Marbio – an analytical platform for natural products

Marbio is an analytical platform at the University of Tromsø - for screening, isolation and identification of bioactive natural products / molecules.

Marbio prepares and screens fraction libraries from extracts provided by Marbank and provides technology and competence within the area of high-throughput screening and natural products drug discovery. The workflow in Marbio relies heavily on automation of sample handling, preparation and analysis, and this is true for all the three workstations; purification, bioactivity screening and identification.

The tight integration of robust screening assays, early identification of known compounds and bioassay-guided purification of novel bioactive compounds is of great advantage.

Infrastructure

  • Autopurification HPLC (isolation of natural products)
  • High-resolution MS (dereplication)
  • Biomek minicore system (liquid handler, CO2 incubator, plate washer, barecode reader, plate reader, shakers, integrated with SCARA)
  • Biomed3000 (antimicrobial screening)
  • Precison liquid handler (kinase screening)
  • Envision Alphascreen multimode detector
  • High-resolution MS-MS and ion mobility (dereplication)
  • Liquid hander/ plate reader

The Marbio screening program: 

  • Antibacterial
  • Anticancer
  • Immunostimulants
  • Anti-inflammatory activities
  • Antioxidants
  • Diabetes

 

 

SCARA robot at Marbio Foto: Jeanette H Andersen

 

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