DDH (Developmental dysplasia of the hip) is the underlying cause in nearly 30% of those < 40 years of age, having a hip replacement due to osteoarthritis. We are following 2400 Norwegian adolescents born in 1988-90 whose hip shape was measured by ultrasound as babies and by radiographs at skeletal maturity. Further, we have secured genetic material from 1800 of these.
The project draws on an unique expertise and knowledge from our partners in London; Prof Carol Dezateux, director at the MRC Centre of Epidemiology for Child Health, London together with statistician Francesco Sera, Consultant Paediatric Orthopaedic Surgeons D. Eastwood and Andreas Roposch, Great Ormond Street Hospital, London and Dr Hans Kristian Blom, Kongsberg sh. A biobank including genetic material has been established in Manchester (Prof Bill Ollier). Rosendahl is the Norwegian PI in these follow-up studies.
Dr. Laborie was awarded a post-doc post (HelseVest) 50% 2017-23, and will, together with Dr Kaya Jacobsen, PhD, lead on the project "Pathway analysis: characterizing biological mechanisms underlying developmental hip dysplasia at skeletal maturity in the Bergen Birth Hip Cohort". Dr Kaya Jacobsen, currently working at the Department of Orthopedics in Førde, was awarded a prize for best scientific presentation at "Høstmøtene" for both Radiology and Orthopaedics 2019.