Professor

Odeberg, Jacob Olof

Department of Clinical Medicine
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Biomarkers for prediction, diagnosis and prognosis of VTE

Pathophysiology of thrombosis

Education: 

1990    M. Sci in Chemical Engineering, Royal Institute of Technology (KTH), Stockholm Sweden 

1998    PhD in Biochemistry, KTH, Stockholm, Sweden.

2002    MD, Karolinska Institute (KI), Stockholm, Sweden.

2005    Certified physician, Karolinska University Hospital, Stockholm, Sweden  

2012    Specialist in Internal Medicine, Karolinska University Hospital, Stockholm.

2013    Specialist in Haematology, Karolinska University Hospital, Stockholm, Sweden  

Current positions:

2018-   Professor in Medicine (Hematology), K.G. Jebsen Thrombosis Research and Expertise Centre (TREC), Department of Clinical Medicine, The Arctic University of Norway, Tromsø 

2018-   Senior Consultant, University Hospital North Norway, Tromsø

2013-   Professor in Clinically Applied Proteomics, KTH, SciLifeLab, Stockholm

Previous academic positions:

2008-12          Associate Professor, Department of Proteomics, KTH, Stockholm

2006-08          Associate Professor, Department of Gene Technology, KTH, Stockholm

2002-12          Researcher, Department of Medicine, Atherosclerosis Research Unit, Karolinska Institute (KI), Stockholm, Sweden.

2000-05          Researcher, Department of Molecular Biotechnology, KTH, Stockholm

1999-00          Post Doc, Department of Biotechnology, KTH, Stockholm

Previous clinical positions:

2013- 218          Consultant in Hematology, Coagulation unit, Centre for Hematology,    Karolinska University Hospital Stockholm 

2005-2013         Resident in Internal Medicine & Haematology, Karolinska University Hospital

2002-05             Internship, Karolinska University Hospital.

Fellowships:

2009-12           Clinical Senior Researcher Fellowship, Stockholm County Council (SLL), Sweden

2002-05           Clinical Intern Research Fellowship, Stockholm County Council (SLL), Sweden

Publications:

85 original peer-reviewed articles listed in PubMed.

Supervision of PhD students:

Ongoing PhDs: 1 as main supervisor.

Completed PhDs: 3 as main supervisor, 5 as co-supervisor.

Professor at K. G. Jebsen TREC - Thrombosis Research and Expertice Center

(2014-2018) 

  1. Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sjöstedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, Uhlén M. Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics. Mol Cell Proteomics. 2014 Feb;13(2):397-406.
  2. Odeberg J, Freitag M, Forssell H, Vaara I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of smoking and impaired glucose homoeostasis on the outcome in patients presenting with an acute coronary syndrome: a cross-sectional study. BMJ Open. 2014 Jul 3;4(7):e005077
  3. Bruzelius M, Strawbridge RJ, Trégouët DA, Wiggins KL, Gertow K, Sabater-Lleal M, Öhrvik J, Bergendal A, Silveira A, Sundström A, Kieler H, Syvänen AC, Smith NL, Morange PE, Odeberg J, Hamsten A. Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism.Thromb Res. 2014 Aug;134(2):426-32.
  4. Bergendal A, Persson I, Odeberg J, Sundström A, Holmström M, Schulman S, Björgell O, Kieler H. Association of venous thromboembolism with hormonal contraception and thrombophilic genotypes. Obstet Gynecol. 2014 Sep;124(3)
  5. Habuka M, Fagerberg L, Hallström BM, Kampf C, Edlund K, Sivertsson Å, Yamamoto T, Pontén F, Uhlén M, Odeberg J. The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling.PLoS One. 2014 Dec 31;9(12):e116125.
  6. Bruzelius M, Bottai M, Sabater-Lleal M, Strawbridge RJ, Bergendal A, Silveira A, Sundström A, Kieler H, Hamsten A, Odeberg J. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. J Thromb Haemost. 2015 Feb;13(2):219-27.
  7. Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F. Proteomics. Tissue-based map of the human proteome. Science. 2015 Jan 23;347(6220):1260419. 1088 Citations.
  8. Bruzelius M, Ljungqvist M ,Bottai M, BergendalA, Strawbridge RJ, Holmström M, Silveira A, Kieler H, Hamsten A, Lärfars G, Odeberg J (2015). F11 is associated with recurrent VTE in women: A prospective cohort study. Thrombosis and Haemostasis 115(2)
  9. Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, Lengquist M, Åkesson S, Wheelock C, Maegdefessel L, Gabrielsen A, Odeberg J, Hansson G, Paulsson-Berne G, Hedin U. Gene expression signatures, pathways and networks in carotid atherosclerosis. Journal of Internal Medicine 2016 Mar;279(3)
  10. Odeberg J, Freitag M, Forssell H, Vaara, I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of pre-existing inflammation on the outcome of acute coronary syndrome: a cross sectional study. British Medical Journal Open, 2016;6:e009968 doi:10.1136/bmjopen-2015-009968
  11. Ljungqvist M, Holmström M, Kieler H, Odeberg J, Lärfars G. Cardiovascular disease and mortality after a first episode of venous thromboembolism in young and middle-aged women. Thrombosis Research, 2016 Feb;138:80-5
  12. Edsgard D, Jesus Iglesias M, Reilly SJ, Hamsten A, Tornvall P, Odeberg J*, Emanuelsson O*. GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information. Scientific Reports 2016 Feb 18;6:21134. * Joint corresponding author
  13. Lal S, Nguyen L, Tezone R, Ponten F, Odeberg J, Li A, Dos Remedios C. Tissue microarray profiling in human heart failure. Proteomics. 2016 Sep;16(17):2319-26. PMID:27364902
  14. Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojević V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous T, Hamsten A, Hedin U. Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1947-61.
  15. Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J. Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome. Cell Systems. 2016 Sep 28;3(3):287-301.e3. PMID:27641958 
    Commentary Editorial article in same issue: Rau C.D., Gao C., Wang Y. ‘Deconvolution of the Human Endothelial Transcriptome’ Cell Systems. 2016 Sep 28;3(3):218-220.e3
  16. Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J. PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood. 2016 Dec 8;128(23):e59-e66. PMID:27742707 
  17. Schmidt D, Majeed A, Bruzelius M, Odeberg J, Holmström M, Agren A. Haeamophilia, 2016. A prospective diagnostic accuracy study evaluating ROTEM and TEG in 100 patients with Von Willebrand disease.  Haemophilia. 2016 Oct 26 doi 10.1111/ hae 13121. PMID:27785858
  18. Schmidt DE, Bruzelius M, Majeed A, Odeberg J, Holmström M, Ågren A. Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease. Thromb Haemost. 2017 Jul 26;117(8):1528-1533. 
  19. Majeed A, Ågren A, Holmström M, Bruzelius M, Chaireti R, Odeberg J, Hempel EL, Magnusson M, Frisk T, Schulman S. Management of rivaroxaban or apixaban associated major bleeding with prothrombin complex concentrates: a cohort study. Blood. 2017 Aug 23. PMID: 2883543
  20. Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J*, Hedin U*. Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.  JACC Basic Transl Sci. 2018 Aug 1;3(4):464-480. *Shared corresponding author
  21. Odeberg J, Wirsén A, Norberg Å, Frie J, Printz G, Lagercrantz H, Gudmundsson GH, Agerberth B, Jonsson B. A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial. Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:782-789.
  22. Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM (2018) A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein Scientific Reports 8(1):14668
     
     

 

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