Mette Kjær
Mette Kjær
Tverrfaglig distriktsmedisinsk forskningsgruppe mette.kjar@uit.no Tromsø

Kjær, Mette



  • Jens Kjeldsen-Kragh, Dean Fergusson, Mette Kjær, Lani Lieberman, Andreas Greinacher, Michael F. Murphy et al.:
    Fetal/neonatal alloimmune thrombocytopenia: A systematic review of impact of HLA-DRB3∗01:01 on fetal/neonatal outcome
    Blood Advances 2020 ARKIV / DOI
  • Mette Kjær, Christof Geisen, Cigdem Ahaein Akkøk, Agneta Wikman, Ulrich Sachs, James B. Bussel et al.:
    Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia
    Transfusion and Apheresis Science 2020 ARKIV / DOI
  • Maria Averina, Tor Hervig, Sandra Huber, Mette Kjær, Einar Klæboe Kristoffersen, Bjørn Johan Bolann :
    Environmental pollutants in blood donors: The multicentre Norwegian donor study
    Transfusion Medicine 2020 ARKIV / DOI
  • Jesper Dahl, Bjørn Skogen, Mette Kjær, Anne Husebekk, Jens Kjeldsen-Kragh, Heidi Tiller :
    A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
    Transfusion 2020 ARKIV / DOI
  • Jillian M. Baker, Nadine Shehata, James Bussel, Michael F. Murphy, Andreas Greinacher, Tamam Bakchoul et al.:
    Postnatal intervention for the treatment of FNAIT: a systematic review
    Journal of Perinatology 2019 DOI
  • Lani Lieberman, Andreas Greinacher, Michael F. Murphy, James Bussel, Tamam Bakchoul, Stacy Corke et al.:
    Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach
    British Journal of Haematology 2019 DOI
  • Jens Kjeldsen-Kragh, Thomas Larsen Titze, Benedicte Alexandra Lie, John T. Vaage, Mette Kjær :
    HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women
    Blood Advances 2019 ARKIV / DOI
  • Mette Kjær, Gerald Bertrand, Tamam Bakchoul, Edwin Massey, Jillian Baker, Lani Lieberman et al.:
    Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia: a systemic review
    Vox Sanguinis 2018 DOI
  • Dian Winkelhorst, Michael F. Murphy, Andreas Greinacher, Nadine Shehata, Taman Bakchoul, Edwin Massey et al.:
    Antenatal management in fetal and neonatal alloimmune thrombocytopenia: A systematic review
    Blood 2017 DOI
  • Mette Kjær, Heidi Tiller, Gøril Heide, Jens Kjeldsen-Kragh, Bjørn Ragnar Skogen, Anne Husebekk :
    Fetal exposure to maternal human platelet antigen-1a does not induce tolerance. An analytical observational study
    PLOS ONE 2017 ARKIV / DOI
  • Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Zubiavrre Martinez et al.:
    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model
    Reproductive Biology and Endocrinology 2017 ARKIV / DOI
  • Heidi Tiller, Anne Husebekk, Bjørn Ragnar Skogen, Jens Kjeldsen-Kragh, Mette Kjær Killie :
    True risk of fetal/neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study
    BJOG: An International Journal of Obstetrics and Gynaecology 2016 DOI
  • Ying-Jan Weng, Anne Husebekk, Bjørn Ragnar Skogen, Mette Kjær, Liang-Tzung Lin, Thierry Burnouf :
    Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia
    PLOS ONE 2016 ARKIV / DOI
  • Anette Mörtberg, Stephan Meinke, Petra Berg, Mette Kjær, Jens Kjeldsen-Kragh, Kerstin Järås et al.:
    Sensitive detection of platelet-specific antibodies with a modified MAIPA using biotinylated antibodies and streptavidin-coated beads
    JIM - Journal of Immunological Methods 2016 DOI
  • Issaka Yougbaré, Sean Lang, Hong Yang, Pingguo Chen, Xu Zhao, Wei-She Tai et al.:
    Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
    Journal of Clinical Investigation 2015 DOI
  • Mariana Eksteen, Heidi Tiller, Maria Averina, Gøril Heide, Mette Kjær Killie, Cedric Ghevaert et al.:
    Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy
    Journal of Immunology 2015 ARKIV / DOI
  • Rick Kapur, Iwan Kustiawan, Anne Cathrine Vestrheim, Carolien A. M. Koeleman, Remco Visser, Helga Einarsdottir et al.:
    A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
    Blood 2014 DOI
  • Anne Husebekk, M El Ekiaby, G Gorgy, Mette Kjær Killie, Camilla Uhlin Hansen, Wahida Salma et al.:
    Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies
    Transfusion and Apheresis Science 2012 DOI
  • Heidi Tiller, Mette Kjær Killie, Anne Husebekk, Bjørn Ragnar Skogen, Heyu Ni, Jens Kjeldsen-Kragh et al.:
    Platelet antibodies and fetal growth: maternal antibodies against fetal platelet antigen 1a are strongly associated with reduced birthweight in boys
    Acta Obstetricia et Gynecologica Scandinavica 2012 DOI
  • Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Martin L. Olsson, Bjørn Ragnar Skogen :
    The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
    Clinical & Developmental Immunology 2012 FULLTEKST / ARKIV / DOI
  • Heidi Tiller, Mette Kjær Killie, Pingguo Chen, Mariana Eksteen, Anne Husebekk, Bjørn Ragnar Skogen et al.:
    Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model
    Transfusion 2012 DOI
  • Mette Kjær Killie, Wahida Salma, eirin listau Bertelsen, Bjørn Ragnar Skogen, Anne Husebekk :
    Quantitative MAIPA: Comparison of different MAIPA protocols
    Transfusion and Apheresis Science 2010 DOI
  • Bjørn Ragnar Skogen, Mette Kjær Killie, Jens Kjeldsen-Kragh, Maria Therese Ahlen, Heidi Tiller, Tor Brynjar Stuge et al.:
    Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention
    Expert Review of Hematology 2010 DOI
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie et al.:
    Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals
    ISBT Science Series 2010
  • Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Bjørn Ragnar Skogen :
    Is it time to implement HPA-1 screening in pregnancy?
    Current opinion in hematology 2009 DOI
  • Heidi Tiller, Mette Kjær Killie, Bjørn Ragnar Skogen, Pål Øian, Anne Husebekk :
    Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme
    BJOG: An International Journal of Obstetrics and Gynaecology 2009 DOI
  • Bjørn Ragnar Skogen, Anne Husebekk, Mette Kjær Killie, J Kjeldsen-Kragh :
    Neonatal Alloimmune Thrombocytopenia is Not What It was A Lesson Learned from a Large Prospective Screening and Intervention Program
    Scandinavian Journal of Immunology 2009 DOI
  • Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells
    Blood 2009 DOI
  • Mette Kjær Killie, Anne Husebekk, Jens Kjeldsen-Kragh, Bjørn Ragnar Skogen :
    A prospective study of maternal anti-HPA1a antibody level as a potential predictor for alloimmune thrombocytopenia in the newborn
    Haematologica 2008 ARKIV / DOI
  • J Kjeldsen-Kragh, Anne Husebekk, Mette Kjær Killie, Bjørn Ragnar Skogen :
    Is it time to include screening for neonatal alloimmune thrombocytopenia in the general antenatal health care programme?
    Transfusion and Apheresis Science 2008 DOI
  • Jens Kjeldsen-Kragh, Mette Kjær Killie, G Tomter, E Golebiowska, I Randen, R Hauge et al.:
    A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia
    Blood 2007 DOI
  • Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Bjørn Ragnar Skogen :
    Treatment and prevention of alloimmune thrombocytopenias
    Hematology education 2007
  • Heidi Tiller, Mette Kjær, Maria Therese Ahlen, Jens Kjeldsen-Kragh :
    Føtal/neonatal alloimmun trombocytopeni (FNAIT) - hvordan redusere risiko for intrakraniell blødning hos foster/ nyfødt - erfaringer fra Norge
    Bestpractice Onkologi/Hematologi 2019
  • Mette Kjær, Jens Kjeldsen-Kragh, Cathrine Fiskum, Irene Leinan, Bjørn Skogen, Anne Husebekk :
    Screening for fetal and neonatal alloimmune thrombocytopenia ? lessons learned from a Norwegian screening program
    Acta Obstetricia et Gynecologica Scandinavica 2018 DOI
  • Sandra Huber, Maria Averina, Inger Njølstad, Anne-Sofie Furberg, Bjørn Johan Bolann, Mette Kjær et al.:
    Perfluoroalkyl substances in different cohorts from North Norway
    2017
  • Heidi Tiller, Mette Kjær Killie, Anne Husebekk, Bjørn Ragnar Skogen, Jens Kjeldsen-Kragh :
    The natural course of HPA-1a-immunized subsequent pregnancies and clinical outcome of neonates
    American Journal of Obstetrics and Gynecology 2014
  • Mariana Eksteen, Mette Kjær Killie, Anne Husebekk, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    A NOVEL HUMAN MONOCLONAL HPA-1A-SPECIFIC ANTIBODY IS A USEFUL TOOL FOR DIAGNOSTICS IN FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA
    Vox Sanguinis 2013
  • R Kapur, Arne Vestrheim, C Koeleman, L Porcelijn, D. Jackson, B Kumpel et al.:
    A PROMINENT LACK OF IGG1 FC-FUCOSYLATION OF PLATELET-ALLOANTIBODIES IN PREGNANCY
    Vox Sanguinis 2013
  • Anne Husebekk, Heidi Tiller, Mette Kjær Killie, Mariana Eksteen, Maria Therese Ahlen, Tor Brynjar Stuge et al.:
    TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT)
    Vox Sanguinis 2012
  • G Bertrand, T. Bakchoul, K. Javela, Mette Kjær Killie, C Kaplan :
    Interlaboratory workshop on anti-HPA-1a alloantibody quantification with the mAb-specific immobilization of platelet antigen technique
    Journal of Thrombosis and Haemostasis 2012 DOI
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie et al.:
    MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION
    Placenta 2011
  • Jens Kjeldsen-Kragh, Anne Husebekk, Mette Kjær Killie, Bjørn Ragnar Skogen :
    The pathophysiology of FNAIT cannot be deduced from highly selected retrospective data
    Blood 2011 DOI
  • Heidi Tiller, Pingguo Chen, Bjørn Ragnar Skogen, Mette Kjær Killie, Anne Husebekk, Mariana Eksteen et al.:
    Administration of Anti-Platelet Antibodies Prevents the Anti-Platelet Immune Response and Bleeding Complications of Neonatal Immune Thrombocytopenia in a Murine Model
    Blood 2009
  • Heidi Tiller, Mette Kjær Killie, Anne Husebekk, Bjørn Ragnar Skogen, Heyu Ni, Jens Kjeldsen-Kragh et al.:
    Association Between Maternal Anti-HPA1a Antibodies and Birth Weight of the Newborn
    Blood 2009
  • J Kjeldsen-Kragh, Michael Kim, Mette Kjær Killie, Anne Husebekk, J Freedman, John W Semple :
    In HPA 1a-immunized women the decrease in anti-HPA 1a antibody level during pregnancy is not associated with anti-idiotypic antibodies
    Haematologica 2009 ARKIV / DOI
  • Mette Kjær Killie, Jens Kjeldsen-Kragh, Anne Husebekk, Bjørn Ragnar Skogen, Jan Abel Olsen, ivar sØnbØ Kristiansen :
    Cost-effectiveness of screening for neonatal alloimmune thrombocytopenia was based on invalid assumption. Authors Reply
    BJOG: An International Journal of Obstetrics and Gynaecology 2008
  • Anne Husebekk, Mette Kjær Killie, T Stuge, Heidi Tiller, MT Ahlen, Jens Kjeldsen-Kragh et al.:
    The knowledge of the pathophysiology of fetal/neonatal alloimmune thrombocytopenia is of importance to prevent immunization and to handle the immunized pregnancies in order to prevent hemorrhage
    Vox Sanguinis 2008
  • MK Killie, J Kjeldsen-Kragh, Anne Husebekk, Bjørn Ragnar Skogen, Jan Abel Olsen, IS Kristiansen :
    Cost-effectiveness analysis of screening for neonatal alloimmune thrombocytopenia was based on invalid assumption - Reply
    BJOG: An International Journal of Obstetrics and Gynaecology 2008 DOI
  • H Bessos, Maryana Matviyenko, P Brown, Anne Husebekk, MK Killie, J Seghatchian et al.:
    What's happening - Probing of HPA-1a antigen-antibody interaction by surface plasmon resonance technology
    Transfusion and Apheresis Science 2008 DOI
  • Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Bjørn Ragnar Skogen :
    Treatment and prevention of alloimmune thrombocytopenias
    2007

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