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Bilde av Ghosh, Biswajoy
Bilde av Ghosh, Biswajoy
Researcher and Principal Investigator / Photonics group Department of Physics and Technology biswajoy.ghosh@uit.no +4777660655 Tromsø You can find me here

Biswajoy Ghosh

Job description

Summary
I am a Researcher and Principal Investigator at UiT The Arctic University of Norway, working at the intersection of biomedical engineering, cancer biophysics, mechanobiology, biomaterials, quantitative microscopy, and computational image analysis.

My research focuses on understanding how cancer cells interact with and adapt to their physical microenvironment, and on translating these insights into engineered human disease models and functional technologies for cancer research and drug development. My group combines biomaterials, microengineered tumor models, advanced label-free microscopy, quantitative imaging, and computational analysis to investigate cancer cell behavior, phenotypic plasticity, and therapeutic response.

A central theme of my research is interdisciplinary method and technology development, connecting fundamental cancer biology and biophysics with engineering and clinical translation. This has driven innovations such as Cymoplive, a functional preclinical platform for quantifying cancer cell migration, adaptation, and response to therapeutic perturbation within engineered microenvironments. I am also developing biomaterial and tumor-on-chip approaches for modeling patient-specific cancer biology and improving physiologically relevant preclinical testing.

My research brings together expertise and collaborators across physics, engineering, biomaterials, cell biology, cancer research, computational analysis, and clinical medicine. The broader goal is to develop quantitative technologies that improve our understanding of disease while accelerating the translation of scientific discoveries into useful biomedical and healthcare solutions.

Outside the lab, I enjoy exploring global cuisines in my kitchen—a rather different kind of experimental platform.

Funding
I lead and contribute to interdisciplinary research and innovation projects supported by national, regional, European, and institutional funding programmes, including:

Research Council of Norway (RCN)
Helse Nord Regional Health Authority
European Molecular Biology Organization (EMBO)
MABIT – Marine Biotechnology in Northern Norway
UiT The Arctic University of Norway

These projects span fundamental research, biomedical technology development, cancer modelling, translational research, and research-driven innovation.

Education
PhD in Medical Science and Technology, 2021
Indian Institute of Technology Kharagpur, India
Thesis: Evaluating Fibrosis Linked with Wound Healing and Cancer Using Biophotonics and Biomechanics-based Applications

Master of Technology in Medical Imaging and Informatics, 2014
Indian Institute of Technology Kharagpur, India
Master's thesis conducted jointly with the Technical University of Munich, Germany
Thesis: Correlating Ultrasonic Speckle Distribution to Functional State of a Lesion for Augmenting Specificity in Diagnostic Sonomammography

Bachelor of Technology in Biotechnology, 2012
West Bengal University of Technology, India

Professional Affiliations
American Association for Cancer Research (AACR)
European Association for Cancer Research (EACR)
Tissue Engineering and Regenerative Medicine International Society (TERMIS)
Biophysical Society (BPS)
IEEE Engineering in Medicine and Biology Society (EMBS)
Sigma Xi – The Scientific Research Honor Society
Optica

Current Research Interests
Biomedical engineering · Cancer biophysics · Mechanobiology · Cancer cell migration and phenotypic plasticity · Tumor-on-chip and microphysiological systems · Biomaterials and engineered microenvironments · 3D disease models · Quantitative and computational microscopy · Label-free imaging · Image analysis · Preclinical drug testing · Translational cancer research

  • Nikhil Kumar, Biswajoy Ghosh, Abhay Kumar, Riya Koley, Santanu Dhara, Santanu Chattopadhyay :
    Multilayered “SMART” hydrogel systems for on-site drug delivery applications
    Journal of Drug Delivery Science and Technology 2023 DOI / ARKIV
  • Biswajoy Ghosh :
    Arecanut-induced fibrosis display dual phases of reorganising glycans and amides in skin extracellular matrix
    International Journal of Biological Macromolecules 2021 DOI / ARKIV
  • Biswajoy Ghosh, Krishna Agarwal :
    Erratum: Author Correction: Viewing life without labels under optical microscopes (Communications biology (2023) 6 1 DOI: 10.1038/s42003-023-04934-8)
    Communications Biology 2024 DOI / ARKIV
  • Camille Corrio, Juliette Le Gac, Laura Victoria Schulte-Werning, Biswajoy Ghosh, Komal Agarwal :
    GelMA-Chitosan-Polyethylene Oxide Composite Enhances Proliferation of Fibroblast Cells In-Vitro
    2023 ARKIV
  • Biswajoy Ghosh, Krishna Agarwal :
    GelMA Hydrogel Mechanics Affect the Collective Migration of Fibroblast Cells
    2023 ARKIV

    • The 50 latest publications is shown on this page. See all publications in NVA here →

    Publications outside Cristin

    Journal Arcticles and Pre-prints:

    1. Butola, A., Ghosh, B. , Park, J., Kwon, M., De la Cadena, A., Mukherjee, SS, Bhargava, R., Boppart, SA and Agarwal, K., 2024. Label-free correlative morpho-chemical tomography of 3D kidney mesangial cells. arXiv preprint arXiv:2409.10971. https://doi.org/10.48550/arXiv.2409.10971
    2. Ghosh, B. and Agarwal, K., 2024. Randomly oriented microgrooved hydrogel guides cellular motility, modulates speed, and governs directionality of cellular spread. bioRxiv, pp.2024-09. https://doi.org/10.1101/2024.09.10.612339
    3. Ghosh, B. , Agarwal, K., Habib, A., Agarwal, K. and Melandso, F., 2024. Label-free acoustic and optical microscopy of live tumor spheroids in hydrogel for high-throughput 3D In-vitro drug screening. bioRxiv, pp.2024-08. https://doi.org/10.1101/2024.08.28.610181
    4. Ghosh, B. , Chatterjee, J., Paul, RR, Acuña, S., Lahiri, P., Pal, M., Mitra, P. and Agarwal, K., 2024. Molecular histopathology of matrix proteins through autofluorescence super-resolution microscopy. Scientific Reports, 14(1), p.10524.  https://doi.org/10.1038/s41598-024-61178-0
    5. Ghosh, B. and Agarwal, K., 2023. Viewing life without labels under optical microscopes. Communications Biology, 6(1), p.559. https://doi.org/10.1038/s42003-023-04934-8
    6. Kumar, N., Ghosh, B. , Kumar, A., Koley, R., Dhara, S. and Chattopadhyay, S., 2023. Multilayered “SMART” hydrogel systems for on-site drug delivery applications. Journal of Drug Delivery Science and Technology, 80, p.104111.  https://doi.org/10.1016/j.jddst.2022.104111
    7. Ghosh, B. , Fenton, KA and Agarwal, K., 2023. Mechano-chemical Insights in Diabetic Kidney Disease through 3D Pathotypic Model of Mesangium. bioRxiv, pp.2023-12.  https://doi.org/10.1101/2023.12.10.571017
    8. Bhowmik, A., Ghosh, B ., Pal, M., Paul, RR, Chatterjee, J. and Chakraborty, S., 2022. Portable, handheld, and affordable blood perfusion imager for screening of subsurface cancer in resource-limited settings. Proceedings of the National Academy of Sciences, 119(2), p.e2026201119.  https://doi.org/10.1073/pnas.2026201119
    9. Ghosh, B. , Chatterjee, S., Dhakar, R., Muley, S., Mitra, P. and Chatterjee, J., 2021. Arecanut-induced fibrosis displays dual phases of reorganizing glycans and amides in skin extracellular matrix. International Journal of Biological Macromolecules, 185, pp.251-263.  https://doi.org/10.1016/j.ijbiomac.2021.06.093
    10. Nandi, S., Ghosh, B. , Ghosh, M., Layek, S., Nandi, PK and Sarkar, N., 2021. Phenylalanine Interacts with Oleic Acid-Based Vesicle Membrane. Understanding the Molecular Role of Fibril–Vesicle Interaction under the Context of Phenylketonuria. The Journal of Physical Chemistry B, 125(34), pp.9776-9793.  https://doi.org/10.1021/acs.jpcb.1c05592
    11. Lahiri, P., Mukherjee, S., Ghosh, B. , Das, D., Lahiri, B., Varshney, SK, Pal, M., Paul, RR and Chatterjee, J., 2021. Comprehensive evaluation of PAXgene fixation on oral cancer tissues using routine histology, immunohistochemistry, and FTIR microspectroscopy. Biomolecules, 11(6), p.889.  https://doi.org/10.3390/biom11060889
    12. Ghosh, B. , Bhandari, A., Mandal, M., Paul, RR, Pal, M., Mitra, P. and Chatterjee, J., 2021. Quantitative in situ imaging and grading of oral precancer with attenuation corrected-optical coherence tomography. Oral oncology, 117, p.105216.  https://doi.org/10.1016/j.oraloncology.2021.105216
    13. Chatterjee, R., Ghosh, B. , Mandal, M., Nawn, D., Banerjee, S., Pal, M., Paul, RR, Banerjee, S. and Chatterjee, J., 2021. Pathophysiological relationship between hypoxia associated oxidative stress, Epithelial-mesenchymal transition, stemness acquisition and alteration of Shh/Gli-1 axis during oral sub-mucous fibrosis and oral squamous cell carcinoma. European Journal of Cell Biology, 100(1), p.151146.  https://doi.org/10.1016/j.ejcb.2020.151146
    14. Ghosh, B. , Mandal, M., Mitra, P. and Chatterjee, J., 2021. Attenuation corrected‐optical coherence tomography for quantitative assessment of skin wound healing and scar morphology. Journal of Biophotonics, 14(4), p.e202000357.  https://doi.org/10.1002/jbio.202000357
    15. Ghosh, B. , Chatterjee, J., Paul, R., Lahiri, P., Pal, M., Mitra, P., Ahluwalia, BS and Agarwal, K., 2020. tAF-MUSICAL: autofluorescence super-resolution microscopy for molecular histopathology of matrix proteins in fibrotic diseases.  https://doi.org/10.21203/rs.3.rs-101219/v1
    16. Mandal, M., Ghosh, B. , Rajput, M. and Chatterjee, J., 2020. Impact of intercellular connectivity on epithelial mesenchymal transition plasticity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1867(10), p.118784.  https://doi.org/10.1016/j.bbamcr.2020.118784
    17. Ghosh, B. , Mandal, M., Mitra, P. and Chatterjee, J., 2021. Structural mechanics modeling reveals stress-adaptive features of cutaneous scars. Biomechanics and modeling in mechanobiology, 20, pp.371-377.  https://doi.org/10.1007/s10237-020-01384-7
    18. Ghosh, B. , Kumar, N., Singh, N., Sadhu, AK, Ghosh, N., Mitra, P. and Chatterjee, J., 2020. A quantitative lung computed tomography image feature for multi-center severity assessment of COVID-19. MedRxiv, pp. 2020-07.  https://doi.org/10.1101/2020.07.13.20152231
    19. Kundu, S., Ghosh, B. , Nandi, S., Ghosh, M., Pyne, A., Chatterjee, J. and Sarkar, N., 2020. Surface ligand-controlled wavelength-tunable luminescence of gold nanoclusters: cellular imaging and smart fluorescent probes for amyloid detection. ACS Applied Bio Materials, 3(7), pp.4282-4293.  https://doi.org/10.1021/acsabm.0c00337
    20. Nandi, S., Pyne, A., Ghosh, M., Banerjee, P., Ghosh, B. and Sarkar, N., 2020. Antagonist effects of l-phenylalanine and the enantiomeric mixture containing d-phenylalanine on phospholipid vesicle membrane. Langmuir, 36(9), pp.2459-2473.  https://doi.org/10.1021/acs.langmuir.9b03543
    21. Ghosh, B. , Mandal, M., Mitra, P. and Chatterjee, J., 2017. Optical Coherence Tomography Reveals Mechanobiologically Stable Self-Organizing Di-Fork Architecture of Mice Cutaneous Scars i, ii. bioRxiv, p.181545.  https://doi.org/10.1101/181545
    22. Mandal, M., Ghosh, B. , Anura, A., Mitra, P., Pathak, T. and Chatterjee, J., 2016. Modeling continuum of epithelial mesenchymal transition plasticity. Integrative Biology, 8(2), pp.167-176.  https://doi.org/10.1039/c5ib00219b
    23. Sarkar, A., Barui, A., Ghosh, B. , Mukherjee, A., Sarkar, R., Sengupta, S. and Chatterjee, J., 2016. Autofluorescence signatures for classifying lung cells during epithelial mesenchymal transition. RSC advances, 6(81), pp. 77953-77962.  https://doi.org/10.1039/C6RA16866C
    24. De, B., Bhandari, K., Chakravorty, N., Mukherjee, R., Gundamaraju, R., Singla, RK, Katakam, P., Adiki, SK, Ghosh, B. and Mitra, A., 2015. Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend. World Journal of Diabetes, 6(11), p.1179.  http://doi.org/10.4239/wjd.v6.i11.1179

    Book and Book Chapters

    1. Ghosh, B. and Chatterjee, J., 2023. Advances in medical imaging for wound repair and regenerative medicine. In Regenerative Medicine: Emerging Techniques to Translation Approaches (pp. 57-76). Singapore: Springer Nature Singapore.  https://doi.org/10.1007/978-981-19-6008-6_4

    Conference Proceedings:

    1. Butola, A., Ghosh, B. , Park, J., Kwon, M., De la Cadena, A., Mukherjee, S., Bhargava, R., Boppart, S.A. and Agarwal, K., 2024, June. Morphological imaging of 3D cultured kidney mesangial cells using gradient light interference microscopy. In Digital Holography and Three-Dimensional Imaging (pp. M2B-4). Optica Publishing Group. https://doi.org/10.1364/DH.2024.M2B.4
    2. Ghosh, B. , Fenton, KA, and Agarwal, K. Microenvironment In 3d Hydrogels For Studying Chronic Kidney Diseases. Tissue Engineering International and Regenerative Medicine International Society (TERMIS), 2024, June, Seattle, US.  https://doi.org/10.1089/ten.tea.2024.06979.abs
    3. Agarwal, K. and Ghosh, B . Influence of GelMA-Chitosan Composite on In Vitro Fibroblast Cell Proliferation. Tissue Engineering and Regenerative Medicine International Society (TERMIS), 2024, June, Seattle, US.  https://doi.org/10.1089/ten.tea.2024.06979.abs
    4. Ghosh, B. and Agarwal, K., 2024. Kidney mesangium organotypic culture reveals co-stimulatory mechano-chemical interplay for fibrotic manifestation. Biophysical Journal, 123(3), p.405a. https://doi.org/10.1016/j.bpj.2023.11.2483
    5. Corrio, C., Le Gac, J., Schulte, LW, Ghosh, B. , and Agarwal, K.. GelMA-Chitosan-Polyethylene
      Oxide Composite Enhances Proliferation of Fibroblast Cells In-Vitro. European Research Materials
      Society (EMRS), Warsaw, Portugal, 2023.
    6. Ghosh, B. , Acuna, S., Agarwal, K. MUSI-tAF: Autofluorescence-based Super-Resolution of Collagen
      Fibrils in Fixed Tissues for Density Estimation, Focus on Microscopy (FOM) 2023.
    7. Ghosh, B. , Fenton, KA, and Agarwal, K. Gradient Light Interface Microscopy for Label-free
      Detection of Early Changes in kidney Cells Embedded in a Soft and Stiff Hydrogel Matrix, Focus
      on Microscopy (FOM) 2023.
    8. Ghosh, B. and Agarwal, K., 2023, July. GelMA hydrogel mechanics affect the collective migration of fibroblast cells. In TISSUE ENGINEERING PART A (Vol. 29, No. 13-14). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY ANN LIEBERT, INC. https://doi.org/10.1089/ten.tea.2023.29043.abstracts
    9. Ghosh, B. , Chatterjee, J., 2019, Scarring in an areca nut-induced fibrotic skin tissue environment, TERMIS EU 2019, Rodos, Greece.  Conference Proceedings
    10. Ghosh, B. , Chatterjee, J., Attenuation Normalization in Tissue Optical Coherence Tomography, 40th Conference of IEEE Engineering in Medicine and Biology Conference-2018, Hawai, Honolulu, USA.  Conference Proceedings
    11. Ghosh, B. , Muley, S., Chatterjee, J., Automated Hidden Peak Extraction in FTIR Spectra for Fibrotic Skin Tissues, 40th Conference of IEEE Engineering in Medicine and Biology Conference-2018, Hawai, Honolulu, USA.  Conference Proceedings
    12. Mandal, M., Ghosh, B. , Anura, A., Mitra, P., Pathak, T. and Chatterjee, J., Cellular plasticity derived interaction modeling of epithelial mesenchymal transition, ICCB 2018. Hyderabad, 26-31 January 2018.  Conference Proceedings
    13. Agarwal, K., Ghosh, B. , Wolfson, DL, Oie, CI, Chatterjee, J., and Singh Ahluwalia, BS, Computational Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL) for Fluorescence Imaging, PIERS 2017, NUS, Singapore.  Conference Proceedings
    14. Muley,S., Ghosh, B. , Sharma, A., Chatterjee, J., Framework for Automated Identification of Spectral Hidden Peaks of Skin Tissue Structure Relevant Signatures from Concomitant Raman-FTIR Spectroscopy, PIERS 2017, NUS, Singapore.  Conference Proceedings
    15. Sharma, A., Ghosh, B. , Muley,S., Chatterjee, J., Non-invasive Depth of Field Estimation of Skin Vascularity Using 5-Filter Multispectral Imaging, PIERS 2017, NUS, Singapore.  Conference Proceedings
    16. Ghosh, B. , Karri, SPK, Sheet, D., Garud, H., Ghosh, A., Ray, AK and Chatterjee, J., 2016, December. A generalized framework for stain separation in digital pathology applications. In 2016 IEEE Annual India Conference (INDICON) (pp. 1-4). IEEE. https://doi.org/10.1109/INDICON.2016.7839070
    17. Ghosh, B. , P., Chatterjee, J., A Semi-Supervised Algorithm for Quantification of Tissue Abnormality in Oral Pre-Cancer Histopathology", International CME in Pathology, 7 February 2015.
    18. Mandal, M., Chaudhary, A., Ghosh, B. , Chatterjee, J., Dynamism of E-cadherin and β-catenin Relation in Malignancy, 5th International Conference on Stem Cells and Cancer (ICSCC-2014) Proliferation, Differentiation and Apoptosis, New Delhi, 8-10 November 2014.

    Patent filings and Invention Disclosures:

    1. MarGel- Invention disclosure filed on Sep 2024.
    2. CellTraceD - Invention disclosure filed on Sep 2024
    3. Cytomotility & Cytoplasticity in vitro live cell assay (Cymoplive) , UK International Patent Application 2309453.5 filed on 22nd June 2023.
    4. Fiber resolution targets (FiRsT) , Invention disclosure in Dec 2021, UK International Patent Application 2309111.9 filed on 16th June 2023.

    PhD Thesis:  Ghosh, B. , 2021. Evaluating Fibrosis Linked With Wound Healing and Cancer Using Biophotonics and Biomechanics Based Applications (Doctoral dissertation, IIT Kharagpur).

    https://shodhganga.inflibnet.ac.in/handle/10603/429358

    Research interests

    Key words: Optical imaging, cancer, fibrosis, 3D in vitro disease models, biomaterial, mechanobiology, medical image analysis. 

    Skills :  Histology, Advanced Light Microscopy, Fluorescence microscopy - Fluorescence microscopy, Immunofluorescence, Molecular Cell Biology, Digital Image Analysis, Comsol Multiphysics, MATLAB, Cell Culture, Hydrogel, Confocal Microscope, FTIR - Fourier transform infrared spectroscopy, Label-free imaging, Laboratory Animals, Optical Coherence Tomography, Atomic Force Microscopy, Nanoindentation, Ultrasound imaging.  

    ResearchGate
    ORCID: https://orcid.org/0000-0003-1309-1661

    Member of research group / centre

    Photonics    Norsk innhold
    Teknologibygget Tromsø 3.066


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