Projects

1. Project title: Microalbuminuria; Importance for cardiovascular disease, renal function and the metabolic syndrome. Project leader: Ingrid Toft. Principle investigators: Trond Jenssen, Marit Solbu og Jens Kronborg. Time period: 2005-2012

Brief description: Low-grade urinary albumin excretion (UAE) as predictor of all-cause mortality, development of cardiovascular disease and implications of the metabolic syndrome.

2. Project-title: Mikroalbuminuria and the development of dementia and MRI-verifified changes in brain structures.  Projekt leader: Henrik Schirmer. Principal inverstigators: Sigbjørn Rogne og Marit Solbu. Time period: 2010 -2013

3. Project title: Glomerular filtration rate (GFR), blood pressure and cardiovascular risk factors in the general population (PhD project Ulla Dorte Mathisen, started January 2008). Project leader: Bjørn Odvar Eriksen.  Principal investigator: Ulla Dorte Mathisen. Time period: 2008 - 2011

Brief description: Study of the relationship between ambulatory blood pressure measurement, cardiovascular risk factors and renal function measured according to the gold standard iohexol-clearance, in 1600 persons recruited from the Tromsø 6-study. (the RENIS-T6 study).

4. Project title: Chronic kidney disease and hyperfiltration. Project leader: Bjørn Odvar Eriksen. Principal investigator: Toralf Melsom (PhD project) Time period 2008-2012.

Brief description: It is assumed that conditions like the metabolic syndrome, overweight, or hyperinsulinemia may lead to abnormal high GFR, so-called hyperfiltration. Hyperfiltration will eventually cause renal damage and development of chronic kidney disease. In the hyperfiltration project of the RENIS-T6 study, iohexol-clearance was measured in 1600 participants from the Tromsø-6 study. Pathophysiological processes related to hyperfiltration are investigated. 

5. Project title: The metabolic heart.  Project leaders: Ingrid Toft / Henrik Schirmer.

Principal investigator: Benthe Bryhni. Time period: 2009-2013

Brief description: Studies of the importance of metabolic disturbances such as increment in BMI, HbA1c, hyperproinsulinemia, elevated proinsulin/insulin ratio or high insulin/glukose ratio, for the myocardial left ventricular mass, atrial size, myocardial function, and cardiovascular morbidity and mortality. Prospective cohort-study of persons who underwent echocardiography in Tromsø 4, 5 and 6 studies.

6. Project title: Cystatin C-based measurement of renal function as predictor of cardiovascular risk in the general population. Project leader: Ingrid Toft.  Principal investigator: Ingrid Toft. Time period: 2008-2012

Brief description: Low-grade renal dysfunction is associated with increased cardiovascular risk. Cystatin C is believed to be a more sensitive marker of early renal injury than creatinine. This project compares the predictive value of cystatin C-based and creatinine-based measurement of renal function.

7. Project title: Validation of different formulas to calculate the GFR, based on serum cystatin C concentration. The RENIS-T6 study.  Project leader:: Bjørn Odvar Eriksen. Principal investigator: Bjørn Odvar Eriksen. Time period: 2009 -2011

8. Project title:  Uric acid: Importance for heart and kidney disease. Project leader: Trond Jenssen. Investgators:: Hilde Storhaug / Svetlana Zykova, Kirsti Ytrehus / Monica Bivol / Ingrid Toft / Sarah White / Professor Steve Chadban (Sydney, Australia). Time period: 2009 - 2015

Brief description: The role of uric acid in the development of cardiovascular and renal disease, onset of hypertension and myocardial dysfunction. Longitudinal studies of cohorts from Australia and Tromsø, as well as clinical RCT`s and animal experimental studies.

 9. Project title:  ”Renal oromucosoid excretion, a marker of  glomeruar permeability.

Project leader: Jens Kronborg. Principal investigators: Jens Kronborg / Erik Vitinghus (Randers, Danmark).  Time period: 2011 -2015

Brief description: Relationhip between GFR and renal excretion of orosomucoid, albumin, alpha-1-microglobulin, beta-2-microglobulin, transferring and IgG. Association with metabolic disturbances and the development of cardiovascular disease. Urine samples from 3 consecutive day from 7000 participants of the Tromsø 6 study.

10. Project title:  Renal excretion of the intracellular enzyme N-acetyl glucosamidase (NAG), a marker of tubular dysfunction; Predictive value of NAG excretion for future change in renal function and the development of cardiovascular disease. Project leader: Ingrid Toft.

Principal investigators: Ingrid Toft  /Trond Jenssen. Time period : 2009 – 2012.

Brief description:  Ischemic or toxic damage of the renal tubulus cells causes leakage of the intracellular enzyme NAG into the urine. Tubulus cells are very sensitive to chronic ischemia as theses cells are energy demanding with high mitochondrial density. In addition, tubulus cells are supplied with oxygen-poor blood due to the double capillary system of the nephron. Thus, early changes in the microvasculature may result in a leakage of NAG into the urine. In the present project, we examine the association of NAG-excretion in the Tromsø 4 study (1994/95) and change in renal function / development of cardiovascular disease 5 and 13 years later.

11. Project title:  Healing of diabetic wounds. Projekt leader: Trond Jenssen. Principal investigator: Margrete Berdal. Time aspect:  2010-2011

Brief description:  Experimental studies on the healing diabetic wounds in diabetic db/db mouse. Beneficial effects of interventions such as insulin treatment, macrophage stimulation with β-1,3-D polyglucanes, and different growth factors.

12. Project title: Ultrastructural and molecular analyses of human kidney biopsies: Intervention trial on uric acid nephropathy. Project leader: Trond Jenssen.

Brief description:  Renal transplant patients have increased uric acid levels and high CV risk. In a RCT with 25 renal transplant patients treated with allopurinol and 25 on placebo (total: n=50), graft biopsies will be obtained before inclusion and at the end of the study (after 3 years).The biopsies will be analyzed by standard light microscopy as well as immunogold electrone microscopy to obtain quantitative measurements of glomerular and tubular structures.

 

Others

Members of the Metabolic and Research Group have supervised several medical students on student research student projects.

Professor Trond Jenssen has written the Norwegian Textbook in Nephrology used by the medical students during their medical training together with Anders Hartmann and Joar Julsrud: Hartmann A, Jenssen T, Julsrud J: Nyremedisin - En praktisk veileder. 2. edition. Gyldendal Akademisk, ISBN 978-82-05-38486-6, Oslo 2008, S 1-268.

He has also contributed with several chapters in the textbook “Lærebok for sykepleiere” Gyldendal Akademiske:

Sykdomslære diabetes, Sykdomslære transplantasjon, Undersøkelse diabetes

As well as Medisinsk lærebok for laboratoriepersonell (1 chapter). Stokke O (Ed.):

Jervell J, Jenssen T: Diabetes mellitus.