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Bilde av Kyrrestad, Ingelin
Bilde av Kyrrestad, Ingelin
Researcher Department of Medical Biology ingelin.kyrrestad@uit.no +4741108294 Tromsø

Ingelin Kyrrestad

Job description

Researcher in the Vascular Biology Research Group with a particular focus on liver sinusoidal endothelial cells (LSECs), which efficiently take up and remove unwanted waste products from the blood.

My work aims to understand how cytomegalovirus infects LSECs, and how immunosuppressive drugs such as dexamethasone influence cellular immune responses, inflammation, and susceptibility to virus infection.

Cell biology, infection biology, and proteomics are central approaches to uncover mechanisms of infection, host defense, and drug effects in the liver.

  • Sabin Bhandari, Ingelin Kyrrestad Karlstrøm, Jaione Simon-Santamaria, Ruomei Li, Karolina Joanna Szafranska, Gianina Aurica Dumitriu et al.:
    Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
    Frontiers in Pharmacology 2024 DOI / ARKIV
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
    Frontiers in Cellular and Infection Microbiology 2023 DOI / ARKIV
  • Kjetil Elvevold, Ingelin Kyrrestad, Bård Smedsrød :
    Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution
    Methods in molecular biology 2022 DOI / ARKIV
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
    2023
  • Ingelin Kyrrestad, Javier Sanchez Romano, Anett Kristin Larsen, Ruomei Li, Jaione Simon-Santamaria, Kenneth Bowitz Larsen et al.:
    Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
    2022
  • Ingelin Kyrrestad, Ruomei Li, Sabin Bhandari, Jaione Simon-Santamaria, Bård Smedsrød, Karen Kristine Sørensen :
    A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
    2019
  • Sabin Bhandari, Ruomei Li, Ingelin Kyrrestad, Jack-Ansgar Bruun, Ilona Urbarova, Bård Smedsrød et al.:
    Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
    2019

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    Research interests

    My research interests encompass liver cell biology with a particular focus on liver sinusoidal endothelial cells (LSECs) as key regulators of immune responses and hemostasis. These cells play an essential role in host defense mechanisms and immune tolerance within the hepatic microenvironment. At the same time, they are in direct contact with the systemic circulation, which continuously delivers waste products, pharmaceuticals, and blood-borne pathogens. I am especially interested in how LSECs recognize, internalize, and respond to viruses such as cytomegalovirus, and how this shapes cytokine signaling, inflammatory regulation, and gene expression.

     PhD Thesis (2024)

     

    Teaching

    Engaged in teaching in physiology, anatomy and pharmacology for students at UiT.

    • SYP 1110
    • MED 1501
    • MBI-3015 Human pharmacology and Toxicology
    Researcher profile in Cristin

    Member of research group

    Vascular Biology   English content Vaskulær biologi   Norsk innhold

    Member of project

    SECVIR