Bilde av Svineng, Gunbjørg
Photo: Gry Berntzen
Bilde av Svineng, Gunbjørg
Faculty of Health Sciences gunbjorg.svineng@uit.no +4777646757 41314428 +47-41314428 Tromsø MH2 L.08.324

Gunbjørg Svineng


Dean

Job description

Dean, Faculty of Health Sciences

Professor

https://orcid.org/0000-0002-5947-5647


  • Rabeia Almahmoudi, Abdelhakim Salem, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng, Tuula Salo, Ahmed Al-Samadi :
    The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma
    Cancer Science 2021 ARKIV / DOI
  • Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Whabi, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng et al.:
    Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
    Oncogenesis 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Elin Synnøve Hadler-Olsen, Tonje S. Steigedal, Gunbjørg Svineng :
    Nephronectin as a matrix effector in cancer
    Cancers 25. February 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judit Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    Scientific Reports 2020 ARKIV / DOI
  • Rangita Dawadi, Nabin Malla, Beate Hegge, Imin Wushur, Eli Berg, Gunbjørg Svineng et al.:
    Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Jimita Prashant Toraskar, Synnøve Norvoll Magnussen, Lars Hagen, Animesh Sharma, Linh Hoang, Geir Bjørkøy et al.:
    A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
    Journal of Proteome Research 01. February 2019 ARKIV / FULLTEKST / DOI
  • Samantha Marie Solon-Biet, Victoria Carroll Cogger, Tamara Pulpitel, Devin Wahl, Ximonie Clark, Elena E. Bagley et al.:
    Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
    Nature Metabolism 2019 DOI
  • Jimita Prashant Toraskar, Synnøve Magnussen, Konika Chawla, Gunbjørg Svineng, Tonje S. Steigedal :
    Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif
    FEBS Open Bio 2018 ARKIV / DOI
  • Ingebrigt Sylte, Rangita Dawadi, Nabin Malla, Susannah von Hofsten, Tra-Mi Nguyen, Ann Iren Solli et al.:
    The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
    PLOS ONE 2018 ARKIV / DOI
  • Tonje S. Steigedal, Jimita Prashant Toraskar, Richard P. Redvers, Marit Valla, Synnøve Magnussen, Anna M. Bofin et al.:
    Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs
    Neoplasia 2018 ARKIV / FULLTEKST / DOI
  • Pirjo Åström, Krista Juurikka, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng, Nilva K. Cervigne, Ricardo D. Coletta et al.:
    The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma
    British Journal of Cancer 2017 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen et al.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Oddveig G Rikardsen, Synnøve Magnussen, Gunbjørg Svineng, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen :
    Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
    BMC Oral Health 2015 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen, Robert Hanes et al.:
    Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
    PLOS ONE 2014 ARKIV / DOI
  • Synnøve Magnussen, Oddveig G Rikardsen, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Gunbjørg Svineng :
    Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC)
    PLOS ONE 07. July 2014 ARKIV / DOI
  • Nabin Malla, Eli Berg, Achilleas D. Theocharis, Gunbjørg Svineng, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
    The FEBS Journal 2013 DOI
  • Chandra Sekhar Ravuri, Gunbjørg Svineng, nils-erik Huseby :
    Differential regulation of gamma-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: gamma-glutamyltransferase is regulated in an Nrf2- and NF kappa B-independent manner
    Free radical research 2013 DOI
  • Bodil Irene Fadnes, Anne Husebekk, Gunbjørg Svineng, Øystein Rekdal, Masaki Yanagishita, Svein Olav Kolset et al.:
    The proteoglycan repertoire of lymphoid cells
    Glycoconjugate Journal 2012 ARKIV / DOI
  • Dominik Ausbacher, Gunbjørg Svineng, Terkel Hansen, Morten B. Strøm :
    Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides
    Biochimica et Biophysica Acta - Biomembranes 19. July 2012 DOI
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen :
    Plasmin and the plasminogen activator system in health and disease
    Walter de Gruyter (De Gruyter) 2012 DOI
  • Chandra Sekhar Ravuri, Gunbjørg Svineng, Serhiy Pankiv, nils-erik Huseby :
    Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of gamma gamma-glutamyltransferase expression
    Free radical research 2011 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Chandra Sekhar Ravuri, Ahmad Omair, Oddveig G Rikardsen, Gunbjørg Svineng et al.:
    Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front
    European Journal of Cancer 2011 DOI
  • Hilde Ljones, Elin Synnøve Hadler-Olsen, Synnøve Magnussen, Oddveig G Rikardsen, sonja eriksson Steigen, elisabeth Sundkvist et al.:
    S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
    American Journal of Pathology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Premasany Kanapathippillai, Eli Berg, Gunbjørg Svineng, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity
    Journal of Histochemistry and Cytochemistry 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Oddveig G Rikardsen, Sonja Eriksson Steigen, Premasany Kanapathippillai, Reidar Grenman et al.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    Virchows Archiv 2010 ARKIV / DOI
  • nils-erik Huseby, elisabeth Sundkvist, Gunbjørg Svineng :
    Glutathione and Sulfur Containing Amino Acids: Antioxidant and Conjugation Activities
    John Wiley & Sons 2009
  • Atle Noralf Larsen, Terese Solstad, Gunbjørg Svineng, Marit Seppola, Trond Ø. Jørgensen :
    Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2009 DOI
  • Renate Elenjord, Jasmine Blue Allen, Harald Thidemann Johansen, Harald T. Johansen, hanne Kildalsen, Gunbjørg Svineng et al.:
    Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4
    The FEBS Journal 2009 DOI
  • Gunbjørg Svineng, Chandra Sekhar Ravuri, Oddveig G Rikardsen, Nils-Erik Huseby, Jan-Olof Winberg :
    The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function
    Connective Tissue Research 2008 DOI
  • Eva Sjøttem, Cecilie Rekdal, Gunbjørg Svineng, Sylvia sagen Johnsen, Helle Bagterp Klenow, Rebecca dale Uglehus et al.:
    The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
    Nucleic Acids Research (NAR) 2007 DOI
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar et al.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    2018
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar et al.:
    Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains
    2017
  • Synnøve Magnussen, Imola Wilhelm, Janos Hasko, Judith Molnar, Marit Seppola, Elin Synnøve Hadler-Olsen et al.:
    The metastasis-promoting protein Nephronectin
    2016
  • Gunbjørg Svineng, Terje Steinar Larsen :
    Bli ekspert på menneskekroppen og få en trygg og viktig jobb!
    2015
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress
    2015
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -
    2015
  • Tonje Strømmen Steigedal, Richard Redvers, Bedrich Eckhardt, John Michael Lamar, Judy Doherty, Richard O. Hynes et al.:
    The extracellular matrix protein Nephronectin (Npnt) promotes metastasis via its integrin binding domains
    2014
  • Tonje Steigedal, Gunbjørg Svineng, Richard Redvers, Bedrich Eckhardt, John M. Lamar, Judy Doherty et al.:
    Cellular interactions with the extracellular matrix of tumor microenvironment
    2013
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen et al.:
    Stromal induced expression of uPAR
    2013
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics
    Biopolymers 2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones Wetting, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng et al.:
    Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front
    2011
  • Richard Redvers, Gunbjørg Svineng, Bedrich Eckhardt, Normand Pouliot, Keith Stanley, Louis Reichardt et al.:
    The role of the extracellular matrix molecule Nephronectin/POEM in breast cancer metastasis
    2011
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics
    2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng et al.:
    Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front
    European Journal of Cancer 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, O Rikardsen, sonja eriksson Steigen, Jan-Olof Winberg, Gunbjørg Svineng et al.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2010
  • Stian Sjøli, Olayiwola Adekoya, Yang Jiang, O Akselsen, VT Hansen, Gunbjørg Svineng et al.:
    Novel Inhibitors of Matrix Metalloprotease-9 and-14
    The FEBS Journal 2010
  • Atle Noralf Larsen, Ronny Helland, Gunbjørg Svineng, Trond Ø. Jørgensen :
    Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua)
    2007
  • Chandra Sekhar Ravuri, Synnøve Magnussen, Jan-Olof Winberg, Nils-Erik Huseby, Gunbjørg Svineng :
    The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion
    2007
  • Gunbjørg Svineng :
    Genetic modifications of oral cancer cell lines
    2006
  • Eva Sjøttem, Helle Bagterp Klenow, Cecilie Rekdal, Gunbjørg Svineng, Sylvia Sagen Johnsen, Rebecca Dale Uglehus et al.:
    SPBP and TopBP1: Modulators of Androgen Receptor Activity
    2006

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    Research interests

    Tumorbiology

    Extracellular matrix degrading enzymes; uPAR and MMPs

    Cell adhesion molecules; Integrins

    Extracellular matrix proteins; Nephronectin

    Metastasis related proteins; S100A4


    Member of research group


    CV

    Head of Department, Department of Medical Biology, Faculty of Health Sciences, from 1.08.2017. 

    Affiliated Sydney University, Charles Perkins Center and ANZAC Research Institute, Australia, 2016-2017.

    Head of Tumor Biology Research Group, 2015-2016.

    Visiting researcher at the Peter MacCallum Cancer Centre, Melbourne, Australia. 2010-2011.

    Deputy leader Education, Department of Medical Biology, University of Tromsø from 2009-2016.

    Leader Section of Medical Biochemistry 2006-2009.

    Associate Professor in Medical Biochemistry at the Department of Medical Biology, University of Tromsø from 2005.

    Researcher in Marine Biotechnology, The Norwegian College of Fishery Sciences, University of Tromsø from 2004-2005.

    Post.doc. in the Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø from 2001-2004. Supervisor: Prof. Terje Johansen.

    PhD in Medical Sciences in 1999 from the Univeristy of Uppsala, Sweden. Supervisor: Prof. Staffan Johansson.

    Master of Science, Molecular Biology, in 1993 from the Department of Medical Biology, University of Tromsø, Norway. Supervisor: Prof. Terje Johansen.

     


    MH2 L.08.324

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