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Bilde av Perander, Maria
Bilde av Perander, Maria
Professor Department of Medical Biology maria.perander@uit.no +4777649253 You can find me here

Maria Perander

Job description

Professor at the Department of Medical Biology, RNA and Molecular Pathology group

  • Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Bradley Lorens, Thorarinn Gudjonsson, Gunhild Mari Mælandsmo et al.:
    Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
    Frontiers in Oncology 2023 ARKIV / DOI
  • Christiane Klec, Erik Knutsen, Daniela Schwarzenbacher, Katharina Jonas, Barbara Pasculli, Ellen Heitzer et al.:
    ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform
    Cellular and Molecular Life Sciences (CMLS) 2022 ARKIV / DOI
  • Marta Tellez Gabriel, Xavier Tekpli, Trine M. Reine, Beate Hegge, Stephanie Rose Nielsen, Meng Chen et al.:
    Serglycin is Involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue
    Frontiers in Oncology 14. April 2022 ARKIV / DOI
  • Erik Knutsen, Adrian Harris, Maria Perander :
    Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer
    British Journal of Cancer 2021 ARKIV / DOI
  • Erik Knutsen, Seyed Mohammad Lellahi, Miriam Ragle Aure, Silje Nord, Silje Fismen, Kenneth Bowitz Larsen et al.:
    The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
    Scientific Reports 2020 ARKIV / DOI
  • Marta Tellez Gabriel, Erik Knutsen, Maria Perander :
    Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Seyed Mohammad Lellahi, Ingrid Arctander Rosenlund, Annica Hedberg, Liv Torill Kiær, Ingvild Mikkola, Erik Knutsen et al.:
    The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response
    Journal of Biological Chemistry 2018 ARKIV / DOI
  • Annica Hedberg, Erik Knutsen, Anne Silje Løvhaugen, Tor Erik Jørgensen, Maria Perander, Steinar Daae Johansen :
    Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair
    Mitochondrial DNA. Part A, DNA Mapping, Sequencing, and Analysis 2018 DOI
  • Stine Figenschau, Erik Knutsen, Ilona Urbarova, Christopher Graham Fenton, Bryan Elston, Maria Perander et al.:
    ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes
    Scientific Reports 2018 ARKIV / DOI
  • Skarphedinn Haldorsson, Neha Rohatgi, Manuela Magnusdottir, Kumari Choudhary, Thorarinn Gudjónsson, Erik Knutsen et al.:
    Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition
    Cancer Letters 2017 ARKIV / DOI
  • Maria Perander, Rania Al-Mahdi, Thomas Clemens Jensen, Jennifer Ann Lillebo Nunn, Hanne Kildalsen, Bjarne Herold Johansen et al.:
    Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
    Scientific Reports 2017 ARKIV / DOI
  • Maria Perander, Stephen M Keyse, Ole Morten Seternes :
    New insights into the activation, interaction partners and possible functions of MK5/PRAK
    Frontiers in Bioscience 2016
  • Tonje Fiskaa, Erik Knutsen, Malene Nikolaisen, Tor Erik Jørgensen, Steinar Daae Johansen, maria Perander et al.:
    Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines
    PLOS ONE 2016 ARKIV / DOI
  • Erik Knutsen, maria Perander, Tonje Fiskaa, Steinar Daae Johansen :
    Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research
    Springer 2015 DOI
  • Erik Knutsen, Tonje Fiskaa, anita Ursvik, Tor Erik Jørgensen, maria Perander, Eiliv Lund et al.:
    Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
    PLOS ONE 2013 ARKIV / DOI
  • espen Åberg, Knut Martin Torgersen, Bjarne Herold Johansen, Stephen M Keyse, maria Perander, ole morten Seternes :
    Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif
    Journal of Biological Chemistry 2009 DOI
  • maria Perander, Stephen M Keyse, ole morten Seternes :
    Does MK5 reconcile classical and atypical MAP kinases?
    Frontiers in Bioscience 2008
  • maria Perander, espen Åberg, Bjarne Herold Johansen, Bo Dreyer, Ingrid Jenny Guldvik, heidi Outzen et al.:
    The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5
    Biochemical Journal 2008 DOI
  • espen Michaelsen, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse et al.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
    Journal of Biological Chemistry 2006
  • G Bjørkøy, T Lamark, Andreas Brech, H Outzen, M Perander, A Øvervatn et al.:
    p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Journal of Cell Biology 2005
  • Geir Bjørkøy, Trond Lamark, A Brech, heidi Outzen, maria Perander, Aud Øvervatn et al.:
    p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Journal of Cell Biology 2005
  • Trond Lamark, maria Perander, Heidi Outzen, kurt Kristiansen, Aud Karin Øvervatn, Espen Michaelsen et al.:
    Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.
    Journal of Biological Chemistry 2003 FULLTEKST / DOI
  • Svanhild Nornes, Ingvild Mikkola, Stefan Krauss, Madjid Delghandi, maria Perander, Terje Johansen :
    Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences
    Journal of Biological Chemistry 1996
  • Anne Kristin Mclaren Berge, Kjersti Sellæg, Stine Figenschau, Saikat Das Sajib, Hallvard Lauritz Olsvik, Maria Perander et al.:
    TRIM32 in Head and Neck Cancer
    2023
  • Erik Knutsen, Maria Perander :
    Forhøyede nivåer av NEAT1 er assosiert med HER2 positiv brystkreft
    2020
  • Erik Knutsen, maria Perander, Steinar Daae Johansen, morten Andreassen :
    Study of functional RNA using high-throughput profiling technologies in a human cell model system
    2012
  • maria Perander, Trine Stiberg, Lene Elisabeth Myhren, Espen Hansen, ole morten Seternes, Lars Herfindal et al.:
    Characterization of cytotoxic activities in extracts from two marine invertebrates
    2011
  • Trine Stiberg, maria Perander, Jeanette hammer Andersen, Trond Ø. Jørgensen :
    Screening for compounds from Artic and sub_Artic marine invertebrates with anti-canser activities
    2009
  • Geir Bjørkøy, Trond Lamark, Serliy Pankiv, A Brech, heidi Outzen, maria Perander et al.:
    P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3
    2006
  • Geir Bjørkøy, Trond Lamark, Serliy Pankiv, A Brech, heidi Outzen, maria Perander et al.:
    P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3
    2006
  • Espen Åberg, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse et al.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4
    2006
  • Geir Bjørkøy, Trond Lamark, Serliy Pankiv, A Brech, heidi Outzen, maria Perander et al.:
    P62/SQSTM1: A direct link betwwen polyubiquitinated preotein aggregates and LC3
    2006

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    Research interests

    My research group is interested in long non-coding RNAs that have a potential role in breast cancer development and therapy. Currently, we have two on-going projects:

    1.       Identification and characterization of lncRNAs with regulatory functions in epithelial-mesenchymal transition (EMT)

    2.       Unravelling the function of Nuclear paraspeckle assembly transcript 1 (NEAT1) and paraspeckles in cellular stress responses and breast cancer

    We have performed whole-transcriptome RNA sequencing of 3 mammary EMT cell models (MCF10A, HMLE, and D492). Several EMT-associated lncRNAs have been identified that are abnormally expressed in breast cancer. We are conducting experimental assays to determine their cellular functions.

    NEAT1 is an abundant nuclear lncRNA that is conserved among mammals. The NEAT1 gene is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear ribonucleoprotein bodies called paraspeckles. Abnormal NEAT1 expression and paraspeckle formation are associated with human diseases such as neurodegenerative disorders and cancer. NEAT1 levels and paraspeckle formation are upregulated in response to cellular stress, and emerging evidence suggests that they play a cytoprotective role. In line with this, high NEAT1 levels are associated with therapy resistance in cancer.  We are currently studying the function of NEAT1 and paraspeckles in cellular stress response pathways such as the heat shock response and autophagy. We are also interested in the role of the NEAT1 isoforms in breast cancer.

     

    ORCID: https://orcid.org/0000-0002-1177-2407

    Member of research group

    RNA and molecular pathology research group (RAMP)   Norsk innhold

    Member of project

    Breast cancer-associated long non-coding RNA NEAT1 and paraspeckles in cellular stress responses Epithelial-mesenchymal transition (EMT) in mammary epithelial cells