Manuel K Langer
Job description
Fouling (growth of bacteria and bigger structures on solid surfaces) on marine vessels has a huge impact on fuel consumption and the costs for shipping companies. The highly interdisciplinary AntifoMar project aims for the identification and total synthesis of natural products, isolated from sessile marine invertebrates, which have anti-fouling and anti-biofilm properties. My part in this project is the delopment of synthetic routes for this those compounds and potentialle improve their activity by making drug like analouges.
Susannah von Hofsten,
Manuel K Langer,
Katja Korelin,
Synnøve Norvoll Magnussen,
Dominik Ausbacher,
Trude Anderssen
et al.:
Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
et al.:
Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Francesco Zilioli,
Tor Haug
et al.:
A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
Marianne Hagensen Paulsen,
Magnus Engqvist,
Dominik Ausbacher,
Trude Anderssen,
Manuel K- Langer,
Tor Haug
et al.:
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
Sundus Akhter,
Bjarte Aarmo Lund,
Aya Ismael,
Manuel K Langer,
Johan Mattias Isaksson,
Tony Christopeit
et al.:
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
European Journal of Medicinal Chemistry 2018 DOI
Manuel K Langer
:
Marine natural product inspired synthesis of new membranolytic antimicrobial agents.
2025
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
et al.:
Novel synthetic cationic antimicrobial peptides and their potential as antibiofilm agents
2025
Manuel K Langer,
Thomas Wirth,
Annette Bayer
:
Total Synthesis of Aspergilone A: Towards The Development Of New Antifouling Agents
2024
Manuel K Langer,
Annette Bayer
:
Total synthesis of Aspergilone A in batch and flow - A comparison
2023
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
et al.:
Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
2023
Manuel K Langer,
Jan Fredrik Frantzen
:
Making antibacterial supermolecules
Manuel K Langer,
Elise Kjørstad
:
Forskere har laget draps-molekyler som tar knekken på bakterier
04. June 2023 FULLTEKST
Ataur Rahman,
Manuel K Langer,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson,
Morten B. Strøm
et al.:
Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
2023 PROSJEKT
Manuel K Langer,
Jan Fredrik Frantzen
:
Manuels supermolekyler dreper bakteriene på fem minutter
09. August 2023 DATA
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
et al.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
et al.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023
Susannah von Hofsten,
Marianne Hagensen Paulsen,
Manuel K Langer,
Synnøve Norvoll Magnussen,
Dominik Ausbacher,
Annette Bayer
et al.:
A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
2022
Manuel K Langer
:
Marine natural product inspired synthesis towards new antimicrobial and antifouling agents
2022
Manuel K Langer,
Annette Bayer
:
Tetrasubstituted barbiturates and hydantoins as potential antibiotics
2020
Ataur Rahman,
Manuel Karl Langer,
Hymonti Dey,
Jonathan Hira,
Ekaterina Mishchenko,
Annette Bayer
et al.:
Novel antimicrobial and biofilm-inhibitors from marine resources
2020
Manuel K Langer,
Marianne Hagensen Paulsen,
Morten B. Strøm,
Annette Bayer
:
Amphipathic Hydantoins – potent new antibiotics
2019
Manuel K Langer,
Marianne Hagensen Paulsen,
Morten B. Strøm,
Annette Bayer
:
Amphipathic Hydantoins – potential new antibiotics
Mimicing the marine antimicrobials eusynstyelamides
2018
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Research interests
- Synthesis of tetra-substituted hydantions
- selective alkylation of hydantoins
- targeted substitution of barbituric acid
Teaching
Fall 2018: KJE-1001 - Introduction into chemistry and chemical biology
- Supervision of laboratory exercises
