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Bilde av Larsen, Anett Kristin
Bilde av Larsen, Anett Kristin
Associate professor Department of Medical Biology anett.k.larsen@uit.no +4777625212 +47 95803933 You can find me here

Anett Kristin Larsen

Job description

Anett is an Associate Professor at the Department of Medical Biology. She is teaching Pharmacology to Master students in Biomedicine, Odotology students and Medical students, as well as Veterinary microbiology to Pharmacology students, in addition to supervising both bachelor-, master- and PhD-students. Her main research interests are liver physiology, infection biology and host-microbial interactions.

  • Javier Sánchez Romano, Jaione Simon-Santamaria, Peter Anthony McCourt, Bård Helge Smedsrød, Kim Erlend Mortensen, Antonia Sagona et al.:
    Liver sinusoidal cells eliminate blood-borne phage K1F
    mSphere 2024 ARKIV / DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
    Frontiers in Cellular and Infection Microbiology 2023 ARKIV / DOI
  • Elisabeth Holen, Marit Espe, Anett Kristin Larsen, Pål Asgeir Olsvik :
    Dietary chlorpyrifos-methyl exposure impair transcription of immune-, detoxification- and redox signaling genes in leukocytes isolated from cod (Gadus morhua)
    Fish and Shellfish Immunology 2022 ARKIV / DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo Gøran Ericzon, Kim Erlend Mortensen, Peter Anthony McCourt et al.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 ARKIV / DOI
  • Sabin Bhandari, Anett Kristin Larsen, Peter Anthony McCourt, Bård Smedsrød, Karen Kristine Sørensen :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. October 2021 ARKIV / DOI
  • Javier Sanchez Romano, Karen Kristine Sørensen, Anett Kristin Larsen, Torill Mørk, Morten Tryland :
    Ocular Histopathological Findings in Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) with Infectious Keratoconjunctivitis after Experimental Inoculation with Cervid Herpesvirus 2
    Viruses 2020 FULLTEKST / ARKIV / DOI
  • Pål Asgeir Olsvik, Anett Kristin Larsen, Marc Berntssen, Anders Goksøyr, Odd Andre Karlsen, Fekadu Yadetie et al.:
    Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms
    Frontiers in Genetics 2019 ARKIV / DOI
  • Ingebjørg Helena Nymo, Rolf Rødven, Kimberlee B. Beckmen, Anett Kristin Larsen, Morten Tryland, Lori Quakenbush et al.:
    Brucella antibodies in alaskan true seals and eared seals — two different stories
    Frontiers in Veterinary Science 2018 ARKIV / DOI
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Karen Kristine Sørensen, Marit Seppola, Rolf Rødven, María Pilar Jiménez de Bagüés et al.:
    Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod
    Frontiers in Microbiology 2018 ARKIV / DOI
  • Ingebjørg Helena Nymo, Marit Seppola, Al Dahouk Sascha, Katrine Ryvold Arnesen Bakkemo, María Pilar Jiménez de Bagüés, Jacques Godfroid et al.:
    Experimental challenge of atlantic cod (Gadus morhua) with a brucella pinnipedialis strain from hooded seal (Cystophora cristata)
    PLOS ONE 2016 ARKIV / DOI
  • Anett Kristin Larsen, Jacques Godfroid, Ingebjørg Helena Nymo :
    Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells
    Acta Veterinaria Scandinavica (AVS) 2016 ARKIV / DOI
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Ole Morten Seternes, Berit Bang :
    Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549)
    Toxicology and industrial health 2016 ARKIV / DOI
  • Jacques Godfroid, Xavier De Bolle, R. Martin I.I. Roop, David O'Callaghan, Renée M. Tsolis, Cynthia L. Baldwin et al.:
    The quest for a true One Health perspective of brucellosis
    Revue scientifique et technique - Office international des épizooties 2014 ARKIV
  • Ingebjørg Helena Nymo, Morten Tryland, Kjetil Åsbakk, Jacques Godfroid, Anett Kristin Larsen :
    Brucella-infeksjoner hos sjøpattedyr - fortsatt ubesvarte spørsmål
    Norsk veterinærtidsskrift 2014
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Jan-Olof Winberg, Ole Morten Seternes, Berit Bang :
    Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line
    Food and Chemical Toxicology (FCT) 2014 DOI
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Preben Boysen, Morten Tryland, Jacques Godfroid :
    Entry and Elimination of Marine Mammal Brucella spp. by Hooded Seal (Cystophora cristata) Alveolar Macrophages In Vitro
    PLOS ONE 2013 DOI
  • Anett Kristin Larsen, kurt Kristiansen, Ingebrigt Sylte, Ole Morten Seternes, Berit Bang :
    Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin
    BMC Research Notes 2013 ARKIV / DOI
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Benjamin Briquemont, Karen Kristine Sørensen, Jacques Godfroid :
    Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells
    PLOS ONE 2013 ARKIV / DOI
  • Ingebjørg Helena Nymo, Jacques Godfroid, Kjetil Åsbakk, Anett Kristin Larsen, Carlos G Das Neves, Rolf Rødven et al.:
    A protein A/G indirect enzyme-linked immunosorbent assay for the detection of anti-Brucella antibodies in Arctic wildlife
    Journal of Veterinary Diagnostic Investigation 2013 DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, Hideki Kishimura, Galina N Rudenskaya, Berit Bang :
    Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling
    Toxicological & Environmental Chemistry 2011 ARKIV / DOI
  • Berit Bang, Merethe Larsen, Anett Kristin Larsen, lisbeth Aasmoe :
    Proteases from Salmon Stimulate IL-8 in Airway Epithelial Cells
    Journal of Toxicology and Environmental Health, Part A 2009 DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, lisbeth Aasmoe, Berit Bang :
    Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2
    Toxicology and Applied Pharmacology 2008 DOI
  • Anett Kristin Larsen, Elisabeth Holen, Helmut Segner :
    Editorial: Immunity and disease of aquatic organisms under the combined impact of anthropogenic stressors: mechanisms and disease outcomes
    Frontiers in Marine Science 2023 DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
    2023
  • Javier Sanchez Romano, Jaione Santamaria Simon, Peter Anthony Gerard Mccourt, Christopher Florian Holte, Bård Smedsrød, Antonia Sagona et al.:
    Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Ingelin Kyrrestad Karlstrøm, Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Ruomei Li, Karen Kristine Sørensen :
    Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
    2023
  • Ingelin Kyrrestad, Javier Sanchez Romano, Anett Kristin Larsen, Ruomei Li, Jaione Simon-Santamaria, Kenneth Bowitz Larsen et al.:
    Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Simon-Santamaria, Kim Erlend Mortensen, Bo Gøran Ericzon, Peter Anthony McCourt et al.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Eirik Abrahamsen Lænsman, Anne Lotte Vada Hatlegjerde, Jaione Simon-Santamaria, Kim Erlend Mortensen et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Pål Asgeir Olsvik, Anett Kristin Larsen, Marc Berntssen, Anders Goksøyr, Odd Andre Karlsen, Fekadu Yadetie et al.:
    Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Conference talk
    2019
  • Javier Sanchez Romano, Morten Tryland, Ingebjørg Helena Nymo, Anett Kristin Larsen, Karen Kristine Sørensen :
    Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus
    UiT Norges arktiske universitet 2019
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo G. Ericzon, Bård Smedsrød, Karen Kristine Sørensen :
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    2019
  • Pål Asgeir Olsvik, Anett Kristin Larsen, Marc Berntssen, Anders Goksøyr, Odd Andre Karlsen, Monica Sanden et al.:
    Agricultural pesticides in aquafeeds might harm wild fish feeding on leftover pellets near fish farms.
    2019
  • Javier Sanchez Romano, Anett Kristin Larsen, kjetil helge Elvevold, Christopher Florian Holte, Jaione Simon-Santamaria, Hans H. Hirsch et al.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Jacques Godfroid, Ingebjørg Helena Nymo, Anett Kristin Larsen, Kjetil Åsbakk, Terje D. Josefsen :
    Meldepliktige sykdommer hos rein
    Norsk veterinærtidsskrift 2014
  • Ingebjørg Helena Nymo, Morten Tryland, Jacques Godfroid, Anett Kristin Larsen, Elisabeth Lie, Jean-Jacques Letesson :
    Brucella pinnipedialis in hooded seals (Cystophora cristata): infection biology and effect of PCB 153 exposure under experimental conditions
    2013
  • Kimberly Beckmen, Ingebjørg Helena Nymo, Morten Tryland, Kjetil Åsbakk, Anett Kristin Larsen, Jacques Godfroid et al.:
    Spatio-temporal trends in prevalence of anti-Brucella antibodies in barren-ground caribou (Rangifer tarandus granti) in Alaska - an example of enzootic equilibrium
    2013
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Benjamin Briquemont, Karen Kristine Sørensen, Jacques Godfroid :
    Brucella pinnipedialis hooded seal strain in cell models
    2013
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Karen Kristine Sørensen, Morten Tryland, Jacques Godfroid :
    Brucella pinnipedialis hooded seal (Cystophora cristata) strain invades human macrophages in culture
    2012
  • Anett Kristin Larsen, Ingebjørg Helena Nymo, Karen Kristine Sørensen, Preben Boysen, Morten Tryland, Jacques Godfroid :
    Entry of hooded seal (Cystophora cristata) alveolar macrophages by marine Brucella spp
    2012
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells
    2011
  • Anett Kristin Larsen, Berit Bang, Ole Morten Seternes :
    Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
    UiT Norges arktiske universitet 2010
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549)
    2007

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    Research interests

    In the SECVIR project we are investigating the ability of liver endothelial cells to take up and eliminate virus from the blood. The sinusoidal endothelium in liver has evolved into a specialized scavenger endothelium with important functions in host defence, removing large amounts of connective tissue molecules, lipids, other potential dangerous molecules like possibly virus, from the blood. Our main goal is to investigate if different types of virus is eliminated via the liver by these specialized LSEC and hereby increase our understanding of what role these cells play in the body's antiviral defence.

    This work is a very exciting extension of my main research interest which is cellular mechanisms during infectious diseases, including zoonoses. During my Post Doc my main focus was cell biology and immunology in Arctic species, developing infection models in primary cell cultures isolated from wild animals. I am also very interested in the combined effects of climate- and environmental change on health and immune competence.

    Teaching

    MBI-3015: Human pharmacology and toxicology

    ODO-2009: Biomedicine 2

    MED-2510: Medicine, 3rd year students

    FAR-2205: Infection biology and immunology

    HEL-0700: Academic writing in health- and social sciences

    Researcher profile in Cristin
    Registrations in Munin
    ResearchGate
    ORCID: https://orcid.org/my-orcid

    Member of research group

    Vascular Biology   English content Vaskulær biologi   Norsk innhold

    Member of project

    SECVIR

    CV

    2018-present

    Researcher at the Department of Medical Biology, Faculty of Health Sciences, UiT – the Arctic University of Norway, Tromsø, Norway.

    2017-2018     

    Advisor at the Department of Research and Outreach, Faculty of Biosciences, Fisheries, and Economics, UiT – the Arctic University of Norway, Tromsø, Norway.

    2014-2016        

    Post-doctoral researcher at the University of Tromsø (UiT) – the Arctic University of Norway, Department of Arctic and Marine Biology, Research Group of Arctic Infection Biology

    2011-2013        

    Post-doctoral researcher at the Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, Section of Arctic Veterinary Medicine

    2005-2010          

    PhD-position in medical biology at the University Hospital of North Norway, Department of Occupational- and Environmental Medicine, Tromsø. In collaboration with the University of Tromsø, Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, Tromsø, Norway.

    Title: Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells

    2004-2005       

    Inspector at the Norwegian Food Safety Authority, District Office for Salten, Bodø

    2004     

    Veterinarian, small animal clinic – Dyret i Sentrum, Narvik, Norway 

    1998-2004          

    Cand.Med.Vet at the Norwegian School of Veterinary Sciences, Oslo, Norway