Bilde av Langer, Manuel K
Bilde av Langer, Manuel K
Department of Chemistry manuel.k.langer@uit.no +4777644084 94086741

Manuel K Langer


Research Scientist, Chemical Synthesis and Analysis

Job description

Fouling (growth of bacteria and bigger structures on solid surfaces) on marine vessels has a huge impact on fuel consumption and the costs for shipping companies. The highly interdisciplinary AntifoMar project aims for the identification and total synthesis of natural products, isolated from sessile marine invertebrates, which have anti-fouling and anti-biofilm properties. My part in this project is the delopment of synthetic routes for this those compounds and potentialle improve their activity by making drug like analouges. 


  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. March 2023 ARKIV / DOI
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug et al.:
    Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
    European Journal of Medicinal Chemistry 2023 ARKIV / DOI
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug et al.:
    A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
    European Journal of Medicinal Chemistry 2022 ARKIV / FULLTEKST / DATA / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug et al.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Ataur Rahman, Manuel K Langer, Hans-Matti Blencke, Tor Haug, Johanna U Ericson, Morten B. Strøm et al.:
    Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
    2023 PROSJEKT
  • Manuel K Langer, Annette Bayer :
    Total synthesis of Aspergilone A in batch and flow - A comparison
    2023
  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug et al.:
    Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
    2023
  • Manuel K Langer, Elise Kjørstad :
    Forskere har laget draps-molekyler som tar knekken på bakterier
    04. June 2023 FULLTEKST
  • Manuel K Langer, Jan Fredrik Frantzen :
    Making antibacterial supermolecules
    10. May 2023 OMTALE / FULLTEKST
  • Manuel K Langer, Jan Fredrik Frantzen :
    Manuels supermolekyler dreper bakteriene på fem minutter
    09. August 2023 DATA
  • Ataur Rahman, Manuel K Langer, Bartosz Michno, Hans-Matti Blencke, Tor Haug, Johanna U Ericson et al.:
    In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
    2023
  • Ataur Rahman, Manuel K Langer, Bartosz Michno, Hans-Matti Blencke, Tor Haug, Johanna U Ericson et al.:
    In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
    2023
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
    2022
  • Ataur Rahman, Manuel Karl Langer, Hymonti Dey, Jonathan Hira, Ekaterina Mishchenko, Annette Bayer et al.:
    Novel antimicrobial and biofilm-inhibitors from marine resources
    2020
  • Manuel K Langer, Annette Bayer :
    Tetrasubstituted barbiturates and hydantoins as potential antibiotics
    2020
  • Manuel K Langer, Marianne Hagensen Paulsen, Morten B. Strøm, Annette Bayer :
    Amphipathic Hydantoins – potential new antibiotics Mimicing the marine antimicrobials eusynstyelamides
    2018

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    Research interests

    • Synthesis of tetra-substituted hydantions
    • selective alkylation of hydantoins
    • targeted substitution of barbituric acid

    Teaching

    Fall 2018: KJE-1001 - Introduction into chemistry and chemical biology

    • Supervision of laboratory exercises

     


    Member of research group