Stem Cell Aging and Cancer Research Group lorena.arranz@uit.no +4777620841 Tromsø MH2 L.10.340

Lorena Arranz

Group Leader and NCMM Young Associate Investigator

Job description

Group Leader of Stem Cells Ageing and Cancer Research Group

  • Arranz, Lorena. The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies. Cancers 2022; Volum 14 (3). ISSN 2072-6694.s doi: 10.3390/cancers14030580.
  • Mate, Ianire; Martínez de Toda, Irene; Arranz, Lorena; Álvarez-Sala, Jose Luis; De la Fuente, Mónica. Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients. Experimental Gerontology 2021; Volum 154. ISSN 0531-5565.s 111551 - .s doi: 10.1016/j.exger.2021.111551.
  • Martínez de Toda, Irene; Rattan, Suresh IS; De la Fuente, Mónica; Arranz, Lorena. Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities. Antioxidants 2021; Volum 10 (9). ISSN 2076-3921.s 1397 - .s doi: 10.3390/antiox10091397.
  • Villatoro, Alicia; Konieczny, Joanna; Cuminetti, Vincent; Arranz, Lorena. Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia. Frontiers in Cell and Developmental Biology 2020; Volum 8. ISSN 2296-634X.s 607 - .s doi: 10.3389/fcell.2020.00607.
  • Cuminetti, Vincent; Arranz, Lorena. Bone marrow adipocytes: The enigmatic components of the hematopoietic stem cell niche. Journal of Clinical Medicine 2019; Volum 8 (5). ISSN 2077-0383.s 707 - .s doi: 10.3390/jcm8050707.
  • Grimolizzi, Franco; Arranz, Lorena. Multiple faces of succinate beyond metabolism in blood. Haematologica 2018; Volum 103 (10). ISSN 0390-6078.s 1586 - 1592.s doi: 10.3324/haematol.2018.196097.
  • Konieczny, Joanna; Arranz, Lorena. Updates on old and weary haematopoiesis. International Journal of Molecular Sciences 2018; Volum 19:2567 (9). ISSN 1661-6596.s 1 - 14.s doi: 10.3390/ijms19092567.
  • Bernal Mera, Aurora; Arranz, Lorena. Nestin-expressing progenitor cells: function, identity and therapeutic implications. Cellular and Molecular Life Sciences (CMLS) 2018; Volum 75 (12). ISSN 1420-682X.s 2177 - 2195.s doi: 10.1007/s00018-018-2794-z.
  • Thiyagarajan, Dhivya; Pedersen, Hege Lynum; Seredkina, Natalya; Horvei, Kjersti Daae; Arranz, Lorena; Sonneveld, Ramon; Nijenhuis, Tom; van der Vlag, Johan; Rekvig, Ole Petter. IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Frontiers in Cell and Developmental Biology 2018; Volum 6. ISSN 2296-634X.s doi: 10.3389/fcell.2018.00007.
  • Arranz, Lorena; Arriero Sanchez, Maria Del Mar; Villatoro, Alicia. Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications. Blood reviews 2017; Volum 31 (5). ISSN 0268-960X.s 306 - 317.s doi: 10.1016/j.blre.2017.05.001.
  • Arranz, Lorena; Armas, Antonio. Celulas madre en las neoplasias hematopoyeticas. (data) 2020.
  • Cuenca-Zamora, EJ; Ruiz-Pividal, JF; Zamora-Plana, L; Bellosino, B; De la Morena-Barrio, ME; Bohdan, N; Marin-Quilez, A; Cifuentes, R; Martinez-Montesinos, L; Aroca, C; Vicente, V; Corral, J; Arranz, Lorena; Teruel-Montoya, Raúl; Ferrer-Marin, F. THE GERMINAL VARIANTS RS6336/RS6339 OF NTRK1 PREDISPOSE TO CHRONIC MYELOPROLIFERATIVE NEOPLASIAS. Haematologica 2019; Volum 104. ISSN 0390-6078.s 59 - 60.
  • Ho, Ya-Hsuan; del Toro, Raquel; Rivera-Torres, Jose; Rak, Justyna; Korn, Claudia; García-García, Andrés; Kubovcakova, Lucia; Macías, David; Arranz, Lorena; González-Gómez, Cristina; Wittner, Monika; Nienhold, Ronny; Waller, Amie K; Foster, Holly R; López-Otin, Carlos; Johnson, Randall S; Nerlov, Claus; Vainchenker, William; Ghevaert, Cedric; Louache, Fawzia; Skoda, Radek C.; Andrés, Vicente; Mendez-Ferrer, Simon. Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms. Blood 2018; Volum 132. ISSN 0006-4971.s 3842 - 3842.
  • Look at all works in CRIStin →

    Publications outside Cristin

    SELECTED PUBLICATION LIST (2010-2014) h index 25

    Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda RC, Schwaller J, Méndez-Ferrer S. Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis. Cell Stem Cell 2014, 15:791-804. (IF – 22.151)

    Isern J, García-García A, Martín AM, Arranz L, Martín-Pérez D, Torroja C, Sánchez-Cabo F, Méndez-Ferrer S. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem-cell-niche function. eLife 2014, 10.7554/eLife.03696. (IF – 8.519)

    Arranz L, Sánchez-Aguilera A, Martín-Pérez D, Isern J, Langa X, Tzankov A, Lundberg P, Muntión S, Tzeng Y-S, Lai D-M, Schwaller J, Skoda RC, Méndez-Ferrer S. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature 2014, 512:78-81. (IF – 42.351)

    Arranz L, Urbano-Ispizúa A, Méndez-Ferrer S. Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells. Haematologica 2013, 98:993-995. (IF – 5.935)

    Isern J, Martín-Antonio B, Ghazanfari R, Martín AM, del Toro R, Sánchez-Aguilera A, Arranz L, Martín-Pérez D, López JA, Suárez-Lledó M, Marín P, Van Pel M, Vázquez J, Fibbe WE, Scheding S, Urbano-Ispizúa A, Méndez-Ferrer S. Self-renewing human mesenspheres promote hematopoietic stem cell expansion. Cell Rep 2013, 3:1714-1724. (IF – 7.207)

    Arranz L, Méndez-Ferrer S. Network anatomy and in vivo physiology of mesenchymal stem cells. Inflamm Regen 2013, 33:38-47.

    Arranz L, Naudí A, De la Fuente M, Pamplona R. Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage. Age (Dordr) 2013, 35:621-635. (IF – 6.280)

    Arranz L, De Castro NM, Baeza I, Giménez-Llort L, De la Fuente M. “Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease”. J Alzheimers Dis 2011, 25:727-737. (IF – 4.261)

    Baeza I, De Castro NM, Arranz L, Fdez-Tresguerres J, De la Fuente M. “Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males”. Biogerontology 2011, 12:227-238. (IF – 3.411)

    Baeza I, De Castro NM, Arranz L, De la Fuente M. “Soybean and green tea polyphenols improve immune function and redox status in very old ovariectomized mice”. Rejuvenation Res 2010, 13:665-674. (IF – 4.225)

    Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M. “Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice”. Rejuvenation Res 2010, 13: 415-428. Erratum in: Rejuvenation Res 2010, 13:627. (IF – 4.225)

    Arranz L, Caamaño J, Lord JM, De la Fuente M. “Preserved immune functions and controlled leucocyte oxidative stress in long-lived mice: possible role of nuclear factor-kappaB”. J Gerontol A Biol Sci Med Sci 2010, 65:941-950. (IF – 3.988)

    Arranz L, Lord JM, De la Fuente M. “Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice”. Age (Dordr) 2010, 32:451-466. (IF – 6.280)

    Arranz L, De Castro NM, Baeza I, De la Fuente M. “Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice”. Biogerontology 2010, 11:475-482. (IF – 3.411)


    De la Fuente M, Arranz L. “The importance of the environment in brain aging: Be happy, live longer!” Brain Aging and Therapeutic Interventions 2013, pp: 79-94. DOI 10.1007/978-94-007-5237-5_6.


    Simón Méndez Ferrer, Lorena Arranz Salas and Joan Isern Marín. “Terapia neurorregeneradora/neurocompensatoria para el tratamiento de las neoplasias mieloproliferativas”. Number: P-05571. Country: Spain. Priority date: 10th May 2013. Entity holding: Centro Nacional de Investigaciones Cardiovasculares (CNIC).

    Simón Méndez Ferrer, Abel Sánchez-Aguilera Peño and Lorena Arranz Salas. “Moduladores selectivos de la señalización por los receptores de estrógenos para el tratamiento de las leucemias y neoplasias mieloproliferativas”. Number: P9550ES00. Country: Spain. Priority date: 21st May 2013. Entity holding: Centro Nacional de Investigaciones Cardiovasculares (CNIC).

    MH2 L.10.340

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