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Bilde av Mikkola, Ingvild
Bilde av Mikkola, Ingvild
Professor in Molecular Biology Cell Signaling and Targeted Therapy ingvild.mikkola@uit.no +4777646643 480 30498 You can find me here

Ingvild Mikkola

Job description

Research and teaching.

Research on molecular mechanisms in cancer development.

Lectures in cell biology, biochemistry and embryology for first- and second year students in pharmacy, medicine and odontology. Supervision of master and PhD students.

  • Lisa Zeyen Øyås, Ole Morten Seternes, Ingvild Mikkola :
    Crosstalk between p38 MAPK and GR Signaling
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Anup Shrestha, Henrike Bruckmüller, Hanne Kildalsen, Gurjit Kaur, Matthias Gaestel, Hilde Ljones Wetting et al.:
    Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription
    Scientific Reports 2020 ARKIV / DOI
  • Seyed Mohammad Lellahi, Ingrid Arctander Rosenlund, Annica Hedberg, Liv Torill Kiær, Ingvild Mikkola, Erik Knutsen et al.:
    The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response
    Journal of Biological Chemistry 2018 ARKIV / DOI
  • Roth Sarah Andrea, Øyvind Holsbø Hald, Steffen Fuchs, Cecilie Løkke, Ingvild Mikkola, Trond Flægstad et al.:
    MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN
    OncoTarget 2018 ARKIV / DOI
  • Beate Hegge, Eva Sjøttem, Ingvild Mikkola :
    Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
    BMC Cancer 2018 ARKIV / DOI
  • Lars Peter Engeset Austdal, Sigrid Bjørnstad, Gro Haarklou Mathisen, Petra Aden, Ingvild Mikkola, Ragnhild Elisabeth Paulsen et al.:
    Glucocorticoid effects on cerebellar development in a chicken embryo model: exploring changes in PAX6 and Metalloproteinase-9 after exposure to dexamethasone
    Journal of Neuroendocrinology (JNE) 2016 DOI
  • Siri Forsdahl, Yury Kiselev, Rune Hogseth, Janne erikke Mjelle, Ingvild Mikkola :
    Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in Flpln-3T3 cells stably expressing either the Pax6 or the Pax6(5a) Isoform
    PLOS ONE 2014 ARKIV / DOI
  • Yury Kiselev, Tonje Engevik Eriksen, Siri Forsdahl, Lan Nguyen, ingvild Mikkola :
    3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes
    PLOS ONE 2012 ARKIV / DOI
  • Franz Gruber, Tuija Lundan, Rasmus Goll, Aleksandra Silye, Ingvild Mikkola, Ole Petter Rekvig et al.:
    BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?
    Medical Oncology (MO) 2012 DOI
  • Franz Gruber, Thomas Ernst, Yury Kiselev, A Hochhaus, ingvild Mikkola :
    Detection of Drug-Resistant Clones in Chronic Myelogenous Leukemia Patients during Dasatinib and Nilotinib Treatment
    Clinical Chemistry 2010 DOI
  • Thomas Ernst, Franz Gruber, Oliver Pelz-Ackermann, J Maier, M Pfirrmann, MC Muller et al.:
    A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib
    Haematologica 2009 ARKIV / DOI
  • Jack-Ansgar Bruun, Ernst I.s. Thomassen, Kurt Kristiansen, Garth Daryl Tylden, Turid Holm, Ingvild Mikkola et al.:
    The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
    Nucleic Acids Research (NAR) 2005 ARKIV
  • Ingvild Mikkola, Barry Heavey, Markus Horcher, Meinrad Busslinger :
    Reversion of B Cell Commitment upon Loss of Pax5 Expression
    Science 2002 DOI
  • Svanhild Nornes, Michael Clarkson, Ingvild Mikkola, Marit Pedersen Delghandi, Anne Bardsley, Juan Pedro Martinez et al.:
    Zebrafish contains two Pax6 genes involved in eye development
    Mechanisms of Development 1998
  • Svanhild Nornes, Ingvild Mikkola, Stefan Krauss, Madjid Delghandi, maria Perander, Terje Johansen :
    Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences
    Journal of Biological Chemistry 1996
  • Rachel Macdonald, K. Anukampa Barth, Nigel Holder, Ingvild Mikkola, Stephen W. Wilson :
    Midline signalling is required for Pax gene regulation and patterning of the eyes
    Development 1995
  • R. Macdonald, Q. Xu, A. Barth, Ingvild Mikkola, N. Holder, Anders Fjose et al.:
    Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain
    Neuron 1994
  • Ingvild Mikkola, Anders Fjose, John Y. Kuwada, Stephen Wilson, Per Henrik Guddal, Stefan Krauss :
    The Paired Domain-Containing Nuclear Factor pax[b] Is Expressed in Specific Commissural lnterneurons in Zebrafish Embryos
    Journal of Neurobiology 1992
  • Yury Kiselev, Andrey Yurjevich Valkov, Lill-Tove Busund, Roy M. Bremnes, Igor Snapkov, Ingvild Mikkola et al.:
    Transcription factor PAX6 is expressed in human soft tissue sarcomas and confers negative impact on patients' survival
    2014
  • Franz Gruber, Thomas Ernst, Kimmo Porkka, Richard Alan Engh, ingvild Mikkola, Jacqueline Maier et al.:
    Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients
    Leukemia 2012 DOI
  • Franz Gruber, H Hjorth-Hansen, ingvild Mikkola, L Stenke, Terje Johansen :
    A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib
    Leukemia 2006
  • ingvild Mikkola :
    The quest for new target genes for the transcription factor Pax6
    2005
  • ingvild Mikkola, Rune Hogseth, Terje Johansen :
    Chromatin Immunoprecipitation (ChIP) as a method for identification of new target genes for Pax6
    2004
  • Ingvild Mikkola :
    Regulation of two members of of the Pax family of transcription factors; Involvement of alternative splicing, phosphorylation and protein-protein interactions
    UiT Norges arktiske universitet 1999

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    Teaching

    FAR-1201 (Cellbiology and Biochemistry), emneleder

    MED-2501, Delemne 2.2 (Reproduction, embryology and genetics), lecturer

    ODO-2008, Delemne 2.2 (Reproduction, embryology and genetics), lecturer


    Member of research group

    Cell Signalling and Targeted Therapy   English content

    Member of project

    Stress activated signaling pathways in cancer development