Bilde av Småbrekke, Lars
Bilde av Småbrekke, Lars
Klinisk farmasi og farmakoepidemiologi, forskningsgruppe lars.smabrekke@uit.no +4777645792 +4799249663 You can find me here

Lars Småbrekke


Professor. Research group leader. Pharmacoepidemiology

Job description

I'm responsible for the courses Far-2101 and Far-3101, and contributes in teaching in several other courses on master & PhD level.


The research projects are mainly focused on consumption of antibiotics, antimicrobial resistance, and are based on data from population studies (e.g. The Tromsø studies & FitFutures), the Norwegian Prescription Database and clinical data from hospital practice.


  • Eirin Guldsten Robinson, Hanna Gyllensten, Jeanette Schultz Johansen, Kjerstin Havnes, Anne Gerd Granås, Trine Strand Bergmo et al.:
    A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
    Drugs & Aging 2023 ARKIV / DOI
  • Ann Helen Jakobsen, Lars Småbrekke, Timothy F. Chen, Kjell H. Halvorsen :
    Exploring stakeholders' perspectives on the quality of services provided through community pharmacies
    Research in Social and Administrative Pharmacy 2023 ARKIV / DOI
  • Trine Strand Bergmo, Vilde Sandsdalen, Unn Sollid Manskow, Lars Småbrekke, Marit Waaseth :
    Internet Use for Obtaining Medicine Information: Cross-sectional Survey
    JMIR Formative Research 2023 ARKIV / DOI
  • Niclas Peter Raffelsberger, Dorota Julia Buczek, Kristian Svendsen, Lars Småbrekke, Anna Kaarina Pöntinen, Iren Høyland Löhr et al.:
    Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates
    mSphere 2023 ARKIV / DOI
  • Jeanette Schultz Johansen, Kjell H. Halvorsen, Kristian Svendsen, Kjerstin Havnes, Eirin Guldsten Robinson, Hilde Ljones Wetting et al.:
    Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial
    BMC Health Services Research 2022 ARKIV / DOI
  • Mari Johannessen Walquist, Kristian Svendsen, Beate Hennie Garcia, Trine Strand Bergmo, Anne Elise Eggen, Kjell H. Halvorsen et al.:
    Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study
    BMC Public Health 2022 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population
    Epidemiology and Infection 2022 FULLTEKST / ARKIV / DOI
  • Dina Benedicte Berg Stensen, Rafael Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen et al.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    International Journal of Infectious Diseases 2022 ARKIV / FULLTEKST / DOI
  • Therese von Hanno, Live Lund Hareide, Lars Småbrekke, Bente Morseth, Monica Sneve, Maja Gran Erke et al.:
    Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study
    Investigative Ophthalmology and Visual Science 2022 ARKIV / DOI
  • Sigbjørn Svalestuen, Kristian Svendsen, Anne Elise Eggen, Lars Småbrekke :
    Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study
    BMJ Open 2022 ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen et al.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Sanna Beckstrøm, Kristian Svendsen, Lars Småbrekke :
    Antibacterial use by birth year and birth season in children 0-2 years in Norway
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    European Journal of Endocrinology (EJE) 2021 FULLTEKST / ARKIV / DOI
  • June Utnes Høgli, Beate Hennie Garcia, Kristian Svendsen, Vegard Skogen, Lars Småbrekke :
    Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study
    BMC Pulmonary Medicine 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
    BMC Endocrine Disorders 2020 ARKIV / DOI
  • Kirsten Midttun Gravningen, Nigel Field, Hege Salvesen Blix, Anne Mette Asfeldt, Lars Småbrekke :
    Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study
    PLOS ONE 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
    PLOS ONE 2019 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen et al.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population
    PLOS ONE 2019 ARKIV / FULLTEKST / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study
    Scientific Reports 2019 ARKIV / DOI
  • Cecilia S. Sambakunsi, Lars Småbrekke, Christine A. Varga, Vernon Solomon, John S. Mponda :
    Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi
    Malawi Medical Journal 2019 ARKIV / DOI
  • O D'Annibali, G Bonaldo, Monia Donati, Lars Småbrekke, Domenico Motola, A Vaccheri :
    Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database
    Journal of Antimicrobial Chemotherapy 01. August 2019 DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. November 2019 ARKIV / DOI
  • Pål Haugen, Gunnar Skov Simonsen, Raul Primicerio, Anne-Sofie Furberg, Lars Småbrekke :
    Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study.
    Pharmaceutical statistics 2018 ARKIV / DOI
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
    Journal of Crohn's and Colitis 2018 ARKIV / DOI
  • Bjørg Haldorsen, Christian G Giske, Dennis S Hansen, Kristjan Orri Helgason, Gunnar Kahlmeter, Iren Høyland Löhr et al.:
    Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
    Journal of Antimicrobial Chemotherapy 2018 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord et al.:
    Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
    Antimicrobial Agents and Chemotherapy 2018 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study
    PLOS ONE 2017 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database
    Pharmacoepidemiology and Drug Safety 2017 DOI
  • June Utnes Høgli, Beate Hennie Garcia, frode Skjold, Vegard Skogen, Lars Småbrekke :
    An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital
    BMC Infectious Diseases 2016 SAMMENDRAG / FULLTEKST / ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
    Pharmacoepidemiology and Drug Safety 2016 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Arnfinn Sundsfjord, Lars Småbrekke, Ørjan Samuelsen :
    The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011
    Infectious Diseases 2015 DOI
  • Mauro Melis, Chiara Biagi, Lars Småbrekke, Francesco Nonino, Elena Buccellato, Monia Donati et al.:
    Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database
    CNS Drugs 2015 DOI
  • Beate Hennie Garcia, Trude Giverhaug, June U. Høgli, Frode Skjold, Lars Småbrekke :
    A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado]
    Pharmacy Practice 2015 ARKIV / DOI
  • June Utnes Høgli, Lars Småbrekke, Beate Garcia :
    MAT-CAP: A novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia
    Pharmacoepidemiology and Drug Safety 2014 DOI
  • Beate Hennie Garcia, Sissel Lisa Storli, Lars Småbrekke :
    A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences
    BMC Research Notes 2014 ARKIV / DOI
  • Angela Lupattelli, Øystein Karlstad, Anders Engeland, Lars Småbrekke, Kristine Olsen, Aina Øvrebust et al.:
    The Norwegian Society for Pharmacoepidemiology
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Johanna Ericson Sollid, Gunnar Skov Simonsen et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general population in Norway
    2021
  • Dina Benedicte Berg Stensen, Rafael A. Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen et al.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    2021
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna Ericson Sollid et al.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    2021
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    Erratum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study (Journal of Crohn's and Colitis DOI: 10.1093/ecco-jcc/jjy008)
    Journal of Crohn's and Colitis 2019 DOI
  • Ann Helen Jakobsen, Kjell H. Halvorsen, Lars Småbrekke :
    Forslag til kvalitetsindikatorer for primærapotek
    2019
  • Lyn Middleton, F Lampiao, Tomas F. Zimba, SM Muzime, Gunnar Skov Simonsen, Lars Småbrekke et al.:
    Sharing Knowledge Transforming Societies. The Norhed Programme 2013-2020
    African Minds 2019
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    To the editor
    JAMA Internal Medicine 2018 DOI
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    Lower cancer incidence-warfarin effect or immortal time bias?
    JAMA Internal Medicine 2018 DOI
  • Martin Sørensen, Annette Kuehn, E.N. Clare Mills, Carol Ann Costello, Markus Ollert, Lars Småbrekke et al.:
    Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial
    Journal of Allergy and Clinical Immunology 2017 DOI
  • Dina Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen et al.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. The Tromsø Study Fit Futures 2.
    2017
  • Kristian Svendsen, Håvard Wahl Kongsgård, Pål Haugen, Lars Småbrekke :
    Does travel time to pharmacies and general physicians influence the use of antibiotics in Norway?
    2016
  • Tone Ruud Engen, Beate Hennie Garcia, Kjell H. Halvorsen, Marit Waaseth, Lars Småbrekke, Hilde Ljones Wetting :
    Er det trygt å velge billigere resept-medisiner?
    22. January 2015 DATA
  • Beate Hennie Garcia, Trude Giverhaug, J. Utnes, Lars Småbrekke :
    A follow-up program for patients with established coronary heart disease led by a clinical pharmacist: a randomized controlled trial
    International Journal of Clinical Pharmacology Research 2013
  • June Utnes Høgli, Lars Småbrekke, Beate Garcia :
    A medication assessment tool for community acquired pneumonia (MAT-CAP): design and validation
    International Journal of Clinical Pharmacology Research 2013

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