Sigrid Kufaas Brækkan
Professor
Job description
Professor , Thrombosis Research Group (TREC)
Vania Maris Morelli,
Omri Snir,
Kristian Dalsbø Hindberg,
Kristian Hveem,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
Blood 2024 DOI
Carl-Arne Arnesen,
Line Holtet Evensen,
Kristian Hveem,
Maiken Elvestad Gabrielsen,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Paul S. de Vries,
Paula Reventun,
Michael R. Brown,
Adam S. Heath,
Jennifer E. Huffman,
Ngoc-Quynh Le
et al.:
A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels
Blood 2024 DOI
Dana Meknas,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Maria A. De Winter,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A. H. Kaasjager
et al.:
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
loannis T. Farmakis,
Stefano Barco,
Lukas Hobohm,
Sigrid Kufaas Brækkan,
Jean M. Connors,
George Giannakoulas
et al.:
Maternal mortality related to pulmonary embolism in the United States, 2003–2020
Steven P. Grover,
Tomohiro Kawano,
Jun Wan,
Pansakorn Tanratana,
Zsofia Polai,
Young J. Shim
et al.:
C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
Oda Leknessund,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
Tobias Frischmuth,
Birgitte Gladsø Tøndel,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
Vårin Eiriksdatter Wikan,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Ellen Elisabeth Brodin,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
Monique J.T. Crobach,
Rayna J.S. Anijs,
Sigrid Kufaas Brækkan,
Marianne T. Severinsen,
Jens Hammerstrøm,
Hanne Skille
et al.:
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
et al.:
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
Steven P. Grover,
Omri Snir,
Kristian Dalsbø Hindberg,
Tatianna M. Englebert,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
et al.:
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
Espen Waage Skjeflo,
Line Holtet Evensen,
Søren Beck Jensen,
Nadezhda Latysheva,
Annika Elisabet Michelsen,
Thor Ueland
et al.:
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
Fridtjof Balteskard Rinde,
Camilla Tøvik Jørgensen,
Heidi Hassel Pettersen,
John Bjarne Hansen,
Waleed Ghanima,
Sigrid Kufaas Brækkan
:
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
Camilla Tøvik Jørgensen,
Sigrid Kufaas Brækkan,
Eli Førsund,
Heidi Hassel Pettersen,
Eirik Tjønnfjord,
Waleed Ghanima
et al.:
Incidence of venous thromboembolism, recurrence, and bleeding after isolated superficial vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
Camilla Tøvik Jørgensen,
Mazdak Tavoly,
Elise Førsund,
Heidi Hassel Pettersen,
Eirik Tjønnfjord,
Waleed Ghanima
et al.:
Incidence of bleeding and recurrence in isolated distal deep vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Pål Aukrust,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
et al.:
Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
Samantha Swamy,
Thor Ueland,
John Bjarne Hansen,
Omri Snir,
Sigrid Kufaas Brækkan
:
Plasma levels of P-selectin and future risk of incident venous thromboembolism
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
et al.:
Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
Omri Snir,
line Wilsgård,
Nadezhda Latysheva,
Casper Ullsten-Wahlund,
Sigrid Kufaas Brækkan,
Kristian Dalsbø Hindberg
et al.:
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
Lisa Jakobsen,
Tobias Frischmuth,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism
Aniket Mishra,
Rainer Malik,
Tsuyoshi Hachiya,
Tuuli Jürgenson,
Shinichi Namba,
Daniel C. Posner
et al.:
Stroke genetics informs drug discovery and risk prediction across ancestries
Christabel Esi Damoah,
Omri Snir,
Kristian Dalsbø Hindberg,
Peter Garred,
Judith K Ludviksen,
Sigrid Kufaas Brækkan
et al.:
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Elias Allarai,
Wei-Hsuan Lee,
Stephen Burgess,
Susanna C. Larsson,
Sara Lindstrom,
Lu Wang
et al.:
Genetically predicted cortisol levels and risk of venous thromboembolism
Line Holtet Evensen,
Carl-Arne Arnesen,
Frits Richard Rosendaal,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem
et al.:
The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Joakim Knutsen Sejrup,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
et al.:
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Venous thromboembolism and risk of depression: a population-based cohort study
Florian Thibord,
Derek Klarin,
Jennifer A. Brody,
Ming-Huei Chen,
Michael G. Levin,
Daniel I. Chasman
et al.:
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Camilla Tøvik Jørgensen,
Mazdak Tavoly,
Heidi Hassel Pettersen,
Eli Førsund,
Christina Roaldsnes,
Magnus Kringstad Olsen
et al.:
The venous thrombosis registry in Østfold Hospital (TROLL registry) - design and cohort description
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Socioeconomic status and risk of incident venous thromboembolism
Journal of Thrombosis and Haemostasis 2021 DOI
Espen Waage Skjeflo,
Sigrid Kufaas Brækkan,
Judith K Ludviksen,
Omri Snir,
Kristian Hindberg,
Tom Eirik Mollnes
et al.:
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Magnus Edvardsen,
Ellen-Sofie Hansen,
Kristian Hindberg,
Vania Maris Morelli,
Thor Ueland,
Pål Aukrust
et al.:
Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid K. Brækkan,
John-Bjarne Hansen
et al.:
Plasma levels of leptin and risk of future incident venous thromboembolism
Magnus Edvardsen,
Kristian Hindberg,
Ellen-Sofie Hansen,
Vania Maris Morelli,
Thor Ueland,
Pål Aukrust
et al.:
Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
Hanne Skille,
Benedikte Paulsen,
Kristian Hveem,
Marianne T. Severinsen,
Maiken Elvestad Gabrielsen,
Søren R. Kristensen
et al.:
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
Gro Grimnes,
Soerajja Bhoelan,
Kristian Hindberg,
Mark Davids,
Max Nieuwdorp,
Tom E. Mollnes
et al.:
Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John-Bjarne Hansen,
Henrik Toft Sørensen
:
Risk of a permanent work-related disability pension after incident venous thromboembolism in Denmark: A population-based cohort study
Carl Arne Løchen Arnesen,
Katalin Veres,
Erzsébet Horváth-Puhó,
John-Bjarne Hansen,
Henrik Toft Sørensen,
Sigrid K. Brækkan
:
Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
Ellen-Sofie Hansen,
Fridtjof Balteskard Rinde,
Magnus Edvardsen,
Kristian Hindberg,
Nadezhda Latysheva,
Pål Aukrust
et al.:
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
et al.:
Galectin-3-binding protein and future venous thromboembolism
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Steven P. Grover,
Sigrid Kufaas Brækkan,
Nigel Mackman,
John Bjarne Hansen
:
“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Linda Sundler Björkman,
Sigrid Kufaas Brækkan,
Bengt Zöller,
John Bjarne Hansen,
Nigel Mackman
:
“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
Journal of Thrombosis and Haemostasis 2023 DOI
Sigrid Kufaas Brækkan
:
Thea (21) fikk blodpropp - etterlyser mer forskning
05. April 2021
Sigrid Kufaas Brækkan
:
Arvelig blodpropp: Dette sier ekspertene om corona-vaksinering
31. March 2021
Sigrid Kufaas Brækkan
:
Haga fikk blodpropp under samling: – Det var et sjokk
16. April 2021
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Research interests
My main research interest is the epidemiology and pathogenesis of venous thromboembolism (VTE). In order to optimize prevention and treatment of the disease, it is crucial to better understand the mechanisms of venous thrombus formation and how risk factors contribute to or interplay in this process.
I have trained as an epidemiologist within the field of thrombosis and hemostasis, and worked with studies on the relationship between arterial and venous thrombosis, life-style factors and VTE, biomarkers for future VTE, cancer-related VTE, as well as complications after VTE.
Publications
>165 original full papers in peer-reviewed journals listed in PubMed. Contributed to more than 200 abstracts presented at and published in conjunction with scientific international meetings/conferences.
Supervision of PhD-students
Completed PhDs: Main supervisor: 4; Co-supervisor: 20
Ongoing PhDs: 4 as main supervisor and 7 as co-supervisor
Other relevant professional experiences
2021-dd Associate Editor in Journal of Thrombosis and Haemostasis (JTH)
2016-2021 Appointed as methodological reviewer in JTH
2016-2018 Member of the junior advisory board for the European Congress on Thrombosis and Haemostasis (ECTH)
Awards
Young Investigator Award ISTH2016 (International Society of Thrombosis and Haemostasis)
Faculty of Health Sciences Young Investigator Award 2017
Member of research group
Member of project
PREVENT
Mission-VTE
Milestone VTE
Genetics and VTE
PEPSI-VTE
Obesity-related VTE
Biomarkers of VTE risk
Diagnostic biomarkers of VTE
Cancer-associated VTE (CAT)
Sex-differences in VTE
Arterial and venous thrombosis
Life-style factors and VTE
VTE recurrence
Hypoxia-dependent proteins and VTE
Epidemiology of VTE
Risk of bleeding after VTE
CV
Academic degree
2010 PhD in Health Sciences, University of Tromsø, Tromsø, Norway
2005 Master of Pharmacy, University of Tromsø, Tromsø, Norway
Previous academic positions
2012-13 Visiting Post Doc, Dep. of Clinical Epidemiology, Leiden University Medical Center
2010-12 Post Doctoral Fellow, Hematological Research Group, University of Tromsø (UiT)
2008-09 Assistant Professor, Department of Pharmacy, UiT
2006-08 PhD Research Fellow, Center for Atherothrombotic Research in Tromsø, UiT
2005-06 Assistant Professor, Department of Pharmacy, UiT
Publications
>165 original full papers in peer-reviewed journals listed in PubMed. Contributed to more than 200 abstracts presented at and published in conjunction with scientific international meetings/conferences.
Awards
Young Investigator Award ISTH2016 (International Society of Thrombosis and Haemostasis)
Faculty of Health Sciences Young Investigator Award 2017
Supervision of PhD-students
Completed PhDs: Main supervisor: 4; Co-supervisor: 20
Ongoing PhDs: 4 as main supervisor and 7 as co-supervisor