Marbio prepares and screens fraction libraries from extracts provided by Marbank and provides technology and competence within the area of high-throughput screening and natural products drug discovery. The workflow in Marbio relies heavily on the automation of sample handling, preparation and analysis, and this is true for all the three workstations; purification, bioactivity screening and identification.

The tight integration of robust screening assays, early identification of known compounds and bioassay-guided purification of novel bioactive compounds is of great advantage.

Infrastructure

• Autopurification HPLC (isolation of natural products)
• High-resolution MS (dereplication)
• Biomek minicore system (liquid handler, CO2 incubator, plate washer, barecode reader, plate reader, shakers, integrated with SCARA)
• Biomed3000 (antimicrobial screening)
• Precison liquid handler (kinase screening)
• Envision Alphascreen multimode detector
• High-resolution MS-MS and ion mobility (dereplication)
• Liquid hander/ plate reader
• Q-Pix colony picker