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Bilde av Kyrrestad, Ingelin
Bilde av Kyrrestad, Ingelin
PhD candidate Department of Medical Biology ingelin.kyrrestad@uit.no +4741108294

Ingelin Kyrrestad

Job description

PhD candidate at vascular biology research group

  • Sabin Bhandari, Ingelin Kyrrestad Karlstrøm, Jaione Simon-Santamaria, Ruomei Li, Karolina Joanna Szafranska, Gianina Aurica Dumitriu et al.:
    Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
    Frontiers in Pharmacology 2024 ARKIV / DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
    Frontiers in Cellular and Infection Microbiology 2023 ARKIV / DOI
  • Kjetil Elvevold, Ingelin Kyrrestad, Bård Smedsrød :
    Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution
    Methods in molecular biology 2022 ARKIV / DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
    2023
  • Ingelin Kyrrestad, Javier Sanchez Romano, Anett Kristin Larsen, Ruomei Li, Jaione Simon-Santamaria, Kenneth Bowitz Larsen et al.:
    Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
    2022
  • Sabin Bhandari, Ruomei Li, Ingelin Kyrrestad, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød et al.:
    Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
    2019
  • Ingelin Kyrrestad, Ruomei Li, Sabin Bhandari, Jaione Simon-Santamaria, Bård Smedsrød, Karen Kristine Sørensen :
    A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
    2019

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    Research interests

    Ingelin is studying the cell biology of the liver, and especially liver sinusoidal endothelial cells, that are very active in blood clearance as they take up and degrade a large array of bloodborne macromolecules, colloids and nanoparticles. These cells are in direct contact with a large volume of blood, as they are lining the small sinusoids of the liver. They are known to be endocytically active scavenger cells, but there is limited knowledge about their role in the development of liver injury. The focus of this PhD project is to reveal how LSEC can contribute to toxic liver injury and how cytotoxicity of LSEC can be studied in vitro to increase the understanding of their role in liver damage caused by various drugs. Ingelin is also involved in the SECVIR project, investigating if LSEC also take up and degrade bloodborne viruses. 

    Teaching

    Assisting teacher in cell biology and physiology at MED 1501.

    Researcher profile in Cristin

    Member of research group

    Vascular Biology   English content Vaskulær biologi   Norsk innhold

    Member of project

    SECVIR