Publications

2019

 

  • Helland R, Bjørkeng EK, Rothweiler U, Sydnes MO, Pampanin DM. The crystal structure of haemoglobin from Atlantic cod. Acta Crystallogr F Struct Biol Commun. 2019.


  • Tarnowski K, Klimecka M, Ciesielski A, Goch G, Kulik A, Fedak H, Poznanski J, Lichocka M, Pierechod M, Engh RA, Dadlez M, Dobrowolska G, Bucholc M.Two SnRK2-interacting Calcium Sensor Isoforms Negatively Regulate SnRK2 Activity by Different Mechanisms. Plant Physiol. 2019

  •  Haglund Halsør MJ, Rothweiler U, Altermark B, Uttakleiv Ræder IL. The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer. Acta Crystallographica Section D: Biological Crystallography 2019

 

2018

 

  • Czarna A, Wang J, Zelencova D, Liu Y, Deng X, Choi HG, Zhang T, Zhou W, Chang JW, Kildalsen H, Seternes OM, Gray NS, Engh RA, Rothweiler U. Novel scaffolds for Dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A) inhibitors.J Med Chem. 2018 Sep 3;61(17):7560-7572. doi: 10.1021/acs.jmedchem.7b01847. Epub 2018 Aug 23.PMID:30095246


  • Thakkar BS, Svendsen JSM, Engh RA. Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization. Molecules. 2018 

 

2017

 
  • Thakkar, Balmukund; Albrigtsen, Marte; Svendsen, John Sigurd Mjøen; Andersen, Jeanette Hammer; Engh, Richard Alan. Biofocussed chemoprospecting: An efficient approach for drug discovery. Chemical Biology and Drug Design 2017; Volum 90 (1). ISSN 1747-0277.s 128 - 140.s doi: 10.1111/cbdd.12934.

 

  • Narayanan D, Gani OABSM, Gruber FXE, Engh RA. Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.J Cheminform. 2017 Jul 4;9(1):43. doi: 10.1186/s13321-017-0229-8.

 

  • Woywod C, Gruber FX, Engh RA, Flå T. Dynamical models of mutated chronic myelogenous leukemia cells for a post-imatinib treatment scenario: Response to dasatinib or nilotinib therapy. PLoS One. 2017 Jul 5;12(7):e0179700. doi: 10.1371/journal.pone.0179700. eCollection 2017.

     

  • Tuveng TR, Rothweiler U, Udatha G, Vaaje-Kolstad G, Smalås A, Eijsink VGH. Structure and function of a CE4 deacetylase isolated from a marine environment. PLoS One. 2017 Nov 6;12(11):e0187544. doi: 10.1371/journal.pone.0187544. eCollection 2017.

 

  • Thakkar, Balmukund; Albrigtsen, Marte; Svendsen, John Sigurd Mjøen; Andersen, Jeanette Hammer; Engh, Richard Alan. Biofocussed chemoprospecting: An efficient approach for drug discovery. Chemical Biology and Drug Design 2017. ISSN 1747-0277.s doi: 10.1111/cbdd.12934.


  • Thakkar BS, Svendsen JM, Engh RA. Cis/Trans Isomerization in Secondary Amides: Reaction Paths, Nitrogen Inversion, and Relevance to Peptidic Systems. J Phys Chem A. 2017 

 

2016

  • Rothweiler, Ulli; Stensen, Wenche; Brandsdal, Bjørn Olav; Isaksson, Johan; Leeson, Frederick Alan; Engh, Richard Alan; Svendsen, John Sigurd Mjøen. Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules. Journal of Medicinal Chemistry 2016; Volum 59 (21). ISSN 0022-2623.s 9814 - 9824.s doi: 10.1021/acs.jmedchem.6b01086.

 

  • Ivan, Taavi; Enkvist, Erki; Viira, Birgit; Manoharan, Ganesh babu; Raidaru, Gerda; Pflug, Alexander; Alam, Kazi Asraful; Zaccolo, Manuela; Engh, Richard Alan; Uri, Asko. Bifunctional ligands for inhibition of tight-binding protein-protein interactions. Bioconjugate chemistry 2016; Volum 27 (8). ISSN 1043-1802.s 1900 - 1910.s doi: 10.1021/acs.bioconjchem.6b00293.

2015

  • Rothweiler, Ulli; Eriksson, Jonas; Stensen, Wenche; Leeson, Frederick Alan; Engh, Richard Alan; Svendsen, John Sigurd. Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors. European Journal of Medicinal Chemistry 2015; Volum 94. ISSN 0223-5234.s 140 - 148.s doi: 10.1016/j.ejmech.2015.02.035.

 

  • Lauber, Birgit S.; Hardegger, Leo A.; Alam, Kazi Asraful; Lund, Bjarte Aarmo; Dumele, Oliver; Harder, Michael; Kuhn, Bernd; Engh, Richard Alan; Diederich, François. Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic. Chemistry - A European Journal 2015; Volum 22 (1). ISSN 0947-6539.s 211 - 221.s doi: 10.1002/chem.201503552.

 

  • Gani, Osman A.B.S.M.; Thakkar, Balmukund; Narayanan, Dilip; Alam, Kazi Asraful; Kyomuhendo, Peter; Rothweiler, Ulli; Tello-Franco, Veronica; Engh, Richard Alan. Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches. Biochimica et Biophysica Acta - Proteins and Proteomics 2015; Volum 1854 (10). ISSN 1570-9639.s 1605 - 1616.s doi: 10.1016/j.bbapap.2015.05.004.

 

  • Martin, Eric; Knapp, Stefan; Engh, Richard Alan; Moebitz, Henrik; Varin, Thibault; Roux, Benoit; Meiler, Jens; Berdini, Valerio; Baumann, Alexander; Vieth, Michal. Perspective on computational and structural aspects of kinase discovery from IPK2014. Biochimica et Biophysica Acta - Proteins and Proteomics 2015; Volum 1854 (10). ISSN 1570-9639.s 1595 - 1604.s doi: 10.1016/j.bbapap.2015.03.014.

 

  • Alexeeva, Marina; Åberg, Espen; Engh, Richard Alan; Rothweiler, Ulli. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 1207 - 1215.s doi: 10.1107/S1399004715005106.

2014

  • Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S.. Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (11). ISSN 0907-4449.s 3043 - 3056.s doi: 10.1107/S1399004714021099.

 

  • Illert, Anna L; Seitz, Anna K.; Rummelt, Christoph; Kreutmair, Stefanie; Engh, Richard Alan; Goodstal, Samantha; Peschel, Christian; Duyster, Justus; von Bubnoff, Nikolas. Inhibition of aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and aurora kinases R763/ AS703569 and PHA-739358 in BCR-ABL transformed cells. PLoS ONE 2014; Volum 9 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0112318.

2013

  • Gani, Osman A.B.S.M.; Narayanan, Dilip; Engh, Richard Alan. Evaluating the Predictivity of Virtual Screening for Abl Kinase Inhibitors to Hinder Drug Resistance. Chemical Biology and Drug Design 2013; Volum 82 (5). ISSN 1747-0277.s 506 - 519.s doi: 10.1111/cbdd.12170.

2012

  • Åberg, Espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli; Oliveira, Taiana Maia De; Engh, Richard Alan. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry (Print) 2012; Volum 393 (10). ISSN 1431-6730.s 1121 - 1129.s doi: 10.1515/hsz-2012-0248.

 

  • Østnes Hanssen, Kine; Andersen, Jeanette hammer; Stiberg, Trine; Engh, Richard Alan; Svenson, Johan; Genevière, Anne-Marie; Hansen, Espen. Antitumoral and Mechanistic Studies of Ianthelline Isolated from the Arctic Sponge Stryphnus fortis. Anticancer Research 2012; Volum 32 (10). ISSN 0250-7005.s 4287 - 4297.

 

  • Pflug, Alexander; Johnson, Kenneth; Engh, Richard Alan. Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2012; Volum 68. ISSN 1744-3091.s 873 - 877.s doi: 10.1107/S1744309112028655.

2011

  • von Bubnoff, N.; Gorantla, S.P.; Engh, Richard Alan; Oliveira, Taiana Maia De; Thöne, S.; Åberg, Espen; Peschel, C.; Duyster, J.. The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro. Oncogene 2011; Volum 30 (8). ISSN 0950-9232.s 933 - 943.s doi: 10.1038/onc.2010.476.

 

  • Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; Von der Saal, W; Limberg, A; Georges, G; Engh, Richard Alan; Goller, B; Rueger, P; Rueth, M. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. Journal of Medicinal Chemistry 2011; Volum 54 (1). ISSN 0022-2623.s 312 - 319.s doi: 10.1021/jm101346r.

 

  • Kancha, Rama Krishna; von Bubnoff, Nikolas; Bartosch, Natalie; Peschel, Christian; Engh, Richard Alan; Duyster, Justus. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS ONE 2011; Volum 6(10):e26760. ISSN 1932-6203.s doi: 10.1371/journal.pone.0026760.

 

  • Pflug, Alexander; Oliveira, Taiana Maia De; Bossemeyer, Dirk; Engh, Richard Alan. Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase. Biochemical Journal 2011; Volum 440. ISSN 0264-6021.s 85 - 93.s doi: 10.1042/BJ20110592.

 

  • Rothweiler, Ulli; Åberg, Espen; Johnson, Kenneth; Hansen, Tom Egil; Jørgensen, Jorunn B; Engh, Richard Alan. p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation. Journal of Molecular Biology 2011; Volum 411 (2). ISSN 0022-2836.s 474 - 485.s doi: 10.1016/j.jmb.2011.06.013.

  • Orth, Michael; Mayer, Bernd; Rehm, Kinga; Rothweiler, Ulli; Heidmann, Doris; Holak, Tad A; Stemmann, Olaf. Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO Journal 2011; Volum 30 (14). ISSN 0261-4189.s 2868 - 2880.

 

  • Oliveira, Taiana Maia De; Ahmad, Rafi; Engh, Richard Alan. VX680 Binding in Aurora A: pi-pi Interactions Involving the Conserved Aromatic Amino Acid of the Flexible Glycine-Rich Loop. Journal of Physical Chemistry A 2011; Volum 115 (16). ISSN 1089-5639.s 3895 - 3904.s doi: 10.1021/jp108286r.

2010

  • Pflug, Alexander; Rogozina, Jevgenia; Lavogina, Darja; Enkvist, Erki; Uri, Asko; Engh, Richard Alan; Bossemeyer, Dirk. Diversity of Bisubstrate Binding Modes of Adenosine Analogue-Oligoarginine Conjugates in Protein Kinase A and Implications for Protein Substrate Interactions. Journal of Molecular Biology 2010; Volum 403 (1). ISSN 0022-2836.s 66 - 77.s doi: 10.1016/j.jmb.2010.08.028.

 

  • Gani, Osman A.B.S.M.; Engh, Richard Alan. Protein kinase inhibition of clinically important staurosporine analogues. Natural product reports (Print) 2010; Volum 27 (4). ISSN 0265-0568.s 489 - 498.s doi: 10.1039/b923848b.

2009

  • von Bubnoff, N; Engh, Richard Alan; Åberg, Espen; Sanger, J; Peschel, C; Duyster, J. FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro. Cancer Research 2009; Volum 69 (7). ISSN 0008-5472.s 3032 - 3041.s doi: 10.1158/0008-5472.CAN-08-2923.

2008

  • Engh, Richard Alan. Protein kinase inhibitors highlight the complexities of drug-target non-covalent interactions. Biotechnology & Biotechnological Equipment (Sofia) 2008; Volum 22. ISSN 1310-2818.s 772 - 777.

  • Rothweiler, Ulli; Czarna, Anna Lucja; Krajewski, Marcin; Ciombor, Jolanta; Kalinski, Cédric; Khazak, Vladimir; Ross, Günther; Skobeleva, Natalia; Weber, Lutz; Holak, Tad A. Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction. ChemMedChem 2008. ISSN 1860-7179.

 

  • Rothweiler, Ulli; Czarna, Anna Lucja; Weber, Lutz; Popowicz, Grzegorz; Brongel, Kinga; Kowalska, Kaja; Orth, Michael; Stemmann, Olaf; Holak, Tad A. NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins. Journal of Medicinal Chemistry 2008. ISSN 0022-2623.

2007

  • Krajewski, Marcin; Rothweiler, Ulli; D'Silva, Loyola; Majumdar, Sudipta; Klein, Christian; Holak, Tad A. An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments. Journal of Medicinal Chemistry 2007. ISSN 0022-2623.

 

  • Popowicz, Grzegorz; Czarna, Anna Lucja; Rothweiler, Ulli; Szwagierczak, Aleksandra; Krajewski, Marcin; Weber, Lutz; Holak, Tad A. Molecular Basis for the Inhibition of p53 by Mdmx. Cell Cycle 2007. ISSN 1538-4101.

2005

  • D'Silva, Loyola; Ozdowy, Przemyslaw; Krajewski, Marcin; Rothweiler, Ulli; Singh, Mahavir; Holak, Tad A. Monitoring the Effects of Antagonists on Protein−Protein Interactions with NMR Spectroscopy. Journal of the American Chemical Society 2005. ISSN 0002-7863.

 

  • Krajewski, Marcin; Ozdowy, Przemyslaw; D'Silva, Loyola; Rothweiler, Ulli; Holak, Tad A. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nature Medicine 2005. ISSN 1078-8956.