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Bilde av Flaten, Gøril Eide
Photo: Stina Guldbrandsen
Bilde av Flaten, Gøril Eide
Department of Pharmacy goril.flaten@uit.no +4777646169 Tromsø FARM F3.105

Gøril Eide Flaten

Professor in Drug Transport and Delivery

  • Lisa Myrseth Hemmingsen, Barbara Giordani, Marianne Hagensen Paulsen, Zeljka Vanic, Gøril Eide Flaten, Beatrice Vitali et al.:
    Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
    Biomaterials Advances 2023 ARKIV / DOI
  • Gøril Eide Flaten :
    Lotion
    Store Norske Leksikon (Nettutgaven) 2023 DOI
  • Philip Ben Rainsford, Birta R. Sarre, Margherita Falavigna, Bjørn Olav Brandsdal, Gøril Eide Flaten, Martin Jakubec et al.:
    WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport
    Biochimica et Biophysica Acta - Biomembranes 2022 ARKIV / DOI
  • Zahari Vinarov, Bertil Abrahamsson, Per Artursson, Hannah Batchelor, Philippe Berben, Andreas Bernkop-Schnürch et al.:
    Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
    Advanced Drug Delivery Reviews 2021 ARKIV / DOI
  • Gøril Eide Flaten, Zeljka Vanic, Natasa Skalko-Basnet :
    The Role of In Vitro Skin Models in Optimization of Dermal Drug Delivery
    CRC Press 2021
  • Marek Soltys, David Zuza, Tereza Boleslavska, Sarah Machac Akhlasova, Martin Balouch, Pavel Kovacik et al.:
    Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics
    International Journal of Pharmaceutics 2021 ARKIV / DOI
  • May Wenche Jøraholmen, Selenia Ternullo, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    Advanced Drug Delivery Systems for Biologics
    John Wiley & Sons 2021
  • Margherita Falavigna, Sunniva Brurok Myklebost, Mette Klitgaard, Gøril Eide Flaten :
    Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs
    International Journal of Pharmaceutics 2021 ARKIV / DOI
  • Margherita Falavigna, Martina Pattacini, Richard Wibel, Fabio Sonvico, Natasa Skalko-Basnet, Gøril Eide Flaten :
    The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations
    Pharmaceutics 2020 ARKIV / DOI
  • Margherita Falavigna, Mette Klitgaard, Ragna Berthelsen, Anette Mullertz, Gøril Eide Flaten :
    Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model
    Journal of Pharmaceutical Sciences 2020 ARKIV / DOI
  • Margherita Falavigna, Paul C. Stein, Gøril Eide Flaten, Massimiliano Pio Di Cagno :
    Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin
    Pharmaceutics 2020 ARKIV / DOI
  • Margherita Falavigna, Mette Klitgaard, Erik Steene, Gøril Eide Flaten :
    Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability
    European Journal of Pharmaceutical Sciences 2019 ARKIV / DOI
  • Margherita Falavigna, Mette Klitgaard, Christina Brase, Selenia Ternullo, Natasa Skalko-Basnet, Gøril Eide Flaten :
    Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development
    International Journal of Pharmaceutics 2018 ARKIV / DOI
  • Selenia Ternullo, Purusotam Basnet, Ann Mari Holsæter, Gøril Eide Flaten, Louis de Weerd, Natasa Skalko-Basnet :
    Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Philippe Berben, Annette Bauer-Brandl, Martin Brandl, Bernard Faller, Gøril Eide Flaten, Ann-Cathrine Jacobsen et al.:
    Drug permeability profiling using cell-free permeation tools: Overview and applications
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Gøril Eide Flaten :
    Drasjere
    Store Norske Leksikon (Nettutgaven) 2023 FULLTEKST
  • Gøril Eide Flaten, Malin Iden :
    Holdbarhet for solkrem: Sjekk datoen
    05. April 2023 FULLTEKST
  • Gøril Eide Flaten, Anne Marie Vennerød :
    Talkum
    Store Norske Leksikon (Nettutgaven) 2023 FULLTEKST
  • Gøril Eide Flaten, Ivar Øye :
    Liniment
    Store Norske Leksikon (Nettutgaven) 2022 FULLTEKST
  • Gøril Eide Flaten :
    Dråpeteller
    Store Norske Leksikon (Nettutgaven) 2022 FULLTEKST
  • Gøril Eide Flaten :
    Granulater
    Store Norske Leksikon (Nettutgaven) 2022 FULLTEKST
  • Gøril Eide Flaten, Anne Marie Vennerød :
    Tablett
    Store Norske Leksikon (Nettutgaven) 2022 FULLTEKST
  • Gøril Eide Flaten, Andreas Velle :
    Morgenklubben med Loven og Co om holbarhet på solkrem
    28. April 2022
  • Jan Fredrik Frantzen, Natasa Skalko-Basnet, Gøril Eide Flaten :
    Kvinnelig rekrutteringssuksess med egen professor-filosofi
    08. March 2022
  • Lisa Myrseth Hemmingsen, Gøril Eide Flaten, Morten B. Strøm, Natasa Skalko-Basnet :
    Membrane-active antimicrobials – in synergy with nature – the role of chitosan
    2022
  • Maxim Bril'kov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson, Gøril Eide Flaten :
    Bacterially produced in vitro mambrane model systems from resistant- and non-resistant clinical isolates
    2022
  • Malin Iden, Gøril Eide Flaten :
    Sjekk datoen
    13. April 2022
  • Danielsen Veronica, Gøril Eide Flaten :
    Hvorfor havner de største nøttene øverst?
    Nyskjerrigper 2021
  • Gøril Eide Flaten :
    The importance of mucus as an absorption barrier and the use of the Mucus-PVPA
    2021
  • Gøril Eide Flaten :
    Liposomes
    2021
  • Audun Hetland, Gøril Eide Flaten, Per M Aslaksen, Joar Vittersø :
    Hjernen gjennom livet. Digitalt tilbakeblikk
    22. September 2021
  • Gøril Eide Flaten :
    NRKs pitchkonkurranse: Svaret i tarmen
    11. November 2021
  • Margherita Falavigna, Sunniva Brurok, Mette Klitgaard, Gøril Eide Flaten :
    Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations
    2021
  • Margherita Falavigna, Sunniva Brurok, Mette Klitgaard, Gøril Eide Flaten :
    Simultaneous in vitro lipolysis-permeation model predicts in vivo drug absorption from lipid-based formulations
    2021
  • Hans Petter Treider, Gøril Eide Flaten :
    Virker solkremen fra ifjor
    12. June 2020
  • Gøril Eide Flaten :
    Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of food, pH and intestinal fluids on drug permeability
    2020
  • Audun Hetland, Gøril Eide Flaten, Joar Vittersø, Per M Aslaksen :
    Hjernen
    2020
  • Audun Hetland, Joar Vittersø, Per M Aslaksen, Gøril Eide Flaten :
    Hjernen gjennom livet
    2020
  • Margherita Falavigna, Mette Klitgaard, Ragna Berthelsen, Anette Mullertz, Gøril Eide Flaten :
    New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations
    2020
  • Margherita Falavigna, Mette Klitgaard, Ragna Berthelsen, Anette Mullertz, Gøril Eide Flaten :
    New combined in vitro lipolysis-permeation model predicts the in vivo absorption of fenofibrate from SNEDDS formulations
    2020
  • Margherita Falavigna, Mette Klitgaard, Erik Steene, Gøril Eide Flaten :
    Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability
    2019
  • Gøril Eide Flaten :
    Lipid based nanocarriers in drug delivery
    2019
  • Margherita Falavigna, Mette Klitgaard, Erik Steene, Gøril Eide Flaten :
    Simulating the intestinal environment with the mucus-PVPA in vitro model: the impact of pH and simulated intestinal fluids on drug permeability.
    2019
  • Margherita Falavigna, Mette Klitgaard, Natasa Skalko-Basnet, Gøril Eide Flaten :
    Mucus-PVPA: an in vitro permeability screening tool for the investigation of intestinal drug absorption
    2019
  • Margherita Falavigna, Christina Brase, Mette Klitgaard, Natasa Skalko-Basnet, Gøril Eide Flaten :
    Mucus-PVPA : a permeability-screening tool for drug discovery and formulation development in mucosal tissues
    2018
  • Margherita Falavigna, Mette Klitgaard, Christina Brase, Selenia Ternullo, Natasa Skalko-Basnet, Gøril Eide Flaten :
    The mucus-PVPA (phospholipid vesicle-based permeation assay) as a permeability-screening tool to elucidate essential drug properties in drug discovery and formulation development in mucosal tissues
    2018
  • Gøril Eide Flaten :
    Hvordan velge de beste kandidatene for fremtidens legemidler?
    05. April 2018
  • Gøril Eide Flaten, Marit Anne Hauan, Geir Hevnskjel Ringvold :
    Observatoriet
    01. June 2018
  • Gøril Eide Flaten, Elisabeth Øvreberg :
    42 millioner kroner for utvikling av persontilpasset medisin
    31. January 2018
  • Gøril Eide Flaten, Marit Anne Hauan, Geir Hevnskjel Ringvold :
    Jubileumspodcast
    05. April 2018

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    Research interests

    The main focus of my research is permeability of drug through and into different absorption
    barriers, both in respect of understanding the mechanisms and factors affecting the permeability of compounds, and means to improve the permeability through use of advanced delivery systems. I have, in particular, experience with Advanced nanoparticulate drug delivery systems mainly for poorly soluble drugs as well as use of liposomes as model for cell membranes in interactions with peptides and proteins. My expertise thus spans from development of models for permeability screening as well as estimation of permeability of drugs and drug candidates, formulation of poorly soluble drugs,  characterization of nanoparticulate delivery systems, biopharmaceutical characterisation of delivery systems (cell toxicity and permeability) to in vivo biodistribution studies in mouse models. Administration sites in focus have been the intestine, vagina, and skin, but I have also experience with parenteral formulations for tumour targeted delivery.

     

    List of areas of research interests:

     

     

     

     

     

     

     

     

     

     

    Dissemination to sosiety availeble online

    Forskningspodcast fra UiT Norges arktiske universitet (2018)

    Hvordan velge de beste kandidatene for fremtidens legemidler? (2018)

    42 millioner kroner for utvikling av persontilpasset medisin (2018)

    Så lenge holder solkremen din (2017)

    Er det sant at man må kaste solkremen etter ett år? (2016)

    Skammelig nedprioritering (2016)

    Er kvinnesykdommer mindre viktige? (2016)

    Skammelig nedprioritering av forskning på kvinnesykdommer (2016)

    Finner de beste legemidlene – uten dyreforsøk (2015)

    Gjennombrudd: Dyreforsøk med brannskader kan erstattes (2014)

    Hermer stoffopptak via hud og tarm (2012)

    Legemidler og barrierer (2012)

    Teaching

    I am teaching in the following subjects:

    FAR-1101 Farmasi grunnemne
     
    FAR-1401 Fysikalsk farmasi (emneleder)

    FAR-2401 Basal legemiddelproduksjon

    FAR-2402 Legemiddelformulering og biofarmasi

    FAR-3401 Avansert legemiddelteknologi og biofarmasi

    FAR-3043 Masteremne i nanoteknologi
     
    FAR-8043 PhD-emne i nanomedisin

    ResearchGate
    ORCID: https://orcid.org/0000-0002-0934-9773

    Member of research group

    Drug Transport and Delivery   English content
    FARM F3.105

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