Bilde av How, Ole-Jakob
Bilde av How, Ole-Jakob
Professor Department of Medical Biology ole-jakob.how@uit.no +4777645450 98821821

Ole-Jakob How



  • Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen et al.:
    Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model
    Resuscitation Plus 2023 ARKIV / DOI
  • Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Ole-Jakob How :
    The β3 adrenergic receptor antagonist L-748,337 attenuates dobutamine-induced cardiac inefficiency while preserving inotropy in anesthetized pigs
    Journal of Cardiovascular Pharmacology and Therapeutics 23. September 2021 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs
    Physiological Reports 2020 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs
    Journal of Cardiovascular Pharmacology and Therapeutics 14. July 2020 ARKIV / DOI
  • Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Combined therapy with dobutamine and omecamtiv mecarbil in pigs with ischemic acute heart failure is attributed to the effect of dobutamine
    Journal of Cardiovascular Pharmacology and Therapeutics 2019 ARKIV / DOI
  • Leif Reidar Brenk Rønning, Jens Petter Bakkehaug, Lars Rødland, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure
    Physiological Reports 2018 ARKIV / DOI
  • Torvind Næsheim, Ole-Jakob How, Truls Myrmel :
    Propulsion of blood through the right heart circulatory system
    Scandinavian Cardiovascular Journal 2017 DOI
  • Jens Petter Bakkehaug, Torvind Næsheim, Erik Torgersen Engstad, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How :
    Reversing dobutamine-induced tachycardia using ivabradine increases stroke volume with neutral effect on cardiac energetics in left ventricular post-ischaemia dysfunction
    Acta Physiologica 2016 DOI
  • Anders Benjamin Kildal, Thor Allan Stenberg, Espen Sanden, Truls Myrmel, Ole-Jakob How :
    Prolonged observation time reveals temporal fluctuations in the sublingual microcirculation in pigs given arginine vasopressin
    Journal of applied physiology 2015 DOI
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    Circulation: Heart Failure 2015 DOI
  • Nils Thomas Songstad, David Johansen, Ole-Jakob How, Per Ivar Kaaresen, Kirsti Ytrehus, Ganesh Acharya :
    Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats
    PLOS ONE 2014 ARKIV / DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Espen Sanden, Ole-Jakob How, Martin Hagve, Kirsti Ytrehus et al.:
    The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations
    PLOS ONE 2014 ARKIV / DOI
  • Thor Allan Stenberg, Anders Benjamin Kildal, Ole-Jakob How, Truls Myrmel :
    Adrenomedullin-epinephrine cotreatment enhances cardiac output and left ventricular function by energetically neutral mechanisms
    American Journal of Physiology. Heart and Circulatory Physiology 15. April 2012 DOI
  • Ole Magnus Filseth, Ole-Jakob How, Timofey Kondratyev, Tor Magne Gamst, Georg Sager, Torkjel Tveita :
    Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo
    Critical Care Medicine 2012 DOI
  • Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert et al.:
    Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
    American Journal of Physiology. Heart and Circulatory Physiology 2012 DOI
  • Ganesh Acharya, James Huhta, Mervi Haapsamo, Ole-Jakob How, Tiina Erkinaro, J Räsänen :
    Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia
    Journal of Pregnancy 2011 ARKIV / DOI
  • Stig eggen Hermansen, Trine Kalstad, Ole-Jakob How, truls Myrmel :
    Inflammation and reduced endothelial function in the course of severe acute heart failure
    Translational Research: The Journal of Laboratory and Clinical Medicine 2011 ARKIV / DOI
  • Ole Magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita :
    Post-hypothermic cardiac left ventricular systolic dysfunction after rewarming in an intact pig model
    Critical Care 2010 FULLTEKST / DOI
  • Assami Rösner, Ole-Jakob How, Erling Johan Aarsæther, Thor Allan Stenberg, Thomas Vennø Andreasen, Timofei Kondratiev et al.:
    High Resolution Speckle Tracking Dobutamine Stress Echocardiography Reveals Heterogeneous Responses in Different Myocardial Layers: Implication for Viability Assessments
    Journal of the American Society of Echocardiography 2010 DOI
  • Ole-Jakob How, Assami Rösner, Anders Benjamin Kildal, Thor Allan Stenberg, Petter Fosse Gjessing, Stig Eggen Hermansen et al.:
    Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock
    Translational Research: The Journal of Laboratory and Clinical Medicine 2010 DOI
  • Stig Müller, Ole-Jakob How, Øyvind Jakobsen, Stig Eggen Hermansen, Assami Røsner, Thor Allan Stenberg et al.:
    Oxygen-Wasting Effect of Inotropy Is There a Need for a New Evaluation? An Experimental Large-Animal Study Using Dobutamine and Levosimendan
    Circulation: Heart Failure 2010 DOI
  • A Rösner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller et al.:
    Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate
    European Heart Journal-Cardiovascular Imaging 2009 DOI
  • Stig eggen Hermansen, truls Myrmel, Magna Hansen, Ole-Jakob How, Stig Müller, Marius Håke Roaldsen :
    How many acute heart failure patients need a ventricular assist device?
    Scandinavian Cardiovascular Journal 2008 DOI
  • Stig eggen Hermansen, Magna Hansen, Marius Håke Roaldsen, Stig Müller, Ole-Jakob How, truls Myrmel :
    Utilization and outcome of coronary revascularization and valve procedures in acute heart failure – an evaluation based on the classification from the European Society of Cardiology
    Interactive Cardiovascular and Thoracic Surgery 2008 DOI
  • Assami Røsner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller et al.:
    Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate
    European Heart Journal-Cardiovascular Imaging 2008
  • Leif Erik Vinge, Thomas Von Lueder, Ellen Aasum, Eirik Qvigstad, Jørgen A. Gravning, Ole-Jakob How et al.:
    Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth – GRK3 controls cardiac a1-adrenergic receptor responsiveness
    Journal of Biological Chemistry 2008 DOI
  • Ellen Aasum, Ahmed Murtaz Khalid, Oddrun Anita Gudbrandsen, Ole-Jakob How, Rolf Berge, Terje Larsen :
    Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    Journal of Molecular and Cellular Cardiology 2008 DOI
  • Stig Müller, Ole-Jakob How, Stig eggen Hermansen, Thor Allan Stenberg, Georg Sager, truls Myrmel :
    Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
    Critical Care 2008 DOI
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice
    American Journal of Physiology. Endocrinology and Metabolism 2007 DOI
  • Ole-Jakob How, Erling Sverre Nordøy :
    Seawater drinking restores water balance in dehydrated harp seals
    Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology 2007 DOI
  • Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, AJ Myrray et al.:
    Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice
    Archives of Physiology and Biochemistry 2007
  • Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, bent aksel nielsen et al.:
    Real Time Feedback of Chest Compressions by Hands-Free Carotid Doppler in a Porcine Model
    Circulation 2023
  • Sandra Núῆez-Egido, Samuel Jakob Geiseler, Lars P. Folkow, Ole-Jakob How :
    Mitochondria bioenergetics; diving vs non-diving mammals
    2022
  • Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen et al.:
    RescueDoppler: Non-invasive Handsfree Carotid Doppler Ultrasound For Continuous Hemodynamic-guided Resuscitation
    Circulation 2022 DOI
  • Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen et al.:
    Abstract 301: RescueDoppler: Non-invasive Handsfree Carotid Doppler Ultrasound For Continuous Hemodynamic-guided Resuscitation
    2020
  • Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning et al.:
    Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"
    Circulation: Heart Failure 2015 DOI
  • Ole-Jakob How, Torvind Næsheim, Jens Petter Bakkehaug, Timofey Kondratyev, Espen W. Remme, Truls Myrmel :
    Elevated preload is critical for synchronization of myocardial lengthening (e) and mitral inflow (E) in acute ischemic acute heart failure
    The FASEB Journal 2013
  • Nils Thomas Songstad, David Johansen, Ole-Jakob How, Kirsti Ytrehus, Ganesh Acharya :
    Effect of chronic pressure load on heart structure and function in pregnant rats
    2012
  • James Huhta, Juha Rasanen, Mervi Haapsamo, Tiina Erkinaro, Ganesh Acharya, Ole-Jakob How :
    Effect of angiotensin II on the left ventricular function in fetal sheep with metabolic acidemia
    American Journal of Obstetrics and Gynecology 2011
  • Ole magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita :
    CARDIAC FUNCTION DURING SEVERE IMMERSION HYPOTHERMIA AND REWARMING IN PIGS
    Intensive Care Medicine 2010
  • OM Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Georg Sager, Torkjel Tveita :
    DOPAMINE INFUSIONS IN NORMOTHERMIA, SEVERE HYPOTHERMIA AND DURING REWARMING: PHARMACOKINETICS AND CARDIOVASCULAR FUNCTION IN A PIG MODEL OF SURFACE COOLING AND REWARMING
    Intensive Care Medicine 2010
  • Stig eggen Hermansen, T Næsheim, Ole-Jakob How, truls Myrmel :
    Circulatory assistance in acute heart failure - where do we go from here?
    Scandinavian Cardiovascular Journal 2009 DOI
  • Ole-Jakob How, Ellen Aasum, Terje Larsen :
    Work-independent assessment of efficiency in ex vivo working rodent hearts within the PVA-MVO2 framework
    Acta Physiologica 2007 DOI
  • J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum et al.:
    Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload
    European Heart Journal 2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum :
    In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function
    Journal of Molecular and Cellular Cardiology 2007 DOI
  • Stig Müller, O Jakobsen, Ole-Jakob How, truls Myrmel :
    Levosimendan improves mechanical efficiency in stunned pig hearts
    European Journal of Heart Failure 2007
  • J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum et al.:
    Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload
    2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum :
    Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice
    2007
  • Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum :
    In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function
    2007
  • Ellen Aasum, Anne Dragøy Hafstad, Ole-Jakob How, Ahmed Murtaz Khalid, Terje Larsen :
    Improved cardiac metabolism enhances cardiac efficiency and ischemic tolerance in type 2 diabetes
    Circulation 2006

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    Research interests

    Patophsyiology with special intrest in hemodynamics, cardiac function, cardiac energetics, metabolism and new treatment strategies for acute heart failure

    Teaching

    Human physiology at all levels. Special intrest in cardiovascular and renal physiology


    Member of research group



    CV

    OLE-JAKOB HOW
    Born: 10.05.1973, male, Norwegian, married with two children born 2008 and 2010
     
    EDUCATION
    2006                PhD: 22.06.2006. Medical Faculty, Department of Medical Biology, University of Tromsø, Norway. Title; Oxygen wastage in the diabetic heart
    2000                Master in zoophysiology, Medical Faculty, Department of Arctic Biology, University of Tromsø, Norway. Title; "Gjenopprettelse av homeostase ved sjøvannsdrikking hos dehydrert grønlandssel (Phoca groenlandica)"
     
    CURRENT AND PREVIOUS POSITIONS
    2023 -             Professor (20%) in Zoology at Faculty of Biosciences and Aquaculture, Nord University, Norway
    2015-              Professor in Medical Biology at Cardiovascular Research Group, Faculty of Health Sciences, UiT, Norway
    2012-2021      20% Advisor at University of Oslo, UIO in relation to the National PhD school, NORHEART
    2010- 2015     Associate professor at Cardiovascular Research Group, Faculty of Health Sciences, UiT, Norway.  ½ time teaching at Med School and ½ time research
    2007-2010      Postdoctoral fellowship at the Laboratory for Surgical Research, Faculty of Medicine, University of Tromsø and Department of cardiothoracic and vascular surgery, University Hospital Northern Norway.
    2003-2006      PhD fellowship at Department of Medical Physiology, Faculty of Medicine, University of Tromsø. Part time (25%) lecturer in physiology at Faculty of Medicine, University of Tromsø, Norway.
    2002-2003      Student counsellor at the office for student service, Faculty of Medicine, University of Tromsø, Norway.
    2000-2003      Teacher in biology and natural science at a private high school (Norsk Privatgymnas) in Tromsø, Norway. External examiner in biology and natural science at Kongsbakken Public High School, Tromsø, Norway.
     
    MOBILITY
    2018-2019      Visiting fellow (14 months) at ACBD, The Alfred Hospital, (Head C. Hagemeyer) and at Dept of Physiology (Head R. Evans), Monash University, Melbourne, Australia.
    2009                Research fellow (10 months) at Copenhagen Muscle Research Centre (Head; Professor Bengt Saltin) University of Copenhagen, Denmark
    2005                Research fellow (3 months) at the Hatter Institute of Cardiovascular Research (Head: Professor Lionel Opie), University of Cape Town, Cape Town, South Africa (Mitochondrial respiration in diabetic hearts)
    2003                Research fellow (1 month) in Department of Pharmacology and Therapeutics (Head: Professor David L. Severson), University of Calgary, Calgary, Canada. (Pressure volume measurements in isolated mice hearts)
     
    LEADERSHIP AND BOARD MEMBERSHIPS
    2021-              Elected scientific member of the faculty board, Faculty of Health Sciences, UiT, The Arctic University of Norway
    2021-              Elected deputy scientific member of the University board, UiT, The Arctic University of Norway
    2012-              Regional manager North at the Norwegian PhD school for Heart Research (NORHEART)
    2016-2017      Group leader (substitute) at Cardiovascular Research Group, Department of Medical Biology, UiT, Tromsø.
    2014-2015      Leader (substitute) of the Physiology teaching unit at Department of Medical Biology, UiT, Tromsø
    2017 - 2021    Position of trust at The Norwegian Association of Researchers (Forskerforbundet).
    2020 -             Scientific council member at Department of Medical Biology, UiT, Tromsø
    2014-              Course leader for national PhD course Mechanical and metabolic function of the Heart. NORHEART/UIT
    2020-              Course leader Human Physiology (M.Sc.), at Department of Medical Biology, UiT, Tromsø
    1997-2000      Student representative at: 1) University board at UNIS, Svalbard, 2) Medical Faculty Board (Fagområdet medisin) UiT, Tromsø and 3) Department of Medical Biology, UiT, Tromsø
     
    SUPERVISION (main in bold fonts)
    2007-2022      6 PhD,  J. P Bakkehaug, A. B Kildal, T Næsheim, S Muller  and I Andersen,.  5 Master A Kildal, E Sanden, T Stenberg and E ,Engstad and L Rødland and K. Jansen
    2016 -             Currently 2 PhD L Rønning, and L Rødland. All candidates; Faculty of Health Sciences, UiT, The Arctic University of Norway
     
    FELLOWSHIPS AND AWARDS
    2009                Best Poster Presentation at 7th Annual CHFR Symposium, Centre for Heart Failure Research, Oslo, Norway 2009.
    2004                Poster prize: Signal transduction in the Cardiovascular System, The Physiological Society, Warsaw, Poland.
    2004                Young investigator stipend: 24th annual meeting in the International Society of Heart Research, European section, Dresden, Germany
     
    GRANTS
    Only achieved grants where OJ How is principal investigator are listed;
    2010- Norwegian Council for Heart Research; PhD scholarship Jens P Bakkehaug Approx. 3 000 000 NOK
    2011- Norwegian Council for Heart Research; operating grant-100 000 NOK.
    2011- Uit, Arctic University of Norway; Short-term scholarship N. Boardmann. 300 000 NOK
    2012- Lærdal Foundation for Acute Medicine; operating grant; 250 000 NOK.
    2012- Blix Foundation for Medical Research; operating grant; 35 000 NOK.
    2012- Norwegian Council for Heart Research; operating grant-100 000 NOK.
    2012- Health Authorities of Northern Norway; two year PhD scholarship Anders B Kildal - 2 000 000 NOK
    2013- Norwegian Council for Heart Research; operating grant-150 000 NOK
    2013- Health Authorities of Northern Norway; operating grant – 1 700 000 NOK
    2014- Health Authorities of Northern Norway; one year PhD scholarship Anders B Kildal – 1 000 000 NOK
    2017- Health Authorities of Northern Norway; Incubator support Cardiovascular PET, operating grant 3 000 000 NOK
    2018- Health Authorities of Northern Norway; Novel inotrope support for AHF, operating grant 500 000 NOK
    2021 - UiT AKM- operating grant 1 300 000 NOK
    TRACK RECORD
    36 authorships of international peer review papers, of which 6 as first-, 10 as last- and 11 as corresponding- author. Thirty as original manuscripts including preclinical and/or clinical data. Four as literature review or expert opinions.  
    Pubmed link.
    https://www.ncbi.nlm.nih.gov/pubmed?term=How+OJ%5Bauthor%5D&cmd=detailssearch