Antibiotics, Population Biology, Biochemistry, Pharmacology, Tuberculosis, Infectious Diseases,Public Health, Mathematical Modelling

• Phage therapy, phage–bacteria evolutionary ecology, phage resistance evolution, evolutionary biology, and microbial ecology.

• Acinetobacter baumannii as both an opportunistic pathogen and model organism for studying how bacteria evolve resistance to phages.

• Phage biology, with a focus on lytic phages and in particular the phage I discovered during my postdoc in the US: Mystique.

JOB DESCRIPTION

Trude Anderssen is affiliated with the Natural Products and Medicinal Chemistry Research Group and teaches at various chemistry-related laboratory courses for pharmacy students. She provides in-house training in HSE for new students/employees at the research group.

RESEARCH INTERESTS

She assists on various research projects, including toxicity testing of synthesis products.

TEACHING

Teaches laboratory courses in the following subjects:

FAR-1302 Pharmaceutical Organic Chemistry
FAR-2301 Medicinal chemistry and natural products chemistry
FAR-2302 Pharmaceutical analysis

Bergmo is working as a senior researcher at the Norwegian Centre for E-health Research. She has a Master in Economics and a PhD i Health Service Research. Her research field is e-health and digital health services and her main competence is health economics and implementation science. She is currently involved in digital medicines mangement projects within e-prescribing and shared medication lists across the levels of care.

JOB DESCRIPTION

Agnethe Hansen Bæverud is a Researcher in the Natural Products and Medicinal Chemistry Research Group at the Department of Pharmacy at UiT The Arctic University of Norway. Her research projects are focused on exploiting the potential of marine resources as a solution to sustainable value creation in industrial waste management, with the overall scope of green, circular economy. Her work contributions include analysis of biomolecule composition through global/targeted metabolomics/lipidomics.

RESEARCH INTERESTS

1) Analysis of marine organisms

2) Pigment analysis

2) Global/targeted metabolomics and lipidomics

3) Method development for LC- and GC-MS/MS analyses

RESEARCHGATE: Agnethe Bæverud

ORCID: Agnethe Bæverud

ONGOING RESEARCH PROJECTS:

BMFishFeed – Development of a bacterial meal with a tailored high-lipid content for use as feed additive in aquaculture

EKSAM - Ekstraksjon av Antioksidanter i Marine Alger (Extraction of antioxidants from marine algae)

PHYSIS - Preliminary Mapping of Phytohormones in Cultivated Brown Algae for the Development of Sustainable biostimulants

TEACHING:

Master level:

FAR-3312 Advanced Practical Analytical Chemistry - Lab course

FAR-3301 Advanced Pharmaceutical Chemistry - Lab course 

Contact:

Position: Researcher

E-mail: Agnethe.h.baverud@uit.no

Work phone: +47 77 64 51 17

Solid tumors create a distinctive acidic microenvironment due to their rapid growth and altered metabolic processes. This acidosis is a critical component of tumor biology with a pH range between  6,5 - 6,9, influencing cancer progression and therapy response. This PhD study is dedicated to unraveling the complexities of tissue acidosis and its specific implications on epithelial cancer cells.

Key Research Objectives:

1. Acidosis Characterization: Investigate and characterize the effects of acidic microenvironment in solid tumors, on a panel of epithelial cancer cells. 

2. Cellular Responses: Delve into the molecular and functional responses of epithelial cancer cells to tissue acidosis. This will involve studying changes in gene expression, protein function, and alterations in cellular behavior under acidosis conditions.

3. Tumor Progression: Examine the role of tissue acidosis in various facets of tumor progression, including cell proliferation, invasion, and resistance to therapies. Understand how acidosis contributes to the aggressiveness of epithelial cancers.

4. Therapeutic Insights: Explore potential strategies for exploitning the acidic tumor microenvironment, with the aim of enhancing cancer treatment outcomes. 

The main focus of my research is permeability of drug through and into different absorption barriers, both in respect of understanding the mechanisms and factors affecting the permeability of compounds, and means to improve the permeability through use of advanced delivery systems. I have, in particular, experience with Advanced nanoparticulate drug delivery systems mainly for poorly soluble drugs as well as use of liposomes as model for cell membranes in interactions with peptides and proteins. My expertise thus spans from development of models for permeability screening as well as estimation of permeability of drugs and drug candidates, formulation of poorly soluble drugs,  characterization of nanoparticulate delivery systems, biopharmaceutical characterisation of delivery systems (cell toxicity and permeability) to in vivo biodistribution studies in mouse models. Administration sites in focus have been the intestine, vagina, and skin, but I have also experience with parenteral formulations for tumour targeted delivery.

 List of areas of research interests:

• Permeability through biological barriers (watch movie to learn more).
• The phospholipid vesicle-based permeation assay (PVPA)
• Liposomes as drug carriers
• Liposomes as model systems for cells and bacteria in interaction studies
• Delivery of lipophilic drug compounds

Dissemination to sosiety availeble online

Sjekk datoen

Forskningspodcast fra UiT Norges arktiske universitet

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