Marbio prepares and screens fraction libraries from extracts provided by Marbank and provides technology and competence within the area of high-throughput screening and natural products drug discovery. The workflow in Marbio relies heavily on automation of sample handling, preparation and analysis, and this is true for all the three workstations; purification, bioactivity screening and identification.

The tight integration of robust screening assays, early identification of known compounds and bioassay-guided purification of novel bioactive compounds is of great advantage.

Infrastructure

• Autopurification HPLC (isolation of natural products)
• High-resolution MS (dereplication)
• Biomek minicore system (liquid handler, CO2 incubator, plate washer, barecode reader, plate reader, shakers, integrated with SCARA)
• Biomed3000 (antimicrobial screening)
• Precison liquid handler (kinase screening)
• Envision Alphascreen multimode detector
• High-resolution MS-MS and ion mobility (dereplication)
• Liquid hander/ plate reader