malachy Ifeanyi Okeke, American University of Nigeria
Professor Clarissa Damaso, Instituto de Biofisica Carlos Chagas Filho, Univeridade Federal do Rio de Janeiro - 1. opponent.
Ph.d. Simon Weli, Norwegian veterinary Institute - 2. opponent.
Professor Inigo Martinez, Institutt for klinisk medisin, UiT Norges arktiske universitet – leder av komité.
Disputasleder: Professor emeritus Terje Larsen, UiT Norges arktiske universitet